ES2044901T3 - Procedimiento para la preparacion de un derivado de imidazol y su utilizacion. - Google Patents

Procedimiento para la preparacion de un derivado de imidazol y su utilizacion.

Info

Publication number
ES2044901T3
ES2044901T3 ES87117820T ES87117820T ES2044901T3 ES 2044901 T3 ES2044901 T3 ES 2044901T3 ES 87117820 T ES87117820 T ES 87117820T ES 87117820 T ES87117820 T ES 87117820T ES 2044901 T3 ES2044901 T3 ES 2044901T3
Authority
ES
Spain
Prior art keywords
group
derivative
preparation
pyridile
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87117820T
Other languages
English (en)
Inventor
Yasushi Honma
Hajime Tamaki
Tetsuo Magaribuchi
Mine Takido
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tanabe Pharma Corp
Original Assignee
Tanabe Seiyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co Ltd filed Critical Tanabe Seiyaku Co Ltd
Application granted granted Critical
Publication of ES2044901T3 publication Critical patent/ES2044901T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE DESCRIBEN NUEVOS IMIDAZOLES DE LA FORMULA (I) DONDE EL ANILLO A ES UN GRUPO PIRIDILO O UN GRUPO PIRIDILO SUSTITUIDO; EL ANILLO B ES UN GRUPO FENILO O UN GRUPO FENILO SUSTITUIDO; R1 Y R2 SON ATOMOS DE HIDROGENO O ESTAN COMBINADOS JUNTOS PARA FORMAR UN GRUPO DE LA FORMULA (CH2)Q; M ES 1 O 2; N ES 0, 1 O 2; Y Q ES 3 O 4, O UNA SAL DEL MISMO. DICHO DERIVADO (I) Y LA SAL DEL MISMO SON UTILES COMO AGENTES ANTIULCERA. TAMBIEN SE EXPLICA UN PROCESO DE PREPARACION DE DICHOS DERIVADOS, JUNTO CON PRODUCTOS INTERMEDIOS QUIMICOS FORMADOS DURANTE DICHO PROCESO. TAMBIEN SE PROPORCIONAN COMPOSICIONES FARMACEUTICAS QUE LO CONTIENEN. ADEMAS SE EXPLICA EL USO DE DICHOS COMPUESTOS PARA LA FABRICACION DE MEDICAMENTOS CON VALOR TERAPEUTICO.
ES87117820T 1986-12-02 1987-12-02 Procedimiento para la preparacion de un derivado de imidazol y su utilizacion. Expired - Lifetime ES2044901T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP28751286 1986-12-02
JP8047587 1987-03-31
JP21581387 1987-08-28

Publications (1)

Publication Number Publication Date
ES2044901T3 true ES2044901T3 (es) 1994-01-16

Family

ID=27303307

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87117820T Expired - Lifetime ES2044901T3 (es) 1986-12-02 1987-12-02 Procedimiento para la preparacion de un derivado de imidazol y su utilizacion.

Country Status (15)

Country Link
US (3) US5002945A (es)
EP (1) EP0270091B1 (es)
JP (1) JPH064623B2 (es)
KR (1) KR930004843B1 (es)
CN (1) CN1020902C (es)
AU (1) AU597446B2 (es)
DE (1) DE3782621T2 (es)
DK (1) DK631587A (es)
ES (1) ES2044901T3 (es)
FI (1) FI91754C (es)
FR (1) FR2607502B1 (es)
GR (1) GR3006257T3 (es)
HU (2) HU201751B (es)
IL (1) IL84554A (es)
TW (1) TW203048B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4634711A (en) * 1985-08-02 1987-01-06 Smithkline Beckman Corporation Pyridylalkyl imidazole-2-thiols
JP2614756B2 (ja) * 1988-08-10 1997-05-28 日本ケミファ株式会社 イミダゾール誘導体およびその製造法ならびにこれを含有する抗潰瘍剤
MY106533A (en) * 1990-02-20 1995-06-30 Sumitomo Chemical Co A 4-tert.-butyl imidazole derivative and its production and use.
SE9002043D0 (sv) * 1990-06-07 1990-06-07 Astra Ab Improved method for synthesis
CA2036148A1 (en) * 1990-06-29 1991-12-30 Hiroki Tomioka A 1-phenylimidazole derivative and its production and use
MY110439A (en) * 1991-02-07 1998-05-30 Ishihara Sangyo Kaisha N-phenylcarbamate compound, process for preparing the same and biocidal composition for control of harmful organisms
US5252590A (en) * 1991-06-28 1993-10-12 Sumitomo Chemical Company, Limited 1-pyridylimidazole derivative
US5635521A (en) * 1991-09-23 1997-06-03 Sandoz Ltd. Imidazolylmethyl-pyridines
DE19541146A1 (de) * 1995-10-25 1997-04-30 Schering Ag Imidazolderivate und deren Verwendung als Stickstoffmonoxid-Synthase-Inhibitoren
EP1682133A1 (en) 2003-11-03 2006-07-26 AstraZeneca AB Imidazo 1,2-a pyridine derivatives for the treatment of silent gastro-esophageal reflux
EP2261218B1 (en) * 2004-05-26 2013-04-03 Eisai R&D Management Co., Ltd. Imidazole compound for use as an intermediate in the production of cinnamide compounds
JPWO2006038738A1 (ja) * 2004-10-08 2008-05-15 武田薬品工業株式会社 受容体機能調節剤
TWI370130B (en) 2005-11-24 2012-08-11 Eisai R&D Man Co Ltd Two cyclic cinnamide compound
TW200848054A (en) 2007-02-28 2008-12-16 Eisai R&D Man Co Ltd Two cyclic oxomorpholine derivatives
AR068121A1 (es) 2007-08-31 2009-11-04 Eisai R&D Man Co Ltd Compuestos multiciclicos para tratar enfermedades neurodegenerativas

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1234058A (es) * 1968-10-21 1971-06-03
IN148930B (es) * 1977-09-19 1981-07-25 Hoffmann La Roche
DE2963572D1 (en) * 1978-04-11 1982-10-21 Ciba Geigy Ag Mercapto-imidazole derivatives, their preparation, mercapto-imidazole derivatives for the treatment of inflammatory diseases and their pharmaceutical compositions
SE7804231L (sv) * 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
US4492708A (en) * 1982-09-27 1985-01-08 Eli Lilly And Company Antiviral benzimidazoles
DE3369845D1 (en) * 1982-12-20 1987-04-02 Merck & Co Inc 5-(amino or substituted amino) imidazoles
GB8307865D0 (en) * 1983-03-22 1983-04-27 Fujisawa Pharmaceutical Co Benzimidazole derivatives
FI833794A0 (fi) * 1983-10-18 1983-10-18 Farmos Oy Substituerade 2-merkapto-imidazoler
GB8417171D0 (en) * 1984-07-05 1984-08-08 Beecham Group Plc Compounds
CA1341314C (en) * 1984-07-06 2001-11-06 David Cox Derivatives of benzimidazole, benzothiazole and benzoxazole
AU568441B2 (en) * 1984-09-24 1987-12-24 Upjohn Company, The 2-(pyridylalkenesulfinyl) benzimidazole derivatives
US4600430A (en) * 1985-02-22 1986-07-15 Eli Lilly And Company Pyridinylimidazolidinone compounds
US4634711A (en) * 1985-08-02 1987-01-06 Smithkline Beckman Corporation Pyridylalkyl imidazole-2-thiols
US4591377A (en) * 1985-09-10 1986-05-27 Stauffer Chemical Company Herbicidal esters of 2-bromo-4-methylimidazole-5-carboxylic acid
IL82401A0 (en) * 1986-05-06 1987-11-30 Merrell Dow Pharma Dopamine beta hydroxy-lase inhibiting imidazole derivatives and pharmaceutical compositions containing them
JPH0674273B2 (ja) * 1986-06-19 1994-09-21 日産化学工業株式会社 イミダゾ−ルスルホンアミド誘導体、製法および除草剤

Also Published As

Publication number Publication date
AU8181287A (en) 1988-06-02
AU597446B2 (en) 1990-05-31
DK631587D0 (da) 1987-12-01
JPH064623B2 (ja) 1994-01-19
IL84554A (en) 1992-03-29
EP0270091A1 (en) 1988-06-08
FI91754B (fi) 1994-04-29
FR2607502B1 (fr) 1990-01-19
HUT49128A (en) 1989-08-28
FI875102L (fi) 1988-06-03
KR930004843B1 (ko) 1993-06-09
TW203048B (es) 1993-04-01
HU201751B (en) 1990-12-28
US4996217A (en) 1991-02-26
GR3006257T3 (es) 1993-06-21
IL84554A0 (en) 1988-04-29
FR2607502A1 (fr) 1988-06-03
FI91754C (fi) 1994-08-10
EP0270091B1 (en) 1992-11-11
DE3782621D1 (de) 1992-12-17
DE3782621T2 (de) 1993-04-22
US5002945A (en) 1991-03-26
HU204812B (en) 1992-02-28
US5053417A (en) 1991-10-01
HU905023D0 (en) 1991-01-28
CN1020902C (zh) 1993-05-26
DK631587A (da) 1988-06-03
KR880007477A (ko) 1988-08-27
FI875102A0 (fi) 1987-11-18
JPH01131175A (ja) 1989-05-24
CN87108111A (zh) 1988-09-28

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