ES2047149T3 - Procedimiento para la obtencion de compuestos complejos. - Google Patents

Procedimiento para la obtencion de compuestos complejos.

Info

Publication number
ES2047149T3
ES2047149T3 ES89810018T ES89810018T ES2047149T3 ES 2047149 T3 ES2047149 T3 ES 2047149T3 ES 89810018 T ES89810018 T ES 89810018T ES 89810018 T ES89810018 T ES 89810018T ES 2047149 T3 ES2047149 T3 ES 2047149T3
Authority
ES
Spain
Prior art keywords
procedure
beta
complex compounds
metal ion
dicarbonyl compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89810018T
Other languages
English (en)
Inventor
Heinrich H Dr Peter
Theophile Moerker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Application granted granted Critical
Publication of ES2047149T3 publication Critical patent/ES2047149T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/02—Iron compounds
    • C07F15/025—Iron compounds without a metal-carbon linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F19/00—Metal compounds according to more than one of main groups C07F1/00 - C07F17/00
    • C07F19/005—Metal compounds according to more than one of main groups C07F1/00 - C07F17/00 without metal-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

SE DESCRIBE UN PROCESO PARA LA OBTENCION DE COMPLEJOS DE CHELATO QUE PUEDEN UTILIZARSE EN LA MEDICINA DIAGNOSTICA, POR EJEMPLO COMO MEDIO DE CONTRASTE O RADIOTERAPEUTICO. EN ESTE PROCESO SE RECOMPLEJIZA UN COMPLEJO DE UN COMPUESTO DE (BETA) - DICARBONILO Y UN ION METALICO, POR EJEMPLO UN METAL - ACETIL - ACETONATO, EL CUAL SE PUEDE DILUIR BNIEN EN UNA SOLUCION ORGANICA MEZCLABLE CON AGUA, CON UNA CANTIDAD ESTEQUIOMETRICA O UN DEFICIT DE UN CHELATIFICADOR, CUYA AFINIDAD DE ENLACE AL ION METALICO SEA MAS ALTA DE LA DEL COMPUESTO DE (BETA) DICARBONILO.
ES89810018T 1988-01-20 1989-01-11 Procedimiento para la obtencion de compuestos complejos. Expired - Lifetime ES2047149T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH18488 1988-01-20

Publications (1)

Publication Number Publication Date
ES2047149T3 true ES2047149T3 (es) 1994-02-16

Family

ID=4181183

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89810018T Expired - Lifetime ES2047149T3 (es) 1988-01-20 1989-01-11 Procedimiento para la obtencion de compuestos complejos.

Country Status (10)

Country Link
US (1) US5051523A (es)
EP (1) EP0325559B1 (es)
JP (1) JP2633944B2 (es)
AT (1) ATE98631T1 (es)
CA (1) CA1329208C (es)
DE (1) DE58906384D1 (es)
DK (1) DK170048B1 (es)
ES (1) ES2047149T3 (es)
IE (1) IE62816B1 (es)
PT (1) PT89476B (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX12394A (es) * 1987-07-23 1993-12-01 Ciba Geigy Ag Procedimiento par la obtencion de carbamatos de polietilenglicol.
IL91047A (en) * 1989-07-19 1993-06-10 Yissum Res Dev Co Zinc complexes for the treatment of free radical- induced diseases
AU7346091A (en) * 1990-03-02 1991-09-18 Byk Gulden Lomberg Chemische Fabrik Gmbh Preparations for mr diagnosis
US5196412A (en) * 1991-03-06 1993-03-23 Johnson Matthey, Inc. Gallium compounds
WO1993003045A1 (en) * 1991-08-09 1993-02-18 The Regents Of The University Of California Process for purer organic metal ion chelate complexes
IL106064A (en) * 1993-06-18 1997-11-20 Yissum Res Dev Co Gallium complexes for the treatment of free radical-induced diseases
PT768302E (pt) * 1995-09-29 2005-11-30 Novartis Ag Novas hidroxipiridinonas
US5886173A (en) * 1997-07-30 1999-03-23 Pharmacyclics, Inc. Metallation of macrocycles with 2,4-dicarbonyl-metal complexes
US6083966A (en) 1998-08-31 2000-07-04 University Of Florida Thiazoline acid derivatives
US7112671B2 (en) * 2000-08-30 2006-09-26 Pharmacyclics, Inc. Non-symmetric tripyrranes in the synthesis of novel macrocycles
WO2005034949A1 (en) 2003-09-09 2005-04-21 University Of Florida Desferrithiocin derivatives and their use as iron chelators
PL1866296T3 (pl) 2005-04-04 2017-05-31 University Of Florida Research Foundation, Inc. Polieterowe analogi desferritiocyny
US20100098640A1 (en) * 2005-06-20 2010-04-22 Cohen Seth M Multidentate Pyrone-Derived Chelators for Medicinal Imaging and Chelation
CA2684837A1 (en) * 2006-12-12 2008-10-30 Raymond J. Bergeron, Jr. Desferrithiocin analogue actinide decorporation agents
DE102007008655A1 (de) 2007-02-20 2008-08-21 Henkel Ag & Co. Kgaa Siderophor-Metall-Komplexe als Bleichkatalysatoren
US8324397B2 (en) 2007-03-15 2012-12-04 University Of Florida Research Foundation, Inc. Desferrithiocin polyether analogues
EP2697352A1 (en) 2011-04-12 2014-02-19 The Procter and Gamble Company Metal bleach catalysts
US20140343110A1 (en) 2011-12-16 2014-11-20 University Of Florida Research Foundation, Inc. Uses of 4'-desferrithiocin analogs
AU2014352780A1 (en) 2013-11-22 2016-06-09 University Of Florida Research Foundation, Inc. Desferrithiocin analogs and uses thereof
CA2971824A1 (en) 2014-12-22 2016-06-30 Mordechai Chevion New metal complexes of nocardamine and their use in pharmaceutical compositions
WO2016176343A1 (en) 2015-04-27 2016-11-03 University Of Florida Research Foundation, Incorporated Metabolically programmed metal chelators and uses thereof
JP7033545B2 (ja) * 2016-03-31 2022-03-10 シールド ティーエックス （ユーケー） リミテッド 配位子修飾及び配位子コーティングされた水酸化第二鉄からマルトール第二鉄組成物を生成するための方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3634407A (en) * 1969-06-19 1972-01-11 Ciba Geigy Corp Heavy metal complexes of trihydroxamic acids
DE3170401D1 (en) * 1980-07-28 1985-06-13 Ciba Geigy Ag Triazoline derivatives and processes for their preparation
JPS59199636A (ja) * 1983-04-26 1984-11-12 Nippon Mejifuijitsukusu Kk 放射性診断剤
US4707352A (en) * 1984-01-30 1987-11-17 Enzo Biochem, Inc. Method of radioactively labeling diagnostic and therapeutic agents containing a chelating group
GB8410289D0 (en) * 1984-04-19 1984-05-31 Callingham B A Pharmaceutical compositions
GB8413772D0 (en) * 1984-05-30 1984-07-04 Nyegaard & Co As Chemical compounds
US4687658A (en) * 1984-10-04 1987-08-18 Salutar, Inc. Metal chelates of diethylenetriaminepentaacetic acid partial esters for NMR imaging
US4758422A (en) * 1985-01-04 1988-07-19 Salutar Inc. Ferrioxamine paramagnetic contrast agents for MR imaging
US4637929A (en) * 1985-01-04 1987-01-20 Salutar, Inc. Ferrioxamine-paramagnetic contrast agents for MR imaging, composition, apparatus and use
DE3772785D1 (de) * 1986-01-23 1991-10-17 Squibb & Sons Inc 1-substituiertes-4,7,10-triscarboxymethyl-1,4,7,10-tetraazacyclododecan und analoga.

Also Published As

Publication number Publication date
DK170048B1 (da) 1995-05-08
DE58906384D1 (de) 1994-01-27
IE62816B1 (en) 1995-03-08
PT89476B (pt) 1993-12-31
PT89476A (pt) 1990-02-08
EP0325559A2 (de) 1989-07-26
EP0325559B1 (de) 1993-12-15
DK22589D0 (da) 1989-01-19
IE890160L (en) 1989-07-20
EP0325559A3 (en) 1990-11-22
DK22589A (da) 1989-07-21
CA1329208C (en) 1994-05-03
JP2633944B2 (ja) 1997-07-23
ATE98631T1 (de) 1994-01-15
US5051523A (en) 1991-09-24
JPH0276827A (ja) 1990-03-16

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