ES2049254T3 - Aparato y procedimiento para la dilucion y mezcla de muestras liquidas. - Google Patents

Aparato y procedimiento para la dilucion y mezcla de muestras liquidas.

Info

Publication number
ES2049254T3
ES2049254T3 ES88307946T ES88307946T ES2049254T3 ES 2049254 T3 ES2049254 T3 ES 2049254T3 ES 88307946 T ES88307946 T ES 88307946T ES 88307946 T ES88307946 T ES 88307946T ES 2049254 T3 ES2049254 T3 ES 2049254T3
Authority
ES
Spain
Prior art keywords
chamber
sample
mixing
application
relation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88307946T
Other languages
English (en)
Inventor
Ian Gibbons
Robert S Hillman
Channing R Robertson
Michael M Gorin
Michael E Cobb
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biotrack Inc
Original Assignee
Biotrack Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/090,026 external-priority patent/US4868129A/en
Priority claimed from US07/117,791 external-priority patent/US5077017A/en
Application filed by Biotrack Inc filed Critical Biotrack Inc
Application granted granted Critical
Publication of ES2049254T3 publication Critical patent/ES2049254T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/38—Diluting, dispersing or mixing samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/45—Magnetic mixers; Mixers with magnetically driven stirrers
    • B01F33/452—Magnetic mixers; Mixers with magnetically driven stirrers using independent floating stirring elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/80—Forming a predetermined ratio of the substances to be mixed
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/02—Food
    • G01N33/04—Dairy products

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Health & Medical Sciences (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Accessories For Mixers (AREA)

Abstract

APARATO PARA DILUIR UNA MUESTRA CON UN DILUYENTE, QUE CONSTA DE UNA CAMARA MEDIDORA DE VOLUMEN FIJO, UNA CAMARA RECEPTORA DE VOLUMEN FIJO EN COMUNICACION CON LA ANTERIOR, UN ORIFICIO DE AIREACION DE GAS EN LA CAMARA DE RECEPCION, UNA CONEXION DE DETENCION DEL FLUJO ENTRE LA CAMARA MEDIDORA Y LA RECEPTORA, UN PUNTO DE APLICACION DE LA MUESTRA EN RELACION CON LA CAMARA DE MEDICION, SIENDO LA DIFERENCIA DE ALTURA ENTRE EL LUGAR DE APLICACION DE LA MUESTRA Y LA CONEXION INSUFICIENTE PARA QUE APAREZCA UNA PRESION HIDROSTATICA CAPAZ DE SUPERAR LA CONTRAPRESION EN LA CONEXION CUANDO LA MUESTRA SE APLICA, ASI COMO EL DILUYENTE EN RELACION CON LA CAMARA DE MEDICION. LA MUESTRA Y EL DISOLVENTE SE AÑADEN SECUENCIALMENTE AL APARATO PARA CONSEGUIR LA DISOLUCION SIN NECESIDAD DE OTRAS OPERACIONES. EN UN SEGUNDO DISEÑO, UN CARTUCHO DE DILUCION Y MEZCLA CONSTA DE UN PUNTO DE APLICACION DE LA MUESTRA, UNA CAMARA MEZCLADORA EN RELACION CON EL ANTERIOR, UN PUNTO DE APLICACION DEL DISOLVENTE EN RELACION CONLA CAMARA DE MEZCLA, UNA CAMARA DE AISLAMIENTO DE LA MEZCLA CONECTADA HIDROSTATICAMENTE A LA DE MEZCLADO, UNA PRIMERA VALVULA QUE IMPIDE DE FORMA SELECTIVA LA CIRCULACION DESDE EL PUNTO DE APLICACION DE DISOLVENTE A LA CAMARA DE MEZCLADO Y UNA CAMARA DE AISLANTE DE LA MEZCLA CONECTADA HIDROSTATICAMENTE A LA CAMARA DE MEZCLA. EL INVENTO INCLUYE IGUALMENTE UN METODO PARA UTILIZAR ESTE CARTUCHO PARA DILUIR SECUENCIALMENTE UNA MUESTRA CON UNO O VARIOS DILUYENTES.
ES88307946T 1987-08-27 1988-08-26 Aparato y procedimiento para la dilucion y mezcla de muestras liquidas. Expired - Lifetime ES2049254T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/090,026 US4868129A (en) 1987-08-27 1987-08-27 Apparatus and method for dilution and mixing of liquid samples
US07/117,791 US5077017A (en) 1987-11-05 1987-11-05 Integrated serial dilution and mixing cartridge

Publications (1)

Publication Number Publication Date
ES2049254T3 true ES2049254T3 (es) 1994-04-16

Family

ID=26781444

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88307946T Expired - Lifetime ES2049254T3 (es) 1987-08-27 1988-08-26 Aparato y procedimiento para la dilucion y mezcla de muestras liquidas.

Country Status (6)

Country Link
EP (1) EP0305210B1 (es)
JP (1) JPH0756492B2 (es)
AU (1) AU615208B2 (es)
CA (1) CA1333850C (es)
DE (1) DE3886140T2 (es)
ES (1) ES2049254T3 (es)

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US5104813A (en) * 1989-04-13 1992-04-14 Biotrack, Inc. Dilution and mixing cartridge
US5225163A (en) * 1989-08-18 1993-07-06 Angenics, Inc. Reaction apparatus employing gravitational flow
WO1991002589A1 (en) * 1989-08-18 1991-03-07 Cambridge Bioscience Corporation Reaction apparatus and method employing gravitational flow
US5230866A (en) * 1991-03-01 1993-07-27 Biotrack, Inc. Capillary stop-flow junction having improved stability against accidental fluid flow
EP0501796A3 (en) * 1991-03-01 1993-10-06 Biotrack, Inc. Capillary stop-flow junction having improved stability against accidental fluid flow
US6143247A (en) 1996-12-20 2000-11-07 Gamera Bioscience Inc. Affinity binding-based system for detecting particulates in a fluid
EP1577010A3 (en) * 1995-12-05 2005-11-16 Tecan Trading AG Microsystem platform and its use
ATE291225T1 (de) * 1995-12-05 2005-04-15 Gamera Bioscience Corp Vorrichtung und verfahren zum bewegen von fluiden mittels zentrifugalbeschleunigung bei der automatischen laborbehandlung
US6709869B2 (en) 1995-12-18 2004-03-23 Tecan Trading Ag Devices and methods for using centripetal acceleration to drive fluid movement in a microfluidics system
US6143248A (en) * 1996-08-12 2000-11-07 Gamera Bioscience Corp. Capillary microvalve
EP0983504A2 (en) 1997-05-23 2000-03-08 Gamera Bioscience Corporation Devices and methods for using centripetal acceleration to drive fluid movement in a microfluidics system
US6632399B1 (en) 1998-05-22 2003-10-14 Tecan Trading Ag Devices and methods for using centripetal acceleration to drive fluid movement in a microfluidics system for performing biological fluid assays
WO1999009394A1 (en) 1997-08-15 1999-02-25 Alexion Pharmaceuticals, Inc. Apparatus for performing assays at reaction sites
SE9803734D0 (sv) * 1998-10-30 1998-10-30 Amersham Pharm Biotech Ab Liquid handling system
US6193471B1 (en) * 1999-06-30 2001-02-27 Perseptive Biosystems, Inc. Pneumatic control of formation and transport of small volume liquid samples
EP1234053B1 (en) * 1999-11-15 2007-04-18 I-Stat Corporation Apparatus and method for assaying coagulation in fluid samples
DE10057895B4 (de) * 2000-11-22 2009-06-18 peS Gesellschaft für medizinische Diagnosesysteme mbH Vorrichtung und Verfahren zur Probenvorbereitung flüssiger Proben
US7429354B2 (en) 2001-03-19 2008-09-30 Gyros Patent Ab Structural units that define fluidic functions
ATE492342T1 (de) 2001-08-28 2011-01-15 Gyros Patent Ab Mikrokammern und mikrofluidische strukturen zur handhabung kleiner flüssigkeitsmengen
EP1483052B1 (en) 2001-08-28 2010-12-22 Gyros Patent Ab Retaining microfluidic microcavity and other microfluidic structures
US6919058B2 (en) 2001-08-28 2005-07-19 Gyros Ab Retaining microfluidic microcavity and other microfluidic structures
CA2468041A1 (en) 2001-11-20 2003-05-30 Burstein Technologies, Inc. Optical bio-discs and microfluidic devices for analysis of cells
AU2003215340A1 (en) * 2002-02-22 2003-09-09 Nanostream, Inc. Ratiometric dilution devices and methods
JP4210783B2 (ja) 2002-09-26 2009-01-21 アークレイ株式会社 分析用具
DE102004022423A1 (de) * 2004-05-06 2005-12-15 Siemens Ag Mikrofluidiksystem
JP2007003414A (ja) * 2005-06-24 2007-01-11 Arkray Inc 分析装置用カートリッジ
JP4660662B2 (ja) * 2005-09-06 2011-03-30 アークレイ株式会社 カートリッジ
JP4797619B2 (ja) * 2005-12-22 2011-10-19 東レ株式会社 分析チップおよび被検物質の分析方法
JP5241209B2 (ja) * 2007-11-26 2013-07-17 株式会社日立ハイテクノロジーズ 試料前処理用デバイス及び試料分析方法
US9040285B2 (en) 2008-12-18 2015-05-26 Koninklijkle Philips N.V. Sensing device for sensing a fluid
JP5888885B2 (ja) * 2010-06-23 2016-03-22 アークレイ株式会社 測定装置、測定方法、測定プログラム、および測定システム
WO2014076521A1 (en) * 2012-11-15 2014-05-22 Agilent Technologies, Inc. Sample dilution to specifiable dilution ratio
JP5833716B1 (ja) * 2014-07-24 2015-12-16 日本電信電話株式会社 血液凝固検査方法および血液凝固検査用流路チップ
CA3290154A1 (en) 2016-01-29 2025-11-29 Purigen Biosystems, Inc. Isotachophoresis for purification of nucleic acids
CN110869127A (zh) * 2017-04-21 2020-03-06 美飒生物技术公司 流控式测试盒
CN115569515A (zh) 2017-08-02 2023-01-06 普瑞珍生物系统公司 用于等速电泳的系统、设备和方法
CN117109990A (zh) * 2018-02-27 2023-11-24 芯易诊有限公司 获得定量样品混合物的装置及方法
CN108393105B (zh) * 2018-04-20 2023-08-25 华南师范大学 一种微流控芯片及其控制系统、控制方法
JP7343191B2 (ja) * 2019-01-17 2023-09-12 日本分光株式会社 液体クロマトグラフィー用スタティックミキサー
CN116459722A (zh) * 2023-04-26 2023-07-21 南京望知星医药科技有限公司 一种用于罗红霉素分散片的制备装置
WO2025136179A1 (en) * 2023-12-21 2025-06-26 Delaval Holding Ab Distribution unit for providing a milk sample mixed with a stainer liquid to a milk analyse device

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* Cited by examiner, † Cited by third party
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SE330624B (es) * 1965-09-02 1970-11-23 Medicinskkemiska Lab Calab Ab
US3799742A (en) * 1971-12-20 1974-03-26 C Coleman Miniaturized integrated analytical test container
US3869068A (en) * 1974-06-06 1975-03-04 Hyperion Inc Diluter probe assembly
US4426451A (en) * 1981-01-28 1984-01-17 Eastman Kodak Company Multi-zoned reaction vessel having pressure-actuatable control means between zones
US4503012A (en) * 1983-04-19 1985-03-05 American Monitor Corporation Reagent dispensing system
FI834387A0 (fi) * 1983-11-30 1983-11-30 Labsystems Oy Foerfarande foer utspaedning av vaetskeprov

Also Published As

Publication number Publication date
EP0305210A2 (en) 1989-03-01
EP0305210A3 (en) 1989-10-11
AU2163988A (en) 1989-03-02
JPH0756492B2 (ja) 1995-06-14
DE3886140D1 (de) 1994-01-20
DE3886140T2 (de) 1994-05-19
AU615208B2 (en) 1991-09-26
EP0305210B1 (en) 1993-12-08
JPH01257268A (ja) 1989-10-13
CA1333850C (en) 1995-01-10

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