ES2051690T3 - Un complejo y su procedimiento de preparacion. - Google Patents
Un complejo y su procedimiento de preparacion.Info
- Publication number
- ES2051690T3 ES2051690T3 ES86307849T ES86307849T ES2051690T3 ES 2051690 T3 ES2051690 T3 ES 2051690T3 ES 86307849 T ES86307849 T ES 86307849T ES 86307849 T ES86307849 T ES 86307849T ES 2051690 T3 ES2051690 T3 ES 2051690T3
- Authority
- ES
- Spain
- Prior art keywords
- complex
- preparation procedure
- molecula
- immunogen
- pharmacy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/44—Antibodies bound to carriers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/385—Haptens or antigens, bound to carriers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Vending Machines For Individual Products (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Abstract
LA PRESENTE INVENCION SE REFIERE A UN COMPLEJO DE UN FARMACO, HORMONA, PEPTIDO BIOACTIVO, O INMUNOGENO CON EL SOPORTE DE LA MOLECULA DE VITAMINA B12 Y UN METODO PARA SUMINISTRAR DICHO COMPLEJO AL INTESTINO DE UN VERTEBRADO HUESPED CON EL FIN DE SUMINISTRAR EL COMPLEJO A LA CIRCULACION DEL HUESPED Y ELICITAR POR TANTO UNA RESPUESTA FARMACOLOGICA AL FARMACO, HORMONA O MOLECULA BIOACTIVA O ELICITAR UNA RESPUESTA INMUNOLOGICA SISTEMICA AL INMUNOGENO. LA INVENCION TAMBIEN PROPORCIONA UN METODO PARA LA PRODUCCION DEL COMPLEJO. ADEMAS LA INVENCION PROPORCIONA MEDICAMENTOS QUE CONTIENEN EL COMPLEJO.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AUPH283885 | 1985-10-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2051690T3 true ES2051690T3 (es) | 1994-07-01 |
Family
ID=3771313
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES86307849T Expired - Lifetime ES2051690T3 (es) | 1985-10-10 | 1986-10-10 | Un complejo y su procedimiento de preparacion. |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US5428023A (es) |
| EP (1) | EP0220030B1 (es) |
| JP (1) | JPH08779B2 (es) |
| KR (1) | KR940003057B1 (es) |
| CN (1) | CN1045391C (es) |
| AT (1) | ATE64534T1 (es) |
| CA (1) | CA1330791C (es) |
| DK (1) | DK167099B1 (es) |
| ES (1) | ES2051690T3 (es) |
| GR (1) | GR3002160T3 (es) |
| HK (1) | HK69094A (es) |
| IL (1) | IL80264A (es) |
| IN (1) | IN165029B (es) |
| NZ (1) | NZ217821A (es) |
| WO (1) | WO1987002251A1 (es) |
| ZA (1) | ZA867703B (es) |
Families Citing this family (80)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5643889A (en) * | 1984-07-11 | 1997-07-01 | Temple University-Of The Commonwealth System Of Pennsylvania | Cholesterol conjugates of 2'5'-oligoadenylate derivatives and antiviral uses thereof |
| US5550111A (en) * | 1984-07-11 | 1996-08-27 | Temple University-Of The Commonwealth System Of Higher Education | Dual action 2',5'-oligoadenylate antiviral derivatives and uses thereof |
| NZ217821A (en) * | 1985-10-10 | 1989-07-27 | Biotech Australia Pty Ltd | Oral delivery system; complex of active agent and vitamin b12 or analogue thereof |
| US4842868A (en) * | 1986-09-26 | 1989-06-27 | Helwing Robert F | Covalently bonded active agents with carbonium ion base groups |
| US5807832A (en) * | 1987-06-09 | 1998-09-15 | Biotech Australia Pty Limited | Oral delivery of biologically active substances bound to vitamin B12 |
| US4997815A (en) * | 1988-11-01 | 1991-03-05 | Children's Hospital Medical Center Of Northern California | Method for augmenting fetal hemoglobin by treatment with activin and/or inhibin |
| US5108921A (en) * | 1989-04-03 | 1992-04-28 | Purdue Research Foundation | Method for enhanced transmembrane transport of exogenous molecules |
| US5688488A (en) * | 1989-04-03 | 1997-11-18 | Purdue Research Foundation | Composition and method for tumor imaging |
| IL93982A0 (en) * | 1989-04-03 | 1991-01-31 | Purdue Research Foundation | Method for enhancing transmembrane transport of exogenous molecules |
| FR2649321A1 (fr) * | 1989-07-07 | 1991-01-11 | Inst Nat Sante Rech Med | Compositions a base de derives nucleotidiques, leurs procedes de preparation, et leurs utilisations notamment en tant que compositions pharmaceutiques |
| GR900100249A (el) * | 1990-03-28 | 1992-06-30 | Purdue Research Foundation | Μεθοδος δια την ηυξημενην δια των μεμβρανων μεταφοραν εξωγενων μοριων. |
| HK1002252A1 (en) * | 1991-04-02 | 1998-08-07 | Biotech Australia Pty. Limited | Oral delivery systems for microparticles |
| JPH08510260A (ja) * | 1993-05-20 | 1996-10-29 | バイオテック・オーストラリア・プロプライエタリー・リミテッド | Lhrh拮抗剤 |
| US5548064A (en) * | 1993-05-24 | 1996-08-20 | Biotech Australia Pty Limited | Vitamin B12 conjugates with EPO, analogues thereof and pharmaceutical compositions |
| US5449720A (en) * | 1993-05-24 | 1995-09-12 | Biotech Australia Pty Limited | Amplification of the VB12 uptake system using polymers |
| US5739287A (en) * | 1994-04-08 | 1998-04-14 | University Of Washington | Biotinylated cobalamins |
| CA2187346C (en) * | 1994-04-08 | 2010-06-29 | A. Charles Morgan, Jr. | Receptor modulating agents and methods relating thereto |
| US5869465A (en) * | 1994-04-08 | 1999-02-09 | Receptagen Corporation | Methods of receptor modulation and uses therefor |
| US5840880A (en) * | 1994-04-08 | 1998-11-24 | Receptagen Corporation | Receptor modulating agents |
| US5574018A (en) * | 1994-07-29 | 1996-11-12 | Amgen Inc. | Conjugates of vitamin B12 and proteins |
| EP0781142A4 (en) * | 1994-09-01 | 2003-04-09 | Allied Medical Res Associates | Compositions and methods for delivery of polypeptides |
| EP1015475A1 (en) * | 1995-10-19 | 2000-07-05 | Receptagen Corporation | Vitamin b 12? receptor modulating agents and methods related thereto |
| US5739313A (en) * | 1995-11-13 | 1998-04-14 | Regents Of The University Of Minnesota | Radionuclide labeling of vitamin B12 and coenzymes thereof |
| ES2244006T3 (es) * | 1996-08-27 | 2005-12-01 | University Of Utah Research Foundation | Bioconjugados y administracion de agentes bioactivos. |
| US6054133A (en) * | 1997-07-10 | 2000-04-25 | The Regents Of The University Of California | Anti-microbial targeting for intracellular pathogens |
| WO1999065529A1 (en) * | 1998-06-15 | 1999-12-23 | Alza Corporation | Nucleic acid-cobalamin complexes and their use in gene therapy |
| FR2787029A1 (fr) * | 1998-12-09 | 2000-06-16 | Biovector Therapeutics | Utilisation dans une composition pharmaceutique pour l'administration par voie nasale de vitamine b12 pour la delivrance d'agents actifs au systeme nerveux central |
| US20010008627A1 (en) | 1999-01-22 | 2001-07-19 | Soll David R. | Hiv-encoded chemoattractant |
| US6806363B1 (en) * | 1999-04-16 | 2004-10-19 | Mayo Foundation For Medical Education & Research | Cobalamin conjugates useful as antitumor agents |
| DE19930729A1 (de) * | 1999-07-05 | 2001-01-11 | Achim Goepferich | Blockcopolymere zur Herstellung biomimetischer Oberflächen |
| JP2003531105A (ja) | 1999-10-15 | 2003-10-21 | メイオウ・フアウンデーシヨン・フオー・メデイカル・エジユケイシヨン・アンド・リサーチ | 造影剤および治療薬として有用なコバラミン結合体 |
| MXPA02003771A (es) * | 1999-10-15 | 2005-04-28 | Mayo Foundation | Conjugados de cobalamina, utiles como agentes para obtencion de imagen y como agentes anti-tumor. |
| US7591995B2 (en) * | 1999-10-15 | 2009-09-22 | Mayo Foundation For Medical Education And Research | Cobalamin conjugates useful as imaging and therapeutic agents |
| CN1441676B (zh) | 2000-03-31 | 2012-08-22 | 普渡研究基金会 | 用配体-免疫原缀合物治疗的方法 |
| EP1754712A3 (en) * | 2000-10-25 | 2009-01-14 | Mayo Foundation For Medical Education And Research | Transcobalamin binding conjugates useful for treating abnormal cellular proliferation |
| CA2427146A1 (en) * | 2000-10-25 | 2002-07-18 | Mayo Foundation For Medical Education And Research | Transcobalamin binding conjugates useful for treating abnormal cellular proliferation |
| WO2002067995A1 (en) * | 2001-02-26 | 2002-09-06 | Council Of Scientific And Industrial Research | Carrier systems comprising vitamin b12 - biodegradable micro particulate conju gates for peroral delivery of drugs, peptides/proteins and vaccines |
| CN101979095A (zh) | 2001-05-02 | 2011-02-23 | 普渡研究基金会 | 巨噬细胞介导的疾病的治疗和诊断 |
| US6752986B2 (en) | 2001-05-24 | 2004-06-22 | The Cleveland Clinic Foundation | Composition and methods for affecting metallocorrinoid uptake |
| WO2003000010A2 (en) * | 2001-06-20 | 2003-01-03 | Mayo Foundation For Medical Education And Research | Adenosyl-cobalamin fortified compositions |
| US20060074034A1 (en) * | 2001-09-17 | 2006-04-06 | Collins Douglas A | Cobalamin mediated delivery of nucleic acids, analogs and derivatives thereof |
| EP2168598A1 (en) * | 2001-09-28 | 2010-03-31 | Purdue Research Foundation | Method of Treatment Using Ligand-Immunogen Conjugates |
| JP2005508332A (ja) * | 2001-09-28 | 2005-03-31 | メイオウ・フアウンデーシヨン・フオー・メデイカル・エジユケイシヨン・アンド・リサーチ | 薬剤を送達するための、輸送タンパク質とコンジュゲートコバラミンとの同時投与 |
| US7255874B1 (en) | 2001-12-21 | 2007-08-14 | Closure Medical Corporation | Biocompatible polymers and adhesives: compositions, methods of making and uses related thereto |
| US8043603B2 (en) | 2002-02-07 | 2011-10-25 | Endocyte, Inc. | Folate targeted enhanced tumor and folate receptor positive tissue optical imaging technology |
| US8043602B2 (en) | 2002-02-07 | 2011-10-25 | Endocyte, Inc. | Folate targeted enhanced tumor and folate receptor positive tissue optical imaging technology |
| FR2839407B1 (fr) * | 2002-05-02 | 2004-12-17 | Canon Kk | Procede et dispositif d'ajustement de la taille maximale des sequences d'information transmises dans un reseau de telecommunications |
| JP4801348B2 (ja) | 2002-05-06 | 2011-10-26 | エンドサイト,インコーポレイテッド | ビタミンを標的とした造影剤 |
| KR100440725B1 (ko) * | 2002-06-20 | 2004-07-15 | 주식회사 그린진 바이오텍 | 비생물성 스트레스에 대한 단자엽 식물의 내성을증가시키는 방법 |
| KR20040080778A (ko) | 2003-03-13 | 2004-09-20 | 삼성전자주식회사 | 4색 구동 액정 표시 장치 및 이에 사용하는 표시판 |
| US7232805B2 (en) | 2003-09-10 | 2007-06-19 | Inflabloc Pharmaceuticals, Inc. | Cobalamin conjugates for anti-tumor therapy |
| MX2007001348A (es) * | 2004-08-02 | 2008-03-11 | Bebaas Inc | Composiciones de vitamina b12. |
| EP1893038A1 (en) * | 2005-05-17 | 2008-03-05 | Cargill, Incorporated | Granular lecithins, granular lysolecithins, process for their production and compositions containing them |
| EP1904183B1 (en) | 2005-07-05 | 2014-10-15 | Purdue Research Foundation | Pharmaceutical composition for the treatment of osteoarthritis |
| US20070178141A1 (en) * | 2005-09-07 | 2007-08-02 | Bebaas, Inc. | Vitamin B12 compositions |
| US20130131007A1 (en) | 2005-09-07 | 2013-05-23 | Bebaas, Inc. | Vitamin b12 compositions |
| WO2007030108A1 (en) * | 2005-09-07 | 2007-03-15 | Bebaas, Inc. | Vitamin b-12 compositions |
| US8795633B2 (en) | 2005-09-23 | 2014-08-05 | Purdue Research Foundation | Multiphoton in vivo flow cytometry method and device |
| KR100658436B1 (ko) * | 2005-12-09 | 2006-12-27 | 한국화학연구원 | 아데노실코발라민 함유 피부질환 치료용 외용제 조성물 |
| US20130084329A1 (en) | 2005-12-09 | 2013-04-04 | Hanall Biopharma Co., Ltd. | Compositions for external application, containing adenosylcobalamin for improvement of skin diseases |
| US8168164B2 (en) | 2006-02-03 | 2012-05-01 | Purdue Research Foundation | Targeted conjugates and radiation |
| JP2010509570A (ja) | 2006-11-03 | 2010-03-25 | パーデュー・リサーチ・ファウンデーション | エクスビボフローサイトメトリーの方法および装置 |
| US8586595B2 (en) | 2007-02-07 | 2013-11-19 | Purdue Research Foundation | Positron emission tomography imaging method |
| US20110092416A1 (en) * | 2007-03-05 | 2011-04-21 | Robert Patrick Doyle | Vitamine B12 - Peptide Conjugates for Oral Delivery |
| CA2678646A1 (en) * | 2007-03-05 | 2008-09-12 | Syracuse University | A conjugate of insulin and vitamin b12 for oral delivery |
| US7851342B2 (en) * | 2007-03-30 | 2010-12-14 | Intel Corporation | In-situ formation of conductive filling material in through-silicon via |
| WO2008148001A2 (en) | 2007-05-25 | 2008-12-04 | Purdue Research Foundation | Method of imaging localized infections |
| WO2009020595A2 (en) * | 2007-08-03 | 2009-02-12 | Shaklee Corporation | Nutritional supplement system |
| US20100330161A1 (en) * | 2009-06-29 | 2010-12-30 | Syracuse University Technology Transfer And Industrial Development Office | Oral delivery of tetanus toxoid |
| WO2011130716A2 (en) | 2010-04-16 | 2011-10-20 | Access Pharmaceuticals, Inc. | A nanostructures containing vitamin b12 for facilitated delivery of drugs across biological barriers |
| US8614184B2 (en) | 2010-09-22 | 2013-12-24 | Ronald P. Santasiero | HCG formulations for achieving weight loss |
| CN103501821A (zh) | 2011-03-08 | 2014-01-08 | 艾克塞斯制药公司 | 用于递送活性剂穿过生物膜的靶向纳米载体系统 |
| US9120858B2 (en) | 2011-07-22 | 2015-09-01 | The Research Foundation Of State University Of New York | Antibodies to the B12-transcobalamin receptor |
| AU2013263349B2 (en) | 2012-05-17 | 2016-09-08 | Extend Biosciences, Inc | Carriers for improved drug delivery |
| WO2015126841A1 (en) | 2014-02-18 | 2015-08-27 | Plasmatech Biopharmaceuticals, Inc. | Nutritional and therapeutic mucoadhesive formulations |
| US9616109B2 (en) | 2014-10-22 | 2017-04-11 | Extend Biosciences, Inc. | Insulin vitamin D conjugates |
| WO2016065042A1 (en) | 2014-10-22 | 2016-04-28 | Extend Biosciences, Inc. | Therapeutic vitamin d conjugates |
| US9789197B2 (en) | 2014-10-22 | 2017-10-17 | Extend Biosciences, Inc. | RNAi vitamin D conjugates |
| WO2017030893A1 (en) | 2015-08-14 | 2017-02-23 | Endocyte, Inc. | Method of imaging with a chelating compound |
| KR20250075704A (ko) | 2022-09-30 | 2025-05-28 | 익스텐드 바이오사이언시즈, 인크. | 장기-지속형 부갑상선 호르몬 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2372066A (en) * | 1940-12-23 | 1945-03-20 | Parke Davis & Co | Biological product and process of obtaining same |
| US3042588A (en) * | 1957-04-04 | 1962-07-03 | Distillers Co Yeast Ltd | Process for producing cobalaminpeptide complexes |
| GB963373A (en) * | 1961-12-11 | 1964-07-08 | Glaxo Group Ltd | Improvements in or relating to substituted cobamides |
| GB1152461A (en) * | 1965-06-16 | 1969-05-21 | Ivan Rolovich | New Derivatives of Cobalamins |
| FR5372M (es) * | 1966-02-10 | 1967-10-16 | ||
| BE774108A (fr) * | 1970-10-28 | 1972-04-18 | Boige Jean | Derives de l'hydroxocobalamine, procede pour leur preparation et utilisation de ces derives en therapeutique |
| IT1044233B (it) * | 1973-04-04 | 1980-03-20 | Zambelletti L S P A | Derivati della vitamina bi2 ad azione vitaminica di lunga durata |
| JPS5247012B2 (es) * | 1974-11-16 | 1977-11-29 | ||
| US3981863A (en) * | 1975-02-25 | 1976-09-21 | Micromedic Diagonistics, Inc. | Cyanocobalamin derivatives |
| US4133951A (en) * | 1975-05-08 | 1979-01-09 | The Radiochemical Centre Limited | Vitamin B-12 cobalt-57 and process |
| DE2546474A1 (de) * | 1975-10-17 | 1977-04-21 | Murray M D Israel | Injizierbares pharmazeutisches thyroxinpraeparat und verfahren zu dessen herstellung |
| FR2373285A1 (fr) * | 1976-11-25 | 1978-07-07 | Roussel Uclaf | Nouveaux derives du coenzyme b 12, procede de preparation et application a titre de medicaments de ces nouveaux produits |
| DE2718700A1 (de) * | 1977-04-27 | 1978-11-02 | Hans A Dipl Chem Dr Thoma | Verfahren zur gesamtbestimmung von hormonen und pharmaka |
| US4209614A (en) * | 1978-05-30 | 1980-06-24 | E. R. Squibb & Sons, Inc. | Vitamin B12 derivative suitable for radiolabeling |
| US4377570A (en) * | 1979-01-29 | 1983-03-22 | Merck & Co., Inc. | Immunologically active dipeptidyl saccharides and methods of preparation |
| US4360358A (en) * | 1980-03-07 | 1982-11-23 | Yash Sharma | Immunoassay with solid phase having coating containing blood platelet substitute |
| CA1165238A (en) * | 1980-03-12 | 1984-04-10 | Demetrios P. Papahadjopoulos | Activated liposomes and method |
| EP0067921B1 (en) * | 1981-06-22 | 1987-11-11 | Prutec Limited | A method for determining bioactive substances |
| EP0069450B1 (en) * | 1981-06-22 | 1985-04-10 | TECHNICON INSTRUMENTS CORPORATION (a New York corporation) | Labelled vitamin b12 derivatives, their preparation and use |
| US4454125A (en) * | 1982-04-22 | 1984-06-12 | Demopoulos Harry B | Dry powder formulations having improved flow and compressibility characteristics, and method for the preparation thereof |
| US4452775A (en) * | 1982-12-03 | 1984-06-05 | Syntex (U.S.A.) Inc. | Cholesterol matrix delivery system for sustained release of macromolecules |
| US4603044A (en) * | 1983-01-06 | 1986-07-29 | Technology Unlimited, Inc. | Hepatocyte Directed Vesicle delivery system |
| US4746508A (en) * | 1983-06-06 | 1988-05-24 | Beth Israel Hospital Assn. | Drug administration |
| NZ217821A (en) * | 1985-10-10 | 1989-07-27 | Biotech Australia Pty Ltd | Oral delivery system; complex of active agent and vitamin b12 or analogue thereof |
| US4751285A (en) * | 1986-10-09 | 1988-06-14 | Toohey John I | Derivative of cobalamin containing persulfide sulfur and glutathione |
| US5075109A (en) * | 1986-10-24 | 1991-12-24 | Southern Research Institute | Method of potentiating an immune response |
| IL84167A (en) * | 1986-10-24 | 1991-04-15 | Southern Res Inst | Oral delivery of bioactive agents to and through the peyer's patch by use of microencapsulation |
-
1986
- 1986-10-07 NZ NZ217821A patent/NZ217821A/xx unknown
- 1986-10-09 ZA ZA867703A patent/ZA867703B/xx unknown
- 1986-10-09 IN IN738/CAL/86A patent/IN165029B/en unknown
- 1986-10-09 IL IL80264A patent/IL80264A/xx not_active IP Right Cessation
- 1986-10-09 CA CA000520162A patent/CA1330791C/en not_active Expired - Fee Related
- 1986-10-10 JP JP61505525A patent/JPH08779B2/ja not_active Expired - Fee Related
- 1986-10-10 US US08/061,343 patent/US5428023A/en not_active Expired - Lifetime
- 1986-10-10 CN CN86107590A patent/CN1045391C/zh not_active Expired - Lifetime
- 1986-10-10 WO PCT/AU1986/000299 patent/WO1987002251A1/en not_active Ceased
- 1986-10-10 EP EP86307849A patent/EP0220030B1/en not_active Expired - Lifetime
- 1986-10-10 ES ES86307849T patent/ES2051690T3/es not_active Expired - Lifetime
- 1986-10-10 KR KR1019870700489A patent/KR940003057B1/ko not_active Expired - Fee Related
- 1986-10-10 AT AT86307849T patent/ATE64534T1/de not_active IP Right Cessation
-
1987
- 1987-06-09 DK DK292587A patent/DK167099B1/da not_active IP Right Cessation
-
1991
- 1991-06-20 GR GR91400298T patent/GR3002160T3/el unknown
-
1994
- 1994-07-14 HK HK69094A patent/HK69094A/en not_active IP Right Cessation
-
1995
- 1995-06-07 US US08/479,635 patent/US5589463A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ZA867703B (en) | 1987-06-24 |
| EP0220030A2 (en) | 1987-04-29 |
| JPS63501015A (ja) | 1988-04-14 |
| ATE64534T1 (de) | 1991-07-15 |
| DK292587D0 (da) | 1987-06-09 |
| KR870700361A (ko) | 1987-12-28 |
| IL80264A (en) | 1991-11-21 |
| HK69094A (en) | 1994-07-22 |
| EP0220030B1 (en) | 1991-06-19 |
| DK292587A (da) | 1987-06-09 |
| DK167099B1 (da) | 1993-08-30 |
| GR3002160T3 (en) | 1992-12-30 |
| KR940003057B1 (ko) | 1994-04-13 |
| JPH08779B2 (ja) | 1996-01-10 |
| CN86107590A (zh) | 1987-05-20 |
| EP0220030A3 (en) | 1987-09-30 |
| CA1330791C (en) | 1994-07-19 |
| CN1045391C (zh) | 1999-10-06 |
| IN165029B (es) | 1989-08-05 |
| US5428023A (en) | 1995-06-27 |
| NZ217821A (en) | 1989-07-27 |
| US5589463A (en) | 1996-12-31 |
| IL80264A0 (en) | 1987-01-30 |
| WO1987002251A1 (en) | 1987-04-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2051690T3 (es) | Un complejo y su procedimiento de preparacion. | |
| ES2052645T3 (es) | Acidos poliinsaturados con accion vasocinetica y formulaciones farmaceuticas y cosmeticas que los contienen. | |
| ES2053990T3 (es) | Composiciones de acidos grasos esenciales. | |
| MX9206306A (es) | Peptidos, procedimiento para su produccion y composicion farmaceutica que los contiene. | |
| ES2019570A4 (es) | Dispositivo para el tratamiento termico del cuello de los preformados. | |
| ATE94390T1 (de) | Orale darreichungsformen mit verzoegerter abgabe. | |
| ES2023976B3 (es) | Procedimiento para el enriquecimiento de helio. | |
| MX9302448A (es) | Derivados iminicos ciclicos, procedimientos para su preparacion y medicamentos que contienen estos compuestos. | |
| ES2073533T3 (es) | Uso antivirico de composiciones que constan de acidos grasos esenciales e interferon. | |
| ES8307494A1 (es) | "un procedimiento para preparar una composicion farmaceutica que proporciona un efecto anti-inflamatorio y analgesico junto con un dano gastrico minimizado". | |
| AR025052A1 (es) | Derivados de 2-dialquilaminoalquilbifenilo sustituidos, procedimiento para su preparacion, medicamentos que contienen estos compuestos y el uso de estoscompuestos para la preparacion de medicamentos. | |
| ES2045363T3 (es) | Utilizacion de una composicion dietetica para la inhibicion de la adhesion celular. | |
| MX9201058A (es) | Derivados ciclicos de cetal, procedimiento para supreparacion y composicion farmaceutica que los contiene. | |
| ES2019595B3 (es) | Empleo de glicofurol para licuacion de preparaciones medicas, para el llenado en capsulas de gelatina blanda | |
| AR030662A1 (es) | Beta-tio-alfa-aminoacidos, procedimiento para su fabricacion, medicamentos que contienen estos compuestos y el uso de los tioaminoacidos para la preparacion de medicamentos | |
| ES2018667B3 (es) | Derivados del acido 4-qionolon-3-carboxilico, procedimiento para su obtencion y preparados farmaceuticos que los contienen. | |
| ES8702438A1 (es) | Un metodo para preparar un peptido | |
| ES544664A0 (es) | Procedimiento para el diagnostico in vitro del sexo | |
| ES2081476T3 (es) | Uso de acidos grasos especificos en la fabricacion de un medicamento para su suministro por iontoforesis. | |
| AR003434A1 (es) | Compuesto de tiludronato, composiciones farmaceuticas que los contienen y proceso para producir dicho compuesto y procedimiento para producir lascomposiciones farmaceuticas. | |
| NO863082D0 (no) | Preparat for intramuskulaer injeksjon av legemidler, vitaminer eller vaksiner. | |
| IL37729A0 (en) | Cycloaliphatic difunctional nitrogen-containing sulphonic acid esters,their manufacture and their use as medicines | |
| ES2036523T3 (es) | 4-aminoarildihidropiridinlactonas, procedimiento para su obtencion y su empleo en medicamentos. | |
| ES2101831T3 (es) | Procedimiento y productos intermedios para la preparacion de perhidro-1h-pirido(1,2-a)pirazinas ansioliticas. | |
| ES491356A0 (es) | Metodo para producir preparados medicinales para el trata- miento de carcinomas |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
Ref document number: 220030 Country of ref document: ES |