ES2052172T3 - Agentes antialergicos basados en diazepina. - Google Patents

Agentes antialergicos basados en diazepina.

Info

Publication number
ES2052172T3
ES2052172T3 ES90302826T ES90302826T ES2052172T3 ES 2052172 T3 ES2052172 T3 ES 2052172T3 ES 90302826 T ES90302826 T ES 90302826T ES 90302826 T ES90302826 T ES 90302826T ES 2052172 T3 ES2052172 T3 ES 2052172T3
Authority
ES
Spain
Prior art keywords
ring
antialergic
diazepine
agents
nitrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90302826T
Other languages
English (en)
Inventor
Kelvin Dr Cooper
Michael Jonathan Dr Fray
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PFIZER
Pfizer Inc
Original Assignee
PFIZER
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB898906813A external-priority patent/GB8906813D0/en
Priority claimed from GB898926246A external-priority patent/GB8926246D0/en
Application filed by PFIZER, Pfizer Inc filed Critical PFIZER
Application granted granted Critical
Publication of ES2052172T3 publication Critical patent/ES2052172T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

ANTAGONISTAS DEL FACTOR DE AGLOMERACION DE PLAQUETAS DE LAS FORMULAS (I), (II) O (III): EN DONDE A ES BENZENO, PIRIDINA, NAFTALENO, QUINOLINA, TIOFENO, BENZOTIOFENO, PIRAZOL O ISOTIAZOL OPCIONALMENTE SUSTITUIDOS, X ES O, S O NH Y ES 1,4 FENILENO O UN GRUPO DE LA FORMULA EN DONDE R1 ES H O C1-C4 ALQUILO OPCIONALMENTE SUSTITUIDO R2 Y R3 SON H O C1-C4 ALQUILO, B ES UN ANILLO DE FUSION DE 5 O 6 MIEMBROS QUE CONTIENE ATOMOS DE NITROGENO, HET ES UN ANILLO HETEROCICLICO SUSTITUIDO DE 5 MIEMBROS QUE CONTIENE NITROGENO O UN ANILLO DE PIRIDINA, FUSIONANDOSE EL ANILLO OPCIONALMENTE CON UN ANILLO HETEROCICLICO QUE CONTENGA BENZENO O NITROGENO.
ES90302826T 1989-03-23 1990-03-15 Agentes antialergicos basados en diazepina. Expired - Lifetime ES2052172T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB898906813A GB8906813D0 (en) 1989-03-23 1989-03-23 Therapeutic agents
GB898926246A GB8926246D0 (en) 1989-11-21 1989-11-21 Therapeutic agents

Publications (1)

Publication Number Publication Date
ES2052172T3 true ES2052172T3 (es) 1994-07-01

Family

ID=26295132

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90302826T Expired - Lifetime ES2052172T3 (es) 1989-03-23 1990-03-15 Agentes antialergicos basados en diazepina.

Country Status (21)

Country Link
US (1) US5008263A (es)
EP (1) EP0389189B1 (es)
JP (1) JPH0684371B2 (es)
KR (1) KR920003981B1 (es)
CN (1) CN1045783A (es)
AT (1) ATE105839T1 (es)
AU (1) AU627286B2 (es)
CA (1) CA2012666C (es)
DE (1) DE69008906T2 (es)
DK (1) DK0389189T3 (es)
ES (1) ES2052172T3 (es)
FI (1) FI98463C (es)
HU (1) HUT61006A (es)
IE (1) IE62857B1 (es)
IL (1) IL93776A (es)
MY (1) MY106322A (es)
NO (1) NO175151C (es)
NZ (1) NZ233047A (es)
PH (1) PH27513A (es)
PT (1) PT93526B (es)
YU (1) YU47344B (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9010404D0 (en) * 1990-05-09 1990-06-27 Pfizer Ltd Therapeutic agents
GB9015524D0 (en) * 1990-07-13 1990-08-29 Pfizer Ltd Therapeutic agents
GB9019409D0 (en) * 1990-09-05 1990-10-17 Pfizer Ltd Therapeutic agents
GB9019833D0 (en) * 1990-09-11 1990-10-24 Pfizer Ltd Therapeutic agents
AU666318B2 (en) * 1991-06-28 1996-02-08 Smithkline Beecham Corporation Bicyclic fibrinogen antagonists
US5939412A (en) * 1992-06-26 1999-08-17 Smithkline Beecham Corporation Bicyclic fibrinogen antagonists
IL108524A0 (en) * 1993-02-03 1994-05-30 Gensia Inc Imidazodiazepine analogs
US5500439A (en) * 1993-12-09 1996-03-19 Alteon Inc. Aminopyrazoles
MA23420A1 (fr) * 1994-01-07 1995-10-01 Smithkline Beecham Corp Antagonistes bicycliques de fibrinogene.
ATE224377T1 (de) * 1994-04-29 2002-10-15 Takeda Chemical Industries Ltd Kondensierte heterocyclische verbindung, deren herstellung und verwendung als gnrh antagonisten
US6458784B1 (en) 1994-06-29 2002-10-01 Smithkline Beecham Corporation Vitronectin receptor antagonists
FR2733749B1 (fr) * 1995-05-05 1997-06-13 Oreal Compositions pour la teinture des fibres keratiniques contenant des diamino pyrazoles, procede de teinture, nouveaux diamino pyrazoles et leur procede de preparation
US5726171A (en) * 1995-06-07 1998-03-10 Merck & Co Inc N-(1-alkyl-5-phenyl-2,3,4,5-tetrahydro-1H-benzo B! 1,4!diazepin-3yl)-acetamides
US5977101A (en) * 1995-06-29 1999-11-02 Smithkline Beecham Corporation Benzimidazoles/Imidazoles Linked to a Fibrinogen Receptor Antagonist Template Having Vitronectin Receptor Antagonist Activity
WO1997007103A2 (en) * 1995-08-15 1997-02-27 Novartis Ag Pesticidal indazole derivatives
US6172222B1 (en) * 1998-06-08 2001-01-09 American Home Products Corporation Diaminopyrazoles
US6458823B1 (en) 1998-06-08 2002-10-01 Wyeth Diaminopyrazoles
US6949542B2 (en) * 2002-02-06 2005-09-27 Hoffman-La Roche Inc. Dihydro-benzo[b][1,4]diazepin-2-one derivatives
US8518933B2 (en) 2009-04-23 2013-08-27 Abbvie Inc. Modulators of 5-HT receptors and methods of use thereof
US8546377B2 (en) 2009-04-23 2013-10-01 Abbvie Inc. Modulators of 5-HT receptors and methods of use thereof
TW201307347A (zh) 2010-11-01 2013-02-16 Arqule Inc 經取代苯並－咪唑並－吡啶並－二氮呯化合物
KR101675984B1 (ko) * 2015-02-23 2016-11-14 한양대학교 에리카산학협력단 티에노디아제핀 유도체 또는 이의 약학적으로 허용가능한 염, 및 이를 유효성분으로 포함하는 약학적 조성물
CN105153195B (zh) * 2015-09-01 2017-09-26 汤文建 一种三环吡唑[1,5‑d][1,4]苯并氧氮杂卓酮衍生物及其制备方法与用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU527689B2 (en) * 1974-09-11 1983-03-17 F. Hoffmann-La Roche & Co. Imidazodiazepine derivatives
DK476885D0 (da) * 1985-10-17 1985-10-17 Ferrosan As Heterocycliske forbindelser og fremgangsmaader til fremstilling heraf
EP0230942B1 (de) * 1986-01-21 1992-04-29 Boehringer Ingelheim Kg Thieno-1,4-diazepine

Also Published As

Publication number Publication date
NO901329D0 (no) 1990-03-22
EP0389189B1 (en) 1994-05-18
HU901794D0 (en) 1990-06-28
AU5214890A (en) 1990-11-01
IE62857B1 (en) 1995-03-08
US5008263A (en) 1991-04-16
JPH0314577A (ja) 1991-01-23
IE901055L (en) 1990-09-23
PH27513A (en) 1993-08-18
NO175151C (no) 1994-09-07
NO175151B (no) 1994-05-30
FI98463B (fi) 1997-03-14
EP0389189A3 (en) 1991-08-21
YU47344B (sh) 1995-01-31
KR920003981B1 (ko) 1992-05-21
YU56390A (sh) 1992-12-21
IL93776A (en) 1994-10-21
HUT61006A (en) 1992-11-30
NZ233047A (en) 1992-06-25
DK0389189T3 (da) 1994-06-20
PT93526A (pt) 1990-11-07
CA2012666A1 (en) 1990-09-23
MY106322A (en) 1995-05-30
CA2012666C (en) 1997-01-28
NO901329L (no) 1990-09-24
IL93776A0 (en) 1990-12-23
DE69008906T2 (de) 1994-08-25
JPH0684371B2 (ja) 1994-10-26
FI98463C (fi) 1997-06-25
PT93526B (pt) 1996-08-30
ATE105839T1 (de) 1994-06-15
KR900014387A (ko) 1990-10-23
FI901441A0 (fi) 1990-03-22
DE69008906D1 (de) 1994-06-23
CN1045783A (zh) 1990-10-03
EP0389189A2 (en) 1990-09-26
AU627286B2 (en) 1992-08-20

Similar Documents

Publication Publication Date Title
ES2052172T3 (es) Agentes antialergicos basados en diazepina.
DE3587913D1 (de) Imidazodiazepin-Derivate.
ES2036551T3 (es) Compuestos heterociclicos.
IL108731A (en) 6, N-DISUBSTITUTED-£1, 2, 4| TRIAZOLO-£1, 5-a| PYRIMIDINE- 7-AMINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS FUNGICIDES
ATE157978T1 (de) Substituierte kondensierte pyrazolverbindungen und ihre verwendung als herbizide
ES2055705T3 (es) Fungicidas.
EP1130016A4 (en) DERIVATIVES OF THIOCARBAMATE ACID
MY112411A (en) Indole derivatives.
ES2064103T3 (es) Derivados de bifenil-guanidina sustituidos en posicion orto y agentes antidiabeticos o hipoglicemicos que los contienen.
AR247881A1 (es) Amido compuestos, salvo cuando sean de aplicacion para el hombre y animales superiores, utiles para formular composiciones insecticidas y acaricidas, composiciones que los contienen y procedimiento
MX9301045A (es) Procedimiento para preparar antagonistas receptores de fibrinogeno.
FI903936A0 (fi) Saett att behandla hypertrofi och hyperplasi i hjaerta och blodkaerl.
ES2058064T3 (es) Derivados de beta-carbolina sustituidos con fenoxi, su preparacion y su utilizacion como medicamentos.
PE51499A1 (es) Derivados de 5-aroilnaftaleno
DE69101378D1 (de) Heterocyclische verbindungen, ihre darstellung und verwendung.
ES2076215T3 (es) Nuevos derivados de imidazol.
DE68908761D1 (de) Monopersulfate von stickstoffenthaltenden heterocyclischen Polypercarbonsäuren.
PT92494A (pt) Processo para a preparacao de novos derivados do indol
TH35345A (th) ไนโตรเจนเฮเทอโรไซเคิลที่ถูกแทนที่ ขบวนการสำหรับการเตรียมสารเหล่านี้ และการใช้เป็นยาฆ่าแมลงของสารเหล่านี้
TH54455A3 (es)
CO4130164A1 (es) Compuestos y composiciones insecticidas a base de diamino- quinazolinas y metodos de utilizacion
ES2112774A1 (es) Nuevos derivados azolicos con actividad antifungica.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 389189

Country of ref document: ES