ES2052559T3 - Procedimiento para preparar heparina de bajo peso molecular. - Google Patents

Procedimiento para preparar heparina de bajo peso molecular.

Info

Publication number
ES2052559T3
ES2052559T3 ES87303835T ES87303835T ES2052559T3 ES 2052559 T3 ES2052559 T3 ES 2052559T3 ES 87303835 T ES87303835 T ES 87303835T ES 87303835 T ES87303835 T ES 87303835T ES 2052559 T3 ES2052559 T3 ES 2052559T3
Authority
ES
Spain
Prior art keywords
molecular weight
heparine
bpm
low molecular
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87303835T
Other languages
English (en)
Inventor
Jorgen Ilum Nielsen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Nordisk AS
Original Assignee
Novo Nordisk AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk AS filed Critical Novo Nordisk AS
Application granted granted Critical
Publication of ES2052559T3 publication Critical patent/ES2052559T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C08B37/0078—Degradation products

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

LA INVENCION TRATA DE UN METODO PARA LA PRODUCCION DE HEPARINA DE BAJO PESO MOLECULAR (HEPARINA BPM) POR DESPOLIMERIZACION ENZIMATICA DE HEPARINA CON HEPARINASA, QUE SE CARACTERIZA PORQUE LA HEPARINA ES ALIMENTADA DE FORMA CONTINUA A LA ZONA DE DESPOLIMERIZACION, LA HEPARINA-BPM DESPOLIMERIZADA SE SOMETE A ULTRAFILTRACION, LA PORCION RETENIDA SE RECICLA A LA ZONA DE DESPOLIMERIZACION Y LA HEPARINA BPM SE RECUPERA DEL FILTRADO. EL PROCESO PERMITE PRODUCIR HEPARINA BPM CON EL PESO MOLECULAR QUE SE DESEE Y POLIDISPERSIDAD BAJA DENTRO DE LIMITES ESTRECHOS POR COMPROBACION CONTINUA O FRECUENTE DEL PESO MOLECULAR Y LA POLIDISPERSIDAD DE LA HEPARINA PRODUCIDA Y CORRECCION DE LOS PARAMETROS DEL PROCESO DE DESPOLIMERIZACION A FIN DE COMPENSAR LAS DESVIACIONES PRODUCIDAS EN LOS PARAMETROS CITADOS CON RELACION A LOS VALORES DESEADOS.
ES87303835T 1986-04-30 1987-04-29 Procedimiento para preparar heparina de bajo peso molecular. Expired - Lifetime ES2052559T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK196886A DK196886D0 (da) 1986-04-30 1986-04-30 Fremstilling af polysaccharider

Publications (1)

Publication Number Publication Date
ES2052559T3 true ES2052559T3 (es) 1994-07-16

Family

ID=8109192

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87303835T Expired - Lifetime ES2052559T3 (es) 1986-04-30 1987-04-29 Procedimiento para preparar heparina de bajo peso molecular.

Country Status (12)

Country Link
EP (1) EP0244235B1 (es)
JP (1) JPS62283102A (es)
AT (1) ATE84801T1 (es)
AU (1) AU585709B2 (es)
CA (1) CA1334080C (es)
DE (1) DE3783644T2 (es)
DK (1) DK196886D0 (es)
ES (1) ES2052559T3 (es)
FI (1) FI89943C (es)
GR (1) GR3006929T3 (es)
IE (1) IE60409B1 (es)
NO (1) NO167577C (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK196986D0 (da) * 1986-04-30 1986-04-30 Novo Industri As Fremstilling af polysaccharider
FR2663639B1 (fr) * 1990-06-26 1994-03-18 Rhone Poulenc Sante Melanges de polysaccharides de bas poids moleculaires procede de preparation et utilisation.
USRE38743E1 (en) 1990-06-26 2005-06-14 Aventis Pharma S.A. Mixtures of particular LMW heparinic polysaccharides for the prophylaxis/treatment of acute thrombotic events
US5707973A (en) * 1991-04-23 1998-01-13 Rhone-Poulenc Rorer S.A. Sulfated polysaccharids for treatment or prevention of thromboses
FR2675806B1 (fr) * 1991-04-23 1994-06-10 Rhone Poulenc Rorer Sa Polysaccharides sulfates, procede de preparation, composition pharmaceutique et utilisation.
US6001820A (en) * 1995-03-31 1999-12-14 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
US5763427A (en) * 1995-03-31 1998-06-09 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
US5744457A (en) * 1995-03-31 1998-04-28 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
US5767269A (en) * 1996-10-01 1998-06-16 Hamilton Civic Hospitals Research Development Inc. Processes for the preparation of low-affinity, low molecular weight heparins useful as antithrombotics
SI0946185T2 (sl) * 1996-11-27 2010-08-31 Aventis Pharma Inc Farmacevtski sestavek, ki obsega spojino z anti-Xa-aktivnostjo in antagonistično spojino za agregacijo ploščic
US6075013A (en) * 1997-06-06 2000-06-13 Hamilton Civic Hospitals Research Development Inc. Modified low molecular weight heparin that inhibits clot associated coagulation factors
HK1045532A1 (zh) * 1999-06-30 2002-11-29 Hamilton Civic Hospitals Research Development, Inc. 抑制与凝结有关凝结因子的肝素成份
US7575886B2 (en) 2002-03-11 2009-08-18 Momenta Pharmaceuticals, Inc. Analysis of sulfated polysaccharides
EP1582531A1 (en) * 2004-03-24 2005-10-05 Aventis Pharma S.A. Process for oxidizing unfractionated heparins and detecting presence or absence of glycoserine in heparin and heparin products
RU2295538C2 (ru) * 2005-03-01 2007-03-20 Гематологический научный центр РАМН Способ получения гепаринов с низкой молекулярной массой
EP1792621B1 (en) 2005-11-30 2012-04-04 Istituto di Ricerche Chimiche e Biochimiche "G. Ronzoni" Orally administrable heparin derivatives
US9139876B1 (en) 2007-05-03 2015-09-22 Momenta Pharmacueticals, Inc. Method of analyzing a preparation of a low molecular weight heparin
RU2377993C2 (ru) * 2007-11-08 2010-01-10 Государственное учреждение гематологический научный центр Российской академии медицинских наук (ГУ ГНЦ РАМН) Способ получения низкомолекулярного гепарина
CN102791742B (zh) 2010-01-19 2014-12-24 动量制药公司 评价肝素制剂
WO2012115952A1 (en) 2011-02-21 2012-08-30 Momenta Pharmaceuticals, Inc. Evaluating heparin preparations
CN102690862B (zh) * 2012-06-08 2015-01-28 上海太阳生物技术有限公司 抗凝血酶ⅲ(at-ⅲ)测定试剂盒(发色底物法)
WO2022015794A1 (en) 2020-07-14 2022-01-20 Optimvia, Llc Methods for synthesizing non-anticoagulant heparan sulfate
AU2020310172A1 (en) 2019-07-09 2022-03-03 Optimvia Llc Methods for synthesizing anticoagulant polysaccharides
CN111763702A (zh) * 2020-07-13 2020-10-13 福州大学 一种制备硫酸乙酰肝素寡糖的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4351938A (en) * 1980-05-19 1982-09-28 Riker Laboratories, Inc. Anticoagulant substance
US4396762A (en) * 1981-08-24 1983-08-02 Massachusetts Institute Of Technology Heparinase derived anticoagulants
DE3244214A1 (de) * 1982-11-30 1984-05-30 B. Braun Melsungen Ag, 3508 Melsungen Verfahren zur reinigung und fraktionierung von heparin
DK196986D0 (da) * 1986-04-30 1986-04-30 Novo Industri As Fremstilling af polysaccharider

Also Published As

Publication number Publication date
IE871152L (en) 1987-10-30
EP0244235B1 (en) 1993-01-20
FI871909L (fi) 1987-10-31
EP0244235A2 (en) 1987-11-04
NO167577B (no) 1991-08-12
DE3783644T2 (de) 1993-05-13
ATE84801T1 (de) 1993-02-15
JPH0542918B2 (es) 1993-06-30
NO871784L (no) 1987-11-02
AU7225387A (en) 1987-11-05
FI89943C (fi) 1993-12-10
EP0244235A3 (en) 1988-09-28
NO871784D0 (no) 1987-04-29
DK196886D0 (da) 1986-04-30
GR3006929T3 (es) 1993-06-30
DE3783644D1 (de) 1993-03-04
CA1334080C (en) 1995-01-24
AU585709B2 (en) 1989-06-22
FI871909A0 (fi) 1987-04-29
IE60409B1 (en) 1994-07-13
NO167577C (no) 1991-11-20
JPS62283102A (ja) 1987-12-09
FI89943B (fi) 1993-08-31

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