ATE84801T1 - Verfahren zur herstellung von heparin mit niedrigem molekulargewicht. - Google Patents

Verfahren zur herstellung von heparin mit niedrigem molekulargewicht.

Info

Publication number: ATE84801T1
Authority: AT; Austria
Prior art keywords: heparin; molecular weight; lmw; production; depolymerization
Prior art date: 1986-04-30

Application number

AT87303835T

Other languages

English (en)

Inventor

Jorgen Ilum Nielsen

Original Assignee

Novo Nordisk As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-04-30

Filing date

1987-04-29

Publication date

1993-02-15

1987-04-29 Application filed by Novo Nordisk As filed Critical Novo Nordisk As

1993-02-15 Application granted granted Critical

1993-02-15 Publication of ATE84801T1 publication Critical patent/ATE84801T1/de

Links

239000003055 low molecular weight heparin Substances 0.000 title abstract 7
229940127215 low-molecular weight heparin Drugs 0.000 title abstract 7
238000004519 manufacturing process Methods 0.000 title abstract 3
238000000034 method Methods 0.000 title abstract 3
HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 abstract 2
229960002897 heparin Drugs 0.000 abstract 2
229920000669 heparin Polymers 0.000 abstract 2
108010022901 Heparin Lyase Proteins 0.000 abstract 1
238000012691 depolymerization reaction Methods 0.000 abstract 1
230000002255 enzymatic effect Effects 0.000 abstract 1
239000000706 filtrate Substances 0.000 abstract 1
239000000047 product Substances 0.000 abstract 1
239000012465 retentate Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
- C08B37/0078—Degradation products

Landscapes

Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Materials Engineering (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Polymers & Plastics (AREA)
Organic Chemistry (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

AT87303835T 1986-04-30 1987-04-29 Verfahren zur herstellung von heparin mit niedrigem molekulargewicht. ATE84801T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DK196886A DK196886D0 (da)	1986-04-30	1986-04-30	Fremstilling af polysaccharider
EP87303835A EP0244235B1 (de)	1986-04-30	1987-04-29	Verfahren zur Herstellung von Heparin mit niedrigem Molekulargewicht

Publications (1)

Publication Number	Publication Date
ATE84801T1 true ATE84801T1 (de)	1993-02-15

Family

ID=8109192

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT87303835T ATE84801T1 (de)	1986-04-30	1987-04-29	Verfahren zur herstellung von heparin mit niedrigem molekulargewicht.

Country Status (12)

Country	Link
EP (1)	EP0244235B1 (de)
JP (1)	JPS62283102A (de)
AT (1)	ATE84801T1 (de)
AU (1)	AU585709B2 (de)
CA (1)	CA1334080C (de)
DE (1)	DE3783644T2 (de)
DK (1)	DK196886D0 (de)
ES (1)	ES2052559T3 (de)
FI (1)	FI89943C (de)
GR (1)	GR3006929T3 (de)
IE (1)	IE60409B1 (de)
NO (1)	NO167577C (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK196986D0 (da) *	1986-04-30	1986-04-30	Novo Industri As	Fremstilling af polysaccharider
USRE38743E1 (en)	1990-06-26	2005-06-14	Aventis Pharma S.A.	Mixtures of particular LMW heparinic polysaccharides for the prophylaxis/treatment of acute thrombotic events
FR2663639B1 (fr) *	1990-06-26	1994-03-18	Rhone Poulenc Sante	Melanges de polysaccharides de bas poids moleculaires procede de preparation et utilisation.
US5707973A (en) *	1991-04-23	1998-01-13	Rhone-Poulenc Rorer S.A.	Sulfated polysaccharids for treatment or prevention of thromboses
FR2675806B1 (fr) *	1991-04-23	1994-06-10	Rhone Poulenc Rorer Sa	Polysaccharides sulfates, procede de preparation, composition pharmaceutique et utilisation.
US5763427A (en) *	1995-03-31	1998-06-09	Hamilton Civic Hospitals Research Development Inc.	Compositions and methods for inhibiting thrombogenesis
US6001820A (en) *	1995-03-31	1999-12-14	Hamilton Civic Hospitals Research Development Inc.	Compositions and methods for inhibiting thrombogenesis
US5744457A (en) *	1995-03-31	1998-04-28	Hamilton Civic Hospitals Research Development Inc.	Compositions and methods for inhibiting thrombogenesis
US5767269A (en) *	1996-10-01	1998-06-16	Hamilton Civic Hospitals Research Development Inc.	Processes for the preparation of low-affinity, low molecular weight heparins useful as antithrombotics
AU754936B2 (en) *	1996-11-27	2002-11-28	Aventis Pharmaceuticals Inc.	Pharmaceutical composition comprising a compound having anti-Xa activity and a platelet aggregation antagonist compound
AU7753898A (en) *	1997-06-06	1998-12-21	Hamilton Civic Hospitals Research Development, Inc.	Modified low molecular weight heparin that inhibits clot associated coagulation factors
CZ20014665A3 (cs) *	1999-06-30	2002-05-15	Hamilton Civic Hospitals Research Development, Inc	Prostředek s obsahem heparinu se střední molekulovou hmotností
JP4828795B2 (ja)	2002-03-11	2011-11-30	モメンタファーマシューティカルズインコーポレイテッド	硫酸化多糖類の分析
EP1582531A1 (de) *	2004-03-24	2005-10-05	Aventis Pharma S.A.	Verfahren zur Oxydierung nicht-fraktionierten Heparins und die Detektion der Anwesenheit oder Abwesenheit von Glykoserin in Heparin und in von Heparin abgeleiteten Produkten
RU2295538C2 (ru) *	2005-03-01	2007-03-20	Гематологический научный центр РАМН	Способ получения гепаринов с низкой молекулярной массой
EP1792621B1 (de)	2005-11-30	2012-04-04	Istituto di Ricerche Chimiche e Biochimiche "G. Ronzoni"	Oral verabreichbare Heparinderivate
US9139876B1 (en)	2007-05-03	2015-09-22	Momenta Pharmacueticals, Inc.	Method of analyzing a preparation of a low molecular weight heparin
RU2377993C2 (ru) *	2007-11-08	2010-01-10	Государственное учреждение гематологический научный центр Российской академии медицинских наук (ГУ ГНЦ РАМН)	Способ получения низкомолекулярного гепарина
WO2011090948A1 (en)	2010-01-19	2011-07-28	Momenta Pharmaceuticals, Inc.	Evaluating heparin preparations
WO2012115952A1 (en)	2011-02-21	2012-08-30	Momenta Pharmaceuticals, Inc.	Evaluating heparin preparations
CN102690862B (zh) *	2012-06-08	2015-01-28	上海太阳生物技术有限公司	抗凝血酶ⅲ(at-ⅲ)测定试剂盒(发色底物法)
WO2022015794A1 (en)	2020-07-14	2022-01-20	Optimvia, Llc	Methods for synthesizing non-anticoagulant heparan sulfate
JP2022540849A (ja)	2019-07-09	2022-09-20	オプティムヴィア、エルエルシー	抗凝固性多糖類の合成方法
CN111763702A (zh) *	2020-07-13	2020-10-13	福州大学	一种制备硫酸乙酰肝素寡糖的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4351938A (en) *	1980-05-19	1982-09-28	Riker Laboratories, Inc.	Anticoagulant substance
US4396762A (en) *	1981-08-24	1983-08-02	Massachusetts Institute Of Technology	Heparinase derived anticoagulants
DE3244214A1 (de) *	1982-11-30	1984-05-30	B. Braun Melsungen Ag, 3508 Melsungen	Verfahren zur reinigung und fraktionierung von heparin
DK196986D0 (da) *	1986-04-30	1986-04-30	Novo Industri As	Fremstilling af polysaccharider

1986
- 1986-04-30 DK DK196886A patent/DK196886D0/da not_active Application Discontinuation
1987
- 1987-04-29 EP EP87303835A patent/EP0244235B1/de not_active Expired - Lifetime
- 1987-04-29 ES ES87303835T patent/ES2052559T3/es not_active Expired - Lifetime
- 1987-04-29 FI FI871909A patent/FI89943C/fi not_active IP Right Cessation
- 1987-04-29 DE DE8787303835T patent/DE3783644T2/de not_active Expired - Fee Related
- 1987-04-29 NO NO871784A patent/NO167577C/no not_active IP Right Cessation
- 1987-04-29 AT AT87303835T patent/ATE84801T1/de not_active IP Right Cessation
- 1987-04-30 CA CA000536095A patent/CA1334080C/en not_active Expired - Fee Related
- 1987-04-30 JP JP62104845A patent/JPS62283102A/ja active Granted
- 1987-04-30 AU AU72253/87A patent/AU585709B2/en not_active Ceased
- 1987-05-11 IE IE115287A patent/IE60409B1/en not_active IP Right Cessation
1993
- 1993-01-28 GR GR930400176T patent/GR3006929T3/el unknown

Also Published As

Publication number	Publication date
GR3006929T3 (de)	1993-06-30
EP0244235A3 (en)	1988-09-28
JPS62283102A (ja)	1987-12-09
FI871909A0 (fi)	1987-04-29
AU7225387A (en)	1987-11-05
IE871152L (en)	1987-10-30
DK196886D0 (da)	1986-04-30
NO871784D0 (no)	1987-04-29
DE3783644D1 (de)	1993-03-04
EP0244235A2 (de)	1987-11-04
EP0244235B1 (de)	1993-01-20
NO167577B (no)	1991-08-12
ES2052559T3 (es)	1994-07-16
FI89943C (fi)	1993-12-10
CA1334080C (en)	1995-01-24
JPH0542918B2 (de)	1993-06-30
NO871784L (no)	1987-11-02
FI89943B (fi)	1993-08-31
AU585709B2 (en)	1989-06-22
IE60409B1 (en)	1994-07-13
FI871909L (fi)	1987-10-31
NO167577C (no)	1991-11-20
DE3783644T2 (de)	1993-05-13

Legal Events

Date	Code	Title	Description
1993-07-15	UEP	Publication of translation of european patent specification
2005-01-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE84801T1 (de)	1993-02-15	Verfahren zur herstellung von heparin mit niedrigem molekulargewicht.
ATE114677T1 (de)	1994-12-15	Verfahren zur herstellung von propylenpolymeren mit langkettiger endabzweigung und ihre verwendung.
DE3768431D1 (de)	1991-04-11	Waessrige schreibfluessigkeiten sowie ein verfahren zu deren herstellung.
ATE86665T1 (de)	1993-03-15	Verfahren zur herstellung der 2-keto-lgulons\|ure.
HUT52823A (en)	1990-08-28	Process for producing transcription-based, nucleinic acid multiplying/detecting systems
ATE268788T1 (de)	2004-06-15	Verfahren zur herstellung von polyisocyanaten
ATE141619T1 (de)	1996-09-15	Verfahren zur herstellung von polymeren mit niedrigem molekulargewicht
ATE137493T1 (de)	1996-05-15	Verfahren zur herstellung von zwischenprodukten zur verwendung in der herstellung von alkoxyiminoacetamide
AT380687B (de)	1986-06-25	Verfahren zur herstellung von n-phosphonometyl-glycin
DE3772847D1 (de)	1991-10-17	Verfahren zur herstellung von 2-methyl-1,4-naphthochinon.
DE59007037D1 (de)	1994-10-13	Verfahren zur Herstellung von perlförmigen expandierbaren Styrolpolymerisaten.
ATE129705T1 (de)	1995-11-15	Phenothiazindimere und oligomere, verfahren zur herstellung und verwendung zur verhütung von reaktorinkrustierungen.
ATE74933T1 (de)	1992-05-15	Verfahren zum herstellen von propylen-ethylenpolymerisaten.
ATE1386T1 (de)	1982-08-15	Waessrige dispersionen von oligomeren oder polymeren kunststoffen, ein verfahren zu ihrer herstellung sowie ihre verwendung.
DE3579896D1 (de)	1990-10-31	Verfahren zur herstellung von 2,2,4-trimethyl-1,3-pentandiolmonoisobutyrat.
DE3382073D1 (de)	1991-02-07	Verfahren zur herstellung von polyacetal polymeren und monomere hierfuer.
ATE133204T1 (de)	1996-02-15	Verfahren zur kontinuierlichen umsetzung von cephalosporinderivaten zu glutaryl-7-amino- cephalosporansäurederivaten
ATE57191T1 (de)	1990-10-15	Verfahren zur herstellung eines polyacetalpolymeren.
ATE103329T1 (de)	1994-04-15	Verfahren zur herstellung von hgiairestriktionsendonuklease und -methylase.
DK217087A (da)	1987-10-31	Fremstilling af lmw-heparin
ATE136043T1 (de)	1996-04-15	Verfahren zur herstellung von ethylen- alkylcarbonsäurevinylester-mischpolymerisaten
DE3874846D1 (de)	1992-10-29	Verfahren zur herstellung von harnstoff.
ATE76662T1 (de)	1992-06-15	Enzymatisches verfahren zur herstellung von 3substituierten cephalosporinen.
ATE62674T1 (de)	1991-05-15	Verfahren zur herstellung von n-allylpiperidinderivaten.
ATE128112T1 (de)	1995-10-15	Verfahren zur herstellung von cyclopropylmethylketon.