ES2052636T3 - Sistema de suministro para la administracion controlada y de compuestos analogos a lhrh. - Google Patents

Sistema de suministro para la administracion controlada y de compuestos analogos a lhrh.

Info

Publication number
ES2052636T3
ES2052636T3 ES88107345T ES88107345T ES2052636T3 ES 2052636 T3 ES2052636 T3 ES 2052636T3 ES 88107345 T ES88107345 T ES 88107345T ES 88107345 T ES88107345 T ES 88107345T ES 2052636 T3 ES2052636 T3 ES 2052636T3
Authority
ES
Spain
Prior art keywords
lhrh
analoged
compounds
supply system
controlled administration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88107345T
Other languages
English (en)
Inventor
Lynda M Sanders
Ramon A Burns Jr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syntex USA LLC
Original Assignee
Syntex USA LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex USA LLC filed Critical Syntex USA LLC
Application granted granted Critical
Publication of ES2052636T3 publication Critical patent/ES2052636T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A61K9/2036—Silicones; Polysiloxanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Organic Chemistry (AREA)
  • Reproductive Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Reduction Or Emphasis Of Bandwidth Of Signals (AREA)
  • Materials For Medical Uses (AREA)

Abstract

LA INVENCION SE REFIERE A UN SISTEMA DE LIBERACION POLIMERICO IMPLANTABLE PARA LA ADMINISTRACION CONTROLADA Y CONTINUA DE UN ANALOGO DE LA HORMONA LIBERADORA DE HORMONALUTEINIZANTE (LHRH) QUE COMPRENDE UNA MATRIZ DE CAUCHO DE SILICONA EN LA QUE SE DISPERSA DE 30 A 42% EN PESO DE UNA FASE SOLUBLE EN AGUA, EN FORMA DE PARTICULAS, QUE CONTIENE UN ANALOGO DE LHRH O UNA SAL SUYA FARMACEUTICAMENTE ACEPTABLE.
ES88107345T 1987-05-08 1988-05-06 Sistema de suministro para la administracion controlada y de compuestos analogos a lhrh. Expired - Lifetime ES2052636T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/047,738 US5028430A (en) 1987-05-08 1987-05-08 Delivery systems for the controlled administration of LHRH analogs

Publications (1)

Publication Number Publication Date
ES2052636T3 true ES2052636T3 (es) 1994-07-16

Family

ID=21950670

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88107345T Expired - Lifetime ES2052636T3 (es) 1987-05-08 1988-05-06 Sistema de suministro para la administracion controlada y de compuestos analogos a lhrh.

Country Status (11)

Country Link
US (1) US5028430A (es)
EP (1) EP0293632B1 (es)
JP (1) JPH0686391B2 (es)
AT (1) ATE81285T1 (es)
AU (1) AU621294B2 (es)
CA (1) CA1336579C (es)
DE (1) DE3875160T2 (es)
ES (1) ES2052636T3 (es)
GR (1) GR3005901T3 (es)
IE (1) IE62969B1 (es)
NZ (1) NZ224520A (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5387419A (en) * 1988-03-31 1995-02-07 The University Of Michigan System for controlled release of antiarrhythmic agents
IL87982A0 (en) * 1988-10-10 1989-03-31 Israel Oceanographic & Limnolo Compositions and methods for manipulating ovulation and spawning in fish
MY107937A (en) * 1990-02-13 1996-06-29 Takeda Chemical Industries Ltd Prolonged release microcapsules.
ATE184776T1 (de) * 1991-10-21 1999-10-15 Peptech Limited Biokompatibles implantat für die zeitliche abstimmung der ovulation von stuten
EP0572932B1 (en) * 1992-06-02 2000-09-13 C.R. Bard, Inc. Method and implant device for long term delivery of drugs
US5981719A (en) 1993-03-09 1999-11-09 Epic Therapeutics, Inc. Macromolecular microparticles and methods of production and use
US6090925A (en) 1993-03-09 2000-07-18 Epic Therapeutics, Inc. Macromolecular microparticles and methods of production and use
DE4342091A1 (de) * 1993-12-09 1995-06-14 Asta Medica Ag Erzeugnisse zur Anwendung von initial hohen Dosen von Cetrorelix und Herstellung einer Kombinationspackung zur Verwendung bei Therapie von Krankheiten
US5733565A (en) * 1996-02-23 1998-03-31 The Population Council, Center For Biomedical Research Male contraceptive implant
US5968895A (en) * 1996-12-11 1999-10-19 Praecis Pharmaceuticals, Inc. Pharmaceutical formulations for sustained drug delivery
US20070185032A1 (en) * 1996-12-11 2007-08-09 Praecis Pharmaceuticals, Inc. Pharmaceutical formulations for sustained drug delivery
US6117441A (en) * 1998-07-02 2000-09-12 The Population Council, Inc. Silicone core long term androgen delivery implant
US7179483B2 (en) * 2000-04-26 2007-02-20 Watson Pharmaceuticals, Inc. Compositions and methods for transdermal oxybutynin therapy
US7029694B2 (en) * 2000-04-26 2006-04-18 Watson Laboratories, Inc. Compositions and methods for transdermal oxybutynin therapy
JP2003531157A (ja) 2000-04-26 2003-10-21 ワトソン ファーマシューティカルズ， インコーポレイテッド オキシブチニン治療に関連した有害な経験の最小化
US20030124177A1 (en) * 2000-04-26 2003-07-03 Watson Pharmaceuticals, Inc. Compositions and methods for transdermal oxybutynin therapy
AUPR602501A0 (en) * 2001-06-29 2001-07-26 Smart Drug Systems Inc Sustained release pharmaceutical composition
AUPR602401A0 (en) * 2001-06-29 2001-07-26 Smart Drug Systems Inc Sustained release delivery system
WO2003022242A1 (en) * 2001-09-11 2003-03-20 Smart Drug Systems Inc Preparation of sustained release pharmaceutical composition
US20060193825A1 (en) * 2003-04-29 2006-08-31 Praecis Phamaceuticals, Inc. Pharmaceutical formulations for sustained drug delivery
US20050112087A1 (en) * 2003-04-29 2005-05-26 Musso Gary F. Pharmaceutical formulations for sustained drug delivery
CN101683317A (zh) * 2004-05-31 2010-03-31 斯玛特药物系统公司 缓释组合物
US20120156049A1 (en) * 2005-12-14 2012-06-21 Hong Shek C Method and coating for protecting and repairing an airfoil surface
WO2009085251A1 (en) * 2007-12-19 2009-07-09 Auburn University Polymer implants for timed release of drugs with particular emphasis on ovulation or spermiation of fish
US20120163981A1 (en) * 2010-12-22 2012-06-28 Hong Shek C Method and coating for protecting and repairing an airfoil surface
KR20200089731A (ko) * 2017-11-23 2020-07-27 덴마크스 텍니스케 유니버시테트 제어가능한 방출 프로파일을 갖는 활성 매트릭스로서의 글리세롤-실리콘 엘라스토머

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE791632A (fr) * 1971-11-20 1973-05-21 Schering Ag Supports a base de caoutchouc siliconique pour agents medicamenteux
US4391797A (en) * 1977-01-05 1983-07-05 The Children's Hospital Medical Center Systems for the controlled release of macromolecules
IT1149971B (it) * 1979-06-11 1986-12-10 Syntex Inc Derivati nonapeptide e decapeptide dell'ormone che rilascia l'ormone luteinizzante
US4234571A (en) * 1979-06-11 1980-11-18 Syntex (U.S.A.) Inc. Nonapeptide and decapeptide derivatives of luteinizing hormone releasing hormone
US4675189A (en) * 1980-11-18 1987-06-23 Syntex (U.S.A.) Inc. Microencapsulation of water soluble active polypeptides
PH19942A (en) * 1980-11-18 1986-08-14 Sintex Inc Microencapsulation of water soluble polypeptides
IE52535B1 (en) * 1981-02-16 1987-12-09 Ici Plc Continuous release pharmaceutical compositions
US4581169A (en) * 1982-12-21 1986-04-08 Syntex (U.S.A.) Inc. Nona-peptide and deca-peptide analogs of LHRH, useful as LHRH antagonists
US4481190A (en) * 1982-12-21 1984-11-06 Syntex (U.S.A.) Inc. Nonapeptide and decapeptide analogs of LHRH useful as LHRH antagonists
NZ217844A (en) * 1985-10-11 1989-10-27 Sumitomo Pharma A sustained release pharmaceutical composition containing silicone elastomer and an albumin
JPS62174031A (ja) * 1985-10-11 1987-07-30 Sumitomo Pharmaceut Co Ltd 高分子量薬物含有徐放性製剤
US4959217A (en) * 1986-05-22 1990-09-25 Syntex (U.S.A.) Inc. Delayed/sustained release of macromolecules

Also Published As

Publication number Publication date
US5028430A (en) 1991-07-02
AU621294B2 (en) 1992-03-12
DE3875160D1 (de) 1992-11-12
NZ224520A (en) 1990-12-21
GR3005901T3 (es) 1993-06-07
JPS6445318A (en) 1989-02-17
DE3875160T2 (de) 1993-03-18
IE881365L (en) 1988-11-08
IE62969B1 (en) 1995-03-08
JPH0686391B2 (ja) 1994-11-02
CA1336579C (en) 1995-08-08
ATE81285T1 (de) 1992-10-15
AU1568288A (en) 1988-11-10
EP0293632A1 (en) 1988-12-07
EP0293632B1 (en) 1992-10-07

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