ES2052801T3 - Procedimiento diastereoselectivo para la preparacion de intermediarios utiles para la sintesis de derivados peptidicos. - Google Patents

Procedimiento diastereoselectivo para la preparacion de intermediarios utiles para la sintesis de derivados peptidicos.

Info

Publication number
ES2052801T3
ES2052801T3 ES89107141T ES89107141T ES2052801T3 ES 2052801 T3 ES2052801 T3 ES 2052801T3 ES 89107141 T ES89107141 T ES 89107141T ES 89107141 T ES89107141 T ES 89107141T ES 2052801 T3 ES2052801 T3 ES 2052801T3
Authority
ES
Spain
Prior art keywords
synthesis
preparation
diastereoselective
procedure
peptidic derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89107141T
Other languages
English (en)
Inventor
Franco Pellacini
Dario Chiarino
Angelo Carenzi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zambon Group SpA
Zambon SpA
Original Assignee
Zambon Group SpA
Zambon SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zambon Group SpA, Zambon SpA filed Critical Zambon Group SpA
Application granted granted Critical
Publication of ES2052801T3 publication Critical patent/ES2052801T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C221/00—Preparation of compounds containing amino groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30—Preparation of optical isomers
    • C07C227/32—Preparation of optical isomers by stereospecific synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C07C317/48—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C317/50—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/43—Y being a hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/63—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

UN PROCESO DIASTEREOSELECTIVO PARA LA PREPARACION DE COMPONENTES DE FORMULA (I), DONDE R Y R1 TIENEN LOS SIGNIFICADOS REPORTADOS EN LA ESPECIFICACION Y LOS ASTERISCOS MUESTRAN LOS CARBONOS ASIMETRICOS, EMPEZANDO DESDE EL CORRESPONDIENTE N - PROTEGIDO 2 - AMINO - 3 - ARIL - PROPANO - 1 - OL ES DESCRITO. LOS COMPONENTES DE FORMULA I SON INTERMEDIARIOS UTILES PARA LA SINTESIS DE PEPTIDOS ACTIVOS FARMACOLOGICAMENTE.
ES89107141T 1988-05-11 1989-04-20 Procedimiento diastereoselectivo para la preparacion de intermediarios utiles para la sintesis de derivados peptidicos. Expired - Lifetime ES2052801T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT20542/88A IT1217567B (it) 1988-05-11 1988-05-11 Processo diastereoselettivo per la preparazione di intermedi utili per la sintesi di derivati peptidici

Publications (1)

Publication Number Publication Date
ES2052801T3 true ES2052801T3 (es) 1994-07-16

Family

ID=11168517

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89107141T Expired - Lifetime ES2052801T3 (es) 1988-05-11 1989-04-20 Procedimiento diastereoselectivo para la preparacion de intermediarios utiles para la sintesis de derivados peptidicos.

Country Status (8)

Country Link
US (1) US5157143A (es)
EP (1) EP0341462B1 (es)
JP (1) JP2860559B2 (es)
AT (1) ATE80380T1 (es)
DE (1) DE68902771T2 (es)
ES (1) ES2052801T3 (es)
GR (1) GR3006432T3 (es)
IT (1) IT1217567B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5648511A (en) * 1990-11-19 1997-07-15 G.D. Searle & Co. Method for making intermediates useful in the synthesis of retroviral protease inhibitors
US6743929B1 (en) * 1992-08-25 2004-06-01 G. D. Searle & Co. Sulfonylalkanoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
ATE284863T1 (de) * 1996-02-08 2005-01-15 Nippon Kayaku Kk Verfahren zur erzeugung optisch aktiver cyanohydrine
JP2001048850A (ja) * 1999-05-28 2001-02-20 Kanegafuchi Chem Ind Co Ltd ノルスタチン誘導体の製造法
JP2002047256A (ja) * 2000-07-26 2002-02-12 Kanegafuchi Chem Ind Co Ltd α−アミノ−α´，α´，α´−トリハロケトン誘導体、α−アミノ−α´，α´，α´−トリハロアルコ−ル誘導体、及び、α−ヒドロキシ−β−アミノカルボン酸誘導体の製造法
WO2007029587A1 (ja) 2005-09-05 2007-03-15 Dainippon Sumitomo Pharma Co., Ltd. βセクレターゼ阻害剤

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2090595B (en) * 1978-11-25 1983-05-11 Nippon Kayaku Kk Threo-3-amino-2-hydroxybutanoylacetice acid derivatives
JPS6033439B2 (ja) * 1980-03-07 1985-08-02 財団法人相模中央化学研究所 ジペプチドの製造方法

Also Published As

Publication number Publication date
EP0341462B1 (en) 1992-09-09
EP0341462A1 (en) 1989-11-15
IT1217567B (it) 1990-03-30
US5157143A (en) 1992-10-20
JP2860559B2 (ja) 1999-02-24
GR3006432T3 (es) 1993-06-21
DE68902771D1 (de) 1992-10-15
JPH0228144A (ja) 1990-01-30
IT8820542A0 (it) 1988-05-11
ATE80380T1 (de) 1992-09-15
DE68902771T2 (de) 1993-01-07

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