ES2052889T3 - Metodo para la sintesis de inhibidores triciclicos de la aromatasa. - Google Patents

Metodo para la sintesis de inhibidores triciclicos de la aromatasa.

Info

Publication number
ES2052889T3
ES2052889T3 ES89202257T ES89202257T ES2052889T3 ES 2052889 T3 ES2052889 T3 ES 2052889T3 ES 89202257 T ES89202257 T ES 89202257T ES 89202257 T ES89202257 T ES 89202257T ES 2052889 T3 ES2052889 T3 ES 2052889T3
Authority
ES
Spain
Prior art keywords
alcoxy
alkyl
group
imidazolil
halogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89202257T
Other languages
English (en)
Inventor
Hubert Jan Jozef Loozen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Akzo NV
Original Assignee
Akzo NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo NV filed Critical Akzo NV
Application granted granted Critical
Publication of ES2052889T3 publication Critical patent/ES2052889T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
    • C07D213/16—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Cosmetics (AREA)

Abstract

LA INVENCION EXPONE INHIBIDORES DE AROMATOSA TRICICLICA, SU PREPARACION Y USO EN COMPOSICIONES FARMACEUTICAS. LA COMPOSICION DE LA INVENCION POSEE LA FORMULA GENERAL (I): DONDE R1 Y R2 INDEPENDIENTEMENTE EL UNO DEL OTRO SON H, HALOGENO, ALQUILO, ALCOXI, ALQUITIO, OH, CN, CF3, NO2, UN GRUPO AMINO INSUSTITUIDO O SUSTITUIDO POR ALQUILO, UN GRUPO NH ACILO, UN GRUPO CARBONAMIDA O UN GRUPO CARBOXILATO LIBRE O ESTERIFICADO; R3 ES H, ALQUILO, ALCOXIALQUILO O ARILALQUILO; R4 ES H, OH, ALCOXI O ARILALQUILO; M ES 1 O 2; N ES 2, 3, O 4. LA LINEA DISCONTINUA REPRESENTA UN ENLACE OPCIONAL: Q EXPRESA IMIDAZOLIL (II), TRIAZOLIL (III) O PIRIDIL (IV); CON LA CONDICION DE QUE CUANDO R1 Y R2 SON H, HALOGENO, ALQUILO, ALCOXI O OH, M=1, N=3, LA LINEA DISCONTINUA NO REPRESENTA UN ENLACE Y Q ES IMIDAZOLIL, R3 Y R4 NO PUEDEN SER AMBOS H; Y TAMBIEN SALES ACEPTABLES FARMACEUTICAS DE ELLOS.
ES89202257T 1988-09-12 1989-09-07 Metodo para la sintesis de inhibidores triciclicos de la aromatasa. Expired - Lifetime ES2052889T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL8802227 1988-09-12

Publications (1)

Publication Number Publication Date
ES2052889T3 true ES2052889T3 (es) 1994-07-16

Family

ID=19852881

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89202257T Expired - Lifetime ES2052889T3 (es) 1988-09-12 1989-09-07 Metodo para la sintesis de inhibidores triciclicos de la aromatasa.

Country Status (15)

Country Link
US (1) US5019585A (es)
EP (1) EP0360324B1 (es)
JP (1) JPH02115124A (es)
KR (1) KR900004699A (es)
AT (1) ATE82270T1 (es)
AU (1) AU619590B2 (es)
DE (2) DE68903465T4 (es)
DK (1) DK445389A (es)
ES (1) ES2052889T3 (es)
FI (1) FI894273A7 (es)
GR (1) GR3007040T3 (es)
IE (1) IE892812L (es)
NZ (1) NZ230559A (es)
PT (1) PT91698B (es)
ZA (1) ZA896787B (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH682878A5 (fr) * 1991-11-01 1993-12-15 Nestle Sa Procédé permettant d'éviter le brunissement d'un produit alimentaire.

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL8003141A (nl) * 1980-05-30 1982-01-04 Akzo Nv Biologisch aktieve tricyclische aminen.
US4605661A (en) * 1984-06-18 1986-08-12 Eli Lilly And Company Aromastase inhibiting α,α-diarylimidazole-4(5)-propionitriles, α,α-diarylimidazole-4(5)-propionamides, and 4(5)-(2,2-diarylethyl)imidazoles
US4801594A (en) * 1984-06-18 1989-01-31 Eli Lilly And Company Aromatase inhibitors

Also Published As

Publication number Publication date
PT91698A (pt) 1990-03-30
DE68903465D1 (en) 1992-12-17
US5019585A (en) 1991-05-28
DK445389D0 (da) 1989-09-08
DE68903465T2 (de) 1993-05-13
NZ230559A (en) 1991-03-26
AU4124589A (en) 1990-03-15
ATE82270T1 (de) 1992-11-15
DE68903465T4 (de) 1994-02-10
FI894273L (fi) 1990-03-13
JPH02115124A (ja) 1990-04-27
FI894273A7 (fi) 1990-03-13
GR3007040T3 (es) 1993-07-30
IE892812L (en) 1990-03-12
ZA896787B (en) 1990-06-27
FI894273A0 (fi) 1989-09-11
AU619590B2 (en) 1992-01-30
EP0360324B1 (en) 1992-11-11
EP0360324A1 (en) 1990-03-28
DK445389A (da) 1990-03-13
KR900004699A (ko) 1990-04-12
PT91698B (pt) 1995-06-30

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