ES8302626A1 - "procedimiento de preparacion de derivados carboxilato". - Google Patents

"procedimiento de preparacion de derivados carboxilato".

Info

Publication number
ES8302626A1
ES8302626A1 ES512574A ES512574A ES8302626A1 ES 8302626 A1 ES8302626 A1 ES 8302626A1 ES 512574 A ES512574 A ES 512574A ES 512574 A ES512574 A ES 512574A ES 8302626 A1 ES8302626 A1 ES 8302626A1
Authority
ES
Spain
Prior art keywords
aryl
preparation
cyclopropane
carboxylates
aminomethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES512574A
Other languages
English (en)
Other versions
ES512574A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pierre Fabre SA
Original Assignee
Pierre Fabre SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pierre Fabre SA filed Critical Pierre Fabre SA
Publication of ES8302626A1 publication Critical patent/ES8302626A1/es
Publication of ES512574A0 publication Critical patent/ES512574A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/14—Radicals substituted by nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

_(PROCEDIMIENTO DE PREPARACION DE DERIVADOS CARBOXILATO . SE HACE REACCIONAR UNA LACTONA DE FORMULA GENERAL (I) CON UN ALCOHOL O UN FENOL R <024>OH EN PRESENCIA DE UN HALOGENURO DE TIONILO DE FORMULA SOX ; SE OBTIENEN LOS DERIVADOS (II), LOS CUALES SON TRATADOS A CONTINUACION CON UNA AMINA CON LO QUE SE OBTIENEN LOS COMPUESTOS (III). R REPRESENTA UN ATOMO DE HIDROGENO, O DE HALOGENO, UN GRUPO ALCOHILO, ALCOXI INFERIOR, NITRO, AMINO, SULFANOHILO O HIDROXI; N REPRESENTA 1, 2 O 3, (R)<009> PUEDE FORMAR CON EL CICLO BENCENICO EL NUCLEO NAFTILO; R REPRESENTA UN GRUPO ALCOHILO O ALCENILO, ARILO O BENCILO; R Y R REPRESENTAN UN ATOMO DE HIDROGENO, UN GRUPO ALOHILO, ALCENILO, ALCINILO U OTROS.
ES512574A 1981-06-23 1982-05-27 "procedimiento de preparacion de derivados carboxilato". Granted ES512574A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8112311A FR2508033A1 (fr) 1981-06-23 1981-06-23 Aryl-1 aminomethyl-2 cyclopropanes carboxylates (z), leur preparation et leur application en tant que medicaments utiles dans le traitement d'algies diverses

Publications (2)

Publication Number Publication Date
ES8302626A1 true ES8302626A1 (es) 1983-02-16
ES512574A0 ES512574A0 (es) 1983-02-16

Family

ID=9259784

Family Applications (1)

Application Number Title Priority Date Filing Date
ES512574A Granted ES512574A0 (es) 1981-06-23 1982-05-27 "procedimiento de preparacion de derivados carboxilato".

Country Status (10)

Country Link
US (2) US4507318A (es)
EP (1) EP0068998B1 (es)
JP (1) JPS58945A (es)
AT (1) ATE15181T1 (es)
AU (1) AU553924B2 (es)
CA (1) CA1199929A (es)
DE (1) DE3265838D1 (es)
ES (1) ES512574A0 (es)
FR (1) FR2508033A1 (es)
ZA (1) ZA824403B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2508033A1 (fr) * 1981-06-23 1982-12-24 Fabre Sa Pierre Aryl-1 aminomethyl-2 cyclopropanes carboxylates (z), leur preparation et leur application en tant que medicaments utiles dans le traitement d'algies diverses
FR2640972B1 (es) * 1988-12-28 1991-04-19 Pf Medicament
US6017957A (en) * 1989-08-08 2000-01-25 The United States Of America As Represented By The Department Of Health And Human Services Partial agonists of the strychnine insensitive glycine modulatory site of the N-methyl-D-aspartate receptor complex as neuropsychopharmacological agents
US5214191A (en) * 1990-05-22 1993-05-25 Cortech, Inc. Oxidant sensitive and insensitive aromatic esters as inhibitors of human neutrophil elastase
US5663416A (en) * 1990-05-22 1997-09-02 Cortech Inc. Oxidant sensitive and insensitive aromatic esters as inhibitors of human neutrophil elastase
US6521619B2 (en) 2000-06-29 2003-02-18 Icos Corporation Aryl phenylcyclopropyl sulfide derivatives and their use as cell adhesion inhibiting anti-inflammatory and immune suppressive agents
BRPI0712823A2 (pt) 2006-06-23 2012-07-24 Abbott Lab derivados de ciclopropil amina como moduladores de receptor de histamina h3
US9108948B2 (en) * 2006-06-23 2015-08-18 Abbvie Inc. Cyclopropyl amine derivatives
US9186353B2 (en) 2009-04-27 2015-11-17 Abbvie Inc. Treatment of osteoarthritis pain
WO2012037258A1 (en) 2010-09-16 2012-03-22 Abbott Laboratories Processes for preparing 1,2-substituted cyclopropyl derivatives
WO2012145234A2 (en) 2011-04-21 2012-10-26 Emory University Cyclopropyl derivatives and methods of use
CN103613513B (zh) * 2013-12-09 2016-01-20 上海现代制药股份有限公司 盐酸米那普仑中间体及其制备方法和应用
UA120571C2 (uk) 2016-03-22 2019-12-26 Мерк Шарп Енд Дохме Корп. Алостеричні модулятори нікотинових ацетилхолінових рецепторів

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2302994A1 (fr) * 1975-03-06 1976-10-01 Fabre Sa Pierre Procede de preparation d'acides aryl-1, hydroxy methyl-2 cyclopropanes carboxyliques et de leurs lactones utiles comme intermediaires de synthese dans l'industrie pharmaceutique
FR2508033A1 (fr) * 1981-06-23 1982-12-24 Fabre Sa Pierre Aryl-1 aminomethyl-2 cyclopropanes carboxylates (z), leur preparation et leur application en tant que medicaments utiles dans le traitement d'algies diverses

Also Published As

Publication number Publication date
US4507318A (en) 1985-03-26
FR2508033B1 (es) 1984-06-29
DE3265838D1 (en) 1985-10-03
AU8508782A (en) 1983-01-06
AU553924B2 (en) 1986-07-31
ATE15181T1 (de) 1985-09-15
ZA824403B (en) 1983-04-27
CA1199929A (fr) 1986-01-28
JPS58945A (ja) 1983-01-06
US4567288A (en) 1986-01-28
ES512574A0 (es) 1983-02-16
EP0068998A1 (fr) 1983-01-05
EP0068998B1 (fr) 1985-08-28
FR2508033A1 (fr) 1982-12-24

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20010301