ES2052949T3 - Complejos de platino de acidos neoalquilicos de isomero unico. - Google Patents

Complejos de platino de acidos neoalquilicos de isomero unico.

Info

Publication number
ES2052949T3
ES2052949T3 ES89402320T ES89402320T ES2052949T3 ES 2052949 T3 ES2052949 T3 ES 2052949T3 ES 89402320 T ES89402320 T ES 89402320T ES 89402320 T ES89402320 T ES 89402320T ES 2052949 T3 ES2052949 T3 ES 2052949T3
Authority
ES
Spain
Prior art keywords
acids
neoalkyllic
platinum complexes
isomer
unique isomer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89402320T
Other languages
English (en)
Inventor
Paul A Tremblay
Frank Pilkiewicz
Mathew Cherian
Joel Portnoff
Robert P Lenk
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Elan Pharmaceuticals LLC
Original Assignee
Liposome Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Liposome Co Inc filed Critical Liposome Co Inc
Application granted granted Critical
Publication of ES2052949T3 publication Critical patent/ES2052949T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
    • C07C53/126—Acids containing more than four carbon atoms
    • C07C53/128—Acids containing more than four carbon atoms the carboxylic group being bound to a carbon atom bound to at least two other carbon atoms, e.g. neo-acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

ESTA INVENCION SE REFIERE A ISOMEROS INDIVIDUALES PUROS DE ACIDOS CARBOXILICOS NEOALQUILICOS Y CONPLEJOS DE PLATINO QUE CONTIENEN LOS NEOACIDOS ISOMEROS INDIVIDUALES. TAMBIEN SE DESCRIBE EL USO DE LIPOSOMAS QUE INCORPORAN ESTOS COMPLEJOS Y USADOS EN QUIMIOTERAPIA ANTITUMOR. SE DESCRIBE UNA FORMULACION DE LIPOSOMA ESPECIALMENTE PREFERIDA QUE CONTIENE UNA FOSFATIDILCOLINA SATURADA.
ES89402320T 1988-08-22 1989-08-22 Complejos de platino de acidos neoalquilicos de isomero unico. Expired - Lifetime ES2052949T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US23496188A 1988-08-22 1988-08-22

Publications (1)

Publication Number Publication Date
ES2052949T3 true ES2052949T3 (es) 1994-07-16

Family

ID=22883487

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89402320T Expired - Lifetime ES2052949T3 (es) 1988-08-22 1989-08-22 Complejos de platino de acidos neoalquilicos de isomero unico.

Country Status (9)

Country Link
EP (1) EP0356332B1 (es)
KR (1) KR920003925B1 (es)
AT (1) ATE106072T1 (es)
AU (1) AU4210089A (es)
CA (1) CA1339034C (es)
DE (1) DE68915490T2 (es)
ES (1) ES2052949T3 (es)
IL (1) IL91374A0 (es)
WO (1) WO1990002111A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0994367A (ja) * 1995-09-28 1997-04-08 Tokai Ind Sewing Mach Co Ltd ミシンフレーム
US5843475A (en) * 1996-12-06 1998-12-01 Board Of Regents, The University Of Texas System Delivery and activation through liposome incorporation of diaminocyclohexane platinum (II) complexes
CN1191067C (zh) * 1997-02-05 2005-03-02 法玛西雅厄普约翰美国公司 高不溶性铂配合物的脂质复合物和脂质体
KR100393419B1 (ko) * 2000-02-18 2003-08-02 썬스타 특수정밀 주식회사 실 끊김 발생시 수틀 이송기능을 갖는 자수기 및 수틀이송 방법
EP1293205A1 (en) * 2001-09-18 2003-03-19 G2M Cancer Drugs AG Valproic acid and derivatives thereof for the combination therapy of human cancers, for the treatment of tumour metastasis and minimal residual disease
WO2003026642A1 (en) * 2001-09-21 2003-04-03 Sumitomo Pharmaceuticals Co., Ltd. Freeze-dried pharmaceutical preparation
EP1631278A4 (en) * 2003-05-20 2006-09-20 Aronex Pharmaceuticals Inc COMBINATION SCHEMOTHERAPY WITH CAPECITABIN AND A LIPOSOMAL PLATINUM COMPLEX
EP2208731B1 (en) * 2009-06-26 2012-08-15 Umicore AG & Co. KG Process for preparation of 1,2-diamino-cyclohexane-platinum(II) complexes

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3441600A (en) * 1966-06-16 1969-04-29 Sinclair Research Inc Liquid esters of neoalkyl polyols and neoalkyl fatty acids
BE755997A (fr) * 1969-09-11 1971-03-10 Bp Chem Int Ltd Production d'acides dicarboxyliques
CA1070289A (en) * 1975-05-19 1980-01-22 Rakhil K. Freidlina Mixtures of poly-branched monocarboxylic acids and process for preparing same
CA1088563A (en) * 1977-03-24 1980-10-28 Anatoli Onopchenko Production of carboxylic acids from olefins and mixtures of olefins
CH624011A5 (es) * 1977-08-05 1981-07-15 Battelle Memorial Institute
JPS5829957B2 (ja) * 1977-09-12 1983-06-25 喜徳 喜谷 新規な白金錯体
SU818654A1 (ru) * 1979-05-07 1981-04-07 Всесоюзный Ордена Трудовогокрасного Знамени Научно-Исследо-Вательский Горнометаллургическийинститут Цветных Металлов "Внии-Цветмет" Вспениватель дл флотации рудцВЕТНыХ МЕТАллОВ
GR75317B (es) * 1980-09-03 1984-07-13 Johnson Matthey Plc
CA1202946A (en) * 1982-10-13 1986-04-08 Himont Incorporated Method for preparing an improved catalyst support
JPS6296A (ja) * 1985-03-06 1987-01-06 Sumitomo Pharmaceut Co Ltd 脂溶性白金（２）錯体
US5041581A (en) * 1985-10-18 1991-08-20 The University Of Texas System Board Of Regents Hydrophobic cis-platinum complexes efficiently incorporated into liposomes

Also Published As

Publication number Publication date
KR920003925B1 (ko) 1992-05-18
KR900701719A (ko) 1990-12-04
IL91374A0 (en) 1990-04-29
EP0356332A2 (en) 1990-02-28
EP0356332B1 (en) 1994-05-25
WO1990002111A1 (en) 1990-03-08
EP0356332A3 (en) 1990-08-29
AU4210089A (en) 1990-03-23
ATE106072T1 (de) 1994-06-15
CA1339034C (en) 1997-04-01
DE68915490D1 (de) 1994-06-30
DE68915490T2 (de) 1995-02-02

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