ES2053097T3 - Sistema de separacion y de irradiacion de fluidos de componentes multiples. - Google Patents
Sistema de separacion y de irradiacion de fluidos de componentes multiples.Info
- Publication number
- ES2053097T3 ES2053097T3 ES90301139T ES90301139T ES2053097T3 ES 2053097 T3 ES2053097 T3 ES 2053097T3 ES 90301139 T ES90301139 T ES 90301139T ES 90301139 T ES90301139 T ES 90301139T ES 2053097 T3 ES2053097 T3 ES 2053097T3
- Authority
- ES
- Spain
- Prior art keywords
- chamber
- irradiation
- separation
- drum
- blood
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000926 separation method Methods 0.000 title abstract 3
- 239000012530 fluid Substances 0.000 title abstract 2
- 239000008280 blood Substances 0.000 abstract 4
- 210000004369 blood Anatomy 0.000 abstract 4
- 239000011247 coating layer Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3681—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by irradiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3681—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by irradiation
- A61M1/3683—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by irradiation using photoactive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
- A61M1/3696—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
- B04B—CENTRIFUGES
- B04B5/00—Other centrifuges
- B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
- B04B5/0442—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
- B04B—CENTRIFUGES
- B04B5/00—Other centrifuges
- B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
- B04B5/0442—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
- B04B2005/0464—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation with hollow or massive core in centrifuge bowl
Landscapes
- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Cardiology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- External Artificial Organs (AREA)
- Physical Water Treatments (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Centrifugal Separators (AREA)
- Cyclones (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Compounds Of Unknown Constitution (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
SE DESCRIBE UN SISTEMA DE IRRADIACION Y SEPARACION DE MULTICOMPONENTES FLUIDOS, CONTENIENDO UN TAMBOR CENTRIFUGO Y UNA FUENTE DE ENERGIA RADIANTE, SITUADA DENTRO DEL TAMBOR. EN UNA PRIMERA VERSION, SE PROPORCIONA UNA CAMARA DE IRRADIACION/SEPARACION RIGIDA DISPONIBLE, CON UN COMPARTIMIENTO EXTERIOR CILINDRICO SITUADO DENTRO DEL TAMBOR, Y EN OPOSICION A LA FUENTE DE ENERGIA RADIANTE. LA SANGRE TOTAL SE SUMINISTRA A LA CAMARA A TRAVES DE UN CIERRE ESTANCO DINAMICO, SITUADO EN EL CENTRO DE LA CAMARA. A MEDIDA QUE SE GIRA LA CAMARA, LA SANGRE SE SEPARA, CON LO QUE LA ENERGIA PROCEDENTE DE LA FUENTE PASA A TRAVES DE LA PARED INTERIOR DE LA CAMARA Y EL PLASMA SEPARADO, PARA IRRADIAR LA CAPA DE REVESTIMIENTO ANTEADO. EN UNA SEGUNDA VERSION, UNO O AMBAS PAREDES DEL COMPARTIMIENTO EXTERIOR DE LA CAMARA SON FLEXIBLES, CON LO QUE LA CAMARA SE ENSANCHARA A MEDIDA QUE LA SANGRE SE BOMBEA DENTRO, Y COLAPSARA, A MEDIDA QUE SE BOMBEA LA SANGRE FUERA.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/305,339 US4921473A (en) | 1989-02-02 | 1989-02-02 | Multicomponent fluid separation and irradiation system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2053097T3 true ES2053097T3 (es) | 1994-07-16 |
Family
ID=23180396
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES90301139T Expired - Lifetime ES2053097T3 (es) | 1989-02-02 | 1990-02-02 | Sistema de separacion y de irradiacion de fluidos de componentes multiples. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US4921473A (es) |
| EP (1) | EP0381528B1 (es) |
| JP (1) | JP2825588B2 (es) |
| KR (1) | KR0137934B1 (es) |
| AT (1) | ATE105716T1 (es) |
| CA (1) | CA2009124C (es) |
| DE (1) | DE69008879T2 (es) |
| ES (1) | ES2053097T3 (es) |
| GR (1) | GR1000725B (es) |
| HK (1) | HK119294A (es) |
| MX (1) | MX171686B (es) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107413536A (zh) * | 2012-02-15 | 2017-12-01 | 肯西纳什公司 | 离心机 |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3051997B2 (ja) * | 1990-12-20 | 2000-06-12 | バクスター、インターナショナル、インコーポレイテッド | 液体中の汚染物を根絶するシステム及び方法 |
| ZA919934B (en) * | 1990-12-20 | 1992-09-30 | Baxter Int | Systems and methods for eradicating contaminants using photoactive materials in fluids like blood using discrete sources of radiation |
| CA2074830C (en) * | 1990-12-20 | 1999-03-02 | Daniel F. Bischof | Systems and methods for simultaneously removing free and entrained contaminants in fluid like blood using photoactive therapy and cellular separation techniques |
| JP3051996B2 (ja) * | 1990-12-20 | 2000-06-12 | バクスター、インターナショナル、インコーポレイテッド | 液体中の汚染物を根絶するためのシステム |
| US5308309A (en) * | 1992-12-23 | 1994-05-03 | Therakos, Inc. | Securing system for centrifuge chamber |
| US5362300A (en) * | 1993-05-27 | 1994-11-08 | E. I. Du Pont De Nemours And Company | Shell-type centrifuge rotor |
| US5569928A (en) * | 1993-12-14 | 1996-10-29 | Therakos, Inc | Photoactivation light array |
| US5527704A (en) | 1994-12-06 | 1996-06-18 | Baxter International Inc. | Apparatus and method for inactivating viral contaminants in body fluids |
| FR2730166B1 (fr) * | 1995-02-08 | 1997-10-31 | Stas Sa | Generateur d'aerosols avec moyen de sterilisation |
| AU710242B2 (en) * | 1996-03-29 | 1999-09-16 | Therakos, Inc. | Photopheresis treatment of leukocytes |
| WO1997037536A1 (en) | 1996-04-09 | 1997-10-16 | Therakos, Inc. | Method for removal of psoralens from biological fluids |
| US5922278A (en) * | 1996-11-19 | 1999-07-13 | Baxter International Inc. | Method and apparatus for inactivating contaminants in biological fluid |
| US6190609B1 (en) | 1996-11-19 | 2001-02-20 | Baxter International Inc. | Methods and apparatus for inactivating contaminants in biological fluid |
| WO1999002215A1 (en) * | 1997-07-10 | 1999-01-21 | Therakos, Inc. | Treatment of inflammatory disorders of the bowel and urinary bladder |
| US7049110B2 (en) * | 1998-07-21 | 2006-05-23 | Gambro, Inc. | Inactivation of West Nile virus and malaria using photosensitizers |
| US20030215784A1 (en) * | 1998-07-21 | 2003-11-20 | Dumont Larry Joe | Method and apparatus for inactivation of biological contaminants using photosensitizers |
| US7498156B2 (en) * | 1998-07-21 | 2009-03-03 | Caridianbct Biotechnologies, Llc | Use of visible light at wavelengths of 500 to 550 nm to reduce the number of pathogens in blood and blood components |
| US6277337B1 (en) | 1998-07-21 | 2001-08-21 | Gambro, Inc. | Method and apparatus for inactivation of biological contaminants using photosensitizers |
| US6258577B1 (en) | 1998-07-21 | 2001-07-10 | Gambro, Inc. | Method and apparatus for inactivation of biological contaminants using endogenous alloxazine or isoalloxazine photosensitizers |
| US7068361B2 (en) * | 1999-06-03 | 2006-06-27 | Baxter International | Apparatus, systems and methods for processing and treating a biological fluid with light |
| US7025877B1 (en) * | 1999-06-03 | 2006-04-11 | Baxter International Inc. | Processing set for processing and treating a biological fluid |
| US6565802B1 (en) * | 1999-06-03 | 2003-05-20 | Baxter International Inc. | Apparatus, systems and methods for processing and treating a biological fluid with light |
| US7445756B2 (en) * | 1999-06-03 | 2008-11-04 | Fenwal, Inc. | Fluid processing sets and organizers for the same |
| US6471392B1 (en) | 2001-03-07 | 2002-10-29 | Holl Technologies Company | Methods and apparatus for materials processing |
| US6742774B2 (en) | 1999-07-02 | 2004-06-01 | Holl Technologies Company | Process for high shear gas-liquid reactions |
| US6723999B2 (en) * | 1999-07-02 | 2004-04-20 | Holl Technologies Company | Electromagnetic wave assisted chemical processing |
| US7538237B2 (en) * | 1999-07-02 | 2009-05-26 | Kreido Laboratories | Process for high shear gas-liquid reactions |
| US6219584B1 (en) | 1999-07-09 | 2001-04-17 | Therakos, Inc. | Method and system for determining an effective amount of light energy to delivery to fluids having targets for the light energy |
| US7094378B1 (en) | 2000-06-15 | 2006-08-22 | Gambro, Inc. | Method and apparatus for inactivation of biological contaminants using photosensitizers |
| US7220747B2 (en) | 1999-07-20 | 2007-05-22 | Gambro, Inc. | Method for preventing damage to or rejuvenating a cellular blood component using mitochondrial enhancer |
| US6495366B1 (en) | 1999-09-03 | 2002-12-17 | Therakos, Inc. | Uninterrupted flow pump apparatus and method |
| US8722422B2 (en) | 1999-09-03 | 2014-05-13 | Therakos, Inc. | Uninterrupted flow pump apparatus and method |
| US6268120B1 (en) | 1999-10-19 | 2001-07-31 | Gambro, Inc. | Isoalloxazine derivatives to neutralize biological contaminants |
| US6793643B1 (en) | 2000-04-21 | 2004-09-21 | Therakos, Inc. | Low extracorporeal volume treatment system |
| TW590780B (en) | 2000-06-02 | 2004-06-11 | Gambro Inc | Additive solutions containing riboflavin |
| US7985588B2 (en) | 2000-06-02 | 2011-07-26 | Caridianbct Biotechnologies, Llc | Induction of and maintenance of nucleic acid damage in pathogens using riboflavin and light |
| US7648699B2 (en) | 2000-06-02 | 2010-01-19 | Caridianbct Biotechnologies, Llc | Preventing transfusion related complications in a recipient of a blood transfusion |
| US9044523B2 (en) | 2000-06-15 | 2015-06-02 | Terumo Bct, Inc. | Reduction of contaminants in blood and blood products using photosensitizers and peak wavelengths of light |
| US6843961B2 (en) * | 2000-06-15 | 2005-01-18 | Gambro, Inc. | Reduction of contaminants in blood and blood products using photosensitizers and peak wavelengths of light |
| US6830806B2 (en) * | 2001-04-12 | 2004-12-14 | Kreido Laboratories | Methods of manufacture of electric circuit substrates and components having multiple electric characteristics and substrates and components so manufactured |
| US20030066624A1 (en) * | 2001-09-13 | 2003-04-10 | Holl Richard A. | Methods and apparatus for transfer of heat energy between a body surface and heat transfer fluid |
| US6787246B2 (en) | 2001-10-05 | 2004-09-07 | Kreido Laboratories | Manufacture of flat surfaced composites comprising powdered fillers in a polymer matrix |
| EP1990055A3 (en) | 2001-11-29 | 2011-11-16 | Therakos, Inc. | Methods for pretreating a subject with extracorporeal photopheresis and/or apoptotic cells |
| US7098360B2 (en) * | 2002-07-16 | 2006-08-29 | Kreido Laboratories | Processes employing multiple successive chemical reaction process steps and apparatus therefore |
| KR20050054935A (ko) * | 2002-09-11 | 2005-06-10 | 크레이도 래버러토리즈 | 재료의 높은 전단혼합과 반응을 위한 방법 및 장치 |
| WO2004030802A2 (en) * | 2002-10-03 | 2004-04-15 | Kreido Laboratories | Apparatus for transfer of heat energy between a body surface and heat transfer fluid |
| US20050287670A1 (en) * | 2004-06-29 | 2005-12-29 | Gulliver Eric A | Cell culturing systems, methods and apparatus |
| JP5258765B2 (ja) * | 2006-07-31 | 2013-08-07 | ハヌマン リミテッド ライアビリティ カンパニー | 血小板富化血漿およびこれらの濃縮物を調製する装置および方法 |
| JP2010535235A (ja) * | 2007-08-01 | 2010-11-18 | カリディアンビーシーティ バイオテクノロジーズ,エルエルシー | 全血の病原性不活性化 |
| WO2009026073A1 (en) * | 2007-08-22 | 2009-02-26 | Caridianbct Biotechnologies, Llc | Prevention of transfusion related acute lung injury using riboflavin and light |
| WO2009079383A1 (en) * | 2007-12-14 | 2009-06-25 | The Trustees Of Columbia University In The City Of New York | Systems, methods, and devices for blood treatment |
| TW201248879A (en) * | 2011-05-18 | 2012-12-01 | Auria Solar Co Ltd | Solar cell module and method of fabricating the same |
| CA2957407C (en) * | 2014-08-14 | 2020-06-30 | Terumo Bct, Inc. | Processing particles |
| DE102015101344A1 (de) * | 2015-01-29 | 2016-08-04 | Gea Mechanical Equipment Gmbh | Separator |
| CN114471968B (zh) * | 2022-02-15 | 2022-12-06 | 山东大学 | 一种pbmc分离方法 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1233327A (fr) * | 1959-03-26 | 1960-10-12 | Appareil pour le traitement du sang | |
| US4086924A (en) * | 1976-10-06 | 1978-05-02 | Haemonetics Corporation | Plasmapheresis apparatus |
| US4140268A (en) * | 1977-03-15 | 1979-02-20 | Haemo-Transfer S.A. | Centrifugating device for biological liquids, having a rotatable container, and supporting bracket therefor |
| US4303193A (en) * | 1979-01-22 | 1981-12-01 | Haemonetics Corporation | Apparatus for separating blood into components thereof |
| US4300717A (en) * | 1979-04-02 | 1981-11-17 | Haemonetics Corporation | Rotary centrifuge seal |
| US4344560A (en) * | 1979-11-02 | 1982-08-17 | Asahi Kasei Kogyo Kabushiki Kaisha | Container, apparatus and method for separating platelets |
| US4428744A (en) * | 1979-12-11 | 1984-01-31 | Frederic A. Bourke, Jr. | Method and system for externally treating the blood |
| US4321919A (en) * | 1979-12-11 | 1982-03-30 | Leukocyte Research, Inc. | Method and system for externally treating human blood |
| US4398906A (en) * | 1979-12-11 | 1983-08-16 | Frederic A. Bourke, Jr. | Method for externally treating the blood |
| US4464166A (en) * | 1981-06-12 | 1984-08-07 | Frederic A. Bourke, Jr. | Method for externally treating the blood |
| US4722790A (en) * | 1982-09-13 | 1988-02-02 | Cawley Leo P | On-line plasma modification means |
| US4613322A (en) * | 1982-12-08 | 1986-09-23 | Edelson Richard Leslie | Method and system for externally treating the blood |
| US4838103A (en) * | 1986-07-03 | 1989-06-13 | Weyer Paul P | Fluid-power device with rollers |
| US4573960A (en) * | 1984-10-29 | 1986-03-04 | Extracorporeal Medical Specialties, Inc. | Three phase irradiation treatment process |
| US4573961A (en) * | 1984-10-29 | 1986-03-04 | Extracorporeal Medical Specialties, Inc. | Electronic control methods for puvapheresis apparatus |
| US4737140A (en) * | 1984-10-29 | 1988-04-12 | Mcneilab, Inc. | Irradiation chamber for photoactivation patient treatment system |
| DE3509992C1 (de) * | 1985-03-20 | 1986-05-22 | Wolfgang 7016 Gerlingen Hiss | Vorrichtung zur Aktivierung von Blut |
| DE8517720U1 (de) * | 1985-06-19 | 1985-11-21 | Celik, Ursula, 5000 Köln | Einrichtung für die Aufbereitung von Blut |
| US4726949A (en) * | 1986-08-26 | 1988-02-23 | Baxter Travenol Laboratories, Inc. | Irradiation of blood products |
-
1989
- 1989-02-02 US US07/305,339 patent/US4921473A/en not_active Expired - Lifetime
-
1990
- 1990-02-01 CA CA002009124A patent/CA2009124C/en not_active Expired - Lifetime
- 1990-02-01 GR GR900100061A patent/GR1000725B/el not_active IP Right Cessation
- 1990-02-02 KR KR1019900001226A patent/KR0137934B1/ko not_active Expired - Fee Related
- 1990-02-02 JP JP2024264A patent/JP2825588B2/ja not_active Expired - Lifetime
- 1990-02-02 EP EP90301139A patent/EP0381528B1/en not_active Expired - Lifetime
- 1990-02-02 DE DE69008879T patent/DE69008879T2/de not_active Expired - Lifetime
- 1990-02-02 AT AT90301139T patent/ATE105716T1/de not_active IP Right Cessation
- 1990-02-02 ES ES90301139T patent/ES2053097T3/es not_active Expired - Lifetime
- 1990-02-02 MX MX019385A patent/MX171686B/es unknown
-
1994
- 1994-11-03 HK HK119294A patent/HK119294A/en not_active IP Right Cessation
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107413536A (zh) * | 2012-02-15 | 2017-12-01 | 肯西纳什公司 | 离心机 |
| CN107413536B (zh) * | 2012-02-15 | 2019-09-06 | 帝斯曼知识产权资产管理有限公司 | 离心机 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP0381528A3 (en) | 1990-12-05 |
| US4921473A (en) | 1990-05-01 |
| ATE105716T1 (de) | 1994-06-15 |
| JPH02277461A (ja) | 1990-11-14 |
| KR0137934B1 (ko) | 1998-04-30 |
| DE69008879D1 (de) | 1994-06-23 |
| EP0381528B1 (en) | 1994-05-18 |
| GR900100061A (en) | 1991-06-28 |
| CA2009124A1 (en) | 1990-08-02 |
| KR900012635A (ko) | 1990-09-01 |
| EP0381528A2 (en) | 1990-08-08 |
| GR1000725B (el) | 1992-11-23 |
| CA2009124C (en) | 1999-10-05 |
| DE69008879T2 (de) | 1994-09-15 |
| MX171686B (es) | 1993-11-10 |
| HK119294A (en) | 1994-11-11 |
| JP2825588B2 (ja) | 1998-11-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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