ES2053411T1 - Sistemas efervescentes dotados de reaccion. - Google Patents

Sistemas efervescentes dotados de reaccion.

Info

Publication number
ES2053411T1
ES2053411T1 ES92912980T ES92912980T ES2053411T1 ES 2053411 T1 ES2053411 T1 ES 2053411T1 ES 92912980 T ES92912980 T ES 92912980T ES 92912980 T ES92912980 T ES 92912980T ES 2053411 T1 ES2053411 T1 ES 2053411T1
Authority
ES
Spain
Prior art keywords
acid
pct
layer
gas
salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES92912980T
Other languages
English (en)
Other versions
ES2053411T3 (es
Inventor
Gerhard Gergely
Thomas Gergely
Irmgard Gergely
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of ES2053411T1 publication Critical patent/ES2053411T1/es
Application granted granted Critical
Publication of ES2053411T3 publication Critical patent/ES2053411T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0007—Effervescent

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Preparation (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Superconductors And Manufacturing Methods Therefor (AREA)
  • Gas Separation By Absorption (AREA)
  • Saccharide Compounds (AREA)

Abstract

LA TABLETA EFERVESCENTE CONTIENE UN SISTEMA EFERVESCENTE DE CRISTALES PORTADORES, POR LO MENOS UN ACIDO ORGANICO COMESTIBLE SOLIDO, POR LO MENOS UN COMPONENTE DESPRENDIENDO GAS BAJO FORMACION DE SAL A TRAVES DE LA REACCION CON EL ACIDO Y POR LO MENOS UNA SAL FORMADA POR EL COMPONENTE DESPRENDIENDO GAS Y EL ACIDO. SOBRE EL CRISTAL PORTADOR SE APLICA UNA PRIMERA CAPA DE OTRO ACIDO Y UNA SEGUNDA CAPA DE UNA SAL PREFERENTEMENTE ACIDO POR LO MENOS UNO DE AMBOS ACIDOS. A PARTIR DE LA CANTIDAD TOTAL DEL ACIDO O DE LOS ACIDOS EMPLEADOS Y DEL COMPONENTE DESPRENDIENDO GAS, ESTA PRESENTE UN 10 A 40 PARTICULARMENTE 10 A 20% EN FORMA DE SAL, PREFERENTEMENTE EN FORMA DE SAL ACIDA. LOS CRISTALES PORTADORES SON ACIDO CITRONICO, ACIDO MALICO, ACIDO TARTARICO, CITRATO MONOSODICO Y/O ACIDO ASCORBINICO. LA PRIMERA CAPA PUEDE CONTENER GLUCONICO-DELTA-LACTONA Y SE RECUBRE PREFERENTEMENTE CON ACIDO CITRONICO, MALICO Y/O ACIDO TARTARICO. PERMANECE UNA CAPA FORMADA COMO MONOSAL EN UNA FRACCION DE LA CANTIDAD TOTALDEL COMPONENTE DESPRENDIENDO GAS A TRAVES DE LA REACCION CON UNO DE LOS ACIDOS EMPLEADOS.
ES92912980T 1991-07-01 1992-06-24 Sistemas efervescentes dotados de reaccion. Expired - Lifetime ES2053411T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH194291 1991-07-01

Publications (2)

Publication Number Publication Date
ES2053411T1 true ES2053411T1 (es) 1994-08-01
ES2053411T3 ES2053411T3 (es) 1995-05-01

Family

ID=4222201

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92912980T Expired - Lifetime ES2053411T3 (es) 1991-07-01 1992-06-24 Sistemas efervescentes dotados de reaccion.

Country Status (9)

Country Link
US (1) US5415870A (es)
EP (1) EP0592484B1 (es)
JP (1) JP3517233B2 (es)
AT (1) ATE117199T1 (es)
CA (1) CA2112663C (es)
DE (1) DE59201238D1 (es)
DK (1) DK0592484T3 (es)
ES (1) ES2053411T3 (es)
WO (1) WO1993000886A1 (es)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
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DE4027927A1 (de) * 1990-09-04 1992-03-05 Bayer Ag Brausekomponente und verfahren zu ihrer herstellung
US5503846A (en) * 1993-03-17 1996-04-02 Cima Labs, Inc. Base coated acid particles and effervescent formulation incorporating same
EP0624364B1 (de) * 1993-04-15 1996-07-24 Gerhard Dr. Gergely Brausesystem mit einem alkali- und/oder metallempfindlichen, pharmazeutischen Wirkstoff, und Verfahren zur Herstellung
ATE219762T1 (de) * 1993-09-07 2002-07-15 Gergely Gerhard Modifizierte kristalle einer festen, essbaren, organischen säure
IL112779A (en) * 1994-03-01 1999-11-30 Gergely Gerhard Granular product or tablet containing an efferescent system and an active pharmaceutical substance and its preparation
DE670160T1 (de) * 1994-03-01 1996-03-14 Gergely, Gerhard, Dr., Wien Ein Brausesystem und einen Arzneiwirkstoff enthaltendes granuläres Produkt bzw. Tablette sowie Verfahren zu deren Herstellung.
DE69419492T2 (de) * 1994-03-01 2000-02-03 Gerhard Gergely Ein Brausesystem und einen Arzneiwirkstoff enthaltendes granuläres Produkt bzw. Tablette sowie Verfahren zu deren Herstellung
US5824339A (en) * 1995-09-08 1998-10-20 Takeda Chemical Industries, Ltd Effervescent composition and its production
US6974595B1 (en) * 1996-05-17 2005-12-13 Proethic Pharmaceuticals, Inc. Pharmaceutical compositions based on Diclofenae
US6077539A (en) * 1996-11-12 2000-06-20 Pozen, Inc. Treatment of migraine headache
US5728401A (en) * 1997-04-16 1998-03-17 Ranbaxy Laboratories, Ltd. Effervescent ranitidine formulations
DE69803594T2 (de) * 1997-10-21 2002-08-08 Gerhard Gergely Brausebasis
DE59706616D1 (de) * 1997-10-27 2002-04-18 Gergely Gerhard Brausezubereitung mit Pflanzenextrakt
WO1999027901A1 (en) * 1997-12-03 1999-06-10 Kao Corporation Solid preparation for oral hygiene
US6235311B1 (en) * 1998-03-18 2001-05-22 Bristol-Myers Squibb Company Pharmaceutical composition containing a combination of a statin and aspirin and method
DE19814257A1 (de) 1998-03-31 1999-10-07 Asta Medica Ag Brauseformulierungen
DE59808063D1 (de) * 1998-06-03 2003-05-28 Gergely Dr & Co Mit Alkali- bzw. Erdalkali-Ionen dotierte Zitronensäure
AT407111B (de) * 1998-12-22 2000-12-27 Gergely Dr & Co Zucker- und/oder zuckeralkoholhältiges matrixmaterial und verfahren zu seiner herstellung
GB9909801D0 (en) * 1999-04-28 1999-06-23 Btg Int Ltd Ultrasound detectable instrument
US6766753B2 (en) * 2001-03-20 2004-07-27 Hank E Pierson Pre-feeder for a main sail
WO2003075884A1 (en) 2002-03-06 2003-09-18 Lifizz, Inc. Effervescent compositions comprising bisphosphonates and methods related thereto
US7488496B2 (en) * 2002-03-06 2009-02-10 Christer Rosen Effervescent compositions comprising bisphosphonates and methods related thereto
AU2004249291B2 (en) * 2003-06-20 2009-07-23 Intrinsic Therapeutics, Inc. Device and method for delivering an implant through an annular defect in an intervertebral disc
US8431171B2 (en) * 2006-07-12 2013-04-30 Purac Biochem B.V. Partially neutralized acid coated food-grade particles
BRPI0714423B1 (pt) 2006-07-12 2016-10-04 Purac Biochem Bv partícula grau alimentício revestida com ácido parcialmente neutralizado, produto alimentício ou bebida, método para preparação da referida partícula e uso de ácido policarboxílico
US8778398B2 (en) 2008-11-04 2014-07-15 Jazz Pharmaceuticals, Inc. Immediate release formulations and dosage forms of gamma-hydroxybutyrate
TR200900881A2 (tr) * 2009-02-05 2010-08-23 Bi̇lgi̇ç Mahmut Tadı ve kokusu maskelenmiş stabil farmasötik bileşimler
CA2794171C (en) 2010-03-24 2018-07-03 Jazz Pharmaceuticals, Inc. Controlled release dosage forms for high dose, water soluble and hygroscopic drug substances
EP2566462B1 (en) * 2010-05-04 2020-07-08 Jazz Pharmaceuticals Inc. Immediate release formulations and dosage forms of gamma-hydroxybutyrate
US9592195B2 (en) * 2010-12-06 2017-03-14 Effrx Pharmaceuticals Sa Stable effervescent bisphosphonate formulations with rapid solubilization characteristics
WO2013115746A1 (en) * 2012-01-31 2013-08-08 Mahmut Bilgic A production method for (effervescent) pharmaceutical compositions comprising an alpha - glucosidase inhibitor (miglitol) and metformin
WO2014065890A1 (en) * 2012-10-25 2014-05-01 Otc Nutrition Llc Fast dissolving solid calcium mineral supplement compositions and process of making
JP5935172B2 (ja) * 2013-01-22 2016-06-15 株式会社東洋新薬 発泡性皮膚外用剤
US20150025025A1 (en) * 2013-07-19 2015-01-22 Ricky McCullough Immuno-modulators for treating functional epithelial syndromes
JP6627485B2 (ja) * 2015-01-28 2020-01-08 ライオン株式会社 ゲル組成物及びその製造方法
US10398662B1 (en) 2015-02-18 2019-09-03 Jazz Pharma Ireland Limited GHB formulation and method for its manufacture
UY37341A (es) 2016-07-22 2017-11-30 Flamel Ireland Ltd Formulaciones de gamma-hidroxibutirato de liberación modificada con farmacocinética mejorada
US12186296B1 (en) 2016-07-22 2025-01-07 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US12478604B1 (en) 2016-07-22 2025-11-25 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11986451B1 (en) 2016-07-22 2024-05-21 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11602512B1 (en) 2016-07-22 2023-03-14 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11602513B1 (en) 2016-07-22 2023-03-14 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11504347B1 (en) 2016-07-22 2022-11-22 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US20180263936A1 (en) 2017-03-17 2018-09-20 Jazz Pharmaceuticals Ireland Limited Gamma-hydroxybutyrate compositions and their use for the treatment of disorders
CA3115122A1 (en) 2018-11-19 2020-05-28 Jazz Pharmaceuticals Ireland Limited Alcohol-resistant drug formulations
EP3930702A1 (en) 2019-03-01 2022-01-05 Flamel Ireland Limited Gamma-hydroxybutyrate compositions having improved pharmacokinetics in the fed state
JP7824025B2 (ja) * 2019-07-12 2026-03-04 ライオン株式会社 粉体組成物、粉体組成物を含有する内服固形製剤及びその製造方法
CN111184694A (zh) * 2020-01-19 2020-05-22 广东青云山药业有限公司 一种口腔速溶颗粒的制备方法
TW202139986A (zh) 2020-02-21 2021-11-01 愛爾蘭商爵士製藥愛爾蘭有限責任公司 治療原發性嗜睡症之方法
WO2022076824A1 (en) 2020-10-08 2022-04-14 Jazz Pharmaceuticals Ireland Limited Sodium oxybate to treat idiopathic hypersomnia
US11779557B1 (en) 2022-02-07 2023-10-10 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11583510B1 (en) 2022-02-07 2023-02-21 Flamel Ireland Limited Methods of administering gamma hydroxybutyrate formulations after a high-fat meal
JP2026513019A (ja) 2023-02-03 2026-04-22 トリス・フアルマ・インコーポレーテツド １晩１回の低ナトリウムオキシベート組成物

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2211485A (en) * 1940-08-13 Effervescent acetyl salicylic acid
US3345265A (en) * 1963-10-09 1967-10-03 Kendall & Co Multiple layer tablet with calcium salt central core separated from soluble fluoride outer coating
US3887700A (en) * 1969-11-28 1975-06-03 Aspro Nicholas Ltd Analgesic formulations
US4127645A (en) * 1976-05-21 1978-11-28 Life Savers, Inc. Effervescent tablet and method
AT374348B (de) * 1980-07-01 1984-04-10 Gergely Gerhard Verfahren zur herstellung von gewuenschtenfalls zu brausetabletten verarbeitbaren brausegranulaten
JPS5756434A (en) * 1980-09-22 1982-04-05 Kao Corp Stabilized foamable composition
US4678661A (en) 1983-09-28 1987-07-07 Gerhard Gergely Effervescent composition and method of making same
FR2593065B1 (fr) * 1986-01-22 1988-09-09 Smith Kline French Lab Couples effervescents, compositions effervescentes d'antagonistes h2 de l'histamine les contenant et leur preparation.
DE3627475A1 (de) * 1986-06-26 1988-01-14 Gergely Gerhard Verfahren zum herstellen eines brausegranulates, danach hergestelltes brausegranulat sowie dessen verwendung
US5064656A (en) * 1989-11-14 1991-11-12 Dr. Gergely & Co. Uncoated pharmaceutical reaction tablet

Also Published As

Publication number Publication date
JPH06508839A (ja) 1994-10-06
WO1993000886A1 (de) 1993-01-21
ES2053411T3 (es) 1995-05-01
DE59201238D1 (de) 1995-03-02
EP0592484B1 (de) 1995-01-18
ATE117199T1 (de) 1995-02-15
DK0592484T3 (da) 1995-06-12
CA2112663C (en) 2002-04-23
JP3517233B2 (ja) 2004-04-12
EP0592484A1 (de) 1994-04-20
CA2112663A1 (en) 1993-01-21
US5415870A (en) 1995-05-16

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