ES2053606T3 - Metodo de preparacion de un inhibidor de alfa-1-proteinasa de alta pureza. - Google Patents
Metodo de preparacion de un inhibidor de alfa-1-proteinasa de alta pureza.Info
- Publication number
- ES2053606T3 ES2053606T3 ES88106017T ES88106017T ES2053606T3 ES 2053606 T3 ES2053606 T3 ES 2053606T3 ES 88106017 T ES88106017 T ES 88106017T ES 88106017 T ES88106017 T ES 88106017T ES 2053606 T3 ES2053606 T3 ES 2053606T3
- Authority
- ES
- Spain
- Prior art keywords
- proteinase inhibitor
- preparation
- high purity
- purity alpha
- alpha
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102000015395 alpha 1-Antitrypsin Human genes 0.000 title abstract 2
- 108010050122 alpha 1-Antitrypsin Proteins 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 239000003638 chemical reducing agent Substances 0.000 abstract 1
- 239000012141 concentrate Substances 0.000 abstract 1
- 230000002779 inactivation Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8121—Serpins
- C07K14/8125—Alpha-1-antitrypsin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
LA INVENCION SE REFIERE A UN INHIBIDOR DE ALFA-1-PROTEINASA CONCENTRADO ALTAMENTE PURIFICADO, Y A UN METODO DE SEPARACION DE PROTEINAS QUE TIENEN ENLACES DISULFURO, CON AGENTES REDUCTORES SUAVES Y A UNA TEMPERATURA SUFICIENTE PARA IMPEDIR LA REAGRUPACION DE LAS PROTEINAS REDUCIDAS. ESTE METODO SE PUEDE COMBINAR CON UN PROCESO DE INACTIVACION TERMICO.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4292587A | 1987-04-27 | 1987-04-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2053606T3 true ES2053606T3 (es) | 1994-08-01 |
Family
ID=21924478
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES88106017T Expired - Lifetime ES2053606T3 (es) | 1987-04-27 | 1988-04-15 | Metodo de preparacion de un inhibidor de alfa-1-proteinasa de alta pureza. |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP0288841B1 (es) |
| JP (1) | JPS63309189A (es) |
| AT (1) | ATE84041T1 (es) |
| AU (1) | AU608832B2 (es) |
| CA (1) | CA1340236C (es) |
| DE (1) | DE3877041T2 (es) |
| ES (1) | ES2053606T3 (es) |
| GR (1) | GR3007058T3 (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4749783A (en) * | 1986-07-11 | 1988-06-07 | Miles Laboratories, Inc. | Viral inactivation and purification of active proteins |
| US5616693A (en) * | 1996-07-01 | 1997-04-01 | Alpha Therapeutic Corporation | Process for seperating alpha-1-proteinase inhibitor from COHN IV1 +1V4 paste |
| GB2318732A (en) | 1996-11-01 | 1998-05-06 | Johnson & Johnson Medical | Wound healing compositions containing alpha-1-antitrypsin |
| US6887678B2 (en) * | 1998-12-02 | 2005-05-03 | Cindy L. Bristow | Method for the quantitative determination of proteinase inhibitors |
| US7777006B2 (en) | 2002-12-31 | 2010-08-17 | Csl Behring L.L.C. | Method for purification of alpha-1-antitrypsin |
| CA2534900A1 (en) * | 2003-08-12 | 2005-02-17 | Octapharma Ag | Process for preparing an alpha-1-antitrypsin solution |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3271827D1 (en) * | 1981-05-01 | 1986-07-31 | Medical Research Inst Of San F | Method for isolating alpha-1-antitrypsin |
| JPS584728A (ja) * | 1981-05-01 | 1983-01-11 | メデイカル・リサ−チ・インステイチユ−ト・オブ・サンフランシスコ・コ−ポレ−シヨン | α−１−抗トリプシンの精製 |
| US4439358A (en) * | 1982-06-17 | 1984-03-27 | Miles Laboratories, Inc. | Method of preparing alpha-1-proteinase inhibitor |
| US4470968A (en) * | 1983-01-13 | 1984-09-11 | Miles Laboratories, Inc. | Pasteurized therapeutically active blood coagulation factor concentrates |
-
1988
- 1988-04-15 DE DE8888106017T patent/DE3877041T2/de not_active Expired - Lifetime
- 1988-04-15 EP EP88106017A patent/EP0288841B1/en not_active Expired - Lifetime
- 1988-04-15 ES ES88106017T patent/ES2053606T3/es not_active Expired - Lifetime
- 1988-04-15 AT AT88106017T patent/ATE84041T1/de not_active IP Right Cessation
- 1988-04-21 AU AU15169/88A patent/AU608832B2/en not_active Expired
- 1988-04-26 JP JP63101492A patent/JPS63309189A/ja active Pending
- 1988-04-26 CA CA000565058A patent/CA1340236C/en not_active Expired - Lifetime
-
1993
- 1993-02-11 GR GR930400290T patent/GR3007058T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0288841A3 (en) | 1989-05-17 |
| DE3877041T2 (de) | 1993-04-22 |
| EP0288841B1 (en) | 1992-12-30 |
| ATE84041T1 (de) | 1993-01-15 |
| AU608832B2 (en) | 1991-04-18 |
| JPS63309189A (ja) | 1988-12-16 |
| AU1516988A (en) | 1988-10-27 |
| DE3877041D1 (de) | 1993-02-11 |
| GR3007058T3 (es) | 1993-07-30 |
| CA1340236C (en) | 1998-12-15 |
| EP0288841A2 (en) | 1988-11-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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