ES2054300T3 - Compuestos heterociclicos que tienen actividad inhibidora de la lipoxigenasa. - Google Patents

Compuestos heterociclicos que tienen actividad inhibidora de la lipoxigenasa.

Info

Publication number
ES2054300T3
ES2054300T3 ES90402692T ES90402692T ES2054300T3 ES 2054300 T3 ES2054300 T3 ES 2054300T3 ES 90402692 T ES90402692 T ES 90402692T ES 90402692 T ES90402692 T ES 90402692T ES 2054300 T3 ES2054300 T3 ES 2054300T3
Authority
ES
Spain
Prior art keywords
lipoxigenase
hetero
alkyl
inhibiting activity
halogen atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90402692T
Other languages
English (en)
Inventor
Masaru - Moakuresuto-T Ubasawa
Shuitiro - Guriin-Hir Kadowaki
Yoshio Hayashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Chemical Corp
Original Assignee
Mitsubishi Kasei Corp
Mitsubishi Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Kasei Corp, Mitsubishi Chemical Industries Ltd filed Critical Mitsubishi Kasei Corp
Application granted granted Critical
Publication of ES2054300T3 publication Critical patent/ES2054300T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

UN NUEVO COMPONENTE HETEROCICLICO DE FORMULA (I) EN LA QUE X REPRESENTA UN ATOMO DE OXIGENO O DE AZUFRE; R1 REPRESENTA UN ATOMO DE HIDROGENO O HALOGENO; R (AL CUADRADO) REPRESENTA UN GRUPO ALQUILO C4-C6, UN ALCOXIALQUILO C2-10, ALQUENIL C3-15; ARALQUIL C7-C12, ALQUINIL C3-C10, ALCADIENIL C4-C12, ALCATRIENIL C6SENTAN INDEPENDIENTEMENTE UN ATOMO DE HIDROGENO, UN GRUPO ALQUILO C1-C6, FENILO O TOLILO, O R3 Y R4 PUEDEN COMBINARSE CON UN ANILLO BENCENICO QUE PUEDE TENER AL MENOS UN ATOMO DE HALOGENO. TAMBIEN SON APTAS LAS SALES DE ESTOS COMPUESTOS. LA COMPOSICION DESCRITA TIENEN EL EFECTO DE INHIBIR LIPOXIGENASA Y SUPRIMIR LA FORMACION DE LEUCOTRIENOS Y, ES UTIL EN LA PREVENCION Y TRATAMIENTO DE INFLAMACION, REUMATISMO Y VARIAS ENFERMEDADES ALERGICAS.
ES90402692T 1989-09-29 1990-09-28 Compuestos heterociclicos que tienen actividad inhibidora de la lipoxigenasa. Expired - Lifetime ES2054300T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP25453089 1989-09-29

Publications (1)

Publication Number Publication Date
ES2054300T3 true ES2054300T3 (es) 1994-08-01

Family

ID=17266325

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90402692T Expired - Lifetime ES2054300T3 (es) 1989-09-29 1990-09-28 Compuestos heterociclicos que tienen actividad inhibidora de la lipoxigenasa.

Country Status (8)

Country Link
US (1) US5206255A (es)
EP (1) EP0420762B1 (es)
JP (1) JPH03173874A (es)
AT (1) ATE88184T1 (es)
CA (1) CA2026227A1 (es)
DE (1) DE69001342T2 (es)
DK (1) DK0420762T3 (es)
ES (1) ES2054300T3 (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5380738A (en) * 1993-05-21 1995-01-10 Monsanto Company 2-substituted oxazoles further substituted by 4-fluorophenyl and 4-methylsulfonylphenyl as antiinflammatory agents
GB9312853D0 (en) * 1993-06-22 1993-08-04 Euro Celtique Sa Chemical compounds
US5922751A (en) * 1994-06-24 1999-07-13 Euro-Celtique, S.A. Aryl pyrazole compound for inhibiting phosphodiesterase IV and methods of using same
US5591776A (en) * 1994-06-24 1997-01-07 Euro-Celtique, S.A. Pheynl or benzyl-substituted rolipram-based compounds for and method of inhibiting phosphodiesterase IV
US5665737B1 (en) * 1994-10-12 1999-02-16 Euro Celtique Sa Substituted benzoxazoles
WO1996011917A1 (en) * 1994-10-12 1996-04-25 Euro-Celtique, S.A. Novel benzoxazoles
US6372770B1 (en) 1994-10-12 2002-04-16 Euro-Celtique, S.A. Benzoxazoles
EP0814809B1 (en) * 1994-12-13 2003-08-13 Euroceltique S.A. Aryl thioxanthines
JP2001523213A (ja) * 1994-12-13 2001-11-20 ユーロ−セルティーク，エス．エイ． 三置換チオキサンチン類
US6025361A (en) * 1994-12-13 2000-02-15 Euro-Celtique, S.A. Trisubstituted thioxanthines
US6166041A (en) * 1995-10-11 2000-12-26 Euro-Celtique, S.A. 2-heteroaryl and 2-heterocyclic benzoxazoles as PDE IV inhibitors for the treatment of asthma
US6075016A (en) * 1996-04-10 2000-06-13 Euro-Celtique S.A. 6,5-fused aromatic ring systems having enhanced phosphodiesterase IV inhibitory activity
US5864037A (en) * 1996-06-06 1999-01-26 Euro-Celtique, S.A. Methods for the synthesis of chemical compounds having PDE-IV inhibitory activity
US5744473A (en) * 1996-09-16 1998-04-28 Euro-Celtique, S.A. PDE IV inhibitors: "bis-compounds"
US20050234394A1 (en) * 2004-03-26 2005-10-20 Rod Ross Dual cylinder vacuum pump for medical aspiration system
MY141272A (en) * 2006-06-29 2010-04-16 Dow Agrosciences Llc High-strength, low-temperature stable herbicidal formulations of fluroxypyr esters
KR100910151B1 (ko) 2007-11-22 2009-07-30 (주)그라쎌 신규한 유기 발광 화합물 및 이를 발광재료로 채용하고있는 전기발광소자
EP2385815B1 (en) * 2009-01-07 2021-06-23 Med-Logics, Inc. Tissue removal devices
US9999710B2 (en) 2009-01-07 2018-06-19 Med-Logics, Inc. Tissue removal devices, systems and methods
CA2844643C (en) 2011-08-11 2019-09-24 Bayer Intellectual Property Gmbh Use and agrochemical composition of carboxylic acid dibutylamides
CA2910034C (en) 2013-04-26 2022-08-30 Med-Logics, Inc. Tissue removal device, systems, and methods using vacuum pulses and ultrasonic vibrations

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3574218A (en) * 1969-08-11 1971-04-06 Egyt Gyogyszervegyeszeti Gyar 2-aryl- or aralkyl-substituted benzazole derivatives
GB1491863A (en) * 1973-10-23 1977-11-16 Lilly Industries Ltd 2,5-or 2,6-disubstituted benzoxazoles
DE2711656A1 (de) * 1977-03-17 1978-09-21 Basf Ag Neue pyridin-3-ole
DE2907089A1 (de) * 1979-02-23 1980-09-04 Hoechst Ag Herbizide mittel
US4594425A (en) * 1984-02-09 1986-06-10 American Home Products Corporation Heterocyclic compounds as antiallergic agents
US4675405A (en) * 1984-09-21 1987-06-23 American Home Products Corporation Quinoline compounds as antiallergic and antithrombotic agents
US4732978A (en) * 1985-10-03 1988-03-22 American Home Products Corporation Novel substituted naphthyloxymethyl quinoline derivatives as anti-inflammatory and antiallergy agents
JPS62142168A (ja) * 1985-10-16 1987-06-25 Mitsubishi Chem Ind Ltd チアゾ−ル誘導体及びそれを有効成分とするロイコトリエンきつ抗剤
US4772703A (en) * 1986-01-27 1988-09-20 American Home Products Corporation 2-(phenoxymethyl)-quinazolines as antiallergic and antiinflammatory agents
US4904786A (en) * 1986-01-27 1990-02-27 American Home Products Corporation Quinoline compounds as antiallergic and antiinflammatory agents
FI91869C (fi) * 1987-03-18 1994-08-25 Tanabe Seiyaku Co Menetelmä antidiabeettisena aineena käytettävien bensoksatsolijohdannaisten valmistamiseksi
CA1322005C (en) * 1987-11-25 1993-09-07 Robert N. Young Benzoheterazoles
EP0318085A3 (en) * 1987-11-25 1990-03-14 Merck Frosst Canada Inc. Heterazole dialkanoic acids
ZA894913B (en) * 1988-07-12 1990-03-28 Ici Pharma Heterocyclic compounds

Also Published As

Publication number Publication date
ATE88184T1 (de) 1993-04-15
US5206255A (en) 1993-04-27
EP0420762A2 (en) 1991-04-03
DE69001342D1 (de) 1993-05-19
EP0420762A3 (en) 1991-07-31
DK0420762T3 (da) 1993-08-16
DE69001342T2 (de) 1993-07-29
JPH03173874A (ja) 1991-07-29
CA2026227A1 (en) 1991-03-30
EP0420762B1 (en) 1993-04-14

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