ATE71620T1 - N-substituierte 3,4-dihydropyrimidinverbindungen als mittel zur behandlung von erkrankungen des kardiovaskularen systems. - Google Patents

N-substituierte 3,4-dihydropyrimidinverbindungen als mittel zur behandlung von erkrankungen des kardiovaskularen systems.

Info

Publication number: ATE71620T1
Authority: AT; Austria
Prior art keywords: agents; substituted; cardiovascular system; carbon atoms; diseases
Prior art date: 1987-02-21

Application number

AT88102557T

Other languages

English (en)

Inventor

Hidetsura Cho

Masaru Ueda

Original Assignee

Suntory Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-02-21

Filing date

1988-02-22

Publication date

1992-02-15

1988-02-22 Application filed by Suntory Ltd filed Critical Suntory Ltd

1992-02-15 Application granted granted Critical

1992-02-15 Publication of ATE71620T1 publication Critical patent/ATE71620T1/de

Links

-1 N-SUBSTITUTED 3,4-DIHYDROPYRIMIDINE COMPOUNDS Chemical class 0.000 title abstract 3
210000000748 cardiovascular system Anatomy 0.000 title abstract 2
201000010099 disease Diseases 0.000 title 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
125000004432 carbon atom Chemical group C* 0.000 abstract 3
125000000217 alkyl group Chemical group 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
239000004004 anti-anginal agent Substances 0.000 abstract 1
229940124345 antianginal agent Drugs 0.000 abstract 1
239000002220 antihypertensive agent Substances 0.000 abstract 1
229940030600 antihypertensive agent Drugs 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000004122 cyclic group Chemical group 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
230000002045 lasting effect Effects 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
230000000304 vasodilatating effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/20—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Cardiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Heart & Thoracic Surgery (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT88102557T 1987-02-21 1988-02-22 N-substituierte 3,4-dihydropyrimidinverbindungen als mittel zur behandlung von erkrankungen des kardiovaskularen systems. ATE71620T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP62038345A JPS63208580A (ja)	1987-02-21	1987-02-21	Ｎ置換３，４−ジヒドロピリミジン誘導体および循環器系疾患治療剤
EP88102557A EP0280227B1 (de)	1987-02-21	1988-02-22	N-Substituierte 3,4-Dihydropyrimidinverbindungen als Mittel zur Behandlung von Erkrankungen des kardiovaskularen Systems

Publications (1)

Publication Number	Publication Date
ATE71620T1 true ATE71620T1 (de)	1992-02-15

Family

ID=12522695

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT88102557T ATE71620T1 (de)	1987-02-21	1988-02-22	N-substituierte 3,4-dihydropyrimidinverbindungen als mittel zur behandlung von erkrankungen des kardiovaskularen systems.

Country Status (6)

Country	Link
US (1)	US4920124A (de)
EP (1)	EP0280227B1 (de)
JP (1)	JPS63208580A (de)
AT (1)	ATE71620T1 (de)
DE (1)	DE3867652D1 (de)
ES (1)	ES2039485T3 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MX9703518A (es)	1994-11-16	1997-08-30	Synaptic Pharma Corp	Dihidropirimidinas y usos de las mismas.
US6268369B1 (en)	1994-11-16	2001-07-31	Synaptic Pharmaceutical Corporation	5-(heterocyclic alkyl)-6-aryl-dihydropyrimidines
US6228861B1 (en)	1995-11-16	2001-05-08	Synaptic Pharmaceutical Corporation	Dihydropyrimidines and uses thereof
US6245773B1 (en)	1996-05-16	2001-06-12	Synaptic Pharmaceutical Corporation	5-(heterocyclic alkyl)-6-aryl-dihydropyrimidines
US6172066B1 (en)	1996-05-16	2001-01-09	Synaptic Pharmaceutical Corporation	Dihydropyrimidines and uses thereof
US6274585B1 (en)	1998-12-23	2001-08-14	Synaptic Pharmaceutical Corporation	Dihydropyrimidines and uses thereof
US6680323B2 (en)	1998-12-23	2004-01-20	Synaptic Pharmaceutical Corporation	Dihydropyrimidines and uses thereof
US6720324B2 (en)	2000-07-05	2004-04-13	Synaptic Pharmaceutical Corporation	Selective melanin concentrating hormone-1 (MCH1) receptor antagonists and uses thereof
US7157461B2 (en)	2003-07-23	2007-01-02	Bristol-Myers Squibb Co.	Substituted dihydropyrimidine inhibitors of calcium channel function

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3234684A1 (de) *	1982-09-18	1984-03-22	Bayer Ag, 5090 Leverkusen	Neue dihydropyrimidine, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln
JPS60214778A (ja) *	1984-03-08	1985-10-28	Suntory Ltd	Ν置換３，４−ジヒドロピリミジン誘導体ならびにその製造法および用途
US4683234A (en) *	1984-05-19	1987-07-28	Suntory Limited	2,6-Dimethyl-3N,5-disubstituted-4-(substituted phenyl)3,4-dihydropyrimidine compounds and a method for treating disorders of cardiocircular system
ATE78816T1 (de) *	1985-03-15	1992-08-15	Suntory Ltd	N-substituierte 3,4-dihydropyrimidinderivate, verfahren zu deren herstellung und diese enthaltende zusammenstellung fuer die behandlung von anordnungen eines kardiovascularen systems.

1987
- 1987-02-21 JP JP62038345A patent/JPS63208580A/ja active Pending
1988
- 1988-02-19 US US07/157,777 patent/US4920124A/en not_active Expired - Fee Related
- 1988-02-22 DE DE8888102557T patent/DE3867652D1/de not_active Expired - Lifetime
- 1988-02-22 AT AT88102557T patent/ATE71620T1/de not_active IP Right Cessation
- 1988-02-22 EP EP88102557A patent/EP0280227B1/de not_active Expired - Lifetime
- 1988-02-22 ES ES198888102557T patent/ES2039485T3/es not_active Expired - Lifetime

Also Published As

Publication number	Publication date
JPS63208580A (ja)	1988-08-30
EP0280227B1 (de)	1992-01-15
ES2039485T3 (es)	1993-10-01
DE3867652D1 (de)	1992-02-27
EP0280227A1 (de)	1988-08-31
US4920124A (en)	1990-04-24

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Legal Events

Date	Code	Title	Description
1992-09-15	UEP	Publication of translation of european patent specification
1998-11-15	REN	Ceased due to non-payment of the annual fee