ES2054630T3 - Peptidos antivirales y medios para tratar infecciones de herpes. - Google Patents

Peptidos antivirales y medios para tratar infecciones de herpes.

Info

Publication number
ES2054630T3
ES2054630T3 ES87107327T ES87107327T ES2054630T3 ES 2054630 T3 ES2054630 T3 ES 2054630T3 ES 87107327 T ES87107327 T ES 87107327T ES 87107327 T ES87107327 T ES 87107327T ES 2054630 T3 ES2054630 T3 ES 2054630T3
Authority
ES
Spain
Prior art keywords
peptides
amino acid
remains
nva
nle
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87107327T
Other languages
English (en)
Inventor
Eric A Cohen
Pierrette Gaudreau
Jacques Michaud
Paul Brauzeau
Yves Langelier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CA 530250 external-priority patent/CA1277901C/en
Application filed by Individual filed Critical Individual
Application granted granted Critical
Publication of ES2054630T3 publication Critical patent/ES2054630T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
    • C12N2710/16622—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/19—Antibiotic
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/22—Viral peptide or viral protein
    • Y10S930/224—Herpes related

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

SE DESCRIBE AQUI PEPTIDOS ANTIVIRALES DE LA FORMULA A-R8-R9-R10-R11-R12-R13-R14-R15-B, EN LA QUE A ES DE 0 A 7 RESTOS DE AMINOACIDO E INCLUYE UN HIDROGENO TERMINAL O UN GRUPO N-ACILO TERMINAL, O A ES UN FENILACETILO CON SUSTITUCION OPCIONAL DE LA POSICION PARA DEL FENILO, R8,R9,R10,R13,R14 Y R15 SON DIVERSOS RESTOS DE AMINOACIDO, CON LA CONDICION DE QUE UNO O MAS DE LOS CUATRO RESTOS AMINOACIDO QUE PRECEDEN INMEDIATAMENTE A R" PUEDAN SUPRIMIRSE OPCIONALMENTE, R11 Y R12 SON, INDEPENDIENTEMENTE, VAL, D-VAL, NVA, D-NVA, LEU, D-LEU, NLE, D-NLE, ILE O D-ILE, Y B ES HIDROXI, AMINO O ALQUILAMINO INFERIOR. LA ACTIVIDAD ANTIVIRAL DE LOS PEPTIDOS PUEDE ACRECENTARSE COMBINANDOLOS CON UN INHIBIDOR DE LAPROTEASA. LOS PEPTIDOS Y LA COMBINACION SON UTILES PARA EL TRATAMIENTO DE LAS INFECCIONES VIRALES DE HERPES EN LOS MAMIFEROS. LEYENDA DE LA FIGURA 1: 1.-ACTIVIDAD DE REDUCTASA DEL CDP 2.-NONAPEPTIDO (MM).
ES87107327T 1986-05-20 1987-05-20 Peptidos antivirales y medios para tratar infecciones de herpes. Expired - Lifetime ES2054630T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CA509527 1986-05-20
CA 530250 CA1277901C (en) 1987-02-20 1987-02-20 Means for treating herpes infections

Publications (1)

Publication Number Publication Date
ES2054630T3 true ES2054630T3 (es) 1994-08-16

Family

ID=25671005

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87107327T Expired - Lifetime ES2054630T3 (es) 1986-05-20 1987-05-20 Peptidos antivirales y medios para tratar infecciones de herpes.

Country Status (6)

Country Link
US (1) US4795740A (es)
EP (1) EP0246630B1 (es)
AU (1) AU602334B2 (es)
DE (1) DE3785388T2 (es)
ES (1) ES2054630T3 (es)
NZ (1) NZ220365A (es)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5066783A (en) * 1986-05-20 1991-11-19 Cohen Eric A Antiviral peptides and means for treating herpes infections
EP0292255A3 (en) * 1987-05-22 1990-08-22 Merck & Co. Inc. Inhibitor of ribonucleotide reductase
FR2620938B3 (fr) * 1987-09-30 1990-01-05 Bontemps Raymond Nouveau dispositif destine a conserver des substances cosmetiques congelables
CA1302887C (en) * 1987-11-24 1992-06-09 Yves Langelier Combination of acyclovir or a derivative thereof and bacitracin
CA1327869C (en) * 1989-02-17 1994-03-15 Yvan Guindon Ribonucleotide reductase inhibitors
CA1340683C (en) * 1989-07-07 1999-07-27 Pierre Louis Beaulieu Antiherpes pentapeptides having a substituted aspartic acid side chain
DE69017113T2 (de) * 1989-07-07 1995-08-03 Bio Mega Boehringer Ingelheim Pentapeptidderivate, wirksam gegen Herpes, die eine ersetzte Asparaginsäureseitenkette enthalten.
CA1340684C (en) * 1989-07-07 1999-07-27 Pierre Louis Beaulieu Antiherpes pentapeptides
CA1340681C (en) * 1989-07-07 1999-07-27 Robert Deziel Antiherpes tetrapeptides having a substituted aspartic acid side chain
CA1340682C (en) * 1989-07-07 1999-07-27 Pierre Lavallee Antiviral peptides having a 2-oxoalkyl amino acid side chain
EP0411333B1 (en) * 1989-07-07 1995-05-31 Bio-Mega/Boehringer Ingelheim Research Inc. Antiherpes tetrapeptide derivatives having a substituted aspartic acid side chain
US5110799A (en) * 1989-07-28 1992-05-05 Merck & Co., Inc. Antiherpetic agents
US5648337A (en) * 1990-07-03 1997-07-15 Bio-Mega/Boehringer Ingelheim Research Inc. Antiherpes pentapeptides
CA2033448C (en) * 1990-12-31 1996-11-26 Boehringer Ingelheim (Canada) Ltd./ Boehringer Ingelheim (Canada) Ltee Antiherpes compositions and method of use
US5574015A (en) * 1992-03-12 1996-11-12 Bio-Mega/Boehringer Ingelheim Research Inc. Isosteric antiherpes peptide derivatives
DE69320390T2 (de) 1992-03-12 1999-02-11 Boehringer Ingelheim (Canada) Ltd., Laval, Quebec Isosterische Peptidderivate gegen Herpes
US5846941A (en) * 1992-03-12 1998-12-08 Boehringer Ingelheim (Canada) Ltd. Isosteric antiherpes peptide derivatives II
IT1280157B1 (it) * 1995-04-12 1998-01-05 Consorzio Di Ricerche Biomedic Procedimento per la preparazione e la conservazione di colture cellulari, o di parti di cellule, allo stato pronto per dosaggi
CA2152541C (en) * 1995-06-23 1998-12-15 Boehringer Ingelheim (Canada) Ltd./ Boehringer Ingelheim (Canada) Ltee Herpes ribonucleotide reductase inhibitors
US5948935A (en) * 1997-01-23 1999-09-07 Boehringer Ingelheim (Canada) Ltd. Process and intermediates for (s)-α-amino-1-carboxycyclopentaneacetic acid
ATE239512T1 (de) * 1998-03-12 2003-05-15 Procter & Gamble Protease-inhibitoren für absorbierende artikel
EP1862471A3 (en) * 2000-02-07 2008-05-28 Wisconsin Alumni Research Foundation Pharmacologically active antiviral peptides and methods of their use
JP4896333B2 (ja) * 2000-02-07 2012-03-14 ウイスコンシン アラムニ リサーチ ファンデーション 薬理活性抗ウイルスペプチドおよびそれらの使用法
DE60221705T2 (de) * 2001-03-22 2008-06-05 The United States of America, represented by the Secretary, Dept. of Health and Human Services, the Natl. Institutes of Health, Office of Technology Transfer Glykosylierungsresistente cyanovirine und damit verbundene konjugate, zusammensetzungen, nukleinsäuren, vektoren, wirtszellen, herstellungsverfahren sowie verfahren zur verwendung nichtglykosylierter cyanovirine
WO2003051835A2 (en) * 2001-12-18 2003-06-26 Proteologics, Inc. Methods and compositions for the inhibition of viral release
WO2005060541A2 (en) * 2003-12-01 2005-07-07 Wisconsin Alumni Research Foundation Peptides and methods for inducing cellular resistance to infection
PL227562B1 (pl) 2011-09-23 2017-12-29 Wrocławskie Centrum Badań Eit + Spółka Z Ograniczoną Zastosowanie antybiotyku bacytracyny do hydrolitycznej degradacji RNA
ES2444299B1 (es) 2012-08-23 2014-12-12 Nutrición Técnica Deportiva, S.L. Uso de un hidrolizado de caseina como agente antiherpético

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB185024A (en) * 1921-09-02 1922-08-31 Singer Mfg Co Motor driven sewing machine
US4126606A (en) * 1976-10-04 1978-11-21 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Physiologically active peptides and a process for preparation thereof
GB2062643B (en) * 1979-11-07 1983-04-07 Mckerns K W Contraceptive polypeptides
DE3100974A1 (de) * 1980-01-18 1982-01-21 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen Thymosin(alpha)(pfeil abwaerts)1(pfeil abwaerts)-fragmente enthaltende arzneimittel mit immunregulierender wirkung, und thymosin(alpha)(pfeil abwaerts)1(pfeil abwaerts)-fragmente
FI83662C (fi) * 1980-07-17 1991-08-12 Scripps Clinic Res Diagnostik antikropp och foerfarande foer dess framstaellning.
IL65184A0 (en) * 1982-03-05 1982-05-31 Yissum Res Dev Co Preparation for the treatment of oral diseases,comprising glycyrrhizin
IL74827A (en) * 1984-05-21 1989-06-30 Salk Inst For Biological Studi Peptides active as gnrh antagonists and pharmaceutical compositions containing them
DE3514587A1 (de) * 1985-04-23 1986-10-30 Victor Dipl.-Chem. Dr.med. 6200 Wiesbaden Brantl Pharmakologisch aktive peptide
IE870507L (en) * 1986-03-07 1987-09-07 Biothechnological Res Partners Bovine virus diarrhea and hog cholera vaccines

Also Published As

Publication number Publication date
US4795740A (en) 1989-01-03
AU7321087A (en) 1987-11-26
EP0246630A2 (en) 1987-11-25
AU602334B2 (en) 1990-10-11
EP0246630A3 (en) 1989-01-04
DE3785388D1 (de) 1993-05-19
EP0246630B1 (en) 1993-04-14
NZ220365A (en) 1990-06-26
DE3785388T2 (de) 1993-09-02

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