ES2054661T3 - Analogos de metiltiorribosa, su preparacion y uso como agentes medicinales y biocidas. - Google Patents

Analogos de metiltiorribosa, su preparacion y uso como agentes medicinales y biocidas.

Info

Publication number
ES2054661T3
ES2054661T3 ES87300871T ES87300871T ES2054661T3 ES 2054661 T3 ES2054661 T3 ES 2054661T3 ES 87300871 T ES87300871 T ES 87300871T ES 87300871 T ES87300871 T ES 87300871T ES 2054661 T3 ES2054661 T3 ES 2054661T3
Authority
ES
Spain
Prior art keywords
methyltiribose
biocides
analogs
preparation
medicinal agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87300871T
Other languages
English (en)
Inventor
Michael K Risco
John H Fitchen
Adolph J Ferro
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
State Oregon By & Through Oreg
Oregon Health and Science University
Original Assignee
State Oregon By & Through Oreg
Oregon Health and Science University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by State Oregon By & Through Oreg, Oregon Health and Science University filed Critical State Oregon By & Through Oreg
Application granted granted Critical
Publication of ES2054661T3 publication Critical patent/ES2054661T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/02—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/14—Acyclic radicals, not substituted by cyclic structures attached to a sulfur, selenium or tellurium atom of a saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Detergent Compositions (AREA)

Abstract

COMPUESTOS DE FORMULA (I) EN LA QUE R ES H,CL,F, BR, I O R1S-, EN DONDE R1 ES UN GRUPO ALQUILO C1-C10 DE CADENA LINEAL O RAMIFICADA O UN GRUPO ALQUILO HALOGENADO DE CADENA LINEAL O RAMIFICADA, Y DONDE R2, R3 Y R4 SON IGUALES O DIFERENTES, SIENDO CADA UNO H- U OH-, CON LA CONDICION DE QUE AL MENOS UNO DE ELLOS SEA HIDROXILO Y LA CONDICION, ADEMAS, DE QUE CUANDO R2, R3 Y R4 SEAN TODOS OH, R1 NO SEA METILO. SON UTILES PARA INHIBIR EL CRECIMIENTO DE MICROORGANISMOS MTR QUINASA- DEPENDIENTES Y PROTOZOOS PARASITOS. LOS COMPUESTOS SON NUEVOS, EXCEPTO AQUELLOS EN QUE R1 ES METILO O ISOBUTILO CUANDO R2,R3 Y R4 SON TODOS OH.
ES87300871T 1986-01-30 1987-01-30 Analogos de metiltiorribosa, su preparacion y uso como agentes medicinales y biocidas. Expired - Lifetime ES2054661T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US82392986A 1986-01-30 1986-01-30

Publications (1)

Publication Number Publication Date
ES2054661T3 true ES2054661T3 (es) 1994-08-16

Family

ID=25240160

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87300871T Expired - Lifetime ES2054661T3 (es) 1986-01-30 1987-01-30 Analogos de metiltiorribosa, su preparacion y uso como agentes medicinales y biocidas.

Country Status (9)

Country Link
EP (1) EP0233031B1 (es)
JP (1) JPS62195397A (es)
AT (1) ATE87923T1 (es)
CA (1) CA1284498C (es)
DE (1) DE3785232T2 (es)
ES (1) ES2054661T3 (es)
IL (1) IL81303A (es)
PH (1) PH24615A (es)
ZM (1) ZM1187A1 (es)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3699103A (en) * 1970-10-07 1972-10-17 Hoffmann La Roche Process for the manufacture of 5-desoxy-l-arabinose and novel intermediates
US4086076A (en) * 1976-01-26 1978-04-25 Stauffer Chemical Company Tetrahydrofuranyl bromoacetates used as biocides

Also Published As

Publication number Publication date
JPS62195397A (ja) 1987-08-28
ZM1187A1 (en) 1988-08-29
EP0233031A2 (en) 1987-08-19
EP0233031B1 (en) 1993-04-07
DE3785232T2 (de) 1993-09-09
DE3785232D1 (de) 1993-05-13
IL81303A (en) 1991-07-18
ATE87923T1 (de) 1993-04-15
CA1284498C (en) 1991-05-28
EP0233031A3 (en) 1989-04-05
PH24615A (en) 1990-08-17

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