ES2134801T3 - Monohidrato de hidrocloruro de tiagabina cristalina, su preparacion y su uso. - Google Patents

Monohidrato de hidrocloruro de tiagabina cristalina, su preparacion y su uso.

Info

Publication number
ES2134801T3
ES2134801T3 ES92908325T ES92908325T ES2134801T3 ES 2134801 T3 ES2134801 T3 ES 2134801T3 ES 92908325 T ES92908325 T ES 92908325T ES 92908325 T ES92908325 T ES 92908325T ES 2134801 T3 ES2134801 T3 ES 2134801T3
Authority
ES
Spain
Prior art keywords
crystal
preparation
hydrochloride monohydrate
tiagabine hydrochloride
tiagabine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92908325T
Other languages
English (en)
Inventor
Henning Petersen
Peter Nielsen
Michael Cain
R Subhash Patel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Nordisk AS
Original Assignee
Novo Nordisk AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk AS filed Critical Novo Nordisk AS
Application granted granted Critical
Publication of ES2134801T3 publication Critical patent/ES2134801T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pain & Pain Management (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Mechanical Treatment Of Semiconductor (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Transceivers (AREA)
  • Mobile Radio Communication Systems (AREA)

Abstract

SE DESCRIBE UN R-ISOMERO DE UN HIDROCLORURO ACIDO DE N-(4,4-DI(3METILTIENO-2-IL)BUT-3-ENIL-NIPECOTICO) CON EL NOMBRE GENERICO DE HIDROCLORURO DE TIAGABINA, UN PROCESO PARA SU PREPARACION, COMPOSICIONES QUE LO CONTIENEN Y SU USO TERAPEUTICO COMO AGENTE ANTIEPILEPTICO
ES92908325T 1991-04-02 1992-03-23 Monohidrato de hidrocloruro de tiagabina cristalina, su preparacion y su uso. Expired - Lifetime ES2134801T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK91582A DK58291D0 (da) 1991-04-02 1991-04-02 Krystalinsk stof og dets fremstilling

Publications (1)

Publication Number Publication Date
ES2134801T3 true ES2134801T3 (es) 1999-10-16

Family

ID=8095193

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92908325T Expired - Lifetime ES2134801T3 (es) 1991-04-02 1992-03-23 Monohidrato de hidrocloruro de tiagabina cristalina, su preparacion y su uso.

Country Status (15)

Country Link
US (1) US5354760A (es)
EP (1) EP0579681B1 (es)
AT (1) ATE180781T1 (es)
AU (1) AU661483B2 (es)
CA (1) CA2107223C (es)
DE (1) DE69229339T2 (es)
DK (2) DK58291D0 (es)
ES (1) ES2134801T3 (es)
FI (1) FI110096B (es)
GR (1) GR3030919T3 (es)
IL (1) IL101358A (es)
NO (1) NO304113B1 (es)
NZ (1) NZ242191A (es)
WO (1) WO1992017473A1 (es)
ZA (1) ZA922297B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5750140A (en) * 1994-05-20 1998-05-12 Novo Nordisk A/S Transdermal delivery of tiagabine
MX9708394A (es) * 1995-05-05 1998-02-28 Novo Nordisk As Composicion farmaceutica que contiene clorhidrato de tiagabina y el proceso para su preparacion.
DE19525598C2 (de) * 1995-07-13 1997-09-25 Max Planck Gesellschaft Schlafmittel
AU736514B2 (en) * 1995-07-13 2001-07-26 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Non-allosteric gabaa agonists for treating sleep disorders
UA52661C2 (uk) * 1996-06-14 2003-01-15 Ново Нордіск А/С Безводна кристалічна форма гідрохлориду r(-)-n-(4,4-ди(3-метилтієн-2-іл)бут-3-еніл) ніпекотинової кислоти
US5914333A (en) * 1996-07-31 1999-06-22 Novo Nordisk A/S Treatment of psychotic disorders
IE970588A1 (en) 1997-08-01 2000-08-23 Elan Corp Plc Controlled release pharmaceutical compositions containing tiagabine
FR2771292B1 (fr) * 1997-11-21 2000-02-18 Ethypharm Lab Prod Ethiques Spheroides contenant de la tiagabine, procede de preparation et compositions pharmaceutiques
US6410520B2 (en) 2000-02-01 2002-06-25 The Procter & Gamble Company Selective crystallization of 3-pyridyl-1-hydroxyethylidene-1, 1-bisphosphonic acid sodium as the hemipentahydrate or monohydrate
US6562974B2 (en) 2000-02-01 2003-05-13 The Procter & Gamble Company Process for making geminal bisphosphonates
EP2316468A1 (en) 2002-02-22 2011-05-04 Shire LLC Delivery system and methods for protecting and administering dextroamphetamine
CN1314684C (zh) * 2003-12-24 2007-05-09 中国科学院上海有机化学研究所 噻加宾及其消旋体和s－构型的合成方法及其无定形粉末的制法
WO2005122698A2 (en) * 2003-12-24 2005-12-29 Sun Pharmaceutical Industries Limited Novel stable polymorphic forms of tiagabine hydrochloride
WO2005092886A1 (en) * 2004-03-29 2005-10-06 Ranbaxy Laboratories Limited Process for the preparation of amorphous form of tiagabine
US20080269495A1 (en) * 2004-08-04 2008-10-30 Prosenjit Bose Process for Preparation of Piperidine Carboxylic Acid
US20060105038A1 (en) * 2004-11-12 2006-05-18 Eurand Pharmaceuticals Limited Taste-masked pharmaceutical compositions prepared by coacervation
US20080064727A1 (en) * 2006-08-18 2008-03-13 Cephalon, Inc. Crystalline forms of tiagabine hydrochloride
US20080051435A1 (en) * 2006-08-18 2008-02-28 Cephalon, Inc. Crystalline and amorphous forms of tiagabine
CN101857591B (zh) * 2009-04-09 2013-06-05 北京京卫燕康药物研究所有限公司 盐酸噻加宾晶型及其制备方法
CN103554093B (zh) * 2013-11-12 2015-10-21 四川科瑞德凯华制药有限公司 噻加宾乙酯盐酸盐及其制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK288385D0 (da) * 1985-06-26 1985-06-26 Novo Industri As Aminosyrederivater
EP0223403B1 (en) * 1985-10-25 1993-08-04 Beecham Group Plc Piperidine derivative, its preparation, and its use as medicament
US4910312A (en) * 1985-11-08 1990-03-20 Warner-Lambert Company Various N-substituted 3-piperidine carboxylic acids or N-substituted 3-pyridinecarboxylic acids and derivatives thereof

Also Published As

Publication number Publication date
NO304113B1 (no) 1998-10-26
EP0579681A1 (en) 1994-01-26
ZA922297B (en) 1992-12-30
DE69229339D1 (de) 1999-07-08
CA2107223A1 (en) 1992-10-03
IL101358A0 (en) 1992-11-15
AU661483B2 (en) 1995-07-27
FI934298L (fi) 1993-09-30
WO1992017473A1 (en) 1992-10-15
AU1641592A (en) 1992-11-02
DK0579681T3 (da) 1999-11-15
JPH06506209A (ja) 1994-07-14
EP0579681B1 (en) 1999-06-02
NO933524L (no) 1993-10-01
US5354760A (en) 1994-10-11
GR3030919T3 (en) 1999-11-30
ATE180781T1 (de) 1999-06-15
FI934298A0 (fi) 1993-09-30
FI110096B (fi) 2002-11-29
DK58291D0 (da) 1991-04-02
IL101358A (en) 1996-08-04
NO933524D0 (no) 1993-10-01
DE69229339T2 (de) 1999-12-30
NZ242191A (en) 1994-07-26
CA2107223C (en) 2005-02-15

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