ES2054860T3 - Nuevos derivados de 9-halogeno-(z)-prostaglandinas, procedimiento para su preparacion, asi como a su utilizacion como medicamentos. - Google Patents

Nuevos derivados de 9-halogeno-(z)-prostaglandinas, procedimiento para su preparacion, asi como a su utilizacion como medicamentos.

Info

Publication number
ES2054860T3
ES2054860T3 ES88730162T ES88730162T ES2054860T3 ES 2054860 T3 ES2054860 T3 ES 2054860T3 ES 88730162 T ES88730162 T ES 88730162T ES 88730162 T ES88730162 T ES 88730162T ES 2054860 T3 ES2054860 T3 ES 2054860T3
Authority
ES
Spain
Prior art keywords
halogen
posttaglandinas
medicines
procedure
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88730162T
Other languages
English (en)
Other versions
ES2054860T5 (es
Inventor
Bernd Dr Buchmann
Werner Dr Skuballa
Helmut Prof Dr Vorbruggen
Bernd Dr Raduchel
Olaf Dr Loge
Walter Dr Elger
Claus-Steffen Dr Sturzebecher
Karl-Heinz Dr Thierauch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25857817&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2054860(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from DE19873724189 external-priority patent/DE3724189A1/de
Priority claimed from DE19873724190 external-priority patent/DE3724190A1/de
Application filed by Schering AG filed Critical Schering AG
Publication of ES2054860T3 publication Critical patent/ES2054860T3/es
Application granted granted Critical
Publication of ES2054860T5 publication Critical patent/ES2054860T5/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0016—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing only hydroxy, etherified or esterified hydroxy groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0025—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing keto groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

LA INVENCION SE REFIERE A DERIVADOS 9-HALOGENO(Z)-PROSTAGLANDINA DE FORMULA (I) DONDE LOS SUSTITUYENTES TIENEN EL SIGNIFICADO QUE SE DETALLA EN LA INVENCION, SUS SALES Y SUS CICLODEXTRICLARATOS Y SU APLICACION FARMACEUTICA.
ES88730162T 1987-07-17 1988-07-15 Derivados de 9-halogeno-(z)-prostaglandinas, procedimiento para su preparacion y su utilizacion como medicamentos. Expired - Lifetime ES2054860T5 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19873724189 DE3724189A1 (de) 1987-07-17 1987-07-17 9-halogen-(z)-(delta)(pfeil hoch)4(pfeil hoch)-prostaglandinderivate, verfahren zu ihrer herstellung und ihrer verwendung als arzneimittel
DE19873724190 DE3724190A1 (de) 1987-07-17 1987-07-17 9-halogen-3-oxa-(z)-(delta)(pfeil hoch)5(pfeil hoch)-prostaglandinderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Publications (2)

Publication Number Publication Date
ES2054860T3 true ES2054860T3 (es) 1994-08-16
ES2054860T5 ES2054860T5 (es) 2003-11-01

Family

ID=25857817

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88730162T Expired - Lifetime ES2054860T5 (es) 1987-07-17 1988-07-15 Derivados de 9-halogeno-(z)-prostaglandinas, procedimiento para su preparacion y su utilizacion como medicamentos.

Country Status (12)

Country Link
US (1) US6225347B1 (es)
EP (1) EP0299914B2 (es)
JP (1) JP2716986B2 (es)
CA (1) CA1322197C (es)
DE (1) DE3880034D1 (es)
DK (1) DK170889B1 (es)
ES (1) ES2054860T5 (es)
HU (1) HU206084B (es)
IE (1) IE62483B1 (es)
IL (1) IL87116A (es)
NZ (1) NZ225436A (es)
WO (1) WO1989000559A1 (es)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3923797A1 (de) * 1989-07-14 1991-01-24 Schering Ag 9-fluor-prostaglandin-derivate, verfahren zu ihrer herstellung und ihre pharmazeutische verwendung
DE4008925A1 (de) * 1990-03-16 1991-09-19 Schering Ag 9-halogenprostaglandin-clathrate und ihre verwendung als arzneimittel
DE4024347A1 (de) * 1990-07-27 1992-01-30 Schering Ag Cyclopentanderivate, verfahren zu ihrer herstellung und ihre pharmazeutische verwendung
DE4036140A1 (de) * 1990-11-09 1992-05-14 Schering Ag 9-halogen-11ss-hydroxy-prostaglandinderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
KR100266834B1 (ko) * 1992-07-24 2000-09-15 우에하라 아끼라 프로스타글란딘 유도체
DE59308617D1 (de) * 1992-08-31 1998-07-02 Schering Ag 9-chlor-prostaglandin-ester und -amide und ihre verwendung für die herstellung von arzneimitteln
DE4229048A1 (de) * 1992-08-31 1994-03-03 Schering Ag Ester von 9-Chlor-Prostaglandinen, Verfahren zu ihrer Herstellung und ihre pharmazeutische Verwendung
DE4229050A1 (de) * 1992-08-31 1994-03-03 Schering Ag Neue 9-Chlor-Prostaglandin-Ester und -amide
ES2105333T3 (es) * 1992-10-13 1997-10-16 Alcon Lab Inc Combinaciones de prostaglandinas y derivados de clonidina para el tratamiento del glaucoma.
WO1994008959A1 (fr) * 1992-10-20 1994-04-28 Taisho Pharmaceutical Co., Ltd. Derive de prostaglandine
US5721273A (en) 1993-12-15 1998-02-24 Alcon Laboratories, Inc. Use of certain 9-halo-13,14-dihydroprostaglandins to treat glaucoma and ocular hypertension
AU687906B2 (en) * 1993-12-15 1998-03-05 Alcon Laboratories, Inc. Use of certain prostaglandin analogues to treat glaucoma and ocular hypertension
US5627209A (en) * 1993-12-15 1997-05-06 Alcon Laboratories, Inc. Use of certain 9-haloprostaglandins to treat glaucoma and ocular hypertension
US5807892A (en) * 1994-09-30 1998-09-15 Alcon Laboratories, Inc. Use of certain prostaglandin analogues to treat glaucoma and ocular hypertension
US6294563B1 (en) 1994-10-27 2001-09-25 Allergan Sales, Inc. Combinations of prostaglandins and brimonidine or derivatives thereof
CA2237898A1 (en) * 1995-11-17 1997-05-29 Louis Desantis Jr. Combination therapy for treating glaucoma
US6441047B2 (en) 1995-11-17 2002-08-27 Alcon Manufacturing Ltd.. Combination therapy for treating glaucoma
AU7680096A (en) * 1995-12-22 1997-07-17 Alcon Laboratories, Inc. Combinations of dp and fp type prostaglandins for lowering iop
US5700835A (en) * 1995-12-22 1997-12-23 Alcon Laboratories, Inc. 3-Oxa-D-prostaglandins for lowering IOP
US5599838A (en) * 1996-02-23 1997-02-04 Taisho Pharmaceutical Co., Ltd. Prostaglandin derivatives
CA2269853A1 (en) * 1996-11-12 1998-05-22 Paul W. Zinke Use of cis-.delta.4 analogs of prostaglandins as ocular hypotensives
US6015922A (en) * 1997-12-19 2000-01-18 Alcon Laboratories, Inc. N-alkyl-N-alkoxycarboxamides and methods of use in prostaglandin synthesis
US6740679B1 (en) * 1999-02-05 2004-05-25 Baylor University Medical Center Nutritional supplement or pharmaceutical preparation comprising triglycerides with seven-carbon fatty acid
US20030162833A1 (en) 2001-08-01 2003-08-28 Roe Charles R. Fatty acid treatment for cardiac patients
HK1048302A1 (zh) 1999-08-13 2003-03-28 大正制药株式会社 前列腺素衍生物
ES2337981T3 (es) * 1999-09-10 2010-05-03 Taisho Pharmaceutical Co., Ltd Derivados de prostaglandina.
GB0012249D0 (en) * 2000-05-19 2000-07-12 Chirotech Technology Ltd Process for the preparation of 11-oxaprostaglandins
US20040266880A1 (en) * 2002-02-22 2004-12-30 Fumie Sato Antipruritics
ATE401895T1 (de) * 2002-08-09 2008-08-15 Taisho Pharmaceutical Co Ltd Antipruritisches mittel
US7737182B2 (en) 2002-08-09 2010-06-15 Taisho Pharmaceutical Co., Ltd. Pharmaceuticals for xerosis
WO2004043471A1 (ja) * 2002-11-13 2004-05-27 Taisho Pharmaceutical Co., Ltd. 鎮痒剤
CA2573054C (en) 2004-07-02 2012-10-09 Baylor Research Institute Glycogen or polysaccharide storage disease treatment method
MY144968A (en) * 2005-04-11 2011-11-30 Xenon Pharmaceuticals Inc Spiro-oxindole compounds and their uses as therapeutic agents
AR053710A1 (es) * 2005-04-11 2007-05-16 Xenon Pharmaceuticals Inc Compuestos espiroheterociclicos y sus usos como agentes terapeuticos
EP3205644A1 (en) 2005-12-29 2017-08-16 Celtaxsys Inc. Diamine derivatives as inhibitors of leukotriene a4 hydrolase
EP2073806B1 (en) 2006-10-12 2012-02-15 Xenon Pharmaceuticals Inc. Use of spiro-oxindole compounds as therapeutic agents
WO2008046049A1 (en) * 2006-10-12 2008-04-17 Xenon Pharmaceuticals Inc. Spiro (furo [3, 2-c] pyridine-3-3 ' -indol) -2' (1'h)-one derivatives and related compounds for the treatment of sodium-channel mediated diseases, such as pain
WO2010045197A1 (en) * 2008-10-17 2010-04-22 Xenon Pharmaceuticals, Inc. Spiro-oxindole compounds and their use as therapeutic agents
HRP20150882T1 (hr) * 2008-10-17 2015-09-25 Xenon Pharmaceuticals Inc. Spirooksindolski spojevi i njihova upotreba kao terapijska sredstva
AR077252A1 (es) 2009-06-29 2011-08-10 Xenon Pharmaceuticals Inc Enantiomeros de compuestos de espirooxindol y sus usos como agentes terapeuticos
PE20170202A1 (es) 2009-10-14 2017-03-24 Xenon Pharmaceuticals Inc Metodos sinteticos para compuestos espiro-oxoindol
US20110086899A1 (en) * 2009-10-14 2011-04-14 Xenon Pharmaceuticals Inc. Pharmaceutical compositions for oral administration
RU2596488C2 (ru) 2010-02-26 2016-09-10 Ксенон Фармасьютикалз Инк. Фармацевтические композиции спиро-оксиндольного соединения для местного введения и их применение в качестве терапевтических агентов
KR20150002794A (ko) 2012-04-12 2015-01-07 제논 파마슈티칼스 인크. 치료제로서 유용한 스파이로-옥시인돌 화합물을 위한 비대칭적 합성
AU2014240042C1 (en) 2013-03-14 2019-09-05 Celltaxis, Llc Inhibitors of leukotriene A4 hydrolase
AR103636A1 (es) 2015-02-05 2017-05-24 Teva Pharmaceuticals Int Gmbh Métodos de tratamiento de neuralgia postherpética con una formulación tópica de un compuesto de espiro-oxindol
WO2017218920A1 (en) 2016-06-16 2017-12-21 Teva Pharmaceuticals International Gmbh Asymmetric synthesis of funapide
US10202362B2 (en) 2016-12-09 2019-02-12 Celtaxsys, Inc. Inhibitors of leukotriene A4 hydrolase
CA3045887A1 (en) 2016-12-09 2018-06-14 Celtaxsys, Inc. Pendant amines and derivatives as inhibitors of leukotriene a4 hydrolase
WO2018107158A1 (en) 2016-12-09 2018-06-14 Celtaxsys, Inc. Monamine and monoamine derivatives as inhibitors of leukotriene a4 hydrolase

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE754114A (fr) 1969-07-29 1971-01-29 Upjohn Co Nouveaux composes de la classe des prostaglandines et leur procede de preparation
US3936487A (en) 1970-06-17 1976-02-03 The Upjohn Company 3-Oxa prostaglandin Fα-type compounds
US3954835A (en) 1972-04-27 1976-05-04 The Upjohn Company 4,5-Cis-didehydro-PGF1 compounds
US3980694A (en) 1974-04-11 1976-09-14 The Upjohn Company 4-Oxa phenyl-substituted PGA compounds
DE2845770A1 (de) 1978-10-19 1980-04-30 Schering Ag Neue prostacyclin-derivate und verfahren zu ihrer herstellung
DE2950027A1 (de) * 1979-12-10 1981-06-11 Schering Ag Berlin Und Bergkamen, 1000 Berlin 9-chlor-prostaglandinderivate, verfahren zur herstellung und verwendung als arzneimittel
DE3048906A1 (de) 1980-12-19 1982-07-15 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3126924A1 (de) * 1981-07-03 1983-01-20 Schering Ag, 1000 Berlin Und 4619 Bergkamen 9-fluor-prostaglandinderivate, verfahren zur herstellung und verwendung als arzneimittel
US4579958A (en) 1983-12-23 1986-04-01 G. D. Searle & Co. 5-fluoro-3-oxa-6,7-didehydro-PGI1 compounds
US4971987A (en) * 1984-07-27 1990-11-20 Schering Aktiengesellschaft New carbacycline, process for their production and their use as a drug
DE3510978A1 (de) * 1985-03-22 1986-09-25 Schering AG, Berlin und Bergkamen, 1000 Berlin Neue 9-halogenprostaglandine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
KR100266834B1 (ko) 1992-07-24 2000-09-15 우에하라 아끼라 프로스타글란딘 유도체

Also Published As

Publication number Publication date
DK170889B1 (da) 1996-03-04
CA1322197C (en) 1993-09-14
NZ225436A (en) 1991-04-26
US6225347B1 (en) 2001-05-01
EP0299914B1 (de) 1993-04-07
IL87116A (en) 1993-03-15
HU206084B (en) 1992-08-28
IE62483B1 (en) 1995-02-08
ES2054860T5 (es) 2003-11-01
EP0299914A1 (de) 1989-01-18
WO1989000559A1 (fr) 1989-01-26
IE882189L (en) 1989-01-17
HUT51222A (en) 1990-04-28
DE3880034D1 (de) 1993-05-13
JPH02502009A (ja) 1990-07-05
IL87116A0 (en) 1988-12-30
EP0299914B2 (de) 2003-04-23
DK132789D0 (da) 1989-03-17
DK132789A (da) 1989-03-17
JP2716986B2 (ja) 1998-02-18

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