ES2056907T3 - Compuestos de acridinio que pueden utilizarse como marcadores quimioluminogenos. - Google Patents

Compuestos de acridinio que pueden utilizarse como marcadores quimioluminogenos.

Info

Publication number
ES2056907T3
ES2056907T3 ES88202802T ES88202802T ES2056907T3 ES 2056907 T3 ES2056907 T3 ES 2056907T3 ES 88202802 T ES88202802 T ES 88202802T ES 88202802 T ES88202802 T ES 88202802T ES 2056907 T3 ES2056907 T3 ES 2056907T3
Authority
ES
Spain
Prior art keywords
acridinium compounds
chemioluminogen
markers
group
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88202802T
Other languages
English (en)
Inventor
Gijsbert Zomer
Johannes Franciscu Stavenuiter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mochida Pharmaceutical Co Ltd
Original Assignee
Mochida Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mochida Pharmaceutical Co Ltd filed Critical Mochida Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2056907T3 publication Critical patent/ES2056907T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K11/00—Luminescent materials, e.g. electroluminescent or chemiluminescent
    • C09K11/06—Luminescent materials, e.g. electroluminescent or chemiluminescent containing organic luminescent materials
    • C09K11/07—Luminescent materials, e.g. electroluminescent or chemiluminescent containing organic luminescent materials having chemically-interreactive components, e.g. reactive chemiluminescent compositions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/805—Optical property

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Luminescent Compositions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Steroid Compounds (AREA)

Abstract

COMPONENTES NUEVAS ACRIDINIO SON PROVISTOS QUE ACCCEDE CON LA FORMULA 1, EN DONDE: A ES UNA PARTE ORGANICA DIVALENTE, TAL COMO UNA CADENA ALKILENO; X ES UN GRUPO QUE PUEDE SER TRANSFORMADO JUNTO CON C-9 DE LA ACRIDINA DENTRO DE UN DIOXETANO POR REACCION CON PEROXIDO DE HIDROGENO, TAL COMO UN GRUPO ASILOXI; Y ES UN CONTADOR, Y Z ES UN GRUPO FUNCIONAL, TAL COMO UN DERIVADO CARBOXIL. ESTOS COMPONENTES ACRIDINIOS SON UTILES COMO ETIQUETAS QUIMIOLUMINOGENICAS PARA AMBOS INMUNOENSAYOS HETEROGENEO Y HOMOGENEO.
ES88202802T 1987-12-18 1988-12-07 Compuestos de acridinio que pueden utilizarse como marcadores quimioluminogenos. Expired - Lifetime ES2056907T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL8703075A NL8703075A (nl) 1987-12-18 1987-12-18 Acridiniumverbindingen als chemiluminescentie-merkstof.

Publications (1)

Publication Number Publication Date
ES2056907T3 true ES2056907T3 (es) 1994-10-16

Family

ID=19851117

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88202802T Expired - Lifetime ES2056907T3 (es) 1987-12-18 1988-12-07 Compuestos de acridinio que pueden utilizarse como marcadores quimioluminogenos.

Country Status (8)

Country Link
US (2) US5521103A (es)
EP (1) EP0324202B1 (es)
JP (1) JPH0819106B2 (es)
AT (1) ATE110366T1 (es)
CA (1) CA1334418C (es)
DE (1) DE3851216T2 (es)
ES (1) ES2056907T3 (es)
NL (1) NL8703075A (es)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5110932A (en) * 1986-10-06 1992-05-05 Ciba Corning Diagnostics Corp. Polysubstituted aryl acridinium esters
DE3750503T2 (de) * 1986-10-22 1995-02-09 Abbott Lab Chemilumineszierende Acridinium- und Phenantridiniumsalze.
US5338847A (en) * 1987-12-31 1994-08-16 London Diagnostics, Inc. Hydrolytically stable chemiluminescent labels and their conjugates, and assays therefrom by adduct formation
US5321136A (en) * 1987-12-31 1994-06-14 London Diagnostics, Inc. Peri substituted fused ring chemiluminescent labels and their conjugates, and assays therefrom
US5290936A (en) * 1987-12-31 1994-03-01 London Diagnostics, Inc. Nitro substituted chemiluminescent labels and their conjugates, and assays therefrom
NZ227506A (en) † 1987-12-31 1992-06-25 London Diagnostics Inc Specific binding assays using chemiluminescent compounds
US5227489A (en) * 1988-08-01 1993-07-13 Ciba Corning Diagnostics Corp. Stable hydrophilic acridinium esters suitable for liposome encapsulation
US5663074A (en) * 1988-09-26 1997-09-02 Chiron Diagnostics Corporation Nucleophilic polysubstituted aryl acridinium ester conjugates and syntheses thereof
US5241070A (en) * 1988-09-26 1993-08-31 Ciba Corning Diagnostics Corp. Nucleophilic polysubstituted aryl acridinium esters and uses thereof
US5340716A (en) * 1991-06-20 1994-08-23 Snytex (U.S.A.) Inc. Assay method utilizing photoactivated chemiluminescent label
WO1994002486A1 (en) * 1992-07-20 1994-02-03 Syntex (U.S.A.) Inc. Novel chemiluminescent compounds and methods of use
US6002000A (en) * 1992-07-20 1999-12-14 Dade Behring Marburg Gmbh Chemiluminescent compounds and methods of use
CA2141451C (en) * 1992-07-31 2003-10-07 John S. Pease Photoactivatable chemiluminescent matrices
JP3584379B2 (ja) * 1993-02-04 2004-11-04 持田製薬株式会社 アクリジニウム化合物およびアクリジニウム化合物複合体
US5593845A (en) * 1993-05-17 1997-01-14 Lumigen, Inc. Aryl N-alkylacridancarboxylate derivatives useful for chemiluminescent detection
US5731148A (en) * 1995-06-07 1998-03-24 Gen-Probe Incorporated Adduct protection assay
EP0761652A1 (en) * 1995-08-01 1997-03-12 Mochida Pharmaceutical Co., Ltd. Acridinium compound having a plurality of luminescent groups and binding groups, and conjugate thereof
US5800999A (en) * 1996-12-16 1998-09-01 Tropix, Inc. Dioxetane-precursor-labeled probes and detection assays employing the same
US6165800A (en) * 1997-05-30 2000-12-26 Bayer Corporation Chemiluminescent energy transfer conjugates and their uses as labels in binding assays
US6017769A (en) * 1998-06-17 2000-01-25 Lumigen, Inc. Non-enzymatic methods of generating chemiluminescence from acridan alkenes
JP4672144B2 (ja) 1998-08-11 2011-04-20 シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレーテッド 近赤外化学発光性アクリジニウム化合物およびその使用。
US6673560B1 (en) 1998-11-25 2004-01-06 Bayer Corporation Measurement of hydride using chemiluminescent acridinium compounds and applications thereof
KR100399370B1 (ko) * 2000-12-22 2003-09-26 김병효 아크리디늄 화합물 및 이를 이용한 화학발광 조성물
US7101683B2 (en) 2001-06-26 2006-09-05 Abbott Laboratories Methods for the simultaneous detection of HCV antigens and HCV antibodies
US6723851B2 (en) 2001-10-31 2004-04-20 Quest Diagnostics Investment Incorporated Chemiluminescent compounds and use thereof
US7309615B2 (en) * 2002-09-27 2007-12-18 Siemens Medical Solutions Diagnostic High quantum yield acridinium compounds and their uses in improving assay sensitivity
US7319041B2 (en) * 2002-09-27 2008-01-15 Siemens Medical Solutions Diagnostic Applications of acridinium compounds and derivatives in homogeneous assays
CA2525685A1 (en) * 2003-05-28 2004-12-09 Amersham Biosciences Uk Limited Differential analysis of cell surface proteins on closed membrane structures by labelling with dyes in the presence of an internal standard
GB0320236D0 (en) * 2003-08-29 2003-10-01 Molecular Light Tech Res Ltd Chemiluminescent compounds
US7682839B2 (en) * 2005-03-14 2010-03-23 Lumigen, Inc. Methods using novel chemiluminescent labels
US20060205094A1 (en) * 2005-03-14 2006-09-14 Lumigen, Inc. Methods using novel chemiluminescent labels
US20070151234A1 (en) * 2005-12-30 2007-07-05 Lampkin Charles B Iii Electricity produced by sustained air pressure
WO2021023252A1 (en) 2019-08-07 2021-02-11 Bgi Shenzhen Co., Ltd. Acridinium ester-containing compounds and methods of using the same for chemiluminescence-based one-color sequencing

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2645594A (en) * 1948-10-19 1953-07-14 Abbott Lab Antiseptic acridane compounds
NL6515469A (es) * 1965-01-22 1966-07-25
US3431264A (en) * 1965-11-05 1969-03-04 American Cyanamid Co 9-cyanoacridans and process for their production
US3615416A (en) * 1969-06-05 1971-10-26 Eastman Kodak Co 9 10-substituted acridines as sensitizers in electrophotographic systems
GB1461877A (en) * 1974-02-12 1977-01-19 Wellcome Found Assay method utilizing chemiluminescence
DE3279029D1 (en) * 1981-12-11 1988-10-20 Welsh Nat School Med Luminescent labelling materials and procedures
EP0103469B1 (en) * 1982-09-10 1989-02-08 The Welsh National School of Medicine Immunological procedure for quantifying substances
JP2509574B2 (ja) * 1985-08-15 1996-06-19 アモコ・コーポレーション 標識付けした核酸
JPS6261969A (ja) * 1985-09-06 1987-03-18 アモコ・コーポレーション アクリジニウムエステルの合成法
US4745181A (en) * 1986-10-06 1988-05-17 Ciba Corning Diagnostics Corp. Polysubstituted aryl acridinium esters
DE3750503T2 (de) * 1986-10-22 1995-02-09 Abbott Lab Chemilumineszierende Acridinium- und Phenantridiniumsalze.

Also Published As

Publication number Publication date
EP0324202B1 (en) 1994-08-24
DE3851216T2 (de) 1995-02-16
US6018047A (en) 2000-01-25
NL8703075A (nl) 1989-07-17
ATE110366T1 (de) 1994-09-15
JPH01199949A (ja) 1989-08-11
US5521103A (en) 1996-05-28
DE3851216D1 (de) 1994-09-29
JPH0819106B2 (ja) 1996-02-28
EP0324202A1 (en) 1989-07-19
CA1334418C (en) 1995-02-14

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