ES2057571T3 - Receptor de pdgf-alfa. - Google Patents

Receptor de pdgf-alfa.

Info

Publication number
ES2057571T3
ES2057571T3 ES90908996T ES90908996T ES2057571T3 ES 2057571 T3 ES2057571 T3 ES 2057571T3 ES 90908996 T ES90908996 T ES 90908996T ES 90908996 T ES90908996 T ES 90908996T ES 2057571 T3 ES2057571 T3 ES 2057571T3
Authority
ES
Spain
Prior art keywords
pdgf
disclosed
dna molecules
alpha
receiver
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90908996T
Other languages
English (en)
Inventor
James D Kelly
Mark J Murray
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zymogenetics Inc
Original Assignee
Zymogenetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zymogenetics Inc filed Critical Zymogenetics Inc
Application granted granted Critical
Publication of ES2057571T3 publication Critical patent/ES2057571T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

MOLECULAS AISLADAS DE ADN QUE CODIFICAN UN NUEVO RECEPTOR PDGF. EL RECEPTOR ENLAZA LAS ISOFORMAS AA, AB Y BB DEL PDGF CON ALTA AFINIDAD. TAMBIEN SE MUESTRAN LAS CELULAS TRANSFECTADAS O TRANSFORMADAS CON LAS MOLECULAS DE ADN. LAS CELULAS SE PUEDEN UTILIZAR DENTRO DE METODOS PARA LA DETECCION DE ACTIVIDAD AGONISTA O ANTAGONISTA EN UN COMPUESTO DE TEST.
ES90908996T 1989-05-22 1990-05-21 Receptor de pdgf-alfa. Expired - Lifetime ES2057571T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US35501889A 1989-05-22 1989-05-22

Publications (1)

Publication Number Publication Date
ES2057571T3 true ES2057571T3 (es) 1994-10-16

Family

ID=23395910

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90908996T Expired - Lifetime ES2057571T3 (es) 1989-05-22 1990-05-21 Receptor de pdgf-alfa.

Country Status (10)

Country Link
US (2) US5371205A (es)
EP (1) EP0474744B1 (es)
JP (1) JPH04505260A (es)
AT (1) ATE109510T1 (es)
AU (1) AU5749690A (es)
CA (1) CA2057854C (es)
DE (1) DE69011329T2 (es)
DK (1) DK0474744T3 (es)
ES (1) ES2057571T3 (es)
WO (1) WO1990014425A1 (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6110737A (en) 1988-02-02 2000-08-29 The Regents Of The University Of California Human platelet-derived growth factor receptor, type A
DK0456766T3 (da) * 1989-02-09 1999-11-08 Us Health Gen for receptor for type alfa-blodplade-afledt vækstfaktor
US6228600B1 (en) 1992-07-20 2001-05-08 The United States Of America As Represented By The Department Of Health And Human Services Immunoassays for the alpha platelet-derived growth factor receptor
US5468468A (en) * 1989-02-09 1995-11-21 The United States Of America, As Represented By The Secretary Of The Department Of Health & Human Services Method for making a monoclonal antibody, monoclonal antibodies to α PD
JPH06503966A (ja) * 1990-12-21 1994-05-12 クリエイティブ　バイオモレキュルズ　インコーポレイテッド 生合成したｐｄｇｆアンタゴニスト
US6605442B1 (en) * 1992-03-19 2003-08-12 The Rockefeller University Methods of testing drugs or agents that modulate the activity of receptor recognition factors
US5326695A (en) * 1992-05-15 1994-07-05 Ludwig Institute For Cancer Research Platelet derived growth factor agonists
US5444151A (en) * 1992-05-15 1995-08-22 Ludwig Institute For Cancer Research Platelet derived growth factor antagonists
US5776755A (en) * 1992-10-09 1998-07-07 Helsinki University Licensing, Ltd. FLT4, a receptor tyrosine kinase
US6107046A (en) * 1992-10-09 2000-08-22 Orion Corporation Antibodies to Flt4, a receptor tyrosine kinase and uses thereof
US6824777B1 (en) 1992-10-09 2004-11-30 Licentia Ltd. Flt4 (VEGFR-3) as a target for tumor imaging and anti-tumor therapy
JP4841724B2 (ja) 1998-10-09 2011-12-21 ベジェニクス ピーティーワイ リミテッド 腫瘍イメージングおよび抗腫瘍治療の標的としてのＦｌｔ４（ＶＥＲＧ−３）
US6667173B2 (en) 2000-12-01 2003-12-23 The Schepens Eye Research Institute Nucleic acids encoding platelet derived growth factor-alpha receptors
JP4669984B2 (ja) 2001-01-19 2011-04-13 ベジェニクス リミテッド 腫瘍画像化のターゲットとしてのＦ１ｔ４（ＶＥＧＦＲ−３）および抗腫瘍療法
US7195876B2 (en) 2002-08-09 2007-03-27 Theravance, Inc. Oncokinase fusion polypeptides associated with hyperproliferative and related disorders, nucleic acids encoding the same and methods for detecting and identifying the same
WO2004046356A1 (ja) * 2002-11-15 2004-06-03 Keio University ＰＤＧＦ受容体α遺伝子のエキソン１β及びその利用
TWI353991B (en) 2003-05-06 2011-12-11 Syntonix Pharmaceuticals Inc Immunoglobulin chimeric monomer-dimer hybrids
WO2005047327A2 (en) 2003-11-12 2005-05-26 Biogen Idec Ma Inc. NEONATAL Fc RECEPTOR (FcRn)-BINDING POLYPEPTIDE VARIANTS, DIMERIC Fc BINDING PROTEINS AND METHODS RELATED THERETO
CA2593212A1 (en) 2005-01-05 2006-07-13 Biogen Idec Ma Inc. Cripto binding molecules
EP1913391B1 (en) * 2005-08-11 2010-12-29 Siemens Healthcare Diagnostics Inc. QUANTITATIVE ASSAYS FOR PDGFR-beta IN BODY FLUIDS
PT2591006T (pt) 2010-07-09 2019-07-29 Bioverativ Therapeutics Inc Moléculas de cadeia simples processáveis e polipéptidos preparados utilizando as mesmas
WO2013012733A1 (en) 2011-07-15 2013-01-24 Biogen Idec Ma Inc. Heterodimeric fc regions, binding molecules comprising same, and methods relating thereto
CN104159922B (zh) 2012-01-10 2018-03-02 比奥根Ma公司 对转运治疗性分子穿过血脑屏障的增强
MY170528A (en) 2013-02-18 2019-08-09 Vegenics Pty Ltd Vegfr-3 ligand binding molecules and uses thereof
ES2893114T3 (es) 2015-02-04 2022-02-08 Bristol Myers Squibb Co Métodos para seleccionar moléculas terapéuticas

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU607306B2 (en) * 1988-02-02 1991-02-28 Regents Of The University Of California, The Human platelet-derived growth factor receptor

Also Published As

Publication number Publication date
DE69011329T2 (de) 1994-12-08
EP0474744A1 (en) 1992-03-18
DK0474744T3 (da) 1994-11-21
WO1990014425A1 (en) 1990-11-29
EP0474744B1 (en) 1994-08-03
DE69011329D1 (de) 1994-09-08
JPH04505260A (ja) 1992-09-17
CA2057854C (en) 2000-01-11
US5371205A (en) 1994-12-06
CA2057854A1 (en) 1990-11-23
US5618678A (en) 1997-04-08
AU5749690A (en) 1990-12-18
ATE109510T1 (de) 1994-08-15

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