ES2057757T3 - Procedimiento para preparar derivados de 1,5-benzotiazepina. - Google Patents

Procedimiento para preparar derivados de 1,5-benzotiazepina.

Info

Publication number
ES2057757T3
ES2057757T3 ES91301939T ES91301939T ES2057757T3 ES 2057757 T3 ES2057757 T3 ES 2057757T3 ES 91301939 T ES91301939 T ES 91301939T ES 91301939 T ES91301939 T ES 91301939T ES 2057757 T3 ES2057757 T3 ES 2057757T3
Authority
ES
Spain
Prior art keywords
sub
derivatives
benzotiazepine
formula
preparing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91301939T
Other languages
English (en)
Inventor
Tadayuki Koumoto
Hironori Hayashi
Toshiya Kadowaki
Masahiko Seto
Toyonari Oine
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tanabe Pharma Corp
Original Assignee
Tanabe Seiyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co Ltd filed Critical Tanabe Seiyaku Co Ltd
Application granted granted Critical
Publication of ES2057757T3 publication Critical patent/ES2057757T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

SE PRESENTA UN PROCESO PARA PREPARAR DERIVADOS DE LA 1,5-BENZOTIAZEPINA DE LA FORMULA: EN LA QUE R SUB 1 ES UN GRUPO ALQUIL INFERIOR, O UNA SAL DEL MISMO QUE COMPRENDE LA EXPOSICION DE DERIVADOS APROPIADOS DE LA FORMULA EN LA QUE R SUB 2 ES UN RESIDUO ESTER Y R SUB 1 ES TAL COMO SE DEFINIO ANTERIORMENTE A UNA CICLIZACION INTRAMOLECULAR EN LA PRESENCIA DE UN COMPUESTO DE ACIDO SULFONICO DE LA FORMULA: R SUB 3SO SUB 3H EN LA QUE R SUB 3 ES UN GRUPO ALQUIL INFERIOR O UN GRUPO FENIL SUBSTITUIDO O INSUBSTITUIDO EN UN SOLVENTE ORGANICO NO HALOGENADO SI SE DESEA, CONVIRTIENDO ASI EL PRODUCTO EN UNA SAL DEL MISMO.
ES91301939T 1990-03-08 1991-03-08 Procedimiento para preparar derivados de 1,5-benzotiazepina. Expired - Lifetime ES2057757T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP5779890 1990-03-08

Publications (1)

Publication Number Publication Date
ES2057757T3 true ES2057757T3 (es) 1994-10-16

Family

ID=13065923

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91301939T Expired - Lifetime ES2057757T3 (es) 1990-03-08 1991-03-08 Procedimiento para preparar derivados de 1,5-benzotiazepina.

Country Status (16)

Country Link
US (1) US5294706A (es)
EP (1) EP0447135B1 (es)
JP (1) JPH085869B2 (es)
KR (1) KR970002879B1 (es)
CN (1) CN1029847C (es)
AT (1) ATE107295T1 (es)
AU (1) AU632218B2 (es)
CA (1) CA2037298C (es)
DE (1) DE69102462T2 (es)
DK (1) DK0447135T3 (es)
ES (1) ES2057757T3 (es)
FI (1) FI93011C (es)
FR (1) FR2659328B1 (es)
HU (1) HU210146B (es)
IE (1) IE65974B1 (es)
IL (1) IL97404A0 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1230057B (it) * 1989-04-13 1991-09-27 Zambon Spa Processo di risoluzione di intermedi utili per la preparazione di 1,5-benzotiazepine
DE69015682T2 (de) * 1989-04-28 1995-05-11 Tanabe Seiyaku Co Verfahren zur Herstellung von 1,5-Benzothiazepinderivaten.
JPH0798813B2 (ja) * 1989-04-28 1995-10-25 田辺製薬株式会社 １，５―ベンゾチアゼピン誘導体の製法
US4983733A (en) * 1989-11-20 1991-01-08 Marion Laboratories, Inc. Process for preparing 2-aromatic-3-halobenzothiazepines
IT1240686B (it) * 1990-04-27 1993-12-17 Luso Farmaco Inst Derivati 1,5-benzotiazepinonici, loro preparazione e uso farmaceutico
IL100157A (en) * 1990-11-29 1995-12-08 Tanabe Seiyaku Co Preparation of a 1,5-benzothiazepine derivative
IT1249318B (it) * 1991-05-23 1995-02-22 Zambon Spa Processo per la preparazione di benzotiazepine per ciclizzazione con acidi fosfonici
AU709280B2 (en) * 1996-02-23 1999-08-26 Tanabe Seiyaku Co., Ltd. Process for preparing 1,5-benzothiazepine derivative
NL1002687C2 (nl) * 1996-03-22 1997-09-23 Dsm Nv Werkwijze voor de bereiding van een benzothiazepine.
TW438787B (en) * 1997-02-27 2001-06-07 Tanabe Seiyaku Co Process for preparing optically active trans-3-substituted glycidic acid ester
IT1295376B1 (it) * 1997-10-22 1999-05-12 Zambon Spa Processo per il riciclo di un sottoprodotto della sintesi del diltiazem
CN112279820B (zh) * 2020-12-18 2021-04-02 苏州开元民生科技股份有限公司 2-(4-甲氧苯基)-3-羟基-2,3-二氢-1,5-苯并硫氮杂卓酮的制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3562257A (en) * 1967-10-28 1971-02-09 Tanabe Seiyaku Co Benzothiazepine derivatives
FR2360124A1 (fr) * 1976-07-30 1978-02-24 Amiens Const Electro Mecan Procede de controle de commutation de la puissance de chauffage dans un appareil electrodomestique a programmateur et dispositif pour la mise en oeuvre dudit procede
JPS5899471A (ja) * 1981-12-07 1983-06-13 Tanabe Seiyaku Co Ltd ベンゾチアゼピン誘導体の新規製造法
EP0098422B1 (de) * 1982-07-07 1987-12-09 Siegfried Aktiengesellschaft Verfahren zur Herstellung von 4-Hydroxy-2-methyl-N-2-pyridyl-2H-1,2-benzothiazin-3-carboxamid 1,1-dioxid
US5008411A (en) * 1988-05-24 1991-04-16 Hoffmann-La Roche Inc. Glycidic acid ester and process of preparation
ZA893392B (en) * 1988-05-24 1990-01-31 Hoffmann La Roche Process for the manufacture of optically active naphthothiazepinones
FR2641535B1 (fr) * 1989-01-11 1991-03-15 Synthelabo Procede de preparation de (+) - (2s, 3s)-hydroxy-3 (methoxy-4 phenyl)-2 dihydro-2,3 5h-benzothiazepine-1,5 one-4
IT1230057B (it) * 1989-04-13 1991-09-27 Zambon Spa Processo di risoluzione di intermedi utili per la preparazione di 1,5-benzotiazepine
DE69015682T2 (de) * 1989-04-28 1995-05-11 Tanabe Seiyaku Co Verfahren zur Herstellung von 1,5-Benzothiazepinderivaten.
JPH0798813B2 (ja) * 1989-04-28 1995-10-25 田辺製薬株式会社 １，５―ベンゾチアゼピン誘導体の製法
US5055575A (en) * 1990-04-12 1991-10-08 Tanabe Seiyaku Co., Ltd. Process for preparing 1,5-benzothiazepine derivatives

Also Published As

Publication number Publication date
HK1000126A1 (en) 1997-12-12
DE69102462T2 (de) 1994-10-06
HUT65340A (en) 1994-05-02
FI911080A7 (fi) 1991-09-09
IE65974B1 (en) 1995-11-29
CN1029847C (zh) 1995-09-27
FR2659328A1 (fr) 1991-09-13
FR2659328B1 (fr) 1994-11-04
EP0447135B1 (en) 1994-06-15
KR910016727A (ko) 1991-11-05
KR970002879B1 (ko) 1997-03-12
HU910742D0 (en) 1991-09-30
AU632218B2 (en) 1992-12-17
FI93011C (fi) 1995-02-10
CA2037298C (en) 1998-08-18
FI93011B (fi) 1994-10-31
DE69102462D1 (de) 1994-07-21
ATE107295T1 (de) 1994-07-15
DK0447135T3 (da) 1994-07-11
AU7199391A (en) 1991-09-12
CA2037298A1 (en) 1991-09-09
IL97404A0 (en) 1992-06-21
FI911080A0 (fi) 1991-03-04
HU210146B (en) 1995-02-28
JPH04234866A (ja) 1992-08-24
CN1054597A (zh) 1991-09-18
JPH085869B2 (ja) 1996-01-24
US5294706A (en) 1994-03-15
IE910755A1 (en) 1991-09-11
EP0447135A1 (en) 1991-09-18

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