ES2058024A1 - Nuevo derivado arilpropionico, procedimiento de fabricacion del mismo y su utilizacion como analgesico. - Google Patents

Nuevo derivado arilpropionico, procedimiento de fabricacion del mismo y su utilizacion como analgesico.

Info

Publication number
ES2058024A1
ES2058024A1 ES09202260A ES9202260A ES2058024A1 ES 2058024 A1 ES2058024 A1 ES 2058024A1 ES 09202260 A ES09202260 A ES 09202260A ES 9202260 A ES9202260 A ES 9202260A ES 2058024 A1 ES2058024 A1 ES 2058024A1
Authority
ES
Spain
Prior art keywords
preparation
analgesic agent
derivative
novel
novel arylpropionic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES09202260A
Other languages
English (en)
Other versions
ES2058024B1 (es
Inventor
Germano Carganico
Casellas David Mauleon
Perez M Luisa Garcia
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratorios Menarini SA
Original Assignee
Laboratorios Menarini SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8278730&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2058024(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Laboratorios Menarini SA filed Critical Laboratorios Menarini SA
Priority to ES09202260A priority Critical patent/ES2058024B1/es
Priority to UA95058442A priority patent/UA44233C2/uk
Priority to US08/428,231 priority patent/US5554789A/en
Priority to DE69311130T priority patent/DE69311130T2/de
Priority to SK603-95A priority patent/SK280550B6/sk
Priority to AU54210/94A priority patent/AU674040B2/en
Priority to NZ257557A priority patent/NZ257557A/en
Priority to DE0668851T priority patent/DE668851T1/de
Priority to HU9501375A priority patent/HU217973B/hu
Priority to JP51169794A priority patent/JP3778516B2/ja
Priority to ES93924604T priority patent/ES2081780T3/es
Priority to HU9802850A priority patent/HU219975B/hu
Priority to MD96-0285A priority patent/MD921G2/ro
Priority to CA002149013A priority patent/CA2149013C/en
Priority to KR1019950701827A priority patent/KR100284838B1/ko
Priority to BR9307408A priority patent/BR9307408A/pt
Priority to RU95112575A priority patent/RU2128160C1/ru
Priority to CZ19951149A priority patent/CZ286621B6/cs
Priority to AT93924604T priority patent/ATE153649T1/de
Priority to DK93924604.7T priority patent/DK0668851T3/da
Priority to PL93308466A priority patent/PL175265B1/pl
Priority to EP93924604A priority patent/EP0668851B1/en
Priority to PCT/EP1993/003127 priority patent/WO1994011332A1/en
Priority to RO95-00865A priority patent/RO118712B1/ro
Publication of ES2058024A1 publication Critical patent/ES2058024A1/es
Application granted granted Critical
Publication of ES2058024B1 publication Critical patent/ES2058024B1/es
Priority to BG99609A priority patent/BG61723B1/bg
Priority to NO951790A priority patent/NO304306B1/no
Priority to FI952230A priority patent/FI108637B/fi
Priority to UY24179A priority patent/UY24179A1/es
Priority to GR960300012T priority patent/GR960300012T1/el
Priority to GR970401991T priority patent/GR3024344T3/el
Priority to HK98105382.8A priority patent/HK1006306B/en
Priority to NO2006007C priority patent/NO2006007I1/no
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/04—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
    • C07C215/06—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic
    • C07C215/10—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic with one amino group and at least two hydroxy groups bound to the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/84—Unsaturated compounds containing keto groups containing six membered aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

NUEVO DERIVADO ARILPROPIONICO, PROCEDIMIENTO DE FABRICACION DEL MISMO Y SU UTILIZACION COMO ANALGESICO. EL NUEVO DERIVADO ARILPROPIONICO, CONSISTE EN LA SAL DE TROMETAMINA DEL ACIDO (+)-(S)-2-3-(3-BENZOILFENIL) PROPIONICO, DE FORMULA I. FORMULA EL PROCEDIMIENTO PARA SU PREPARACION COMPRENDE LA REACCION EN CONDICIONES EQUIMOLARES DEL ACIDO (+)-(S)-2-3-(3-BENZOILFENIL) PROPIONICO (III). FORMULA CON LA TROMETAMINA, HSI2 SCNC (CHSI2 SCOH)SI3 SC EN UN DISOLVENTE POLAR O MEZCLA DE DISOLVENTES POLARES, A UNA TEMPERATURA COMPRENDIDA ENTRE 0G Y REFLUJO DE DISOLVENTE Y DURANTE UN PERIODO COMPRENDIDO ENTRE 1 Y 24 HORAS. ESTE COMPUESTO EXHIBE UNA ELEVADA ACCION COMO ANALGESICO EN TERAPIA HUMANA.
ES09202260A 1992-11-10 1992-11-10 Nuevo derivado arilpropionico, procedimiento de fabricacion del mismo y su utilizacion como analgesico. Expired - Lifetime ES2058024B1 (es)

Priority Applications (32)

Application Number Priority Date Filing Date Title
ES09202260A ES2058024B1 (es) 1992-11-10 1992-11-10 Nuevo derivado arilpropionico, procedimiento de fabricacion del mismo y su utilizacion como analgesico.
UA95058442A UA44233C2 (uk) 1992-11-10 1993-09-11 (+)-(s)-2-(3-бензоїлфеніл) сіль трометаміну пропіонової кислоти, спосіб її одержання, фармацевтична композиція та спосіб одержання знеболюючого та протизапального медпрепарату
RU95112575A RU2128160C1 (ru) 1992-11-10 1993-11-09 Трометаминная соль (+)-(s)-2-(3-бензоилфенил)пропионовой кислоты, способ ее получения, фармацевтическая композиция
DK93924604.7T DK0668851T3 (da) 1992-11-10 1993-11-09 Hidtil ukendt arylpropionsyrederivat, fremgangsmåde til fremstilling heraf og anvendelse heraf som analgetisk middel
SK603-95A SK280550B6 (sk) 1992-11-10 1993-11-09 Trometamín (+)-(s)-2(3-benzoylfenyl)propionát, spô
AU54210/94A AU674040B2 (en) 1992-11-10 1993-11-09 A novel arylpropionic derivative, a process for the preparation and the use thereof as an analgesic agent
NZ257557A NZ257557A (en) 1992-11-10 1993-11-09 Tromethamine salt of (+)-(s)-2-(3-benzoyl phenyl)propionic acid and pharmaceutical compositions, preparation and the use thereof as an analgesic agent
DE0668851T DE668851T1 (de) 1992-11-10 1993-11-09 Arylpropionsäurederivat, verfahren zu seiner herstellung und seine verwendung als analgetikum.
HU9501375A HU217973B (hu) 1992-11-10 1993-11-09 Eljárás ketoprofén trometamin-só és ezt tartalmazó gyógyszerkészítmények előállítására
JP51169794A JP3778516B2 (ja) 1992-11-10 1993-11-09 新規なアリールプロピオン酸誘導体、その製造方法及び鎮痛薬としてのその用途
ES93924604T ES2081780T3 (es) 1992-11-10 1993-11-09 Nuevo derivado arilpropionico, procedimiento para su preparacion y su utilizacion como agente analgesico.
HU9802850A HU219975B (hu) 1992-11-10 1993-11-09 (+)-(S)-Ketoprofén trometamin só és ezt tartalmazó gyógyszerkészítmények
MD96-0285A MD921G2 (ro) 1992-11-10 1993-11-09 Derivaţi arilpropionici, procedeu de obţinere a lor şi compoziţie farmaceutică pe baza lor
CA002149013A CA2149013C (en) 1992-11-10 1993-11-09 A novel arylpropionic derivative, a process for the preparation and the use thereof as an analgesic agent
KR1019950701827A KR100284838B1 (ko) 1992-11-10 1993-11-09 새로운 아릴프로피온 유도체, 그 제조방법 및 진통제로서의 이용방법
BR9307408A BR9307408A (pt) 1992-11-10 1993-11-09 Novo derivado arilpropi nico processo para a prepara-Æo do mesmo e seu uso como agente analgesico
US08/428,231 US5554789A (en) 1992-11-10 1993-11-09 Arylpropionic derivative, a process for the preparation and the use thereof as an analgesic agent
CZ19951149A CZ286621B6 (cs) 1992-11-10 1993-11-09 Tromethaminová sůl (+)-(S)-2-(3-benzoylfenyl)propionové kyseliny, způsob její výroby a farmaceutický prostředek s jejím obsahem
AT93924604T ATE153649T1 (de) 1992-11-10 1993-11-09 Arylpropionsäurederivat, verfahren zu seiner herstellung und seine verwendung als analgetikum
DE69311130T DE69311130T2 (de) 1992-11-10 1993-11-09 Arylpropionsäurederivat, verfahren zu seiner herstellung und seine verwendung als analgetikum
PL93308466A PL175265B1 (pl) 1992-11-10 1993-11-09 Nowa pochodna arylopropionowa sól trometaminowa kwasu (+)-S-2-(3-benzoilofenylo)propionowego, sposób jej wytwarzania i kompozycja farmaceutyczna
EP93924604A EP0668851B1 (en) 1992-11-10 1993-11-09 A novel arylpropionic derivative, a process for the preparation and the use thereof as an analgesic agent
PCT/EP1993/003127 WO1994011332A1 (en) 1992-11-10 1993-11-09 A novel arylpropionic derivative, a process for the preparation and the use thereof as an analgesic agent
RO95-00865A RO118712B1 (ro) 1992-11-10 1993-11-09 Derivat arilpropionic, procedeu de obtinere si utilizare a acestuia ca agent analgezic
BG99609A BG61723B1 (bg) 1992-11-10 1995-05-02 Ново арилпропионово производство, метод за неговотополучаване и използването му като аналгетично средство
NO951790A NO304306B1 (no) 1992-11-10 1995-05-08 Nytt arylpropionsyrederivat, farmas°ytisk blanding inneholdende dette, og anvendelse av det nye derivat ved fremstilling av et medikament
FI952230A FI108637B (fi) 1992-11-10 1995-05-09 Menetelmä lääkeaineena käyttökelpoisen (+)-(S)-2-(3-bentsoyylifenyyli)propaanihapon trometamiinisuolan valmistamiseksi
UY24179A UY24179A1 (es) 1992-11-10 1996-03-14 Procedimiento para la obtención de la sal de trometamina del acido (+)-(s)-2-(3-benzoilfenil)-propionico
GR960300012T GR960300012T1 (en) 1992-11-10 1996-03-31 A novel arylpropionic derivative, a process for the preparation and the use thereof as an analgesic agent.
GR970401991T GR3024344T3 (en) 1992-11-10 1997-07-31 A novel arylpropionic derivative, a process for the preparation and the use thereof as an analgesic agent.
HK98105382.8A HK1006306B (en) 1992-11-10 1998-06-16 A novel arylpropionic derivative, a process for the preparation and the use thereof as an analgesic agent
NO2006007C NO2006007I1 (no) 1992-11-10 2006-07-31 (+)-(S)-2-(3-benzoylfenyl)-propionsyre-trometaminsalt(deksketoprofentrometamol)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES09202260A ES2058024B1 (es) 1992-11-10 1992-11-10 Nuevo derivado arilpropionico, procedimiento de fabricacion del mismo y su utilizacion como analgesico.

Publications (2)

Publication Number Publication Date
ES2058024A1 true ES2058024A1 (es) 1994-10-16
ES2058024B1 ES2058024B1 (es) 1995-05-01

Family

ID=8278730

Family Applications (2)

Application Number Title Priority Date Filing Date
ES09202260A Expired - Lifetime ES2058024B1 (es) 1992-11-10 1992-11-10 Nuevo derivado arilpropionico, procedimiento de fabricacion del mismo y su utilizacion como analgesico.
ES93924604T Expired - Lifetime ES2081780T3 (es) 1992-11-10 1993-11-09 Nuevo derivado arilpropionico, procedimiento para su preparacion y su utilizacion como agente analgesico.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES93924604T Expired - Lifetime ES2081780T3 (es) 1992-11-10 1993-11-09 Nuevo derivado arilpropionico, procedimiento para su preparacion y su utilizacion como agente analgesico.

Country Status (26)

Country Link
US (1) US5554789A (es)
EP (1) EP0668851B1 (es)
JP (1) JP3778516B2 (es)
KR (1) KR100284838B1 (es)
AT (1) ATE153649T1 (es)
AU (1) AU674040B2 (es)
BG (1) BG61723B1 (es)
BR (1) BR9307408A (es)
CA (1) CA2149013C (es)
CZ (1) CZ286621B6 (es)
DE (2) DE69311130T2 (es)
DK (1) DK0668851T3 (es)
ES (2) ES2058024B1 (es)
FI (1) FI108637B (es)
GR (2) GR960300012T1 (es)
HU (2) HU219975B (es)
MD (1) MD921G2 (es)
NO (2) NO304306B1 (es)
NZ (1) NZ257557A (es)
PL (1) PL175265B1 (es)
RO (1) RO118712B1 (es)
RU (1) RU2128160C1 (es)
SK (1) SK280550B6 (es)
UA (1) UA44233C2 (es)
UY (1) UY24179A1 (es)
WO (1) WO1994011332A1 (es)

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ES2124196B1 (es) * 1997-06-04 1999-12-01 Menarini Lab Procedimiento para la fabricacion de una forma farmaceutica semisolida conteniendo dexketoprofeno trometamol y su utilizacion en el tratamiento topico de la inflamacion.
EP2147679B1 (en) 2001-07-25 2014-06-25 Raptor Pharmaceutical, Inc. Compositions for blood-brain barrier transport
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US20080051411A1 (en) * 2002-12-17 2008-02-28 Cink Russell D Salts of Fenofibric Acid and Pharmaceutical Formulations Thereof
EP2392258B1 (en) 2005-04-28 2014-10-08 Proteus Digital Health, Inc. Pharma-informatics system
EP1739072A1 (en) * 2005-06-15 2007-01-03 Laboratorios Menarini S.A. Polymorphic forms of dexketoprofen trometamol, preparation and pharmaceutical compositions thereof
CN101594878A (zh) 2006-09-18 2009-12-02 雷普特药品公司 通过给予受体相关蛋白（rap）-缀合物对肝病症的治疗
TWI364413B (en) * 2008-07-25 2012-05-21 Univ Nat Central Racemic ibuprofen amine salt and synthesis method thereof
BRPI0920300A2 (pt) * 2008-10-31 2020-08-11 C-A-I-R Biosciences Gmbh composto, composição farmacêutica, e, uso de um sal.
PL3395372T3 (pl) 2009-02-20 2022-07-25 EnhanX Biopharm Inc. Układ do dostarczania leków na bazie glutationu
CN102458374A (zh) 2009-05-06 2012-05-16 实验室护肤股份有限公司 包含活性剂-磷酸钙颗粒复合物的皮肤递送组合物及其使用方法
ES2350670B1 (es) * 2009-06-10 2011-12-07 Polichem, S.L. Composicion veterinaria de ketoprofeno
CN101928214B (zh) * 2009-06-19 2012-12-19 黄石世星药业有限责任公司 右旋酮洛芬氨丁三醇的一种合成方法
WO2011001213A1 (en) * 2009-06-30 2011-01-06 Abdi Ibrahim Ilac Sanayi Ve Ticaret Anonim Sirketi A process for preparing dexketoprofen trometamol form a and form b crystals
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
CN102557976B (zh) * 2010-12-15 2015-06-10 辽宁盛京制药有限公司 溴芬酸有机盐及其制备方法、其组合物及用途
TR201104864A2 (tr) 2011-05-18 2012-12-21 B�Lg�� Mahmut Deksketoprofen içeren suda çözünebilir formülasyonlar.
TR201205317A2 (tr) 2011-05-18 2012-12-21 B�Lg�� Mahmut Deksketoprofen içeren efervesan formülasyonlar.
CN102381986A (zh) * 2011-07-25 2012-03-21 南京特丰药业股份有限公司 一种右旋布洛芬氨丁三醇盐及其口服溶液的制备方法
WO2013022410A2 (en) 2011-08-08 2013-02-14 Mahmut Bilgic Production method for effervescent formulations comprising dexketoprofen
WO2013095315A1 (en) 2011-12-19 2013-06-27 Mahmut Bilgic Formulations comprising dexketoprofen (particle size 300-2500 micrometer)
WO2013100877A1 (en) 2011-12-27 2013-07-04 Mahmut Bilgic Dexketoprofen formulations
ES2501415T3 (es) 2012-06-06 2016-02-22 Galenicum Health S.L. Composiciones farmacéuticas estables de acción rápida
EP2759293A1 (en) 2013-01-25 2014-07-30 Laboratorios Lesvi, S.L. Pharmaceutical compositions of (+)-(s)-2-(3-benzoylphenyl)propionic acid tromethamine salt
EP2764875A1 (en) 2013-02-06 2014-08-13 Galenicum Health S.L. Process for preparing a stable pharmaceutical composition comprising dexketoprofen trometamol
ITMI20130210A1 (it) 2013-02-14 2014-08-15 Menarini Lab Composizioni farmaceutiche contenenti dexketoprofene e tramadolo
TR201616365A1 (tr) 2016-11-14 2018-05-21 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Deksketoprofen ve eletri̇ptanin oral farmasöti̇k kompozi̇syonlari
WO2018096517A1 (en) * 2016-11-28 2018-05-31 Parayil Sarin Novel organic crystalline salt of haloacetic acid
TR201618765A2 (tr) 2016-12-16 2018-07-23 Imuneks Farma Ilac Sanayi Ve Ticaret Anonim Sirketi Ağrı ve enflamasyonun tedavisi için steroid olmayan anti-enflamatuvar ilaçlar ve H2 reseptörü antagonisti kombinasyonları.
KR102552315B1 (ko) * 2020-11-11 2023-07-06 대원제약주식회사 펠루비프로펜 신규 염을 주성분으로 하며 위장장애 부작용이 저감된 약학적 조성물
KR102462607B1 (ko) * 2020-11-11 2022-11-03 대원제약주식회사 펠루비프로펜 신규 염을 주성분으로 하는 안정성이 증가된 약학적 조성물
CN119212991A (zh) * 2022-03-25 2024-12-27 日东制药株式会社 Glp-1受体激动剂化合物之新颖盐类、其制备方法以及包含其的药物组合物

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ATE153649T1 (de) 1997-06-15
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DK0668851T3 (da) 1997-12-22
DE69311130D1 (de) 1997-07-03
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