ES2058053T3 - Un procedimiento para preparar un interferon-beta2a humano recombinante. - Google Patents

Un procedimiento para preparar un interferon-beta2a humano recombinante.

Info

Publication number
ES2058053T3
ES2058053T3 ES86114049T ES86114049T ES2058053T3 ES 2058053 T3 ES2058053 T3 ES 2058053T3 ES 86114049 T ES86114049 T ES 86114049T ES 86114049 T ES86114049 T ES 86114049T ES 2058053 T3 ES2058053 T3 ES 2058053T3
Authority
ES
Spain
Prior art keywords
ifn
beta2a
human
beta2b
interferon
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES86114049T
Other languages
English (en)
Other versions
ES2058053T5 (es
Inventor
Michel Revel
Asher Zilberstein
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yeda Research and Development Co Ltd
Original Assignee
Yeda Research and Development Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26321482&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2058053(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from IL76714A external-priority patent/IL76714A0/xx
Application filed by Yeda Research and Development Co Ltd filed Critical Yeda Research and Development Co Ltd
Application granted granted Critical
Publication of ES2058053T3 publication Critical patent/ES2058053T3/es
Publication of ES2058053T5 publication Critical patent/ES2058053T5/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/565—IFN-beta
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/215—IFN-beta
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5412—IL-6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

EL INTERFERON HUMANO BETA 2A E INTERFERON BETA 2B SON PRODUCIDOS EN FORMA PURIFICADA POR TECNICAS RECOMBINANTES DNA. DOS GENES HUMANOS SEPARADOS HAN SIDO IDENTIFICADOS CUYO CODIGO PARA LA PRODUCCION ES DE IFN-BETA2A Y IFN-BETA2B, RESPECTIVAMENTE. SE HA ESTABLECIDO LA SECUENCIA DE IFN-BETA2A CDNA. ESTOS GENES Y EL CDNA SE HAN CLONADO EN CELULAS MAMIFERAS CON UNA SECUENCIA PROMOTORA PREVIA SV40 Y TALES CLONES GENOMICOS DE LA PRODUCCION DE IFN-BETA2A E IFN-BETA2B. LA ACTIVIDAD ANTIVIRAL DE TALES RECOMBINANTES COMO IFN-BETA2A E IFN-BETA2B ESTA DEMOSTRADA ASI COMO OTRA ACTIVIDAD BIOLOGICA QUE LES IDENTIFICA COMO INTERFERONES HUMANOS. SE HA DEMOSTRADO QUE LA SECRECION IFN-BETA2 ES INDUCIDA EN CELULAS HUMANAS POR CITOQUINAS SIMULADORAS DEL CRECIMIENTO.
ES86114049T 1985-10-14 1986-10-10 Interferon beta2a humano; vectores que contienen genes codantes para el indicado interferon, lineas de celulas que lo producen y utilizacion de dicho interferon a titulo de medicamento. Expired - Lifetime ES2058053T5 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL76714A IL76714A0 (en) 1985-10-14 1985-10-14 Recombined human interferon beta-2 and a method of producing same
US86088386A 1986-05-08 1986-05-08

Publications (2)

Publication Number Publication Date
ES2058053T3 true ES2058053T3 (es) 1994-11-01
ES2058053T5 ES2058053T5 (es) 2000-11-01

Family

ID=26321482

Family Applications (2)

Application Number Title Priority Date Filing Date
ES86114049T Expired - Lifetime ES2058053T5 (es) 1985-10-14 1986-10-10 Interferon beta2a humano; vectores que contienen genes codantes para el indicado interferon, lineas de celulas que lo producen y utilizacion de dicho interferon a titulo de medicamento.
ES92114478T Expired - Lifetime ES2131513T3 (es) 1985-10-14 1986-10-10 Utilizacion de interferon-beta 2a humano para la preparacion de medicamentos.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES92114478T Expired - Lifetime ES2131513T3 (es) 1985-10-14 1986-10-10 Utilizacion de interferon-beta 2a humano para la preparacion de medicamentos.

Country Status (6)

Country Link
EP (4) EP0536520B1 (es)
AU (1) AU602872B2 (es)
CA (1) CA1341369C (es)
DE (4) DE3650715T2 (es)
ES (2) ES2058053T5 (es)
GR (2) GR3030150T3 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6284237B1 (en) 1986-07-08 2001-09-04 Steven C. Clark Methods of treatment using IL-6
IE67035B1 (en) * 1986-07-08 1996-02-21 Genetics Inst Production and use of non-glycosylated IL-6
EP0257406B2 (en) * 1986-08-06 1998-08-12 Ajinomoto Co., Inc. Recombinant B-cell differentiation factor
US4973478A (en) * 1987-07-20 1990-11-27 Allelix Biopharmaceuticals, Inc. Treating inflammation with hepatocyte stimulating factor interferon β2
NZ226799A (en) * 1987-11-06 1991-08-27 Oncogen Breast cancer inhibitory factor and method for inhibiting proliferation of neoplastic cells and compositions therefor
IL85204A0 (en) * 1988-01-26 1988-07-31 Yeda Res & Dev Recombinant human interferon beta2,its preparation and pharmaceutical compositions comprising it
JPH0372429A (ja) * 1988-10-07 1991-03-27 Chugai Pharmaceut Co Ltd 血小板減少症の治療剤
US5641868A (en) * 1991-04-18 1997-06-24 Toray Industries, Inc. Interlekin-6 compositions, and a production process thereof
IT1254359B (it) * 1992-05-11 1995-09-14 Serono Cesare Ist Ricerca Composizioni farmaceutiche contenenti il-6
US5902576A (en) * 1992-10-22 1999-05-11 Yeda Research And Development Co. Ltd. At Weizmann Institute Of Science Antitumor pharmaceutical composition comprising IL-6 transfected cells
US5338834A (en) * 1993-01-26 1994-08-16 Allelix Biopharmaceuticals Inc. Ultrapure human interleukin-6
IL147414A0 (en) 2001-12-31 2002-08-14 Yeda Res & Dev Ifnar2 mutants, their production and use
US8071321B2 (en) 2002-08-29 2011-12-06 Cytocure Llc Methods for up-regulating antigen expression in tumors
EP1608400B1 (en) 2003-03-28 2010-06-23 Faron Pharmaceuticals OY Elevation of adenosine level by cytokine-induced expression of cd73
CN108004270B (zh) * 2017-11-24 2021-06-18 上海交通大学 利用双荧光素酶报告基因检测鸭IFN-β启动子活性的方法
CN112442504B (zh) * 2020-12-10 2023-01-24 电子科技大学 一种重组草鱼白介素-12活性蛋白的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL58765A (en) * 1979-11-21 1986-09-30 Yeda Res & Dev Process for the production of essentially pure messenger rna of human fibroblast interferon and process for the production of interferon beta
JPS60169424A (ja) * 1984-02-15 1985-09-02 Chuzo Kishimoto 新規ヒトｂ細胞分化因子，その製造法およびその使用法
JPS61246197A (ja) * 1985-04-24 1986-11-01 Ajinomoto Co Inc Ｄｎａ
IE67035B1 (en) * 1986-07-08 1996-02-21 Genetics Inst Production and use of non-glycosylated IL-6
EP0257406B2 (en) * 1986-08-06 1998-08-12 Ajinomoto Co., Inc. Recombinant B-cell differentiation factor

Also Published As

Publication number Publication date
EP0220574B1 (en) 1993-07-07
DE3650790D1 (de) 2007-10-11
DE3688671D1 (de) 1993-08-12
DE3650715T2 (de) 1999-06-24
EP0835661A2 (en) 1998-04-15
EP0220574B2 (en) 2000-04-12
EP0220574A1 (en) 1987-05-06
EP0536520B1 (en) 1999-03-03
DE220574T1 (de) 1987-11-26
EP0645452A1 (en) 1995-03-29
AU602872B2 (en) 1990-11-01
ES2058053T5 (es) 2000-11-01
GR3030150T3 (en) 1999-08-31
AU6386786A (en) 1987-04-16
DE3688671T3 (de) 2001-05-03
CA1341369C (en) 2002-06-18
EP0835661B1 (en) 2007-08-29
DE3688671T2 (de) 1993-10-14
EP0536520A1 (en) 1993-04-14
GR3033769T3 (en) 2000-10-31
EP0835661A3 (en) 1998-05-20
ES2131513T3 (es) 1999-08-01
DE3650790T2 (de) 2008-01-24
DE3650715D1 (de) 1999-04-08

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