ES2058265T3 - Piperidinas antagonistas de opiaceos. - Google Patents

Piperidinas antagonistas de opiaceos.

Info

Publication number
ES2058265T3
ES2058265T3 ES88303302T ES88303302T ES2058265T3 ES 2058265 T3 ES2058265 T3 ES 2058265T3 ES 88303302 T ES88303302 T ES 88303302T ES 88303302 T ES88303302 T ES 88303302T ES 2058265 T3 ES2058265 T3 ES 2058265T3
Authority
ES
Spain
Prior art keywords
substituted
alkyl
piperidines
alquilo
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88303302T
Other languages
English (en)
Inventor
Charles Howard Mitch
Dennis Michael Zimmerman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Application granted granted Critical
Publication of ES2058265T3 publication Critical patent/ES2058265T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Obesity (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

LA INVENCION PRESENTA PIPERIDINAS TRANS-3,4 1-SUSTITTUIDAS-3SUSTITUIDAS-4-METIL-4-(3-FENIL-SUSTIUIDAS) COMO ANTAGONISTAS OPIOIDES CAPACES DE BLOQUEAR LOS RECEPTORES MU Y KAPPA EN EL CEREBRO, DE FORMULA (I) DONDE R1 ES HIDROGENO O ALCANOILO C1-C4; R2 ES HIDROGENO, ALQUILO C1-C4 O ALQUENILO C2-C6; R3 ES CICLOALQUILO C4-C8, CICLOALQUENILO C4-C8, ALQUILO C1-C6,ALQUENILO C2-C6, ALQUILO C1-C4 SUSTITUIDO, CICLOALQUILO C4-C8, ALQUILO C1-C4, CICLOALQUENILO C4-C8 SUSTITUIDO O TIOFENO; Z ES (II), (III) O UN ENLACE; R4 ES HIDROGENO, ALQUILO C1-C6 (IV) O (V) R5 ES ALQUILO, ALQUILO C1-C4 O (VI) N ES 1, 2 O 3, O UNA SAL FARMACOLOGICAMENTE ACEPTABLE DE DELLOS.
ES88303302T 1987-04-16 1988-04-13 Piperidinas antagonistas de opiaceos. Expired - Lifetime ES2058265T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US3912187A 1987-04-16 1987-04-16

Publications (1)

Publication Number Publication Date
ES2058265T3 true ES2058265T3 (es) 1994-11-01

Family

ID=21903800

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88303302T Expired - Lifetime ES2058265T3 (es) 1987-04-16 1988-04-13 Piperidinas antagonistas de opiaceos.

Country Status (21)

Country Link
EP (1) EP0287339B1 (es)
JP (1) JP2661699B2 (es)
KR (1) KR960015087B1 (es)
CN (1) CN1017992B (es)
AR (1) AR245933A1 (es)
AT (1) ATE110057T1 (es)
AU (1) AU596290B2 (es)
CA (1) CA1321792C (es)
DE (1) DE3851081T2 (es)
DK (1) DK204388A (es)
EG (1) EG18864A (es)
ES (1) ES2058265T3 (es)
HU (1) HU202492B (es)
IE (1) IE64508B1 (es)
IL (1) IL86061A (es)
MX (1) MX11117A (es)
NZ (1) NZ224236A (es)
PH (1) PH24752A (es)
PT (1) PT87233B (es)
SU (1) SU1598869A3 (es)
ZA (1) ZA882640B (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0299549A3 (en) * 1987-07-09 1989-02-08 Duphar International Research B.V Tertiary 2,5-dialkyl-3-phenyl-piperidine derivatives having opiate-antagonistic activity
ZA922180B (en) * 1991-03-29 1993-09-27 Lilly Co Eli Piperidine derivatives
GB9202238D0 (en) * 1992-02-03 1992-03-18 Wellcome Found Compounds
US5807858A (en) * 1996-06-05 1998-09-15 Delta Pharmaceutical, Inc. Compositions and methods for reducing respiratory depression
US5574159A (en) * 1992-02-03 1996-11-12 Delta Pharmaceuticals, Inc. Opioid compounds and methods for making therefor
US5985880A (en) 1996-06-05 1999-11-16 Delta Pharmaceuticals Compositions and methods for reducing respiratory depression and attendant side effects of mu opioid compounds
US5681830A (en) * 1992-02-03 1997-10-28 Delta Pharmaceuticals, Inc. Opioid compounds
RU2133744C1 (ru) * 1993-07-30 1999-07-27 Дельта Фармасьютикалз, Инк. Пиперазиновые соединения
GB9725114D0 (en) * 1997-11-28 1998-01-28 Pfizer Ltd Treatment of pruritus
GB9810671D0 (en) * 1998-05-18 1998-07-15 Pfizer Ltd Anti-pruritic agents
GB9815618D0 (en) * 1998-07-18 1998-09-16 Univ Manchester Treatment of dyskinesia
TWI244481B (en) 1998-12-23 2005-12-01 Pfizer 3-azabicyclo[3.1.0]hexane derivatives useful in therapy
GB9912413D0 (en) 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
GB9912415D0 (en) 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
GB9912410D0 (en) * 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
GB9912417D0 (en) 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
GB9912411D0 (en) 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
GB9912416D0 (en) 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
MXPA02005335A (es) * 1999-11-29 2003-01-28 Adolor Corp Metodos y composiciones novedosos que incluyen opioides y antagonistas de los mismos.
GB0015562D0 (en) * 2000-06-23 2000-08-16 Pfizer Ltd Heterocycles
DE60226161T2 (de) 2001-10-22 2009-07-02 Pfizer Products Inc., Groton 3-azabicyclo[3.1.0]hexan derivative als antagonisten der opioid rezeptoren
MY140236A (en) * 2002-09-19 2009-12-31 Lilly Co Eli Diarylether compounds useful as opioid receptor antagonists
US7538110B2 (en) 2005-10-27 2009-05-26 Adolor Corporation Opioid antagonists
EP2734041A4 (en) * 2011-07-18 2015-03-25 Adolor Corp METHOD FOR THE PRODUCTION OF PERIPHERAL OPIOID ANTAGONIST COMPOUNDS AND INTERMEDIATE PRODUCTS THEREOF

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR206937A1 (es) * 1974-09-06 1976-08-31 Lilly Co Eli Procedimiento para preparar compuestos de 1-sustituido-4-alquil-4-fenil-piperidina

Also Published As

Publication number Publication date
PT87233B (pt) 1992-07-31
AU1462488A (en) 1988-10-20
AR245933A1 (es) 1994-03-30
EG18864A (en) 1995-06-29
DK204388A (da) 1989-01-05
EP0287339A3 (en) 1991-05-15
CN88102191A (zh) 1988-11-02
IE881125L (en) 1988-10-16
IL86061A (en) 1992-07-15
EP0287339B1 (en) 1994-08-17
PT87233A (pt) 1988-05-01
ATE110057T1 (de) 1994-09-15
NZ224236A (en) 1990-08-28
PH24752A (en) 1990-10-01
CA1321792C (en) 1993-08-31
KR880012551A (ko) 1988-11-28
JPS63277661A (ja) 1988-11-15
CN1017992B (zh) 1992-08-26
AU596290B2 (en) 1990-04-26
DE3851081D1 (de) 1994-09-22
KR960015087B1 (ko) 1996-10-24
EP0287339A2 (en) 1988-10-19
DK204388D0 (da) 1988-04-14
SU1598869A3 (ru) 1990-10-07
HUT46892A (en) 1988-12-28
JP2661699B2 (ja) 1997-10-08
DE3851081T2 (de) 1995-02-16
HU202492B (en) 1991-03-28
IL86061A0 (en) 1988-09-30
ZA882640B (en) 1989-12-27
IE64508B1 (en) 1995-08-09
MX11117A (es) 1993-11-01

Similar Documents

Publication Publication Date Title
ES2072096T3 (es) 4-fenilpiperidinas n-sustituidas antagonistas de opioides.
UA26427A (uk) Похідhі ксаhтиhу у вигляді суміші ізомерів або іhдивідуальhих ізомерів, що мають властивість аhтагоhіста адеhозиhу
ES2162061T3 (es) Derivados de piperidina como antagonistas de la neuroquinina.
ES2143238T3 (es) Derivados de 1-(piperidinil disustituido en posiciones 1,2)-piperazinas sustituidas en posicion 4.
ES2053508T3 (es) Compuestos de acidos 3-pirrolidinil-tio-1-azabiciclo(3.2.0)hept-2-eno-2-carboxilicos.
AR029216A1 (es) Compuestos inhibidores no peptidicos de la union celular dependiente de vla-4 utiles en el tratamiento de enfermedades inflamatorias, autoinmunes y respiratorias; composicion farmaceutica y procedimiento de tratamiento
ES2059408T3 (es) Un proceso para la preparacion de un compuesto.
ES2123287T3 (es) Derivados 3-benzoil benzofuranicos como antagonistas de la hormona tiroidea.
ES2162668T3 (es) Derivados de bifenilo o de fenil-piridina sustituidos, su procedimiento de preparacion y composiciones farmaceuticas que los contienen.
ES2160640T3 (es) Nuevos (r)-5-carbamoil-8-fluoro-3-amino disustituido en n,n-3,4-dihidro-2h-1-benzopiranos.
AR030507A1 (es) Compuesto de pirazolopiridina y los usos farmaceuticos del mismo
EP0638567A4 (en) ADENOSINE INHIBITORS.
DK0687253T3 (da) Hidtil ukendte 4-aminopyridiner, fremgangsmåde til deres fremstilling samt lægemidler indeholdende disse forbindelser
ES2113368T3 (es) Antagonistas de serotonina.
ES2059804T3 (es) Procedimiento de preparacion de eteres de oxima de propenona.
ES2087097T3 (es) Derivados de acidos fenilcarboxilicos que contienen un heterociclo.
IE881125L (en) Piperidine opioid antagonists
NO20025640D0 (no) Substituerte 1-aminoalkyl-laktamer og deres anvendelse som muscarin-reseptor-antagonister
MXPA04003730A (es) Derivados del 3-azabiciclo[3.1.0]hexano.
MX9701955A (es) Antagonistas de neuroquinina.
ES2062425T3 (es) Piridinas, procedimientos de preparacion y medicamentos que las contienen.
ES2090024T3 (es) Compuestos de cefemo y procedimientos para su preparacion.
ES2043863T3 (es) Procedimiento para preparar derivados de la 1,2,5,6-tetrahidropiridina.
ES2108595B1 (es) Derivados de la 3(2h)-piridacinona y procedimiento para su preparacion.
ES2153019T3 (es) Derivados de benzo-dioxano, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 287339

Country of ref document: ES