ES2058557T3 - Monoesteres de un acido arilacetico, su produccion y uso. - Google Patents

Monoesteres de un acido arilacetico, su produccion y uso.

Info

Publication number
ES2058557T3
ES2058557T3 ES89313075T ES89313075T ES2058557T3 ES 2058557 T3 ES2058557 T3 ES 2058557T3 ES 89313075 T ES89313075 T ES 89313075T ES 89313075 T ES89313075 T ES 89313075T ES 2058557 T3 ES2058557 T3 ES 2058557T3
Authority
ES
Spain
Prior art keywords
hydrogen
arylacetic acid
methyl
optically active
protective group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89313075T
Other languages
English (en)
Inventor
Mitsuaki Ohtani
Takaharu Matsuura
Toshiro Konoike
Yoshitaka Araki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Application granted granted Critical
Publication of ES2058557T3 publication Critical patent/ES2058557T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C69/753—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring of polycyclic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/08—Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with the hydroxy or O-metal group of organic compounds
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

LA INVENCION PROVEE UNOS ESTERES OPTICAMENTE ACTIVOS DE ACIDO ARILACETICO DE FORMJLA (II), DONDE R1 ES HIDROGENO O ALQUIL C 1-2 OPCIONALMENTE SUSTITUIDO O FENIL O AMBOS JUNTOS FORMAN UN ALQUILENO C 2-6, ALQUILENO C-2 O C 4-6 O UN ANILLO BICICLICO; R2 ES HIDROGENO O METIL; X ES UN ENLACE SIMPLE O CH2, C=O, N-R4; O, S, CHNHR4, CHCH3, CH-AR O CHOR5 (SIEMPRE QUE X ES UN ENLACE SIMPLE O CH2, C=O, N-R4, O, S, R1 Y R2 NO SON HIDROGENO O METIL), R3 ES HIDROGENO, ALQUIL OP. SUS., ARALQUIL OP. SUS; R4 ES UN GRUPO PROTECTOR O AMINO; R5 ES HIDROGENO O UN GRUPO PROTECTOR HIDROXILICO, Y AR ES ARIL OPCIONALMENTE SUSTITUIDO. ESOS ESTERES PUEDEN SER PREPARADOS POR LA REACCION DE UN ANHIDRIDO ACIDO SIMETRICO CON UN DERIVADO DE ACIDO ARILACETICO (R) O (S) DE ALTA PUREZA OPTICA Y SON UTILES COMO INTERMEDIARIOS PARA VARIOS PRODUCTOS Y MEDICINAS NATURALES OPTICAMENTE ACTIVOS.
ES89313075T 1988-12-14 1989-12-14 Monoesteres de un acido arilacetico, su produccion y uso. Expired - Lifetime ES2058557T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP31573088 1988-12-14

Publications (1)

Publication Number Publication Date
ES2058557T3 true ES2058557T3 (es) 1994-11-01

Family

ID=18068843

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89313075T Expired - Lifetime ES2058557T3 (es) 1988-12-14 1989-12-14 Monoesteres de un acido arilacetico, su produccion y uso.

Country Status (6)

Country Link
US (1) US5117039A (es)
EP (1) EP0373931B1 (es)
KR (1) KR0144685B1 (es)
AT (1) ATE92032T1 (es)
DE (1) DE68907873T2 (es)
ES (1) ES2058557T3 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992022560A1 (fr) * 1991-06-19 1992-12-23 Shionogi Seiyaku Kabushiki Kaisha Intermediaire optiquement actif et production de celui-ci
US6727277B1 (en) 2002-11-12 2004-04-27 Kansas State University Research Foundation Compounds affecting cholesterol absorption
WO2011141934A1 (en) 2010-05-13 2011-11-17 Matrix Laboratories Ltd. An improved process for the preparation of an intermediate of hmg-coa reductase inhibitors
EP2785851A2 (en) 2011-11-28 2014-10-08 Mylan Laboratories, Limited Process for producing chiral statin side chain intermediates employing candida antarctica lipase b
CN103408580B (zh) * 2013-06-03 2014-11-19 南京欧信医药技术有限公司 一种他汀类药物合成中间体的制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT257569B (de) * 1965-05-06 1967-10-10 Kwizda Fa F Johann Verfahren zur Herstellung von bicyclischen oder polycyclischen vicinalen Dicarbonsäuren der trans Konfiguration und deren Derivaten
NZ218115A (en) * 1985-11-18 1990-02-26 Shionogi & Co Bicyclic sulphonamides and pharmaceutical compositions

Also Published As

Publication number Publication date
EP0373931A3 (en) 1991-05-15
HK1003786A1 (en) 1998-11-06
ATE92032T1 (de) 1993-08-15
KR900009533A (ko) 1990-07-04
KR0144685B1 (ko) 1998-07-15
EP0373931A2 (en) 1990-06-20
US5117039A (en) 1992-05-26
EP0373931B1 (en) 1993-07-28
DE68907873T2 (de) 1993-11-11
DE68907873D1 (de) 1993-09-02

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