ES2059263A1 - Procedimiento para la obtencion del (+)-9-amino-1,2,3,4-tetrahidroacridin-1-ol. - Google Patents
Procedimiento para la obtencion del (+)-9-amino-1,2,3,4-tetrahidroacridin-1-ol.Info
- Publication number
- ES2059263A1 ES2059263A1 ES09202148A ES9202148A ES2059263A1 ES 2059263 A1 ES2059263 A1 ES 2059263A1 ES 09202148 A ES09202148 A ES 09202148A ES 9202148 A ES9202148 A ES 9202148A ES 2059263 A1 ES2059263 A1 ES 2059263A1
- Authority
- ES
- Spain
- Prior art keywords
- tetrahydroacridin
- amino
- procedure
- obtaining
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- HLVVITIHAZBPKB-UHFFFAOYSA-N 9-amino-1,2,3,4-tetrahydroacridin-1-ol Chemical compound C1=CC=C2C(N)=C(C(O)CCC3)C3=NC2=C1 HLVVITIHAZBPKB-UHFFFAOYSA-N 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 238000007171 acid catalysis Methods 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000007796 conventional method Methods 0.000 abstract 1
- 230000006883 memory enhancing effect Effects 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DEL -9-AMINO-1,2,3,4-TETRAHIDROACRIDIN-1-OL. PROCEDIMIENTO PARA LA OBTENCION DEL -9-AMINO-1,2,3,4-TETRAHIDROACRIDIN-1-OL (DE FORMULA I). CONSISTE EN CICLAR COMPUESTO DE FORMULA IV EN UN MEDIO DISOLVENTE ADECUADO, CON CATALISIS ACIDA Y AISLAR EL PRODUCTO DESEADO POR LOS METODOS CONVENCIONALES. EL PRODUCTO OBTENIDO POSEE INTERESANTES PROPIEDADES TERAPEUTICAS COMO AGENTE POTENCIADOR DE LA MEMORIA EN LA ENFERMEDAD DE ALZHEIMER.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES9202148A ES2059263B1 (es) | 1992-10-27 | 1992-10-27 | Procedimiento para la obtencion del (+)-9-amino-1,2,3,4-tetrahidroacridin-1-ol. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES9202148A ES2059263B1 (es) | 1992-10-27 | 1992-10-27 | Procedimiento para la obtencion del (+)-9-amino-1,2,3,4-tetrahidroacridin-1-ol. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2059263A1 true ES2059263A1 (es) | 1994-11-01 |
| ES2059263B1 ES2059263B1 (es) | 1995-10-01 |
Family
ID=8278572
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES9202148A Expired - Fee Related ES2059263B1 (es) | 1992-10-27 | 1992-10-27 | Procedimiento para la obtencion del (+)-9-amino-1,2,3,4-tetrahidroacridin-1-ol. |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES2059263B1 (es) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES8701165A1 (es) * | 1984-10-25 | 1986-11-16 | Hoechst Roussel Pharma | Un procedimiento para preparar 9-amino-1,2,3,4-tetrahidro- acridin-1-ol y compuestos relacionados |
| EP0311303A2 (en) * | 1987-10-05 | 1989-04-12 | Pfizer Inc. | 4-aminopyridine derivatives |
| EP0449172A1 (en) * | 1990-03-29 | 1991-10-02 | Hoechst-Roussel Pharmaceuticals Incorporated | A method of reducing a carbonyl containing acridine |
| EP0499231A1 (en) * | 1991-02-13 | 1992-08-19 | Hoechst-Roussel Pharmaceuticals Incorporated | 9-Aminotetrahydroacridines and related compounds, a process for their preparation and their use as medicaments |
-
1992
- 1992-10-27 ES ES9202148A patent/ES2059263B1/es not_active Expired - Fee Related
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES8701165A1 (es) * | 1984-10-25 | 1986-11-16 | Hoechst Roussel Pharma | Un procedimiento para preparar 9-amino-1,2,3,4-tetrahidro- acridin-1-ol y compuestos relacionados |
| ES8801213A1 (es) * | 1984-10-25 | 1988-01-01 | Hoechst Roussel Pharma | Un procedimiento para preparar derivados de acridina y ciclopenta (b) guinolina. |
| ES8802383A1 (es) * | 1984-10-25 | 1988-05-16 | Hoechst Roussel Pharma | Un procedimiento para preparar derivados de acridina y ciclopenta (b) quinolina. |
| EP0311303A2 (en) * | 1987-10-05 | 1989-04-12 | Pfizer Inc. | 4-aminopyridine derivatives |
| EP0449172A1 (en) * | 1990-03-29 | 1991-10-02 | Hoechst-Roussel Pharmaceuticals Incorporated | A method of reducing a carbonyl containing acridine |
| EP0499231A1 (en) * | 1991-02-13 | 1992-08-19 | Hoechst-Roussel Pharmaceuticals Incorporated | 9-Aminotetrahydroacridines and related compounds, a process for their preparation and their use as medicaments |
Also Published As
| Publication number | Publication date |
|---|---|
| ES2059263B1 (es) | 1995-10-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 20001102 |