ES2060076T3 - Nuevos derivados de tetralina. - Google Patents

Nuevos derivados de tetralina.

Info

Publication number
ES2060076T3
ES2060076T3 ES90400031T ES90400031T ES2060076T3 ES 2060076 T3 ES2060076 T3 ES 2060076T3 ES 90400031 T ES90400031 T ES 90400031T ES 90400031 T ES90400031 T ES 90400031T ES 2060076 T3 ES2060076 T3 ES 2060076T3
Authority
ES
Spain
Prior art keywords
new
tetraline
tetraline derivatives
derivatives
aminopeptidase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90400031T
Other languages
English (en)
Inventor
Orchymont Hugues D
Celine Tarnus
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2060076T3 publication Critical patent/ES2060076T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/60—Naphthoxazoles; Hydrogenated naphthoxazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/02—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C225/04—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being saturated
    • C07C225/08—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being saturated and containing rings
    • C07C225/12—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being saturated and containing rings with doubly-bound oxygen atoms bound to carbon atoms being part of rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/01—Compounds containing nitro groups bound to a carbon skeleton having nitro groups bound to acyclic carbon atoms
    • C07C205/03—Compounds containing nitro groups bound to a carbon skeleton having nitro groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
    • C07C205/04—Compounds containing nitro groups bound to a carbon skeleton having nitro groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/27—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups
    • C07C205/28—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C205/31—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/27—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups
    • C07C205/32—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups bound to acyclic carbon atoms and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/20—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/41—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/04—Compounds containing oxirane rings containing only hydrogen and carbon atoms in addition to the ring oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14—All rings being cycloaliphatic
    • C07C2602/26—All rings being cycloaliphatic the ring system containing ten carbon atoms
    • C07C2602/28—Hydrogenated naphthalenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/22—Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings
    • C07C2603/26—Phenanthrenes; Hydrogenated phenanthrenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

ESTA INVENCION SE REFIERE A NUEVOS DERIVADOS DE TETRALINA, A LOS PROCESOS PARA SU PREPARACION, A SU USO COMO INHIBIDORES DE LA AMINOPEPTIDASA Y A SU APLICACION FINAL COMO INMUNOMODULADORES Y AGENTES ANALGESICOS.
ES90400031T 1989-01-09 1990-01-05 Nuevos derivados de tetralina. Expired - Lifetime ES2060076T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP89400056A EP0381902A1 (en) 1989-01-09 1989-01-09 Tetralin derivatives

Publications (1)

Publication Number Publication Date
ES2060076T3 true ES2060076T3 (es) 1994-11-16

Family

ID=8202914

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90400031T Expired - Lifetime ES2060076T3 (es) 1989-01-09 1990-01-05 Nuevos derivados de tetralina.

Country Status (21)

Country Link
US (1) US5041673A (es)
EP (2) EP0381902A1 (es)
JP (1) JP2761955B2 (es)
KR (1) KR0177805B1 (es)
CN (1) CN1022319C (es)
AR (1) AR247722A1 (es)
AT (1) ATE94533T1 (es)
AU (1) AU620676B2 (es)
CA (1) CA2007261C (es)
DE (1) DE69003257T2 (es)
DK (1) DK0378456T3 (es)
ES (1) ES2060076T3 (es)
FI (1) FI100799B (es)
HU (1) HU212494B (es)
IE (1) IE62997B1 (es)
IL (1) IL92986A (es)
NO (1) NO171722C (es)
NZ (1) NZ232031A (es)
PH (1) PH27288A (es)
PT (1) PT92808B (es)
ZA (1) ZA9034B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5071875A (en) * 1989-09-25 1991-12-10 Northwestern University Substituted 2-amidotetralins as melatonin agonists and antagonists
GB9509156D0 (en) 1995-05-05 1995-06-28 Sandoz Ltd Organic compounds
US6844368B1 (en) 1998-12-22 2005-01-18 Edward Roberts Compounds useful in pain management
JP2002533320A (ja) * 1998-12-22 2002-10-08 アストラゼネカ・アクチエボラーグ 疼痛管理に有用な新規なオキソ−アミノテトラリン化合物
PL207809B1 (pl) 2003-11-20 2011-02-28 Invento Społka Z Ograniczoną Odpowiedzialnością Preforma pojemnika z tworzywa sztucznego, zwłaszcza do środków spożywczych
CN102631664B (zh) * 2011-01-28 2014-10-01 上海来益生物药物研究开发中心有限责任公司 3-氨基-2-羟基-4-苯基-缬氨酰-异亮氨酸的应用
WO2021039023A1 (ja) * 2019-08-23 2021-03-04 持田製薬株式会社 ヘテロシクリデンアセトアミド誘導体の製造方法
HUE068289T2 (hu) * 2019-08-23 2024-12-28 Mochida Pharm Co Ltd Eljárás heterociklidén-acetamid származékok elõállítására
CN118812481A (zh) 2019-08-23 2024-10-22 持田制药株式会社 杂环亚基乙酰胺衍生物的制造方法
CN112275147B (zh) * 2020-09-01 2021-08-13 中国科学院山西煤炭化学研究所 一种自聚微孔聚酰亚胺气体分离膜及其制备方法和应用
IL314847A (en) * 2022-02-11 2024-10-01 Adarx Pharmaceuticals Inc TRKB Nigand Conjugate Compounds and Their Uses

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4267373A (en) * 1972-07-03 1981-05-12 E. R. Squibb & Sons, Inc. 5,6,7,8-Tetrahydronaphthalene hypotensive agents
JPS561305B2 (es) * 1972-12-18 1981-01-13
US3993677A (en) * 1975-11-03 1976-11-23 American Cyanamid Company 1,2,3,4-Tetrahydro-4-oxo-1-naphthylisocyanate
US4049717A (en) * 1976-05-13 1977-09-20 American Cyanamid Company Novel 1,2,3,4-tetrahydro-4-oxo-(oxy)-1-naphthylamines and method of preparation thereof
US4041070A (en) * 1976-07-14 1977-08-09 American Cyanamid Company Tetrahydro-4-imino-1-naphthylureas
US4051183A (en) * 1976-09-02 1977-09-27 American Cyanamid Company 1-benzoyl-3-(1,2,3,4-tetrahydro-4-oxo-1-naphthyl)-urea, a novel and useful intermediate for the preparation of animal growth promoting agents
JPS6045179B2 (ja) * 1977-06-08 1985-10-08 フナイ薬品工業株式会社 新規環状アミノアルコ−ル類およびその製造法

Also Published As

Publication number Publication date
FI900083L (fi) 1990-07-10
NO900074D0 (no) 1990-01-08
NO171722B (no) 1993-01-18
EP0378456A1 (en) 1990-07-18
JP2761955B2 (ja) 1998-06-04
CA2007261A1 (en) 1990-07-09
KR0177805B1 (ko) 1999-05-15
IL92986A0 (en) 1990-09-17
NO171722C (no) 1993-04-28
PT92808B (pt) 1995-12-29
AU4782790A (en) 1990-07-12
DE69003257T2 (de) 1994-01-13
FI900083A0 (fi) 1990-01-08
DK0378456T3 (da) 1993-10-25
EP0378456B1 (en) 1993-09-15
CA2007261C (en) 2000-04-11
HUT58271A (en) 1992-02-28
US5041673A (en) 1991-08-20
EP0381902A1 (en) 1990-08-16
NO900074L (no) 1990-07-10
AR247722A1 (es) 1995-03-31
CN1044460A (zh) 1990-08-08
ATE94533T1 (de) 1993-10-15
JPH02233650A (ja) 1990-09-17
AU620676B2 (en) 1992-02-20
CN1022319C (zh) 1993-10-06
IL92986A (en) 1994-05-30
DE69003257D1 (de) 1993-10-21
HU900068D0 (en) 1990-03-28
FI100799B (fi) 1998-02-27
PH27288A (en) 1993-05-04
IE62997B1 (en) 1995-03-08
PT92808A (pt) 1990-07-31
ZA9034B (en) 1990-10-31
NZ232031A (en) 1992-07-28
KR900011709A (ko) 1990-08-02
HU212494B (en) 1996-07-29
IE900067L (en) 1990-07-09

Similar Documents

Publication Publication Date Title
ES2144151T3 (es) Benzotiazepinas hipolipidemicas.
ES2178298T3 (es) Compuestos anti-inflamatorios.
ES2147739T3 (es) Fosfonooximetil-eteres de derivados de taxano.
GT199800158AA (es) Agonistas de prostaglandinas y su uso para tratar trastornos oseos
ES2191320T3 (es) Derivados de piperazina y su uso como agentes anti-inflamatorios.
ES2192708T3 (es) Combinaciones de productos activos fungicidas.
SV2001000004A (es) Difenil ureas w-carboxyaril sustituidas, composición farmacéutica que las comprende y su uso como inhibidores de raf quinasa
MX9301129A (es) Nuevas ciclosporinas y composiciones farmaceuticas que las contienen.
UY24986A1 (es) Compuestos
HN2002000300A (es) Nuevos derivados de piperazina
PA8506301A1 (es) Cristal de 4- carboxamino- 1,2,3,4,- tetrahidroquinolina 2-sustituida
ES2184131T3 (es) Derivados de benzamidina y su utilizacion como medicamentos con efecto antagonista de ltb4.
ES2178055T3 (es) Derivados aminicos substituidos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
ES2060076T3 (es) Nuevos derivados de tetralina.
AR021596A1 (es) Compuestos que inhiben la procolageno c-proteinasa.
ES2154318T3 (es) Agentes antitromboticos.
PA8591901A1 (es) Derivados de 3h-quinazolin-4-ona como inhibidores de mao-b
ES2043665T3 (es) 6,11-dihidro-11-(4-piperidiliden)-5h-benzo-(5,6)-ciclohepta-(1,2-b)-piridinas y composiciones y metodos de uso.
PA8469101A1 (es) Ligandos azabiciclicos de receptores 5ht1
HN2001000235A (es) Derivados puentes de piperazina
CO4600682A1 (es) Protrombinas como antidoto para los inhibidores de la trom- bina
CR6398A (es) Antagonistas de 5ht1 para terapia antidepresiva
SV1998000013A (es) Derivados de 5-aroilnaftaleno ref.-ran 4070\115
ES2189072T3 (es) Nuevo benzo-cicloalquenos heterociclicos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
HN1999000101A (es) Inhibidores de las fkbp.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 378456

Country of ref document: ES