ES2060134T3 - Inhibidor de tejido de metaloproteasas (timp-2). - Google Patents

Inhibidor de tejido de metaloproteasas (timp-2).

Info

Publication number
ES2060134T3
ES2060134T3 ES90870075T ES90870075T ES2060134T3 ES 2060134 T3 ES2060134 T3 ES 2060134T3 ES 90870075 T ES90870075 T ES 90870075T ES 90870075 T ES90870075 T ES 90870075T ES 2060134 T3 ES2060134 T3 ES 2060134T3
Authority
ES
Spain
Prior art keywords
metaloprotease
timp
kilodaltous
collagenase
amino acids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90870075T
Other languages
English (en)
Inventor
Gregory Isaac Goldberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Washington
Washington University in St Louis WUSTL
Original Assignee
University of Washington
Washington University in St Louis WUSTL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Washington, Washington University in St Louis WUSTL filed Critical University of Washington
Application granted granted Critical
Publication of ES2060134T3 publication Critical patent/ES2060134T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/8146—Metalloprotease (E.C. 3.4.24) inhibitors, e.g. tissue inhibitor of metallo proteinase, TIMP

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

UNA VUEVA PROTEINA, QUE ES UN TEJDIO INHIDIDOR DE TETTALOPROTEASAS, SE CARACTERIZA COMO SIGUE: (A) TIENE UN PESO MOLECULAR DE UNOS 24 DILODALTOUS. (B) FORMA UN COMPLEJO ESTABLE NO-COVALENTE CON LA COLAGENASA DEL TIPO IV DE 72-KILODALTOUS PERO NO CON LA DE 92-KILODALTOUS. (C) ES ACTIVADA CON ORGANORMESCUSIALES PARA FORMAR UN ENZIMA COMPETENTE CATALITICAMENTE. (D) TIENE UNA SECUENCIA N-TERMINAL DE AMINOACIDOS DE ESTA FORMA: FIG II. (E) TIENE DOS SECUENCIAS PARCIALES INTERNAS DE AMINOACIDOS DETERMINADAS POR LA DIGESTION TRIPTICA DE TODAS LAS PROTEINAS DE LA FORMA; FIG III Y IV.
ES90870075T 1989-05-26 1990-05-21 Inhibidor de tejido de metaloproteasas (timp-2). Expired - Lifetime ES2060134T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US35804389A 1989-05-26 1989-05-26

Publications (1)

Publication Number Publication Date
ES2060134T3 true ES2060134T3 (es) 1994-11-16

Family

ID=23408062

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90870075T Expired - Lifetime ES2060134T3 (es) 1989-05-26 1990-05-21 Inhibidor de tejido de metaloproteasas (timp-2).

Country Status (5)

Country Link
EP (1) EP0404750B1 (es)
AT (1) ATE109796T1 (es)
DE (1) DE69011433T2 (es)
DK (1) DK0404750T3 (es)
ES (1) ES2060134T3 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE219776T1 (de) * 1989-03-21 2002-07-15 Us Secretary United States Dep Matrizenmetalloproteinase-inhibitor-peptide
JP2877509B2 (ja) * 1989-05-19 1999-03-31 アムジエン・インコーポレーテツド メタロプロテイナーゼ阻害剤
US5714465A (en) 1989-05-19 1998-02-03 Amgen Inc. Method of inhibiting tumor cell dissemination with a metalloproteinase inhibitor
US6022948A (en) 1996-09-17 2000-02-08 Washington University Method of cell surface activation and inhibition
AU7553698A (en) * 1997-05-12 1998-12-08 Nederlandse Organisatie Voor Toegepast- Natuurwetenschappelijk Onderzoek Tno Method and construct for inhibition of cell migration
AU2094101A (en) * 1999-12-13 2001-06-18 Duanqing Pei Leukolysin/mmp25/mt6-mmp
US7247704B2 (en) 2000-12-18 2007-07-24 Arriva Pharmaceuticals, Inc. Multifunctional protease inhibitors and their use in treatment of disease
KR101363455B1 (ko) * 2011-09-09 2014-02-21 (주)케어젠 매트릭스 메탈로프로테아제 활성 억제 펩타이드 및 이의 용도

Also Published As

Publication number Publication date
ATE109796T1 (de) 1994-08-15
EP0404750A1 (en) 1990-12-27
DK0404750T3 (da) 1994-10-03
DE69011433D1 (de) 1994-09-15
EP0404750B1 (en) 1994-08-10
DE69011433T2 (de) 1995-04-06

Similar Documents

Publication Publication Date Title
EA199700239A1 (ru) Ингибиторы тромбина, основанные на аминокислотной последовательности гирудина
DE69435049D1 (de) Chimäre proteine zur vermeidung der komplementaktivierung
CO4600683A1 (es) Bikunina humana
ES2073571T3 (es) Aplicacion de nuevos fragmentos de adn como secuencia que codifica un peptido señal para la secrecion de proteinas maduras, mediante levaduras recombinantes, cassettes de expresion, levaduras transformadas y procedimiento correspondiente de preparacion de proteinas.
ATE92107T1 (de) N-terminale fragmente von menschliches serumalbumin enthaltenden fusionsproteinen.
ES2181689T3 (es) Variantes del factor de crecimiento de hepatocitos.
ES8402351A1 (es) Procedimiento para producir interferon inmune humano.
BR9713108A (pt) Colagenase recombinante do tipo i de clostridium histolytucum e o uso da mesma para o isolamento de células e de grupos de células
ATE295414T1 (de) Menschliche ctla-8 und verwendung von ctla-8 ähnlichen proteinen
ES2184728T3 (es) Proteinas de union a la fibronectina.
ES2127831T3 (es) Unidades de expresion multicistronicas y su aplicacion.
ES2421720T3 (es) Homólogos del factor de necrosis tumoral y ácidos nucleicos que los codifican
ATE97421T1 (de) Gentechnologisch hergestellter pankreatischer sekretorischer trypsininhibitor und seine varianten.
ATE278710T1 (de) Antimikrobiell wirksame peptide
NO940299L (no) Peptid med organbeskyttende aktivitet
DE68927379D1 (de) Plättchen blockierende peptide
AR002742A1 (es) Proteina reguladora del tipo adiposo, procedimiento para producir dicha proteina, formulaciones farmaceuticas que la incluyen, molecula de adn aisladaque codifica dicha proteina, vector y celulas recombinantes que comprenden dicho adn
DE68917837D1 (de) Peptid-Verbindungen.
ATE5314T1 (de) Pharmakologisch aktive peptide und deren zusammensetzungen.
KR870000356A (ko) 메티오닐 단백질로부터 n-말단 메티오닌을 제거하는 방법
AR009819A1 (es) Inhibidores de la proteasa proteinicos estabilizados y sus variantes
MX167236B (es) Peptidos sinteticos de timosina -1 y metodo para su obtencion
PT635025E (pt) Processo para preparar proteinas modificadas
ES2168282T3 (es) D-hidantoinasa recombinante, procedimiento para su preparacion y utilizacion.
ES2146193T1 (es) Proteinas del virus del arrugado de las hojas de la vid (tipo 2) y sus usos.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 404750

Country of ref document: ES