ES2060146T3 - Metaloproteinasas colagenoliticas asociadas con metastasis. - Google Patents

Metaloproteinasas colagenoliticas asociadas con metastasis.

Info

Publication number
ES2060146T3
ES2060146T3 ES90903555T ES90903555T ES2060146T3 ES 2060146 T3 ES2060146 T3 ES 2060146T3 ES 90903555 T ES90903555 T ES 90903555T ES 90903555 T ES90903555 T ES 90903555T ES 2060146 T3 ES2060146 T3 ES 2060146T3
Authority
ES
Spain
Prior art keywords
enzyme
revealed
methods
rat
collagenolytic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90903555T
Other languages
English (en)
Inventor
Motowa Nakajima
Garth L Nicolson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Texas System
University of Texas at Austin
Original Assignee
University of Texas System
University of Texas at Austin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Texas System, University of Texas at Austin filed Critical University of Texas System
Application granted granted Critical
Publication of ES2060146T3 publication Critical patent/ES2060146T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489—Metalloendopeptidases (3.4.24)
    • C12N9/6491—Matrix metalloproteases [MMP's], e.g. interstitial collagenase (3.4.24.7); Stromelysins (3.4.24.17; 3.2.1.22); Matrilysin (3.4.24.23)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Dental Preparations (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

SE REVELAN METODOS Y COMPOSICIONES PARA TESTAR VARIOS TIPOS DE CANCERES HUMANOS, INCLUYENDO EN PARTICULAR CARCINOMA METASTATICO MAMARIO, ASTRACITOMA COLON CARCINOMA, CARCINOMA DE CELULA RENAL, Y MELANOMA TERATOCARCINOMA MALIGNO. EL METODO DE DIAGNOSTICO DE LA INVENCION COMPRENDE LA DETECCION DE METALOPROTEINAS GELATINOLITICAS Y COLAGENOLITICAS TIPO IV TENIENDO UN PESO MOLECULAR DE APROXIMADAMENTE DE 88 A 92 KILODALTONS. ESTE ALTO PESO MOLECULAR DE LA ENZIMA COLAGENOLITICA TIPO IV SE OBSERVA ESTA ASOCIADO CON EL ESTADO CANCEROSO, PUES NO SE OBSERVA EN NINGUNA DE LAS CELULAS NO CANCEROSAS TESTADAS Y ADEMAS TAMPOCO SE HA VISTO EN EL SUERO DE LOS ANIMALES PORTADORES SIN TUMOR. LA ENZIMA ESTA ASOCIADA CON TUMORES DE RATA Y HUMANO, SIENDO LA ENZIMA EN AMBOS CASOS BASTANTE SIMILAR. SE REVELAN METODOS PARA EL AISLAMIENTO DE LA ENZIMA 88/92 KD, SIENDO LA ENZIMA AISLADA UTIL PARA SU USO COMO ENZIMA CONTROL Y ANALISIS DIAGNOSTICOS. ADEMAS, LA ENZIMA AISLADA ES UTIL PARA LA PREPARACION DE ANTICUERPOS,INCLUYENDO ANTICUERPOS MONOCLONALES, TENIENDO ESPECIFICIDAD PARA LA ENZIMA ASOCIADA A METASTASIS. TAMBIEN SE REVELAN TECNICAS PARA EL AISLAMIENTO Y PURIFICACION PARCIAL DE LA ENZIMA A PARTIR DE RATA Y HUMANOS. ADEMAS SE REVELAN METODOS PARA LLEVAR A CABO PRUEBAS ENZIMATICAS E INMUNOLOGICAS PARA EL DIAGNOSTICO DE ENFERMEDADES METASTATICAS Y RECURRENTES.
ES90903555T 1989-02-27 1990-01-29 Metaloproteinasas colagenoliticas asociadas con metastasis. Expired - Lifetime ES2060146T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US31626089A 1989-02-27 1989-02-27

Publications (1)

Publication Number Publication Date
ES2060146T3 true ES2060146T3 (es) 1994-11-16

Family

ID=23228283

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90903555T Expired - Lifetime ES2060146T3 (es) 1989-02-27 1990-01-29 Metaloproteinasas colagenoliticas asociadas con metastasis.

Country Status (9)

Country Link
EP (1) EP0460016B1 (es)
JP (1) JPH04505699A (es)
AT (1) ATE98685T1 (es)
AU (1) AU639906B2 (es)
CA (1) CA2048695A1 (es)
DE (1) DE69005297T2 (es)
DK (1) DK0460016T3 (es)
ES (1) ES2060146T3 (es)
WO (1) WO1990010062A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5324634A (en) * 1992-03-31 1994-06-28 The Research Foundation Of State University Of New York Diagnostic tests measuring gelatinase/inhibitor complexes for detection of aggressive and metastatic cancer
WO1994005807A1 (en) * 1992-08-28 1994-03-17 Dickson Robert B Matrix-degrading metalloproteinase
EP0789758A2 (en) * 1995-09-05 1997-08-20 Celltech Therapeutics Limited Dna sequences coding for a human metalloproteinase and variants thereof
US7041787B2 (en) 2000-12-29 2006-05-09 Kimberly-Clark Worldwide, Inc. Design and use of advanced zinc chelating peptides to regulate matrix metalloproteinases
US20130217034A1 (en) 2010-08-13 2013-08-22 Dentognostics Gmbh Process for avoiding false positive results in a detecting process of an inflammation indicator in a rinse solution for taking up gingival crevicular fluid

Also Published As

Publication number Publication date
CA2048695A1 (en) 1990-09-28
DE69005297D1 (de) 1994-01-27
JPH04505699A (ja) 1992-10-08
EP0460016A1 (en) 1991-12-11
DE69005297T2 (de) 1994-04-21
AU5104790A (en) 1990-09-26
WO1990010062A1 (en) 1990-09-07
ATE98685T1 (de) 1994-01-15
EP0460016B1 (en) 1993-12-15
AU639906B2 (en) 1993-08-12
DK0460016T3 (da) 1994-04-25

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