ES2061179T3 - Preparaciones granuladas y metodo para producirlas. - Google Patents

Preparaciones granuladas y metodo para producirlas.

Info

Publication number
ES2061179T3
ES2061179T3 ES91303569T ES91303569T ES2061179T3 ES 2061179 T3 ES2061179 T3 ES 2061179T3 ES 91303569 T ES91303569 T ES 91303569T ES 91303569 T ES91303569 T ES 91303569T ES 2061179 T3 ES2061179 T3 ES 2061179T3
Authority
ES
Spain
Prior art keywords
fatty acid
acid ester
polyglycerol fatty
active ingredient
pharmacologically active
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91303569T
Other languages
English (en)
Inventor
Minoru Yoshioka
Toshio Kashihara
Hidetoshi Horibe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Application granted granted Critical
Publication of ES2061179T3 publication Critical patent/ES2061179T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/30—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic using agents to prevent the granules sticking together; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K40/00—Shaping or working-up of animal feeding-stuffs
    • A23K40/10—Shaping or working-up of animal feeding-stuffs by agglomeration; by granulation, e.g. making powders
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
    • A23P10/00—Shaping or working of foodstuffs characterised by the products
    • A23P10/20—Agglomerating; Granulating; Tabletting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Glanulating (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Fats And Perfumes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE OBTIENEN PREPARACIONES GRANULADAS ORIGINANDO UN ESTER DE ACIDO GRASO DE POLIGLICEROL GRANULAR Y PREFERIBLEMENTE ESFERICO CON UN PUNTO DE FUSION DE 40 A 80 C, JUNTO CON UN POLVO PARA LA FORMACION DE UN HECHO FLUIDO, Y CALENTANDO LA MEZCLA FLUIDA RESULTANTE A UNA TEMPERATURA CERCANA AL PUNTO DE FUSION DEL ESTER DE ACIDO GRASO DE POLIGLICEROL. EL POLVO PUEDE CONTENER POR LO MENOS UN INGREDIENTE ACTIVO FARMACOLOGICAMENTE. EL ESTER DE ACIDO GRASO DE POLIGLICEROL NO MUESTRA NINGUN POLIMORFISMO DE CRISTAL Y NO DESACTIVA EL INGREDIENTE FARMACOLOGICAMENTE ACTIVO. ADEMAS, LA DISOLUCION Y LIBERACION DEL INGREDIENTE FARMACOLOGICAMENTE ACTIVO PUEDE CONTROLARSE VARIANDO EL HLB DEL ESTER DE ACIDO GRASO DE POLIGLICEROL.
ES91303569T 1990-04-28 1991-04-22 Preparaciones granuladas y metodo para producirlas. Expired - Lifetime ES2061179T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP11438290 1990-04-28

Publications (1)

Publication Number Publication Date
ES2061179T3 true ES2061179T3 (es) 1994-12-01

Family

ID=14636279

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91303569T Expired - Lifetime ES2061179T3 (es) 1990-04-28 1991-04-22 Preparaciones granuladas y metodo para producirlas.

Country Status (10)

Country Link
US (1) US5443846A (es)
EP (1) EP0455391B1 (es)
JP (1) JP3124063B2 (es)
KR (1) KR0171218B1 (es)
AT (1) ATE112675T1 (es)
CA (1) CA2041378C (es)
DE (2) DE69104539T4 (es)
DK (1) DK0455391T3 (es)
ES (1) ES2061179T3 (es)
IE (1) IE65045B1 (es)

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Publication number Priority date Publication date Assignee Title
TW209174B (es) 1991-04-19 1993-07-11 Takeda Pharm Industry Co Ltd
TW282403B (es) * 1993-08-26 1996-08-01 Takeda Pharm Industry Co Ltd
US5891471A (en) * 1993-11-23 1999-04-06 Euro-Celtique, S.A. Pharmaceutical multiparticulates
KR100354702B1 (ko) * 1993-11-23 2002-12-28 유로-셀티크 소시에떼 아노뉨 약학조성물의제조방법및서방형조성물
US5843480A (en) * 1994-03-14 1998-12-01 Euro-Celtique, S.A. Controlled release diamorphine formulation
GB9422154D0 (en) 1994-11-03 1994-12-21 Euro Celtique Sa Pharmaceutical compositions and method of producing the same
US5965161A (en) 1994-11-04 1999-10-12 Euro-Celtique, S.A. Extruded multi-particulates
SE511313C2 (sv) * 1997-01-13 1999-09-06 Gs Dev Ab Komposition med reglerad frisättning innefattande fettsyraester av diacylglycerol
US6303662B1 (en) * 1997-04-18 2001-10-16 Taisho Pharmaceutical Co., Ltd. Microemulsion
US5891476A (en) * 1997-12-22 1999-04-06 Reo; Joe P. Tastemasked pharmaceutical system
US20020029520A1 (en) * 1998-05-21 2002-03-14 Weder Donald E. Decorative attachments and methods of use
DE19918325A1 (de) 1999-04-22 2000-10-26 Euro Celtique Sa Verfahren zur Herstellung von Arzneiformen mit regulierter Wirkstofffreisetzung mittels Extrusion
JP4974419B2 (ja) * 2001-06-12 2012-07-11 東和薬品株式会社 薬物含有徐放性顆粒およびそれを含む錠剤
SE0200154D0 (sv) * 2002-01-21 2002-01-21 Galenica Ab New process
US20050031686A1 (en) * 2002-03-25 2005-02-10 Truffini & Regge' Farmaceutici Srl Gastroresistant tablets for alimentary, dietetic and therapeutic use
DE60318446T2 (de) 2002-07-15 2008-05-21 Alcon Inc. Nichtpolymere lipophile pharmazeutische implantat-zusammensetzungen für die intraokulare anwendung
US8734843B2 (en) * 2003-06-27 2014-05-27 Otsuka Pharmaceutical Co., Ltd. Medicament sustained-release particles and method for preparing the same
US20070059358A1 (en) * 2003-07-02 2007-03-15 Tianjin Tasly Pharmaceutical Co., Ltd., China Matrix adjuvants and the drop pills prepared with them
US7364755B2 (en) * 2003-07-07 2008-04-29 Synthon Ip Inc. Modified calcium phosphate excipient
DE102004049241A1 (de) * 2004-10-09 2006-04-20 Sanofi-Aventis Deutschland Gmbh Trockner und Verfahren zum Steuern eines Trockners
US20060275228A1 (en) * 2005-05-09 2006-12-07 Bissett Donald L Skin care compositions containing idebenone
CN101534808A (zh) 2005-06-27 2009-09-16 拜维尔实验室国际有限公司 丁氨苯丙酮盐的改良释放配制品
WO2007022092A1 (en) * 2005-08-15 2007-02-22 Stepan Company High melt lipids
EP2027777B1 (en) * 2006-04-17 2014-06-04 Meiji Co., Ltd Whey protein-containing granules and method of producing the same
TW200836771A (en) * 2006-10-31 2008-09-16 Kaneka Corp Particulate composition comprising bioactive substance and method of producing the same
US20090246276A1 (en) 2008-01-28 2009-10-01 Graham Jackson Pharmaceutical Compositions
US8287902B2 (en) * 2008-07-23 2012-10-16 Rainbow Medical Ltd. Enhanced-diffusion capsule
JP5230308B2 (ja) * 2008-09-04 2013-07-10 協友アグリ株式会社 溶出が制御された農薬製剤
KR101159890B1 (ko) * 2008-12-22 2012-06-25 주식회사 삼양웰푸드 분말 유지 조성물
US8227399B2 (en) * 2010-02-12 2012-07-24 Evonik Goldschmidt Gmbh Polyglycerol esters and their use
JP5650956B2 (ja) * 2010-08-31 2015-01-07 株式会社ファンケル 混合顆粒剤の製造方法
US9353301B2 (en) * 2013-11-25 2016-05-31 Ecolab Usa Inc. Composition for dust control
JP6178233B2 (ja) * 2013-12-25 2017-08-09 三井化学アグロ株式会社 徐放性農薬製剤及びその製造方法
US9492396B2 (en) 2014-07-15 2016-11-15 Yossi Gross Enhanced drug delivery pill
AU2018360383A1 (en) 2017-11-02 2020-05-21 Natureceuticals Sdn. Bhd. Extract of orthosiphon stamineus, formulations, and uses thereof
US10675248B2 (en) 2018-08-14 2020-06-09 Alma Therapeutics Ltd. Expandable pill
WO2025032355A1 (de) * 2023-08-04 2025-02-13 Ioi Oleo Gmbh Grundlage für suppositorien oder ovula sowie darauf basierende suppositorien- oder ovulamasse und deren verwendung in einem herstellungsverfahren
WO2025134761A1 (ja) * 2023-12-21 2025-06-26 アサヒグループ食品株式会社 錠菓の製造方法及び錠菓の舌触りの滑らかさの向上方法

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ZA723701B (en) * 1971-06-04 1973-04-25 Boehringer Mannheim Gmbh Process for the granulation of powdered tablet masses
US3936391A (en) * 1971-06-16 1976-02-03 Drackett Company Hydrated polyglycerol ester composition
DE2143519B2 (de) * 1971-08-31 1974-05-30 Sandoz Ag, 8500 Nuernberg Verfahren zur Wirbelschichtgranulation pulverförmiger pharmazeutischer Mischungen
JPS4856577A (es) * 1971-11-22 1973-08-08
DE2426812A1 (de) * 1974-06-04 1976-01-02 Klinge Co Chem Pharm Fab Verfahren zur herstellung von granulaten
US4386120A (en) * 1980-01-07 1983-05-31 Nippon Kayaku Kabushiki Kaisha Process for producing polyacrylic acid salt granules easily soluble in water
JPS56140915A (en) * 1980-04-07 1981-11-04 Yamanouchi Pharmaceut Co Ltd Pharmaceutical preparation for solid drug
DE3224619A1 (de) * 1981-07-14 1983-05-19 Freund Industrial Co., Ltd., Tokyo Orale pharmazeutische zusammensetzung
JPS58214333A (ja) * 1982-06-04 1983-12-13 Dai Ichi Seiyaku Co Ltd 粒状物
JPS5944327A (ja) * 1982-09-06 1984-03-12 Taiyo Kagaku Kk Ｌ−アスコルビン酸およびその塩類の安定化法
US4904478A (en) * 1983-08-11 1990-02-27 Mission Pharmacal Company Slow-release sodium fluoride tablet and method for treatment of osteoporosis
US4894233A (en) * 1984-10-05 1990-01-16 Sharma Shri C Novel drug delivery system for decongestants
US4755387A (en) * 1985-03-21 1988-07-05 The Procter & Gamble Company Therapeutic particles
US4820523A (en) * 1986-04-15 1989-04-11 Warner-Lambert Company Pharmaceutical composition
DE3702029A1 (de) * 1987-01-24 1988-08-04 Basf Ag Waessriges oder pulverfoermiges, wasserdispergierbares praeparat eines in wasser schwerloeslichen pharmazeutischen wirkstoffs und verfahren zu seiner herstellung
JP2547995B2 (ja) * 1987-01-26 1996-10-30 昭和電工株式会社 反すう動物用粒剤及びその製造法
DE3721721C1 (de) * 1987-07-01 1988-06-09 Hoechst Ag Verfahren zur Umhuellung von Granulaten
DE3837628A1 (de) * 1988-11-05 1990-05-10 Broesamle Peter Verfahren und vorrichtung zur behandlung von organischen schlaemmen
NZ231281A (en) * 1988-11-08 1991-01-29 Takeda Chemical Industries Ltd Sustained release pharmaceutical preparations comprising the active agent dispersed in a solid matrix of a fatty acid ester of a polyglycerol
CA1331713C (en) * 1988-12-29 1994-08-30 Hitoshi Iijima Granular composition for ruminant
US5017383A (en) * 1989-08-22 1991-05-21 Taisho Pharmaceutical Co., Ltd. Method of producing fine coated pharmaceutical preparation
US5169645A (en) * 1989-10-31 1992-12-08 Duquesne University Of The Holy Ghost Directly compressible granules having improved flow properties

Also Published As

Publication number Publication date
KR910018069A (ko) 1991-11-30
JPH05237A (ja) 1993-01-08
EP0455391A3 (en) 1991-12-18
JP3124063B2 (ja) 2001-01-15
IE911276A1 (en) 1991-11-06
EP0455391A2 (en) 1991-11-06
KR0171218B1 (ko) 1999-01-15
CA2041378C (en) 2002-02-12
ATE112675T1 (de) 1994-10-15
CA2041378A1 (en) 1991-10-29
DE69104539T4 (de) 1995-07-27
EP0455391B1 (en) 1994-10-12
DE69104539D1 (de) 1994-11-17
US5443846A (en) 1995-08-22
DK0455391T3 (da) 1995-03-13
DE69104539T2 (de) 1995-03-23
IE65045B1 (en) 1995-10-04

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