ES2061273T3 - Ensayo para proteinas glicadas de la sangre. - Google Patents

Ensayo para proteinas glicadas de la sangre.

Info

Publication number
ES2061273T3
ES2061273T3 ES91919886T ES91919886T ES2061273T3 ES 2061273 T3 ES2061273 T3 ES 2061273T3 ES 91919886 T ES91919886 T ES 91919886T ES 91919886 T ES91919886 T ES 91919886T ES 2061273 T3 ES2061273 T3 ES 2061273T3
Authority
ES
Spain
Prior art keywords
glycated
protein
proteins
blood
contact
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91919886T
Other languages
English (en)
Inventor
Erling Sundrehagen
Frank Frantzen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Axis Biochemicals AS
Original Assignee
Axis Biochemicals AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Axis Biochemicals AS filed Critical Axis Biochemicals AS
Application granted granted Critical
Publication of ES2061273T3 publication Critical patent/ES2061273T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6842—Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
    • G01N33/721—Haemoglobin
    • G01N33/723—Glycosylated haemoglobin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/815—Test for named compound or class of compounds
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/824—Immunological separation techniques
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25125—Digestion or removing interfering materials
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Devices For Conveying Motion By Means Of Endless Flexible Members (AREA)
  • Mechanical Treatment Of Semiconductor (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

SE PRESENTA UN METODO PARA DESCUBRIR UNA PROTEINA SANGUINEA GLICADA EN UNA MUESTRA, DICHO METODO COMPRENDE LOS PASOS DE A) EFECTUAR OPCIONALMENTE UNA HEMOLISIS DE DICHA MUESTRA PARA LIBERAR LA PROTEINA GLICADA UNIDA A LA CELULA; B) SEPARAR DICHA PROTEINA SANGUINEA GLICADA Y LA CORRESPONDIENTE PROTEINA SANGUINEA NO GLICADA DE DICHA MUESTRA; C) PONER EN CONTACTO DICHA MUESTRA ANTES O DURANTE LA SEPARACION DE DICHAS PROTEINAS GLICADAS Y NO GLICADAS O PONER EN CONTACTO DICHAS PROTEINAS SEPARADAS CON UN PRIMER AGENTE PARA LA FORMACION DE UNA SEÑAL CAPAZ DE UNIRSE A DICHA PROTEINA GLICAL PERO NO A LA CORRESPONDIENTE PROTEINA NO GLICADA; D) OPCIONALMENTE, PONER EN CONTACTO DICHA MUESTRA ANTES O DURANTE LA SEPARACION DE DICHAS PROTEINAS GLICADAS O NO GLICADAS O PONER EN CONTACTO DICHAS PROTEINAS SEPARADAS CON UN SEGUNDO AGENTE FORMADOR DE SEÑAL CAPAZ DE UNIRSE A DICHA PROTEINA GLICADA Y A LA CORRESPONDIENTE PROTEINA NO GLICADA Y; E) PONER DE MANIFIESTO LOS AGENTES FORMADORES DE SEÑAL QUE SE HAN UNIDO A DICHAS PROTEINAS SEPARADAS Y/O QUE NO TIENEN ENLACE CON LA PROTEINA GLICADA O PROTEINA CORRESPONDIENTE NO GLICADA; CON LA CONDICION DE QUE EN DONDE LA PROTEINA GLICADA COMPRENDE HEMOGLOBINA GLICADA DICHO PRIMER AGENTE FORMADOR DE SEÑAL SERA UN ACIDO BORONICO ETIQUETADO CROMOFORO O UNA SAL DEL MISMO QUE TENGA UNA ABSORCION MAXIMA DE ALREDEDOR 600 NM. EN ESTE METODO LA PROTEINA GLICADA QUE SE ETIQUETA POR EL PRIMER AGENTE FORMADOR DE SEÑAL PUEDE SER CUALQUIERA DE LAS PROTEINAS SANGUINEAS. MEDIANTE LA SELECCION APROPIADA DE LAS PROTEINAS BAJO ENSAYO PUEDE OBTENERSE UNA INDICACION DE LA HISTORIA DEL CONTROL DE GLUCOSA EN LA SANGRE DEL PACIENTE A LO LARGO DE UN PERIODO CORTO, MEDIO O LARGO DE TIEMPO (HASTA TRES MESES).
ES91919886T 1990-11-14 1991-11-13 Ensayo para proteinas glicadas de la sangre. Expired - Lifetime ES2061273T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909024771A GB9024771D0 (en) 1990-11-14 1990-11-14 Assay

Publications (1)

Publication Number Publication Date
ES2061273T3 true ES2061273T3 (es) 1994-12-01

Family

ID=10685375

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91919886T Expired - Lifetime ES2061273T3 (es) 1990-11-14 1991-11-13 Ensayo para proteinas glicadas de la sangre.

Country Status (13)

Country Link
US (2) US5506144A (es)
EP (1) EP0557350B1 (es)
JP (1) JP2643027B2 (es)
AT (1) ATE112635T1 (es)
AU (1) AU8866291A (es)
CA (1) CA2096250C (es)
DE (1) DE69104491T2 (es)
DK (1) DK0557350T3 (es)
ES (1) ES2061273T3 (es)
FI (1) FI104519B (es)
GB (1) GB9024771D0 (es)
NO (1) NO311385B1 (es)
WO (1) WO1992008984A1 (es)

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ATE509275T1 (de) * 2003-09-23 2011-05-15 Epinex Diagnostic Inc Schnelltest für glykiertes albumin
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Also Published As

Publication number Publication date
FI932150A0 (fi) 1993-05-12
CA2096250C (en) 2002-09-24
EP0557350A1 (en) 1993-09-01
WO1992008984A1 (en) 1992-05-29
DK0557350T3 (da) 1994-11-07
EP0557350B1 (en) 1994-10-05
DE69104491T2 (de) 1995-02-16
US5506144A (en) 1996-04-09
JPH06502244A (ja) 1994-03-10
NO931747L (no) 1993-07-14
JP2643027B2 (ja) 1997-08-20
US5919708A (en) 1999-07-06
CA2096250A1 (en) 1992-05-15
NO931747D0 (no) 1993-05-13
AU8866291A (en) 1992-06-11
FI932150A7 (fi) 1993-06-03
NO311385B1 (no) 2001-11-19
GB9024771D0 (en) 1991-01-02
ATE112635T1 (de) 1994-10-15
FI104519B (fi) 2000-02-15
DE69104491D1 (de) 1994-11-10

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