ES2061457T3 - 3,5-dicloro-2,4-dimetoxi-6-(triclorometil)piridina. - Google Patents

3,5-dicloro-2,4-dimetoxi-6-(triclorometil)piridina.

Info

Publication number
ES2061457T3
ES2061457T3 ES87112757T ES87112757T ES2061457T3 ES 2061457 T3 ES2061457 T3 ES 2061457T3 ES 87112757 T ES87112757 T ES 87112757T ES 87112757 T ES87112757 T ES 87112757T ES 2061457 T3 ES2061457 T3 ES 2061457T3
Authority
ES
Spain
Prior art keywords
dichloro
triclorometil
dimetoxi
piridina
trichloromethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87112757T
Other languages
English (en)
Inventor
Helen K Tobol
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dow Chemical Co
Original Assignee
Dow Chemical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dow Chemical Co filed Critical Dow Chemical Co
Application granted granted Critical
Publication of ES2061457T3 publication Critical patent/ES2061457T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/69—Two or more oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

LA 3,5-DICLORO-2,4-DIMETOXI-6-(TRICLOROMETIL)PIRIDINA, QUE SE PUEDE PREPARAR A PARTIR DE 2,3,4,5-TETRACLORO-6(TRICLOROMETIL)PIRIDINA Y DE UN METOXIDO DE METAL ALCALINO, ES UN AGENTE ANTICANCER ESPECIALMENTE UTIL PARA EL TRATAMIENTO DE LEUCEMIAS, LINFOMAS, CARCINOMAS MAMARIOS Y SARCOMAS OVARICOS.
ES87112757T 1986-09-10 1987-09-01 3,5-dicloro-2,4-dimetoxi-6-(triclorometil)piridina. Expired - Lifetime ES2061457T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/905,906 US4717726A (en) 1986-09-10 1986-09-10 3,5-dichloro-2,4-dimethoxy-6-(trichloromethyl)pyridine having anti-tumor activity

Publications (1)

Publication Number Publication Date
ES2061457T3 true ES2061457T3 (es) 1994-12-16

Family

ID=25421670

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87112757T Expired - Lifetime ES2061457T3 (es) 1986-09-10 1987-09-01 3,5-dicloro-2,4-dimetoxi-6-(triclorometil)piridina.

Country Status (9)

Country Link
US (1) US4717726A (es)
EP (1) EP0260524B1 (es)
JP (1) JPH0798805B2 (es)
AT (1) ATE99679T1 (es)
CA (1) CA1314049C (es)
DE (1) DE3788693T2 (es)
ES (1) ES2061457T3 (es)
HK (1) HK75296A (es)
IE (1) IE62519B1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6235761B1 (en) * 1996-06-03 2001-05-22 Neil Hartman Compound, composition and method for treating cancer
ATE474575T1 (de) * 1999-01-21 2010-08-15 Southern Res Inst Pyridinverbindungen, ihre verfahren zur herstellung und anwendung
WO2000043010A1 (en) * 1999-01-21 2000-07-27 Southern Research Institute Acyl derivatives of 4-demethylpenclomedine, use thereof and preparation thereof
US7122563B2 (en) * 2005-02-01 2006-10-17 Southern Research Institute Derivatives of 4-demethylpenclomedine, use thereof and preparation thereof
EP1981850B1 (en) 2005-12-13 2017-03-22 Dekk-Tec, Inc. Demethylpenclomedine analogs and their use as anticancer agents

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4190662A (en) * 1978-03-23 1980-02-26 The Dow Chemical Company Halomethyl substituted dialkoxypyridines
US4143144A (en) * 1978-03-23 1979-03-06 The Dow Chemical Company Ethers of 4-halomethylpyridines

Also Published As

Publication number Publication date
US4717726A (en) 1988-01-05
JPS63101364A (ja) 1988-05-06
CA1314049C (en) 1993-03-02
DE3788693D1 (de) 1994-02-17
HK75296A (en) 1996-05-10
EP0260524A2 (en) 1988-03-23
JPH0798805B2 (ja) 1995-10-25
DE3788693T2 (de) 1994-04-28
IE872410L (en) 1988-03-10
EP0260524A3 (en) 1989-10-11
EP0260524B1 (en) 1994-01-05
ATE99679T1 (de) 1994-01-15
IE62519B1 (en) 1995-02-08

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