ES2061463T3 - Compuestos de piperidina y su preparacion y uso. - Google Patents

Compuestos de piperidina y su preparacion y uso.

Info

Publication number
ES2061463T3
ES2061463T3 ES87114648T ES87114648T ES2061463T3 ES 2061463 T3 ES2061463 T3 ES 2061463T3 ES 87114648 T ES87114648 T ES 87114648T ES 87114648 T ES87114648 T ES 87114648T ES 2061463 T3 ES2061463 T3 ES 2061463T3
Authority
ES
Spain
Prior art keywords
alkyl
piperidine compounds
aralcoxi
cicloalquilo
alquilo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87114648T
Other languages
English (en)
Inventor
Jorgen Drejer
Palle Jakobsen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Nordisk AS
Original Assignee
Novo Nordisk AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DK523286A external-priority patent/DK523286D0/da
Priority claimed from DK323487A external-priority patent/DK323487D0/da
Application filed by Novo Nordisk AS filed Critical Novo Nordisk AS
Application granted granted Critical
Publication of ES2061463T3 publication Critical patent/ES2061463T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

NUEVOS COMPUESTOS DE PIPERIDINA QUE TIENEN LA ORMULA (I) DONDE R3 ES 3,4-METILENDIOXIFENILO, ARILO O ETEROARILO QUE SE SUSTITUYENOPCIONALMENTE CON UNO O MAS RUPOS DE C1-6 ALQUILO, C1-6 ALCOXI, C3-8 CICLOALQUILO, C3-5 LQUILENO O ARALCOXI. R1 ES C4-8 ALQUILO RECTO O RAMIFICADO, 1-8 ALCOXI-C4-8-ALQUILO, C4-7 CICLOALQUILO, RILOXI-C3-8-ALQUILO, C4-8-ALQUENILO O C4-8 CICLOALQUILO O 1 PUEDE TAMBIEN SER HIDROGENO O C1-3 ALQUILO CUANDO R3 ES RILO, QUE SE SUSTITUYE CON DOS OMAS DE C1-6 ALQUILO, C1-6 LCOXI, C3-8 CICLOALQUILO, ARALCOXI O CON C3-5 ALQUILENO; X S HIDROGENO O HALOGENO, Y DONDE Y ES O O S, Y UNA SAL DEL ISMO CON UNA SAL FARMACEUTICAMENTE ACEPTABLE. LOS NUEVOS OMPUETSOS SON UTILES EN EL TRATAMIETO DE LA ANOXIA, IGRAÑA, ISQUEMIA Y EPILEPSIA.
ES87114648T 1986-11-03 1987-10-07 Compuestos de piperidina y su preparacion y uso. Expired - Lifetime ES2061463T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK523286A DK523286D0 (da) 1986-11-03 1986-11-03 Piperidine forbindelser, deres fremstilling og anvendelse
DK323487A DK323487D0 (da) 1987-06-25 1987-06-25 Piperidin forbindelser, deres fremstilling og anvendelse

Publications (1)

Publication Number Publication Date
ES2061463T3 true ES2061463T3 (es) 1994-12-16

Family

ID=26066954

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87114648T Expired - Lifetime ES2061463T3 (es) 1986-11-03 1987-10-07 Compuestos de piperidina y su preparacion y uso.

Country Status (14)

Country Link
US (3) US4877799A (es)
EP (1) EP0266574B1 (es)
JP (1) JP2633872B2 (es)
KR (1) KR880006193A (es)
AU (1) AU602735B2 (es)
CA (1) CA1323367C (es)
DE (1) DE3788709T2 (es)
ES (1) ES2061463T3 (es)
FI (1) FI92821C (es)
IE (1) IE66332B1 (es)
IL (1) IL84021A (es)
NZ (1) NZ222155A (es)
PH (1) PH24749A (es)
PT (1) PT86066B (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5017585A (en) * 1986-11-03 1991-05-21 Novo Nordisk A/S Method of treating calcium overload
IE66332B1 (en) * 1986-11-03 1995-12-27 Novo Nordisk As Piperidine compounds and their preparation and use
DK231088D0 (da) * 1988-04-28 1988-04-28 Ferrosan As Piperidinforbindelser, deres fremstilling og anvendelse
AT391269B (de) * 1988-12-30 1990-09-10 Burghart Kurt Pharmazeutische zubereitung
DK640289D0 (da) * 1989-12-18 1989-12-18 Ferrosan As Ny heterocyklisk kemi
IL98757A (en) * 1990-07-18 1997-01-10 Novo Nordisk As Piperidine derivatives their preparation and pharmaceutical compositions containing them
GB9226111D0 (en) * 1992-12-15 1993-02-10 Smithkline Beecham Plc Madicaments
ES2102295B1 (es) * 1994-03-18 1998-04-01 Ferrer Int Nuevos compuestos derivados de la n-benzoilmetil-piperidina.
US5723475A (en) * 1995-02-28 1998-03-03 Suntory Limited Arylpiperidine and arylpiperazine derivatives and medicament containing the same
BR9608471A (pt) * 1995-05-17 1998-12-29 Novo Nordisk As Processo para a preparação de um composto
US6025355A (en) 1997-05-19 2000-02-15 Cambridge Neuroscience, Inc. Pharmaceutically active compounds and methods of use
JP3446468B2 (ja) 1996-04-15 2003-09-16 旭硝子株式会社 ピペリジンカルビノール類の製造方法
JP3882224B2 (ja) 1996-05-31 2007-02-14 旭硝子株式会社 パロキセチンの製造方法
EP1394160A1 (en) 1996-06-13 2004-03-03 SUMIKA FINE CHEMICALS Co., Ltd. Process for preparing crystalline paroxetin hydrochloride
WO1998003172A1 (en) * 1996-07-22 1998-01-29 Suntory Limited Arylpiperidinol and arylpiperidine derivatives and drugs containing the same
CA2231879C (en) * 1996-07-22 2007-01-23 Suntory Limited Arylpiperidinol and arylpiperidine derivatives and pharmaceuticals containing the same
US6242198B1 (en) 1996-07-25 2001-06-05 Cambridge Neuroscience, Inc. Methods of treatment of eye trauma and disorders
US6756389B2 (en) 1996-08-09 2004-06-29 Cambridge Neuroscience, Inc. Pharmaceutically active compounds and methods of use
US6110937A (en) * 1997-04-03 2000-08-29 Syntex Usa, Inc. Phenoxymethyl piperidine derivatives for the treatment of neuropathic pain
WO1998045263A1 (en) * 1997-04-07 1998-10-15 Georgetown University Analogs of cocaine
EE03970B1 (et) 1997-06-10 2003-02-17 Synthon B.V. 4-fenüülpiperidiinühend, selle valmistamine ja kasutamine ning seda sisaldav ravim
CH689805A8 (fr) * 1998-07-02 2000-02-29 Smithkline Beecham Plc Méthanesulfonate de paroxétine, procédé pour sa préparation et compositions pharmaceutiques le contenant.
AU2001290873B2 (en) * 2000-09-11 2006-07-27 Sepracor Inc. Ligands for monoamine receptors and transporters, and methods of use thereof (neurotransmission)
US7294637B2 (en) 2000-09-11 2007-11-13 Sepracor, Inc. Method of treating addiction or dependence using a ligand for a monamine receptor or transporter
US6777554B2 (en) 2001-02-05 2004-08-17 Teva Pharmaceutical Industries Ltd. Preparation of N-methylparoxetine and related intermediate compounds
US8153657B2 (en) * 2003-10-22 2012-04-10 Georgetown University Dopamine-, norepinephrine- and serotonin-transporter-selective heterocyclic compounds and their therapeutic applications
US20070142389A1 (en) * 2005-12-20 2007-06-21 Pfizer Inc. Piperidine derivatives

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1203149A (en) * 1968-06-10 1970-08-26 Ici Ltd Piperidine derivatives
GB1422263A (en) * 1973-01-30 1976-01-21 Ferrosan As 4-phenyl-piperidine compounds
DE2549999A1 (de) * 1975-11-07 1977-05-12 Boehringer Mannheim Gmbh Piperidin-derivate und verfahren zu ihrer herstellung
DK149624C (da) * 1983-03-07 1987-02-02 Ferrosan As Fremgangsmaade til fremstilling af (+)-trans-3-((4-methoxyphenoxy)-methyl)-1-methyl-4-phenylpiperidin eller et farmaceutisk acceptabelt salt heraf ud fra en blanding af enantiomererne
US4585777A (en) * 1984-02-07 1986-04-29 A/S Ferrosan (-)-Trans-4-(4-fluorophenyl)-3-(4-methoxyphenoxy)methylpiperidine for potentiating 5-HT
US4593036A (en) * 1984-02-07 1986-06-03 A/S Ferrosan (-)-Trans-4-(4-fluorophenyl)-3-[(4-methoxyphenoxy)methyl]-1-methylpiperidine useful as 5-HT potentiator
GB8431478D0 (en) * 1984-12-13 1985-01-23 Beecham Group Plc Compounds
EP0223403B1 (en) * 1985-10-25 1993-08-04 Beecham Group Plc Piperidine derivative, its preparation, and its use as medicament
IE66332B1 (en) * 1986-11-03 1995-12-27 Novo Nordisk As Piperidine compounds and their preparation and use

Also Published As

Publication number Publication date
US4985446A (en) 1991-01-15
DE3788709T2 (de) 1994-04-28
IL84021A (en) 1993-02-21
FI92821B (fi) 1994-09-30
EP0266574B1 (en) 1994-01-05
IE66332B1 (en) 1995-12-27
PH24749A (en) 1990-10-01
FI92821C (fi) 1995-01-10
EP0266574A3 (en) 1988-07-20
JP2633872B2 (ja) 1997-07-23
EP0266574A2 (en) 1988-05-11
PT86066B (pt) 1990-11-07
FI874459A7 (fi) 1988-05-04
AU602735B2 (en) 1990-10-25
PT86066A (en) 1987-12-01
DE3788709D1 (de) 1994-02-17
CA1323367C (en) 1993-10-19
US5019582A (en) 1991-05-28
IE872561L (en) 1988-05-03
NZ222155A (en) 1990-08-28
KR880006193A (ko) 1988-07-22
US4877799A (en) 1989-10-31
IL84021A0 (en) 1988-02-29
AU8048287A (en) 1988-05-05
FI874459A0 (fi) 1987-10-09
JPS63126866A (ja) 1988-05-30

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