ES2132882T3 - Compuestos de 1-aril-2-acilamino-etano y su uso como antagonistas de neuroquinina 1. - Google Patents

Compuestos de 1-aril-2-acilamino-etano y su uso como antagonistas de neuroquinina 1.

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Publication number
ES2132882T3
ES2132882T3 ES96901800T ES96901800T ES2132882T3 ES 2132882 T3 ES2132882 T3 ES 2132882T3 ES 96901800 T ES96901800 T ES 96901800T ES 96901800 T ES96901800 T ES 96901800T ES 2132882 T3 ES2132882 T3 ES 2132882T3
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Spain
Prior art keywords
aryl
sub
acilamino
heteroaryl
amino group
Prior art date
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Expired - Lifetime
Application number
ES96901800T
Other languages
English (en)
Inventor
Marc Gerspacher
Sprecher Andreas Von
Silvio Roggo
Robert Mah
Silvio Ofner
Siem Jacob Veenstra
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Novartis AG
Original Assignee
Novartis AG
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Publication of ES2132882T3 publication Critical patent/ES2132882T3/es
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/40—Acylated substituent nitrogen atom
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    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
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    • C07D209/04—Indoles; Hydrogenated indoles
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    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
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    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
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    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
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Abstract

COMPUESTOS DE 1 (I), EN LOS QUE R{SUB,1} ES ARILO O HETEROARILO; R{SUB,2} ES HIDROGENO, ALQUILO INFERIOR O ARILO ES HIDROGENO, ALQUILO INFERIOR, ARILO O HETEROARILO; R{SUB,4} ES ARILO O HETEROARILO; X ES ALQUILENO C{SUB,1} QUENILINO C{SUB,2} C{SUB,7} O ALCANODIENILENO C{SUB,4} ,7}, Y AM ES UN GRUPO AMINO NO SUSTITUIDO O MONO O DISUSTITUIDO, ENTENDIENDOSE TAMBIEN POR UN GRUPO AMINO DISUSTITUIDO UNO QUE INCLUYE UN GRUPO AMINO EN EL QUE EL NITROGENO DEL AMINO ESTA UNIDO A UN ANILLO, O UNA SAL DEL MISMO, QUE POSEEN PROPIEDADES FARMACEUTICAS VALIOSAS Y QUE SON ESPECIALMENTE EFICACES COMO ANTAGONISTAS NK1. SE PREPARAN DE UN MODO CONOCIDO PER SE.
ES96901800T 1995-02-22 1996-02-09 Compuestos de 1-aril-2-acilamino-etano y su uso como antagonistas de neuroquinina 1. Expired - Lifetime ES2132882T3 (es)

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EP0912178A4 (en) * 1996-05-24 2000-08-16 Lilly Co Eli METHOD FOR TREATING THE HIGH PRESSURE
MY132550A (en) 1996-08-22 2007-10-31 Novartis Ag Acylaminoalkenylene-amide derivatives as nk1 and nk2 antogonists
GB0010958D0 (en) * 2000-05-05 2000-06-28 Novartis Ag Organic compounds
GB0203061D0 (en) * 2002-02-08 2002-03-27 Novartis Ag Organic compounds
GB0224788D0 (en) * 2002-10-24 2002-12-04 Novartis Ag Organic compounds
GB2394417A (en) * 2002-10-24 2004-04-28 Novartis Ag Solid dispersion comprising a piperidine substance P antagonist and a carrier
JP5248779B2 (ja) * 2003-12-01 2013-07-31 ケンブリッジ エンタープライズ リミティド 抗炎症剤
US20090156465A1 (en) 2005-12-30 2009-06-18 Sattigeri Jitendra A Derivatives of beta-amino acid as dipeptidyl peptidase-iv inhibitors
JO2630B1 (en) * 2006-04-13 2012-06-17 نوفارتيس ايه جي Organic compounds
GB0607532D0 (en) * 2006-04-13 2006-05-24 Novartis Ag Organic compounds
JP4983616B2 (ja) 2008-01-16 2012-07-25 ソニー株式会社 熱転写記録媒体
WO2013004766A1 (en) 2011-07-04 2013-01-10 Ferrari Giulio Nk-1 receptor antagonists for treating corneal neovascularisation
MX2016009939A (es) * 2014-02-18 2017-01-23 Daiichi Sankyo Co Ltd Derivado de aminopirazolona.
RU2020131446A (ru) 2018-02-26 2022-03-28 Оспедале Сан Раффаэле С.Р.Л. Антагонисты nk-1 для применения в лечении глазной боли
RU2697414C1 (ru) * 2018-05-11 2019-08-14 Общество с ограниченной ответственностью "АЙ БИ ДИ Терапевтикс" Новый антагонист тахикининовых рецепторов и его применение
EP3917509A4 (en) * 2019-01-28 2022-11-09 Mitochondria Emotion, Inc. TRANS-4-HYDROXYCYCLOHEXYLPHENYLAMIDE MITOFUSIN ACTIVATORS AND METHODS OF USE THEREOF
WO2021150499A1 (en) 2020-01-20 2021-07-29 Monomer Software LLC Optical device field of view cleaning apparatus
EP4117673A1 (en) 2020-03-11 2023-01-18 Ospedale San Raffaele S.r.l. Treatment of stem cell deficiency

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SK282237B6 (sk) 2001-12-03
EA199900385A1 (ru) 1999-10-28
AU4623396A (en) 1996-09-11
FI120304B (fi) 2009-09-15
FI973221A0 (fi) 1997-08-04
HUP9800051A3 (en) 1998-08-28
ATE178886T1 (de) 1999-04-15
IL117209A (en) 2001-01-11
IL117209A0 (en) 1996-06-18
MX9706394A (es) 1997-11-29
EA002348B1 (ru) 2002-04-25
SK113997A3 (en) 1998-02-04
EP0810991A1 (en) 1997-12-10
US5929067A (en) 1999-07-27
NO325605B1 (no) 2008-06-23
BR9607335A (pt) 1997-11-25
KR19980702391A (ko) 1998-07-15
PL322001A1 (en) 1998-01-05
CY2198B1 (en) 2002-11-08
CZ266297A3 (en) 1997-11-12
KR100389253B1 (ko) 2003-08-19
FI973221L (fi) 1997-10-20
CA2213080A1 (en) 1996-08-29
DE69602087T2 (de) 1999-09-09
NZ300942A (en) 1998-12-23
NO973857D0 (no) 1997-08-21
GR3030626T3 (en) 1999-10-29
NO973857L (no) 1997-10-01
EP0810991B1 (en) 1999-04-14
HUP9800051A2 (hu) 1998-05-28
PL184226B1 (pl) 2002-09-30
WO1996026183A1 (en) 1996-08-29
CN1081625C (zh) 2002-03-27
CA2213080C (en) 2007-11-13
DE69602087D1 (de) 1999-05-20
TR199700834T1 (xx) 1998-01-21
DK0810991T3 (da) 1999-10-25
ZA961364B (en) 1996-08-22
CZ288345B6 (en) 2001-05-16
AU701560B2 (en) 1999-01-28
CN1175944A (zh) 1998-03-11
HU226562B1 (en) 2009-04-28
JPH11500436A (ja) 1999-01-12
JP3506714B2 (ja) 2004-03-15

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