ES2061646T3 - Complejos de platino antitumorales, su preparacion y su uso en terapeutica. - Google Patents

Complejos de platino antitumorales, su preparacion y su uso en terapeutica.

Info

Publication number
ES2061646T3
ES2061646T3 ES88304140T ES88304140T ES2061646T3 ES 2061646 T3 ES2061646 T3 ES 2061646T3 ES 88304140 T ES88304140 T ES 88304140T ES 88304140 T ES88304140 T ES 88304140T ES 2061646 T3 ES2061646 T3 ES 2061646T3
Authority
ES
Spain
Prior art keywords
therapeutics
preparation
platinum complexes
formula
antitumoral
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88304140T
Other languages
English (en)
Inventor
Yokio Sugimura
Yukiko Kameyama
Toshihiko Hashimoto
Kimio Iino
Tomoyuki Shibata
Shigeki Muramatsu
Tomowo Kobayashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Application granted granted Critical
Publication of ES2061646T3 publication Critical patent/ES2061646T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0086—Platinum compounds
    • C07F15/0093—Platinum compounds without a metal-carbon linkage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

LOS COMPUESTOS DE FORMULA (I) EN LA QUE A Y B SON SEPARADAMENTE MONOAMINAS O JUNTOS FORMAN UNA DIAMINA, Y Z ES UN GRUPO DE FORMULA (II) O (III), EN LAS QUE R1, R2 Y R7 SON VARIOS GRUPOS ORGANICOS, N ES 0, 1 O 2, Y X ES UN ENLACE CARBONO-CARBONO DIRECTO O UN ALQUILENO DE CADENA CORTA) MUESTRAN UNA VALIOSA ACTIVIDAD ANTITUMORAL Y PUEDEN SER PREPARADOS POR REACCION DE UN COMPLEJO AMINO-PLATINO CON UN COMPUESTO QUE PROPORCIONE EL GRUPO REPRESENTADO POR Z.
ES88304140T 1987-05-08 1988-05-06 Complejos de platino antitumorales, su preparacion y su uso en terapeutica. Expired - Lifetime ES2061646T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP11218187 1987-05-08
JP11450087 1987-05-13

Publications (1)

Publication Number Publication Date
ES2061646T3 true ES2061646T3 (es) 1994-12-16

Family

ID=26451415

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88304140T Expired - Lifetime ES2061646T3 (es) 1987-05-08 1988-05-06 Complejos de platino antitumorales, su preparacion y su uso en terapeutica.

Country Status (13)

Country Link
US (2) US5527905A (es)
EP (1) EP0290280B1 (es)
KR (1) KR950008372B1 (es)
CN (1) CN1017803B (es)
AU (1) AU617314B2 (es)
CA (1) CA1308723C (es)
DE (1) DE3887194T2 (es)
DK (1) DK252688A (es)
ES (1) ES2061646T3 (es)
FI (1) FI87572C (es)
HU (1) HU199492B (es)
NO (1) NO178069C (es)
RU (1) RU2039064C1 (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR0164460B1 (ko) * 1995-10-02 1999-03-20 김은영 고분자 백금 착화합물, 그의 제조방법 및 그를 유효성분으로 하는 항암제
US6235782B1 (en) 1998-11-12 2001-05-22 Rifat Pamukcu Method for treating a patient with neoplasia by treatment with a platinum coordination complex
US6235776B1 (en) 1998-11-12 2001-05-22 Cell Pathways, Inc. Method for treating a patient with neoplasia by treatment with a paclitaxel derivative
JP4776843B2 (ja) 1999-10-01 2011-09-21 イムノゲン インコーポレーティッド 免疫複合体及び化学療法剤を用いる癌治療用組成物及び方法
HK1049443A1 (zh) * 1999-11-12 2003-05-16 Angiotech Pharmaceuticals, Inc. 用放射活性疗法和细胞循环抑制剂联合治疗疾病的组合物和方法
KR100363394B1 (ko) 2000-08-21 2002-12-05 한국과학기술연구원 온도감응성을 갖는 포스파젠삼량체-백금착물 복합체, 그의제조방법 및 그를 함유하는 항암제 조성물
WO2004060346A2 (en) 2002-12-30 2004-07-22 Angiotech International Ag Drug delivery from rapid gelling polymer composition
US7138520B2 (en) * 2003-01-13 2006-11-21 Massachusetts Institute Of Technology Coordination complexes having tethered therapeutic agents and/or targeting moieties, and methods of making and using the same
CA2548457C (en) * 2003-12-10 2010-08-24 Toudai Tlo, Ltd. Coordination complex of diaminocyclohexaneplatinum(ii) with block copolymer containing poly(carboxylic acid) segment and antitumor agent comprising the same
ES2704303T3 (es) 2010-08-24 2019-03-15 Dana Farber Cancer Inst Inc Procedimientos para la predicción de una respuesta contra el cáncer
ES2768344T3 (es) 2011-06-17 2020-06-22 Myriad Genetics Inc Métodos y materiales para evaluar el desequilibrio alélico
JP6325453B2 (ja) 2011-12-21 2018-05-16 ミリアド・ジェネティックス・インコーポレイテッド ヘテロ接合性の消失（ｌｏｓｓｏｆｈｅｔｅｒｏｚｙｇｏｓｉｔｙ）を評価するための方法および材料
ES2687024T3 (es) 2012-02-23 2018-10-23 Children's Medical Center Corporation Procedimientos para predecir la respuesta contra el cáncer
CA2867434C (en) 2012-06-07 2021-10-12 Institut Curie Methods for detecting inactivation of the homologous recombination pathway (brca1/2) in human tumors
US10308986B2 (en) 2013-03-14 2019-06-04 Children's Medical Center Corporation Cancer diagnosis, treatment selection and treatment
CA2931181C (en) 2013-12-09 2023-01-24 Institut Curie Methods for detecting inactivation of the homologous recombination pathway (brca1/2) in human tumors
DK3686288T3 (da) 2014-08-15 2023-05-22 Myriad Genetics Inc Fremgangsmåder og materialer til analyse af homolog rekombinationsdeficiens
CN111721842B (zh) * 2019-03-19 2022-07-12 海南长安国际制药有限公司 洛铂中有关物质的检测方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6041077B2 (ja) * 1976-09-06 1985-09-13 喜徳 喜谷 １，２‐ジアミノシクロヘキサン異性体のシス白金（２）錯体
GB2019397B (en) * 1978-04-20 1982-10-27 Johnson Matthey Co Ltd Pt 2 and 4 complexes with amino-acids
IL67789A (en) * 1983-01-31 1986-09-30 Yissum Res Dev Co Amino-substituted malonato platinum(ii)complexes and method for their preparation
AU581101B2 (en) * 1985-09-06 1989-02-09 Sankyo Company Limited Anti-tumour platinum complexes, their preparation and their use
DE3630497A1 (de) * 1986-09-08 1988-03-10 Behringwerke Ag Cis-platin-komplexe, verfahren zu ihrer herstellung und diese verbindungen enthaltende pharmazeutische mittel

Also Published As

Publication number Publication date
NO882012D0 (no) 1988-05-09
EP0290280B1 (en) 1994-01-19
DK252688D0 (da) 1988-05-06
DK252688A (da) 1988-11-09
CN1017803B (zh) 1992-08-12
NO178069C (no) 1996-01-17
EP0290280A2 (en) 1988-11-09
FI882130A0 (fi) 1988-05-06
AU1581388A (en) 1988-11-10
RU2039064C1 (ru) 1995-07-09
AU617314B2 (en) 1991-11-28
KR880013961A (ko) 1988-12-22
DE3887194D1 (de) 1994-03-03
HUT47301A (en) 1989-02-28
FI87572C (fi) 1993-01-25
CA1308723C (en) 1992-10-13
US5633243A (en) 1997-05-27
HU199492B (en) 1990-02-28
DE3887194T2 (de) 1994-07-28
KR950008372B1 (ko) 1995-07-28
US5527905A (en) 1996-06-18
FI87572B (fi) 1992-10-15
NO882012L (no) 1989-02-27
CN1034544A (zh) 1989-08-09
EP0290280A3 (en) 1990-07-25
NO178069B (no) 1995-10-09
FI882130A7 (fi) 1988-11-09

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