ES2061682T3 - Cisteina proteinasas, produccion y uso. - Google Patents

Cisteina proteinasas, produccion y uso.

Info

Publication number
ES2061682T3
ES2061682T3 ES88309842T ES88309842T ES2061682T3 ES 2061682 T3 ES2061682 T3 ES 2061682T3 ES 88309842 T ES88309842 T ES 88309842T ES 88309842 T ES88309842 T ES 88309842T ES 2061682 T3 ES2061682 T3 ES 2061682T3
Authority
ES
Spain
Prior art keywords
production
enzymes
disclosed
distinct
cysteine proteins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88309842T
Other languages
English (en)
Inventor
Andrew D Rowan
David J Buttle
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genzyme Corp
Original Assignee
Genzyme Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genzyme Corp filed Critical Genzyme Corp
Application granted granted Critical
Publication of ES2061682T3 publication Critical patent/ES2061682T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/63—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from plants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00—Drug, bio-affecting and body treating compositions
    • Y10S424/13—Burn treatment

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Botany (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)

Abstract

UNA CISTEINA - PROTEINASA CARACTERIZADA PORQUE ES INMUNOLOGICAMENTE DISTINTA, TIENE UNA MASA MOLECULAR DE ALREDEDOR DE 25000 Y UNA CARGA NETA DISTINTA. TALES ENZIMAS SON ANANAIN Y COMOSAIN QUE SE PUEDEN DISTINGUIR POR SUS ESPECIFICIDADES PARA LAGUNOS SUSTRATOS SINTETICOS. TAMBIEN SE INCLUYE UN PROCESO PARA SU PRODUCCION QUE COMPRENDE LA SEPARACION DE MATERIAL DE UNA PLANTA DE ELABORACION DE PINA Y SU PURIFICACION. ESTAS ENZIMAS SE PUEDEN EMPLEAR EN EL DESBRIDAMIENTO DE TEJIDOS DE COSTRAS DE HERIDAS.
ES88309842T 1987-10-22 1988-10-20 Cisteina proteinasas, produccion y uso. Expired - Lifetime ES2061682T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB878724728A GB8724728D0 (en) 1987-10-22 1987-10-22 Cysteine proteinase

Publications (1)

Publication Number Publication Date
ES2061682T3 true ES2061682T3 (es) 1994-12-16

Family

ID=10625712

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88309842T Expired - Lifetime ES2061682T3 (es) 1987-10-22 1988-10-20 Cisteina proteinasas, produccion y uso.

Country Status (11)

Country Link
US (1) US5106621A (es)
EP (1) EP0313346B1 (es)
JP (1) JP2644006B2 (es)
AT (1) ATE102248T1 (es)
AU (1) AU628790B2 (es)
CA (1) CA1319121C (es)
DE (1) DE3888082T2 (es)
DK (1) DK589388A (es)
ES (1) ES2061682T3 (es)
GB (1) GB8724728D0 (es)
IL (1) IL88078A (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8821049D0 (en) * 1988-09-08 1988-10-05 Health Lab Service Board Method & composition for treatment & prevention of viral infections
IL105699A0 (en) * 1992-06-26 1993-09-22 Genzyme Corp Hydrophilic creams for delivery of therapeutic agents
JP3221997B2 (ja) * 1993-03-26 2001-10-22 株式会社東芝 画像処理装置
US5387517A (en) * 1994-03-23 1995-02-07 Ethicon, Inc. Thiol activated protease from stem bromelain for treating devitalized tissue
US5935572A (en) * 1997-01-10 1999-08-10 Collaborative Laboratories, Inc. Composition containing protease separate from glycosidase for removing nits in treating lice infestation
WO1998038320A1 (en) 1997-02-25 1998-09-03 Cortecs (Uk) Limited Component of bromelain
EP1865055B1 (en) * 1997-02-25 2012-12-05 Sarantis Pty Ltd Component of bromelain
US20020102253A1 (en) 1997-02-25 2002-08-01 Mynott Tracey Lehanne Component of bromelain
US6548556B2 (en) 2000-12-27 2003-04-15 Healthpoint, Ltd. Stable enzymatic wound debrider
US7364565B2 (en) 2001-07-27 2008-04-29 Ramot At Tel Aviv University Ltd. Controlled enzymatic removal and retrieval of cells
EP1539225B1 (en) * 2002-04-23 2012-08-22 Mediwound, Ltd. Apparatus and methods for use in enzymatic escharotomy in burn induced compartment syndrome
CA2501645A1 (en) * 2002-10-10 2004-04-22 Verenium Corporation Proteases, nucleic acids encoding them and methods for making and using them
IL165334A0 (en) 2004-11-22 2006-01-15 Mediwound Ltd Debriding composition from bromelain and methods of producing same
AT502391B1 (de) 2005-09-20 2007-03-15 Univ Innsbruck Inst Fuer Umwel Verfahren zur behandlung von ammoniumhaltigem abwasser
US20110239327A1 (en) * 2007-01-16 2011-09-29 Rosane Curtis Nematicidal Effects of Cysteine Proteinases and Methods of Use Thereof to Treat Nematode Infestation
EP2226382A1 (en) 2009-03-03 2010-09-08 B.R.A.I.N. Biotechnology Research and Information Network AG Protease for wound conditioning and skin care
JP6049714B2 (ja) 2011-07-20 2016-12-21 メディウンド リミテッド 結合組織疾患の治療のためのブロメライン由来タンパク質分解抽出物
WO2013096337A1 (en) 2011-12-20 2013-06-27 Kci Licensing, Inc. Composition for enzymatic debridement
US20150259370A1 (en) * 2014-03-11 2015-09-17 Ecotech Development LLC Integrated process extraction of pineapple biomass into fibers and natural products
CN108472341A (zh) * 2015-08-20 2018-08-31 安纳塔拉生命科学有限公司 具有抗炎活性的酶级分
CA3012299C (en) * 2016-01-31 2022-05-31 Mediwound Ltd. Debriding composition for treating wounds
NZ748416A (en) * 2016-04-18 2022-12-23 Mediwound Ltd Methods of debridement of chronic wounds

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3002891A (en) * 1958-12-12 1961-10-03 Pineapple Res Inst Of Hawaii Process for the preparation of pineapple stem bromelain
US2950227A (en) * 1959-06-05 1960-08-23 Schering Ag Ferments of the papain type and process of making same
US4226854A (en) * 1974-01-08 1980-10-07 Gerold K. V. Klein Debridement of devitalized tissue with hydrolytic enzyme product
US4197291A (en) * 1974-01-08 1980-04-08 Gerold K. V. Klein Hydrolytic enzyme material
US4329430A (en) * 1979-06-04 1982-05-11 Klein Gerold K V Enzyme mixture
US4361551A (en) * 1979-11-05 1982-11-30 Riker Laboratories, Inc. Method of enzymatic debridement
US4286064A (en) * 1979-11-05 1981-08-25 Riker Laboratories, Inc. Process for isolating active debriding agent from bromelain
AU543965B2 (en) * 1979-11-05 1985-05-09 Riker Laboratories, Inc. Method of enzymatic debridement
US4645668A (en) * 1983-08-04 1987-02-24 Biospecifics, Nv Method for the prevention and treatment of scars with enzymes

Also Published As

Publication number Publication date
DE3888082D1 (de) 1994-04-07
DK589388D0 (da) 1988-10-21
IL88078A (en) 1993-08-18
IL88078A0 (en) 1989-06-30
EP0313346B1 (en) 1994-03-02
EP0313346A3 (en) 1990-05-09
CA1319121C (en) 1993-06-15
JP2644006B2 (ja) 1997-08-25
EP0313346A2 (en) 1989-04-26
DK589388A (da) 1989-04-23
ATE102248T1 (de) 1994-03-15
JPH0216977A (ja) 1990-01-19
DE3888082T2 (de) 1994-06-09
US5106621A (en) 1992-04-21
AU2405988A (en) 1989-06-08
GB8724728D0 (en) 1987-11-25
AU628790B2 (en) 1992-09-24

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