ATE102248T1 - Cysteinprotease, herstellung und verwendung. - Google Patents

Cysteinprotease, herstellung und verwendung.

Info

Publication number
ATE102248T1
ATE102248T1 AT88309842T AT88309842T ATE102248T1 AT E102248 T1 ATE102248 T1 AT E102248T1 AT 88309842 T AT88309842 T AT 88309842T AT 88309842 T AT88309842 T AT 88309842T AT E102248 T1 ATE102248 T1 AT E102248T1
Authority
AT
Austria
Prior art keywords
preparation
cysteine protease
enzymes
disclosed
distinct
Prior art date
Application number
AT88309842T
Other languages
English (en)
Inventor
Andrew D Rowan
David J Buttle
Original Assignee
Genzyme Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genzyme Corp filed Critical Genzyme Corp
Application granted granted Critical
Publication of ATE102248T1 publication Critical patent/ATE102248T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/63—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from plants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00—Drug, bio-affecting and body treating compositions
    • Y10S424/13—Burn treatment

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Botany (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)
AT88309842T 1987-10-22 1988-10-20 Cysteinprotease, herstellung und verwendung. ATE102248T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB878724728A GB8724728D0 (en) 1987-10-22 1987-10-22 Cysteine proteinase
EP88309842A EP0313346B1 (de) 1987-10-22 1988-10-20 Cysteinprotease, Herstellung und Verwendung

Publications (1)

Publication Number Publication Date
ATE102248T1 true ATE102248T1 (de) 1994-03-15

Family

ID=10625712

Family Applications (1)

Application Number Title Priority Date Filing Date
AT88309842T ATE102248T1 (de) 1987-10-22 1988-10-20 Cysteinprotease, herstellung und verwendung.

Country Status (11)

Country Link
US (1) US5106621A (de)
EP (1) EP0313346B1 (de)
JP (1) JP2644006B2 (de)
AT (1) ATE102248T1 (de)
AU (1) AU628790B2 (de)
CA (1) CA1319121C (de)
DE (1) DE3888082T2 (de)
DK (1) DK589388A (de)
ES (1) ES2061682T3 (de)
GB (1) GB8724728D0 (de)
IL (1) IL88078A (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8821049D0 (en) * 1988-09-08 1988-10-05 Health Lab Service Board Method & composition for treatment & prevention of viral infections
IL105699A0 (en) * 1992-06-26 1993-09-22 Genzyme Corp Hydrophilic creams for delivery of therapeutic agents
JP3221997B2 (ja) * 1993-03-26 2001-10-22 株式会社東芝 画像処理装置
US5387517A (en) * 1994-03-23 1995-02-07 Ethicon, Inc. Thiol activated protease from stem bromelain for treating devitalized tissue
US5935572A (en) * 1997-01-10 1999-08-10 Collaborative Laboratories, Inc. Composition containing protease separate from glycosidase for removing nits in treating lice infestation
EP1012305A1 (de) 1997-02-25 2000-06-28 Cortecs (UK) Limited Bestandteil von bromelain
WO1998038319A1 (en) * 1997-02-25 1998-09-03 Cortecs (Uk) Limited Component of bromelain
US20020102253A1 (en) 1997-02-25 2002-08-01 Mynott Tracey Lehanne Component of bromelain
US6548556B2 (en) 2000-12-27 2003-04-15 Healthpoint, Ltd. Stable enzymatic wound debrider
US7364565B2 (en) * 2001-07-27 2008-04-29 Ramot At Tel Aviv University Ltd. Controlled enzymatic removal and retrieval of cells
CA2483329C (en) * 2002-04-23 2011-11-01 Mediwound, Ltd. Apparatus and methods for enzymatic escharotomy in burn induced compartment syndrome
MX282672B (es) * 2002-10-10 2011-01-10 Diversa Corp Proteasas, acidos nucleicos que los codifican, y metodos de hacer y usar los mismos.
IL165334A0 (en) 2004-11-22 2006-01-15 Mediwound Ltd Debriding composition from bromelain and methods of producing same
AT502391B1 (de) 2005-09-20 2007-03-15 Univ Innsbruck Inst Fuer Umwel Verfahren zur behandlung von ammoniumhaltigem abwasser
US20110239327A1 (en) * 2007-01-16 2011-09-29 Rosane Curtis Nematicidal Effects of Cysteine Proteinases and Methods of Use Thereof to Treat Nematode Infestation
EP2226382A1 (de) 2009-03-03 2010-09-08 B.R.A.I.N. Biotechnology Research and Information Network AG Protease zur Wundbehandlung und Hautpflege
WO2013011514A1 (en) 2011-07-20 2013-01-24 Mediwound Ltd. Proteolytic extract from bromelain for the treatment of connective tissue disorders
WO2013096337A1 (en) 2011-12-20 2013-06-27 Kci Licensing, Inc. Composition for enzymatic debridement
US20150259370A1 (en) * 2014-03-11 2015-09-17 Ecotech Development LLC Integrated process extraction of pineapple biomass into fibers and natural products
CN108472341A (zh) * 2015-08-20 2018-08-31 安纳塔拉生命科学有限公司 具有抗炎活性的酶级分
RU2732224C9 (ru) * 2016-01-31 2021-06-18 Медивунд Лтд. Раноочищающая композиция для лечения ран
WO2017183018A1 (en) * 2016-04-18 2017-10-26 Mediwound Ltd Methods of debridement of chronic wounds

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3002891A (en) * 1958-12-12 1961-10-03 Pineapple Res Inst Of Hawaii Process for the preparation of pineapple stem bromelain
US2950227A (en) * 1959-06-05 1960-08-23 Schering Ag Ferments of the papain type and process of making same
US4197291A (en) * 1974-01-08 1980-04-08 Gerold K. V. Klein Hydrolytic enzyme material
US4226854A (en) * 1974-01-08 1980-10-07 Gerold K. V. Klein Debridement of devitalized tissue with hydrolytic enzyme product
US4329430A (en) * 1979-06-04 1982-05-11 Klein Gerold K V Enzyme mixture
EP0039726A4 (de) * 1979-11-05 1982-09-27 Riker Laboratories Inc Verfahren zur enzymatischen wundauffrischung.
US4286064A (en) * 1979-11-05 1981-08-25 Riker Laboratories, Inc. Process for isolating active debriding agent from bromelain
US4361551A (en) * 1979-11-05 1982-11-30 Riker Laboratories, Inc. Method of enzymatic debridement
US4645668A (en) * 1983-08-04 1987-02-24 Biospecifics, Nv Method for the prevention and treatment of scars with enzymes

Also Published As

Publication number Publication date
DE3888082D1 (de) 1994-04-07
DE3888082T2 (de) 1994-06-09
AU2405988A (en) 1989-06-08
GB8724728D0 (en) 1987-11-25
JP2644006B2 (ja) 1997-08-25
DK589388D0 (da) 1988-10-21
EP0313346B1 (de) 1994-03-02
ES2061682T3 (es) 1994-12-16
CA1319121C (en) 1993-06-15
US5106621A (en) 1992-04-21
EP0313346A2 (de) 1989-04-26
AU628790B2 (en) 1992-09-24
DK589388A (da) 1989-04-23
JPH0216977A (ja) 1990-01-19
IL88078A0 (en) 1989-06-30
EP0313346A3 (en) 1990-05-09
IL88078A (en) 1993-08-18

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee