ES2061714T3 - Grupos de anclaje inestables frente a acidos para la sintesis de amidas peptidicas mediante el metodo en fase solida. - Google Patents

Grupos de anclaje inestables frente a acidos para la sintesis de amidas peptidicas mediante el metodo en fase solida.

Info

Publication number
ES2061714T3
ES2061714T3 ES88710054T ES88710054T ES2061714T3 ES 2061714 T3 ES2061714 T3 ES 2061714T3 ES 88710054 T ES88710054 T ES 88710054T ES 88710054 T ES88710054 T ES 88710054T ES 2061714 T3 ES2061714 T3 ES 2061714T3
Authority
ES
Spain
Prior art keywords
synthesis
solid phase
hydrogen
phase method
peptidic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88710054T
Other languages
English (en)
Inventor
Gerhard Dr Breipohl
Jochen Dr Knolle
Werner Dr Stuber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Application granted granted Critical
Publication of ES2061714T3 publication Critical patent/ES2061714T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/003—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by transforming the C-terminal amino acid to amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/042—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers characterised by the nature of the carrier
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/18—Fluorenes; Hydrogenated fluorenes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

LA INVENCION SE REFIERE A NUEVOS COMPUESTOS DE LA FORMULA (I), DONDE R1 ES (C1 - C8) - ALQUILO; R2 ES UN RESTO DE AMINOACIDO PROTEGIDO POR UN GRUPO URETANO SEPARABLE BASICAMENTE O POCO ACIDAMENTE, O CON UN GRUPO PROTECTOR AMINO SEPARABLE BASICAMENTE O POCO ACIDAMENTE; R3 ES HIDROGENO O (C1 - C4) - ALQUILO Y Y1 - Y9, RESTOS IGUALES O DISTINTOS, SON HIDROGENO, (C1 - C4) - ALQUILO, (C1 C4)-ALCOXI O - O - (CH2)N - CO - OH, (CON N = 1 A 6), SIENDO UNO DE ESTOS RESTOS - O - (CH2)N - CO - OH; O Y1, Y2, Y5-Y9, RESTOS IGUALES O DISTINTOS, SON HIDROGENO, (C1 - C4) - ALQUILO O (C1 - C4) - ALCOXI; Y3 ES (C1 - C6)ALCOXI O HIDROGENO Y Y4 ES - (CH2)N - COOH O - NH - CO (CH2)N - COOH (CON N = 1 A 6). SE DESCRIBEN TAMBIEN PROCESOS PARA SU OBTENCION ASI COMO LA SINTESIS DE PEPTIDAMIDAS MEDIANTE METODO DE FASE SOLIDA BAJO UTILIZACION DE ESTOS NUEVOS COMPUESTOS (SPACER - ESPACIADORES).
ES88710054T 1987-12-22 1988-12-16 Grupos de anclaje inestables frente a acidos para la sintesis de amidas peptidicas mediante el metodo en fase solida. Expired - Lifetime ES2061714T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3743620 1987-12-22
DE3818576 1988-06-01

Publications (1)

Publication Number Publication Date
ES2061714T3 true ES2061714T3 (es) 1994-12-16

Family

ID=25863103

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88710054T Expired - Lifetime ES2061714T3 (es) 1987-12-22 1988-12-16 Grupos de anclaje inestables frente a acidos para la sintesis de amidas peptidicas mediante el metodo en fase solida.

Country Status (12)

Country Link
US (1) US5124478A (es)
EP (1) EP0322348B1 (es)
JP (1) JP2858766B2 (es)
KR (1) KR0128341B1 (es)
AU (1) AU619512B2 (es)
CA (1) CA1341386C (es)
DE (1) DE3887670D1 (es)
DK (1) DK173320B1 (es)
ES (1) ES2061714T3 (es)
IE (1) IE62358B1 (es)
IL (1) IL88741A (es)
PT (1) PT89297B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2815362B2 (ja) * 1988-02-29 1998-10-27 中外製薬株式会社 ベンズヒドリルアミン誘導体及びその製法
US5233044A (en) * 1989-06-08 1993-08-03 Millipore Corporation Active esters for solid phase peptide synthesis
EP0401797A1 (en) * 1989-06-08 1990-12-12 PerSeptive Biosystems, Inc. Active esters for solid phase peptide synthesis
TW295589B (es) * 1990-08-30 1997-01-11 Hoechst Ag
CS103091A3 (en) * 1991-04-12 1992-10-14 Ustav Organicke Chemie A Bioch Protected substituted benzhydrylamines as shoulders for the synthesis ofpeptides on solid phase, process of their preparation and use
JP3134936B2 (ja) * 1992-10-16 2001-02-13 沖電気工業株式会社 衝撃センサ
PT751779E (pt) * 1993-06-21 2002-05-31 Selectide Corp Ligantes selectivamente clivaveis baseados em ligacoes ester de acido iminodiacetico
LT3872B (en) 1993-12-06 1996-04-25 Hoechst Ag Novel peptides and pharmaceutical compositions containing them
DE4408533A1 (de) 1994-03-14 1995-09-28 Hoechst Ag PNA-Synthese unter Verwendung einer basenlabilen Amino-Schutzgruppe
AUPO324096A0 (en) * 1996-10-24 1996-11-21 University Of Queensland, The Linker peptide
US7524925B2 (en) * 2004-11-18 2009-04-28 Washington State University Protein interaction reporter agents and methods for using same
US20130345392A1 (en) 2011-03-04 2013-12-26 Pfizer Inc Edn3-like peptides and uses thereof
US10308677B2 (en) 2014-12-19 2019-06-04 Cem Corporation Coupling method for peptide synthesis at elevated temperatures
US9969769B2 (en) 2014-12-19 2018-05-15 Cem Corporation Coupling method for peptide synthesis at elevated temperatures

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1768047C3 (de) * 1968-03-26 1979-09-27 Hoechst Ag, 6000 Frankfurt Dimethoxybenthydryl-asparagin- und glutamin-derivate sowie Verfahren zur Herstellung von asparagin- und glutaminhaltigen Peptiden
DE3711866A1 (de) * 1987-04-08 1988-10-27 Hoechst Ag Synthese von peptidamiden mittels festphasenmethode unter verwendung von saeurelabilen ankergruppen

Also Published As

Publication number Publication date
DE3887670D1 (de) 1994-03-17
IL88741A0 (en) 1989-07-31
IE62358B1 (en) 1995-01-25
EP0322348A3 (en) 1990-08-29
AU2743188A (en) 1989-06-22
US5124478A (en) 1992-06-23
DK714588D0 (da) 1988-12-21
AU619512B2 (en) 1992-01-30
PT89297A (pt) 1989-12-29
EP0322348B1 (de) 1994-02-02
DK714588A (da) 1989-06-23
KR0128341B1 (ko) 1998-04-03
JPH02243A (ja) 1990-01-05
JP2858766B2 (ja) 1999-02-17
PT89297B (pt) 1994-11-30
IE883832L (en) 1989-06-22
IL88741A (en) 1994-12-29
CA1341386C (en) 2002-08-27
DK173320B1 (da) 2000-07-24
EP0322348A2 (de) 1989-06-28
KR890009973A (ko) 1989-08-05

Similar Documents

Publication Publication Date Title
ES2061714T3 (es) Grupos de anclaje inestables frente a acidos para la sintesis de amidas peptidicas mediante el metodo en fase solida.
NO20001002L (no) Oxo-substituerte forbindelser, fremgangsmõte for fremstilling, og sammensetninger og metoder for hemming av PARP aktiviteter
PE52396A1 (es) Nuevo compuesto que puede mantener, aumentar o restaurar la sensibilidad de las celulas a los agentes terapeuticos o profilacticos
ES2070175T3 (es) Derivados de acido 4-oxoquinolino-3-carboxilico, su preparacion y su uso.
MX9305379A (es) Nuevos derivados de aminoacidos, procedimiento para su preparacion y preparado farmaceutico que los contiene.
AR013119A1 (es) Derivados de pirimidina -2,4,6-triona, procesos para su produccion y preparados farmaceuticos que los contienen
SV2003000876A (es) Quinazolinas como inhibidores de mmp-13
EP1501803A4 (en) TETRAHYDROPYRANYLCYCLOPENTYLTETRAHYDROISOCHINO LINMODULATORS OF CHEMOKIN RECEPTOR ACTIVITY
ATE153029T1 (de) Verwendung von peptidase-hemmer zur herstellung von medikamenten für die behandlung von schlaganfällen
PE20090620A1 (es) Derivados de 1,2,4,5-tetrahidro-3h-benzazepinas, su procedimiento de preparacion y las composiciones farmaceuticas que las contienen
ATE90107T1 (de) Peptide mit collagenase hemmender wirkung.
ES2161231T3 (es) Compuestos heterociclicos como antagonistas de bradiquinina.
ES440922A1 (es) Un procedimiento para la preparacion de un peptido con una estructura ciclica de disulfuro.
PT93502A (pt) Processo para a preparacao de novos derivados de insulina e de composicoes farmaceuticas que os contem
ES8503654A1 (es) Un procedimiento para la preparacion de una 1,4-dihidro-piridina.
PE20020049A1 (es) Fenilamidas para amina sustituidas como activadores de glucoquinasa
DK149885D0 (da) Fremgangsmaade til fremstilling af optisk aktive alpha-arylalkansyrer og mellemprodukter til brug herved
ES8707243A1 (es) Un procedimiento para preparar derivados de tienopiridona
ES2026669T3 (es) Procedimiento para la preparacion y el uso terapeutico de los beta-d-fenil tioxilosidos.
AR008621A1 (es) Un compuesto derivado de amina succinica, un procedimiento para llevar a cabo su preparacion y una composicion farmaceutica que comprende dichocompuesto
ES2046671T3 (es) Un procedimiento para la preparacion de tetrahidroimidazo(1,4)benzodiazepin-2-tionas.
AR010584A1 (es) Compuestos derivados de 1,2 dihidroxietilpiridina y procesos para prepararlos, intermedios y procesos para preparar estos ultimos
ES2184096T3 (es) Metodo para producir peptidos.
PE20020798A1 (es) COMPUESTO LACTAMICO QUE INHIBE LA LIBERACION DE PEPTIDO ß-AMILOIDE Y/O SU SINTESIS
AR027578A1 (es) Derivados de indano

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 322348

Country of ref document: ES