ES2061772T3 - Inhalante aerosol que comprende un ester de retinol y/o de acido retinico. - Google Patents

Inhalante aerosol que comprende un ester de retinol y/o de acido retinico.

Info

Publication number
ES2061772T3
ES2061772T3 ES89107645T ES89107645T ES2061772T3 ES 2061772 T3 ES2061772 T3 ES 2061772T3 ES 89107645 T ES89107645 T ES 89107645T ES 89107645 T ES89107645 T ES 89107645T ES 2061772 T3 ES2061772 T3 ES 2061772T3
Authority
ES
Spain
Prior art keywords
acid
rethinic
aerosol including
retinol ester
ester
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89107645T
Other languages
English (en)
Inventor
Hans Konrad Dr Med Biesalski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GRADINGER F HERMES PHARMA
Original Assignee
GRADINGER F HERMES PHARMA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GRADINGER F HERMES PHARMA filed Critical GRADINGER F HERMES PHARMA
Application granted granted Critical
Publication of ES2061772T3 publication Critical patent/ES2061772T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/07—Retinol compounds, e.g. vitamin A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Otolaryngology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

UN PREPARADO FARMACEUTICO CONTENIENDO COMO SUBSTANBCIA ACTIVA UN ESTER DEL ACIDO RETINICO Y/O UN ESTER DE RETINOLES. EL PREPARADO SE PRESENTA EN FORMA DE AEROSOL/INHALADOR. EL PREPARADO ES APROPIADO PARA EL TRATAMIENTO TOPICO DE ENFERMEDADES DE LA PIEL EN HOMBRES Y ANIMALES.
ES89107645T 1988-05-04 1989-04-27 Inhalante aerosol que comprende un ester de retinol y/o de acido retinico. Expired - Lifetime ES2061772T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3815221A DE3815221C2 (de) 1988-05-04 1988-05-04 Verwendung einer Retinol- und/oder Retinsäureester enthaltenden pharmazeutischen Zubereitung zur Inhalation zur Einwirkung auf die Schleimhäute des Tracheo-Bronchialtraktes einschließlich der Lungenalveolen

Publications (1)

Publication Number Publication Date
ES2061772T3 true ES2061772T3 (es) 1994-12-16

Family

ID=6353637

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89107645T Expired - Lifetime ES2061772T3 (es) 1988-05-04 1989-04-27 Inhalante aerosol que comprende un ester de retinol y/o de acido retinico.

Country Status (6)

Country Link
US (2) US5112598A (es)
EP (1) EP0352412B1 (es)
JP (1) JP2766666B2 (es)
AT (1) ATE99928T1 (es)
DE (2) DE3815221C2 (es)
ES (1) ES2061772T3 (es)

Families Citing this family (180)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3815221C2 (de) * 1988-05-04 1995-06-29 Gradinger F Hermes Pharma Verwendung einer Retinol- und/oder Retinsäureester enthaltenden pharmazeutischen Zubereitung zur Inhalation zur Einwirkung auf die Schleimhäute des Tracheo-Bronchialtraktes einschließlich der Lungenalveolen
WO1993000951A1 (en) * 1991-07-02 1993-01-21 Inhale, Inc. Method and device for delivering aerosolized medicaments
US6681767B1 (en) * 1991-07-02 2004-01-27 Nektar Therapeutics Method and device for delivering aerosolized medicaments
IT1253711B (it) * 1991-12-17 1995-08-23 Alfa Wassermann Spa Formulazioni farmaceutiche vaginali contenenti rifaximin e loro uso nel trattamento delle infezioni vaginali
DE4203306A1 (de) * 1992-02-06 1993-08-12 Ig Spruehtechnik Gmbh Asthma oder pulmonal-aerosolzubereitungen mit lecithin
ES2179831T3 (es) * 1992-09-29 2003-02-01 Inhale Therapeutic Syst Liberacion en los pulmones de fragmentos activos de hormona paratiroidiana.
TW252974B (es) * 1993-03-23 1995-08-01 Takeda Dharm Industry Co Ltd
NZ281112A (en) 1994-03-07 1998-04-27 Inhale Therapeutic Syst Powdered insulin delivered as an aerosol
US20030113273A1 (en) * 1996-06-17 2003-06-19 Patton John S. Methods and compositions for pulmonary delivery of insulin
ES2245780T3 (es) * 1994-05-18 2006-01-16 Nektar Therapeutics Metodos y composiciones para la formulacion de interferones como un polvo seco.
US6290991B1 (en) * 1994-12-02 2001-09-18 Quandrant Holdings Cambridge Limited Solid dose delivery vehicle and methods of making same
US5944012A (en) * 1996-03-25 1999-08-31 Pera; Ivo E. Method for dispensing antioxidant vitamins by inhalation background of the invention
DE19652790A1 (de) * 1996-12-18 1998-06-25 Hermes Fabrik Pharm Praeparate Pharmazeutische Zubereitungen
US5998486A (en) * 1997-07-08 1999-12-07 Georgetown University School Of Medicine Treatment of emphysema with retinoic acid or other retinoids by inducing formation of gas-exchange units (alveoli)
US20030035778A1 (en) * 1997-07-14 2003-02-20 Robert Platz Methods and compositions for the dry powder formulation of interferon
US6309623B1 (en) * 1997-09-29 2001-10-30 Inhale Therapeutic Systems, Inc. Stabilized preparations for use in metered dose inhalers
US6565885B1 (en) 1997-09-29 2003-05-20 Inhale Therapeutic Systems, Inc. Methods of spray drying pharmaceutical compositions
US20060165606A1 (en) 1997-09-29 2006-07-27 Nektar Therapeutics Pulmonary delivery particles comprising water insoluble or crystalline active agents
US6703050B1 (en) * 1998-09-04 2004-03-09 The Regents Of The University Of Michigan Methods and compositions for the prevention or treatment of cancer
EP1263420B1 (en) * 2000-03-07 2005-09-07 Battelle Memorial Institute Retinoid formulations for aerosolization and inhalation
DE10012151A1 (de) * 2000-03-13 2001-09-27 Gsf Forschungszentrum Umwelt Mittel zur Behandlung von Erkrankungen des Tracheo-Brochialtraktes, insbesondere der COPD
DE10013093B4 (de) 2000-03-17 2005-12-22 Inamed Gmbh Vorrichtung zur kontrollierten Inhalation therapeutischer Aerosole
ES2525087T5 (es) 2000-05-10 2018-06-28 Novartis Ag Polvos basados en fosfolípidos para administración de fármacos
US7871598B1 (en) 2000-05-10 2011-01-18 Novartis Ag Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use
US8404217B2 (en) 2000-05-10 2013-03-26 Novartis Ag Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use
DE10029119B4 (de) * 2000-06-14 2005-12-22 Institut für Aerosol Medizin InAMed GmbH Inhalationsvorrichtung
US6339107B1 (en) 2000-08-02 2002-01-15 Syntex (U.S.A.) Llc Methods for treatment of Emphysema using 13-cis retinoic acid
EP1935869A1 (en) 2000-10-02 2008-06-25 F. Hoffmann-La Roche Ag Retinoids for the treatment of emphysema
DE10051858A1 (de) * 2000-10-19 2002-06-06 Guenther Beisel Verwendung von biologisch abbaubaren, substituierten Kohlenwasserstoffen deren Ester, Ether und/oder Amide als Nasensalbe oder Nasentropfen zur Prophylaxe von inhalationsallergischen Reaktionen und zur Pflege der Nasenschleimhaut
AU2002220121A1 (en) * 2000-11-28 2002-06-11 Lorillard Licensing Company, Llc A smoking article including a selective carbon monoxide pump
US6481442B1 (en) 2000-11-28 2002-11-19 Lorillard Licensing Company, Llc Smoking article including a filter for selectively removing carbonyls
US20030216471A1 (en) * 2001-03-07 2003-11-20 Dahl Alan R Retinoid formulations for aerosolization and inhalation
DE10123749A1 (de) 2001-05-16 2002-12-12 Inamed Gmbh Vorrichtung zum Verabreichen von Aerosolen
US7766013B2 (en) 2001-06-05 2010-08-03 Alexza Pharmaceuticals, Inc. Aerosol generating method and device
US7585493B2 (en) 2001-05-24 2009-09-08 Alexza Pharmaceuticals, Inc. Thin-film drug delivery article and method of use
US7645442B2 (en) 2001-05-24 2010-01-12 Alexza Pharmaceuticals, Inc. Rapid-heating drug delivery article and method of use
US20070122353A1 (en) 2001-05-24 2007-05-31 Hale Ron L Drug condensation aerosols and kits
US7458374B2 (en) 2002-05-13 2008-12-02 Alexza Pharmaceuticals, Inc. Method and apparatus for vaporizing a compound
US7090830B2 (en) 2001-05-24 2006-08-15 Alexza Pharmaceuticals, Inc. Drug condensation aerosols and kits
CA2446904A1 (en) 2001-05-24 2003-04-03 Alexza Pharmaceuticals, Inc. Delivery of drug esters through an inhalation route
WO2003026631A1 (en) * 2001-05-24 2003-04-03 Alexza Molecular Delivery Corporation Delivery of drug esters through an inhalation route
ATE540678T1 (de) 2001-06-11 2012-01-15 Xenoport Inc Prodrugs aus gaba-analoga, zusammensetzungen und ihre verwendungen
US8048917B2 (en) 2005-04-06 2011-11-01 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US7186855B2 (en) * 2001-06-11 2007-03-06 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US7232924B2 (en) * 2001-06-11 2007-06-19 Xenoport, Inc. Methods for synthesis of acyloxyalkyl derivatives of GABA analogs
US6818787B2 (en) * 2001-06-11 2004-11-16 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
DE10137017A1 (de) * 2001-07-30 2003-02-20 Basf Ag Kristallisationsverfahren zur Einstellung kleiner Partikel
KR20050042013A (ko) * 2001-10-30 2005-05-04 넥타르 테라퓨틱스 에이엘, 코포레이션 레티노산의 수용성 중합체 콘쥬게이트
JP2005514393A (ja) 2001-12-19 2005-05-19 ネクター セラピューティクス アミノグリコシドの肺への供給
US20030181416A1 (en) * 2002-01-10 2003-09-25 Comper Wayne D. Antimicrobial charged polymers that exhibit resistance to lysosomal degradation during kidney filtration and renal passage, compositions and method of use thereof
US20040009953A1 (en) * 2002-01-10 2004-01-15 Comper Wayne D. Antimicrobial charged polymers that exhibit resistance to lysosomal degradation during kidney filtration and renal passage, compositions and method of use thereof
WO2003077902A1 (en) * 2002-02-19 2003-09-25 Xenoport, Inc. Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof
US20030185762A1 (en) * 2002-03-22 2003-10-02 Cowan Siu Man L. Highly aqueous liquid carrier formulations
US7189865B2 (en) * 2002-07-23 2007-03-13 Attenuon, Llc Thiomolybdate analogues and uses thereof
WO2004009072A2 (en) 2002-07-23 2004-01-29 The Regents Of The University Of Michigan Tetrapropylammonium tetrathiomolybdate and related compounds for anti-angiogenic therapies
CA2494695C (en) * 2002-08-02 2011-04-05 Ab Science 2-(3-aminoaryl)amino-4-aryl-thiazoles and their use as c-kit inhibitors
US8450302B2 (en) * 2002-08-02 2013-05-28 Ab Science 2-(3-aminoaryl) amino-4-aryl-thiazoles and their use as c-kit inhibitors
AU2003270414A1 (en) * 2002-09-06 2004-03-29 Oregon Health And Science University Effect of vitamin a gel on paranasal sinus mucosal regeneration
EP1549141A4 (en) * 2002-09-27 2008-06-25 Bioenvision Inc METHOD AND COMPOSITIONS FOR THE TREATMENT OF AUTOIMMUNE DISEASES USING CLOFARABIN
EP1551386A4 (en) * 2002-09-27 2009-03-25 Bioenvision Inc METHOD AND COMPOSITIONS FOR TREATING LUPUS WITH CLOFARABIN
US20040167212A1 (en) * 2002-10-07 2004-08-26 Bednarski Mark D. X-nitro compounds, pharmaceutical compositions thereof and uses thereof
HRP20050585A2 (en) * 2002-11-25 2006-02-28 Attenuon Peptides which inhibit angiogenesis, cell migration, cell invasion and cell proliferation, compositions and uses thereof
US20040105818A1 (en) 2002-11-26 2004-06-03 Alexza Molecular Delivery Corporation Diuretic aerosols and methods of making and using them
US7913688B2 (en) 2002-11-27 2011-03-29 Alexza Pharmaceuticals, Inc. Inhalation device for producing a drug aerosol
WO2004052360A1 (en) * 2002-12-11 2004-06-24 Xenoport, Inc. Prodrugs of fused gaba analogs, pharmaceutical compositions and uses thereof
ZA200504940B (en) * 2003-01-28 2006-09-27 Xenoport Inc Amino acid derived prodrugs of propofol, compositions and uses thereof
US7034052B2 (en) 2003-03-12 2006-04-25 Celgene Corporation 7-Amido-isoindolyl compounds and their pharmaceutical uses
EP4101846B1 (en) 2003-04-11 2023-08-02 PTC Therapeutics, Inc. 1,2,4-oxadiazole benzoic acid compounds and their use for nonsense suppression and the treatment of disease
EP1625333A1 (en) 2003-05-21 2006-02-15 Alexza Pharmaceuticals, Inc. Self-contained heating unit and drug-supply unit employing same
MXPA05012722A (es) 2003-05-27 2006-05-25 Attenuon Llc Analogos de tiotungstato y sus usos.
US20050009782A1 (en) * 2003-07-09 2005-01-13 Comper Wayne D. Antiviral charged polymers that exhibit resistance to lysosomal degradation during kidney filtration and renal passage, compositions and methods of use thereof
US7230003B2 (en) * 2003-09-09 2007-06-12 Xenoport, Inc. Aromatic prodrugs of propofol, compositions and uses thereof
AU2004274002B2 (en) * 2003-09-17 2011-04-28 Arbor Pharmaceuticals, Llc Treating or preventing restless legs syndrome using prodrugs of GABA analogs
PT1677767E (pt) * 2003-10-14 2011-10-13 Xenoport Inc Forma cristalina de análogo de ácido gama-aminobutírico
EP1684750B1 (en) 2003-10-23 2010-04-28 AB Science 2-aminoaryloxazole compounds as tyrosine kinase inhibitors
AU2004293443A1 (en) 2003-11-19 2005-06-09 Signal Pharmaceuticals, Llc. Indazole Compounds and methods of use thereof as protein kinase inhibitors
WO2005082382A1 (en) * 2004-02-23 2005-09-09 Attenuon Llc Formulations of thiomolybdate or thiotungstate compounds and uses thereof
US7540286B2 (en) 2004-06-03 2009-06-02 Alexza Pharmaceuticals, Inc. Multiple dose condensation aerosol devices and methods of forming condensation aerosols
CA2571407A1 (en) * 2004-07-12 2006-02-16 Xenoport, Inc. Amino acid derived prodrugs of propofol, compositions and uses thereof
WO2006017351A1 (en) * 2004-07-12 2006-02-16 Xenoport, Inc. Prodrugs of propofol, compositions and uses thereof
US20060128676A1 (en) * 2004-07-13 2006-06-15 Pharmacofore, Inc. Compositions of nicotinic agonists and therapeutic agents and methods for treating or preventing diseases or pain
EP2246086A3 (en) 2004-08-12 2012-11-21 Alexza Pharmaceuticals, Inc. Aerosol drug delivery device incorporating percussively activated heating unit
CA2584338C (en) 2004-11-04 2013-08-06 Xenoport, Inc. Gabapentin prodrug sustained release oral dosage forms
CN102504001B (zh) 2004-12-17 2015-02-25 安那迪斯药品股份有限公司 3,5-二取代的和3,5,7-三取代的-3H-噁唑并以及3H-噻唑并[4,5-d]嘧啶-2-酮化合物及其前药
EP1844000B1 (en) * 2004-12-23 2010-01-27 Xenoport, Inc. Serine amino acid derived prodrugs of propofol, compositions, uses and crystalline forms thereof
WO2006079209A1 (en) * 2005-01-26 2006-08-03 The University Of British Columbia Pulmonary compositions comprising a vitamin a compound and a surfactant and uses thereof
EP1846437A1 (en) 2005-02-01 2007-10-24 Attenuon, LLC ACID ADDITION SALTS OF Ac-PHSCN-NH2
WO2006082588A2 (en) * 2005-02-07 2006-08-10 Pharmalight Inc. Method and device for ophthalmic administration of active pharmaceutical ingredients
AU2006231929B2 (en) 2005-04-04 2012-09-06 Ab Science Substituted oxazole derivatives and their use as tyrosine kinase inhibitors
AU2006272922A1 (en) 2005-07-22 2007-02-01 Amgen Inc. Aniline sulfonamide derivatives and their uses
US7507842B2 (en) * 2005-08-12 2009-03-24 Radiorx, Inc. Cyclic nitro compounds, pharmaceutical compositions thereof and uses thereof
US20070135380A1 (en) 2005-08-12 2007-06-14 Radiorx, Inc. O-nitro compounds, pharmaceutical compositions thereof and uses thereof
JP2009530390A (ja) * 2006-03-23 2009-08-27 アムゲン インコーポレイティッド １−フェニルスルホニル−ジアザ複素環アミド化合物およびヒドロキシステロイドデヒドロゲナーゼ調節因子としてのその使用
CA2653741C (en) 2006-05-26 2015-07-07 Thomas E. Jenkins Controlled release of phenolic opioids
TW200808695A (en) * 2006-06-08 2008-02-16 Amgen Inc Benzamide derivatives and uses related thereto
US7659287B2 (en) * 2006-06-08 2010-02-09 Amgen Inc. Benzamide derivatives and uses related thereto
MX2008016518A (es) 2006-06-22 2009-01-19 Anadys Pharmaceuticals Inc Profarmacos de 5-amino-3-(3'-desoxi-beta-d-ribofuranosil)-tiazolo[ 4,5-d]pirimidin-2,7-dion.
JP5306194B2 (ja) 2006-06-22 2013-10-02 アナディス ファーマシューティカルズ インク ピロ［１，２−ｂ］ピリダジノン化合物
WO2008011406A2 (en) 2006-07-18 2008-01-24 Anadys Pharmaceuticals, Inc. Carbonate and carbamate prodrugs of thiazolo [4,5-d] pyrimidines
US7666888B2 (en) * 2006-07-20 2010-02-23 Amgen Inc. Substituted azole aromatic heterocycles as inhibitors of 11β-HSD-1
US8604244B2 (en) 2010-07-02 2013-12-10 Reviva Pharmaceuticals, Inc. Compositions, synthesis, and methods of using cycloalkylmethylamine derivatives
WO2008034142A2 (en) 2006-09-15 2008-03-20 Reviva Pharmaceuticals, Inc. Synthesis, methods of using, and compositions of cycloalkylmethylamines
EP1905422A1 (en) * 2006-09-28 2008-04-02 Johnson & Johnson Consumer France SAS Stabilized compositons containing retinoids and metal oxide pigments
CA2672212A1 (en) 2006-12-11 2008-06-19 Reviva Pharmaceuticals, Inc. Compositions, synthesis, and methods of using indanone based cholinesterase inhibitors
WO2008088540A2 (en) * 2006-12-26 2008-07-24 Amgen Inc. N-cyclohexyl benzamides and benzeneacetamides as inhibitors of 11-beta-hydroxysteroid dehydrogenases
EP2121088B1 (en) 2007-03-09 2016-07-13 Alexza Pharmaceuticals, Inc. Heating unit for use in a drug delivery device
CA2723672C (en) 2007-05-11 2019-09-03 Adynxx, Inc. Gene expression and pain
EP2162135A4 (en) * 2007-05-21 2012-02-22 Reviva Pharmaceuticals Inc COMPOSITIONS, SYNTHESIS AND METHOD FOR THE APPLICATION OF ATTAINED CHINOLINONE-BASED ANTIPSYCHOTICS
US8415390B2 (en) 2008-05-30 2013-04-09 Microdose Therapeutx, Inc. Methods and compositions for administration of oxybutynin
US9119777B2 (en) 2008-05-30 2015-09-01 Microdose Therapeutx, Inc. Methods and compositions for administration of oxybutynin
US7928111B2 (en) * 2007-06-08 2011-04-19 Senomyx, Inc. Compounds including substituted thienopyrimidinone derivatives as ligands for modulating chemosensory receptors
US20080306076A1 (en) * 2007-06-08 2008-12-11 Senomyx, Inc. Modulation of chemosensory receptors and ligands associated therewith
US8633186B2 (en) 2007-06-08 2014-01-21 Senomyx Inc. Modulation of chemosensory receptors and ligands associated therewith
US9603848B2 (en) * 2007-06-08 2017-03-28 Senomyx, Inc. Modulation of chemosensory receptors and ligands associated therewith
DK2194783T3 (en) 2007-08-10 2017-10-02 Vm Discovery Inc COMPOSITIONS AND PROCEDURES FOR APOPTOS MODULATORS
EP2116263A1 (en) 2008-05-05 2009-11-11 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Reversibly light-switchable drug-conjugates
EP2299814A4 (en) * 2008-05-27 2011-06-15 Reviva Pharmaceuticals Inc COMPOSITIONS, SYNTHESIS AND METHOD FOR USE OF ANTIPSYCHOTICS ON PIPERAZINE BASIS
ES2525551T3 (es) 2008-07-31 2014-12-26 Senomyx, Inc. Composiciones que comprenden potenciadores de dulzor y métodos de producirlas
KR101577159B1 (ko) 2008-07-31 2015-12-11 세노믹스, 인코포레이티드 단맛 향상제의 제조 방법 및 중간체
WO2010042834A1 (en) 2008-10-09 2010-04-15 Anadys Pharmaceuticals, Inc. A method of inhibiting hepatitis c virus by combination of a 5,6-dihydro-1h-pyridin-2-one and one or more additional antiviral compounds
HRP20170357T1 (hr) 2008-10-10 2017-05-05 Vm Discovery, Inc. Sastavi i postupci za liječenje poremećaja zbog konzumacije alkohola, bolova i ostalih bolesti
CA2746220A1 (en) 2008-12-08 2010-07-08 Vm Pharma Llc Compositions of protein receptor tyrosine kinase inhibitors
PT2400968T (pt) 2009-02-26 2016-12-09 Reviva Pharmaceuticals Inc Composições, sintese e métodos de utilização dos derivados de arilpiperazína
MX2012008083A (es) 2010-01-12 2012-08-15 Ab Science Inhibidores de triazol y oxazol quinaza.
WO2011092273A1 (en) 2010-01-28 2011-08-04 Ab Science Treatment of gist with masitinib
US8471041B2 (en) * 2010-02-09 2013-06-25 Alliant Techsystems Inc. Methods of synthesizing and isolating N-(bromoacetyl)-3,3-dinitroazetidine and a composition including the same
WO2012021837A2 (en) 2010-08-12 2012-02-16 Senomyx, Inc. Method of improving stability of sweet enhancer and composition containing stabilized sweet enhancer
US20120321590A1 (en) 2011-04-06 2012-12-20 Anadys Pharmaceuticals, Inc. Bridged polycyclic compounds
EP2736904B1 (en) 2011-07-27 2016-03-16 AB Science Oxazole and thiazole derivatives as selective protein kinase inhibitors (c-kit)
US8664247B2 (en) 2011-08-26 2014-03-04 Radiorx, Inc. Acyclic organonitro compounds for use in treating cancer
CA2850723C (en) 2011-10-07 2019-07-09 Radiorx, Inc. Organonitro thioether compounds and medical uses thereof
US20140308260A1 (en) 2011-10-07 2014-10-16 Radiorx, Inc. Methods and compositions comprising a nitrite-reductase promoter for treatment of medical disorders and preservation of blood products
RU2642074C2 (ru) 2011-12-30 2018-01-24 Ревива Фармасьютикалс, Инк. Композиции, синтез и способы применения производных фенилциклоалкилметиламина
PE20191204A1 (es) 2012-08-06 2019-09-10 Firmenich Incorporated Modificador del sabor dulce
JO3155B1 (ar) 2013-02-19 2017-09-20 Senomyx Inc معدِّل نكهة حلوة
EP2970188A4 (en) 2013-03-15 2016-10-19 Vm Therapeutics Llc NOVEL CRYSTALLINE FORMS
US8999992B2 (en) 2013-03-15 2015-04-07 Vm Pharma Llc Crystalline forms of tryosine kinase inhibitors and their salts
WO2014178892A1 (en) 2013-05-03 2014-11-06 Scanlan Thomas S Use of sobetirome in the treatment of x-linked adrenolenoleukodystrophy
WO2014195032A1 (en) 2013-06-07 2014-12-11 Medical Prognosis Institute A/S Methods and devices for predicting treatment efficacy of fulvestrant in cancer patients
US9346788B2 (en) 2014-02-05 2016-05-24 VM Oncology, LLC TrkA receptor tyrosine kinase antagonists and uses thereof
EP3104712B1 (en) 2014-02-12 2020-05-06 Firmenich Incorporated Improved process for the synthesis of substituted 1-benzyl-3-(1-(isoxazol-4-ylmethyl)-1h-pyrazol-4-yl)imidazolidine-2,4-diones
CN106414433A (zh) 2014-03-24 2017-02-15 Ab科学有限公司 作为脾酪氨酸激酶抑制剂的二氮杂螺烷酮取代的噁唑衍生物
GB2525626A (en) * 2014-04-29 2015-11-04 Alexander Francois Robert Templet Composition and method for inhalable nutritional element
US10336768B2 (en) 2014-06-13 2019-07-02 Yuma Therapeutics, Inc. Pyrimidine compounds and methods using the same
JP6705807B2 (ja) 2014-08-15 2020-06-03 エーダイニクス インコーポレイテッド 疼痛を治療するためのオリゴヌクレオチドデコイ
US10301271B2 (en) 2014-09-17 2019-05-28 Purdue Pharma L.P. Crystalline forms of tyrosine kinase inhibitors and their salts
CN107206007B (zh) 2015-01-12 2021-08-10 雷维瓦药品公司 用于治疗肺高血压的方法
CN107249592A (zh) 2015-01-12 2017-10-13 雷维瓦药品公司 用于治疗阿尔茨海默病的方法
ES2796276T3 (es) 2015-02-05 2020-11-26 Ab Science Compuestos con actividad antitumoral
EP3144307A1 (en) 2015-09-18 2017-03-22 AB Science Novel oxazole derivatives that inhibit syk
MX389514B (es) 2015-10-01 2025-03-20 Firmenich Incorporated Compuestos útiles como moduladores de canal receptor 8 de potencial transitorio de melastatina (trpm8).
JP2018534269A (ja) 2015-10-01 2018-11-22 エリージウム セラピューティクス， インコーポレイテッド 過剰摂取および乱用に抵抗性のポリサブユニットオピオイドプロドラッグ
US10335406B2 (en) 2015-10-01 2019-07-02 Elysium Therapeutics, Inc. Opioid compositions resistant to overdose and abuse
US10342778B1 (en) 2015-10-20 2019-07-09 Epicentrx, Inc. Treatment of brain metastases using organonitro compound combination therapy
US9987270B1 (en) 2015-10-29 2018-06-05 Epicentrix, Inc. Treatment of gliomas using organonitro compound combination therapy
CN109069420A (zh) 2016-01-11 2018-12-21 埃皮辛特瑞柯斯公司 2-溴-1-(3，3-二硝基氮杂环丁烷-1-基)乙酮静脉施用的组合物和方法
SG11201903312VA (en) 2016-10-14 2019-05-30 Epicentrix Inc Sulfoxyalkyl organonitro and related compounds and pharmaceutical compositions for use in medicine
EP3582791A4 (en) 2017-02-20 2021-03-31 The Board of Supervisors of Louisiana State University and Agricultural and Mechanical College HYDROGEN SULPHIDE AND / OR NITRITE IN THE TREATMENT AND PREVENTION OF ATRIAL FIBRILLATION
EP3595663A4 (en) 2017-03-17 2021-01-13 Elysium Therapeutics, Inc. MULTIPLE SUBUNITY OPIOID PRODRUGS WITH RESISTANCE TO OVERDOSE AND ABUSE
EP3634430B1 (en) 2017-06-05 2024-08-07 Flagship Pioneering Innovations V, Inc. Multibiotic agents and methods of using the same
EP3648740A1 (en) 2017-07-07 2020-05-13 EpicentRx, Inc. Compositions for parenteral administration of therapeutic agents
ES3057193T3 (en) 2017-12-28 2026-02-26 Reviva Pharmaceuticals Inc Arylpiperazine compound for use to treat pulmonary fibrosis
WO2019164593A2 (en) 2018-01-08 2019-08-29 Epicentrx, Inc. Methods and compositions utilizing rrx-001 combination therapy for radioprotection
EP3746138B1 (en) 2018-02-02 2025-12-10 Alexza Pharmaceuticals, Inc. Electrical condensation aerosol device
US10933084B2 (en) 2018-04-12 2021-03-02 MatRx Therapeutics Corporation Compositions and methods for treating elastic fiber breakdown
CN112424158A (zh) 2018-05-14 2021-02-26 昌郁医药公司 萘普生和普瑞巴林的1-(酰氧基)-烷基氨基甲酸酯药物缀合物的结晶形式
JP7453210B2 (ja) 2018-08-07 2024-03-19 フィルメニッヒ インコーポレイテッド ５－置換４－アミノ－１Ｈ－ベンゾ［ｃ］［１，２，６］チアジアジン２，２－ジオキシド並びにその配合物及び使用
AU2019392784A1 (en) 2018-12-06 2021-06-10 Flagship Pioneering Innovations V, Inc. Monomethyl fumarate-carrier conjugates and methods of their use
BR112022009331A2 (pt) 2019-11-13 2022-08-09 Rapt Therapeutics Inc Formas cristalinas do receptor de quimiocina c c antagonista tipo 4 e usos das mesmas
US12280058B2 (en) 2020-03-12 2025-04-22 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Gasotransmitter metabolites and Alzheimer's disease
US20230157975A1 (en) * 2020-04-20 2023-05-25 Regenall Limited Treatment of pulmonary fibrosis
CA3185481A1 (en) * 2020-06-01 2021-12-09 Advent Therapeutics, Inc. Pharmaceutical compositions comprising insoluble active ingredients
CN116568279A (zh) * 2020-06-01 2023-08-08 艾德文治疗公司 包含不溶性活性成分的药物组合物
WO2021247963A1 (en) 2020-06-05 2021-12-09 Senda Biosciences, Inc. (s)-alpha-fluoromethyltyrosine as decarboxylase inhibitors for use in the treatment of hypotension
EP4472947A1 (en) 2022-03-07 2024-12-11 Firmenich Incorporated Sweetener compositions
JP2025507547A (ja) 2022-03-10 2025-03-21 フイルメニツヒ ソシエテ アノニム 甘味料組成物
WO2023178283A1 (en) 2022-03-18 2023-09-21 Epicentrx, Inc. Co-crystals of 2-bromo-1-(3,3-dinitroazetidin-1-yl)ethanone and methods
JP2025510598A (ja) 2022-04-11 2025-04-15 フイルメニツヒ ソシエテ アノニム 甘味料組成物
US20260078376A1 (en) 2022-08-26 2026-03-19 Core Biotherapeutics, Inc. Oligonucleotides for the treatment of breast cancer
US20250034115A1 (en) 2023-07-12 2025-01-30 Rapt Therapeutics, Inc. Crystalline forms of c-c chemokine receptor type 4 antagonist and uses thereof

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1617394A1 (de) * 1966-06-30 1971-05-19 Colgate Palmolive Co Aerosol-Hautpflegemittel
US3584115A (en) * 1968-05-31 1971-06-08 Arthur Ira Gebhart Method of applying visible aerosol compositions
US3957966A (en) * 1972-05-19 1976-05-18 Gaf Corporation Stabilized vitamin food coatings
ZA763131B (en) * 1975-05-27 1978-01-25 Syntex Inc Use of flunisolide to treat respiratory diseases
US4124707A (en) * 1976-12-22 1978-11-07 Schering Corporation 7α-Halogeno-3,20-dioxo-1,4-pregnadienes, methods for their manufacture, their use as anti-inflammatory agents, and pharmaceutical formulations useful therefor
DE2843884A1 (de) * 1978-10-07 1980-04-24 Basf Ag Mittel, enthaltend 2-(retinyliden)- malonsaeurederivate
JPS5579319A (en) * 1978-12-07 1980-06-14 Shiyaaman Baaton Method of introducing vitamine a analogue to respiratory tract of smoker
US4241048A (en) * 1979-05-01 1980-12-23 Bristol-Myers Company Suspension composition of benzocaine
US4267173A (en) * 1979-11-05 1981-05-12 Schering Corporation Use of 6β-fluoro-7α-halogenocorticoids as topical anti-inflammatories and pharmaceutical formulations useful therefor
US4614747A (en) * 1983-07-29 1986-09-30 Usv Pharmaceutical Corp. Derivatives of alpha-alkyl polyolefinic carboxylic acid useful in the treatment of psoriasis
JPS60161924A (ja) * 1984-02-01 1985-08-23 Fujisawa Pharmaceut Co Ltd 肺吸収用組成物
US4525341A (en) * 1984-04-09 1985-06-25 Mayor Pharmaceutical Laboratories, Inc. Method of administering vitamins
DE3443627A1 (de) * 1984-11-29 1986-05-28 USV Pharmaceutical Corp., Tuckahoe, N.Y. Polyolefinische (alpha)-alkylcarbonsaeuren und deren derivate, sowie diese verbindungen enthaltende arzneimittel
US4826871A (en) * 1985-03-13 1989-05-02 Gressel Philip D Topical ophthalmic compositions containing one or more retinoids
DE3815221C2 (de) * 1988-05-04 1995-06-29 Gradinger F Hermes Pharma Verwendung einer Retinol- und/oder Retinsäureester enthaltenden pharmazeutischen Zubereitung zur Inhalation zur Einwirkung auf die Schleimhäute des Tracheo-Bronchialtraktes einschließlich der Lungenalveolen

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JPH0256419A (ja) 1990-02-26
US5556611A (en) 1996-09-17
DE3815221C2 (de) 1995-06-29
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US5112598A (en) 1992-05-12
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DE3815221A1 (de) 1989-11-23

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