ES2062017T3 - Acidos y esteres quinolon-carboxilicos amino-sustituidos y azabiciclo puenteados. - Google Patents

Acidos y esteres quinolon-carboxilicos amino-sustituidos y azabiciclo puenteados.

Info

Publication number
ES2062017T3
ES2062017T3 ES89308478T ES89308478T ES2062017T3 ES 2062017 T3 ES2062017 T3 ES 2062017T3 ES 89308478 T ES89308478 T ES 89308478T ES 89308478 T ES89308478 T ES 89308478T ES 2062017 T3 ES2062017 T3 ES 2062017T3
Authority
ES
Spain
Prior art keywords
azabiciclo
quinolon
bridged
esters
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89308478T
Other languages
English (en)
Inventor
Edward Fox Kleinman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PFIZER
Pfizer Inc
Original Assignee
PFIZER
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PFIZER, Pfizer Inc filed Critical PFIZER
Application granted granted Critical
Publication of ES2062017T3 publication Critical patent/ES2062017T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/06—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing isoquinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Catalysts (AREA)

Abstract

COMPUESTOS DE FORMULA (I), DONDE R1 ES H, ALQUILO C1-C6 O UN CATION FARMACEUTICAMENTE ACEPTABLE; Y ES CICLOPROPILO, ETILO O P-FLUOROFENILO; Y X ES H O FLUOR; O X E Y JUNTOS FORMAN UN GRUPO DE FORMULA: (FIG. A) O (FIG. B); Y R2 ES UN GRUPO DE FORMULA: (FIG. C), DONDE R3 ES H O ALQUILO C1-C4; O UNA DE SUS SALES FARMACEUTICAMENTE ACEPTABLES, TIENEN PROPIEDADES ANTIBACTERIANAS.
ES89308478T 1988-08-23 1989-08-22 Acidos y esteres quinolon-carboxilicos amino-sustituidos y azabiciclo puenteados. Expired - Lifetime ES2062017T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1988/002908 WO1990002123A1 (en) 1988-08-23 1988-08-23 Amino-substituted bridged azabicyclic quinolone carboxylic acids and esters

Publications (1)

Publication Number Publication Date
ES2062017T3 true ES2062017T3 (es) 1994-12-16

Family

ID=22208868

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89308478T Expired - Lifetime ES2062017T3 (es) 1988-08-23 1989-08-22 Acidos y esteres quinolon-carboxilicos amino-sustituidos y azabiciclo puenteados.

Country Status (18)

Country Link
EP (1) EP0356193B1 (es)
JP (1) JPH0637495B2 (es)
KR (1) KR910007238B1 (es)
AT (1) ATE101609T1 (es)
AU (1) AU605434B2 (es)
CA (1) CA1334413C (es)
DE (1) DE68913099T2 (es)
DK (1) DK411989A (es)
ES (1) ES2062017T3 (es)
FI (1) FI97386C (es)
IE (1) IE61370B1 (es)
IL (1) IL91331A0 (es)
MY (1) MY107389A (es)
NO (1) NO901764L (es)
NZ (1) NZ230374A (es)
PT (1) PT91498B (es)
WO (1) WO1990002123A1 (es)
ZA (1) ZA896395B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04315332A (ja) * 1991-04-15 1992-11-06 Hitachi Ltd 誤り訂正装置
US5527910A (en) * 1992-12-30 1996-06-18 Cheil Foods & Chemicals, Inc. Pyridone carboxylic acid compounds and their uses for treating infectious diseases caused by bacteria

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3227055A1 (de) * 1982-07-20 1984-01-26 Hoechst Ag, 6230 Frankfurt Neue derivate der 2-aza-bicyclo(2.2.2)octan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie 2-aza-bicyclo(2.2.2)octan-3-carbonsaeure als zwischenstufe und verfahren zu deren herstellung
IE55898B1 (en) * 1982-09-09 1991-02-14 Warner Lambert Co Antibacterial agents
US4571396A (en) * 1984-04-16 1986-02-18 Warner-Lambert Company Antibacterial agents
IE58742B1 (en) * 1984-07-20 1993-11-05 Warner Lambert Co Substituted-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7h-pyrido[1,2,3-de] [1,4]benzoxauine-6-carboxylic acids; sibstituted-5-amino-6-6fluoro-4-oxo.1,4-dihydroquinoline-3 carboxylic acids; substituted-5-amino-6-fluoro-1,4-dihydro-4-oxo-1.8-naphthyridine-3-carboxylic acids; derivatives thereof; pharmaceutical compositions comprising the compounds; and processes for producing the compounds
IN166416B (es) * 1985-09-18 1990-05-05 Pfizer
JPH089597B2 (ja) * 1986-01-21 1996-01-31 杏林製薬株式会社 選択毒性に優れた８‐アルコキシキノロンカルボン酸およびその塩並びにその製造方法
US4803205A (en) * 1987-08-07 1989-02-07 Warner-Lambert Company Quinolones as antibacterial agents

Also Published As

Publication number Publication date
DK411989A (da) 1990-02-24
PT91498A (pt) 1990-03-08
DE68913099D1 (de) 1994-03-24
NO901764L (no) 1990-06-08
IL91331A0 (en) 1990-03-19
IE892683L (en) 1990-02-23
JPH0291072A (ja) 1990-03-30
AU605434B2 (en) 1991-01-10
CA1334413C (en) 1995-02-14
FI97386B (fi) 1996-08-30
AU4011489A (en) 1990-05-03
EP0356193B1 (en) 1994-02-16
DE68913099T2 (de) 1994-05-26
EP0356193A3 (en) 1990-12-27
NZ230374A (en) 1991-07-26
EP0356193A2 (en) 1990-02-28
PT91498B (pt) 1995-05-04
IE61370B1 (en) 1994-11-02
KR900003128A (ko) 1990-03-23
DK411989D0 (da) 1989-08-22
WO1990002123A1 (en) 1990-03-08
ZA896395B (en) 1991-04-24
KR910007238B1 (ko) 1991-09-24
NO901764D0 (no) 1990-04-20
FI901994A0 (fi) 1990-04-20
JPH0637495B2 (ja) 1994-05-18
MY107389A (en) 1995-11-30
FI97386C (fi) 1996-12-10
ATE101609T1 (de) 1994-03-15

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