ES2062092T3 - Nuevo uso de imidazo(2,1-a)isoquinoleinas substituidas con heteroarilo en 5 o con arilo en 5. - Google Patents

Nuevo uso de imidazo(2,1-a)isoquinoleinas substituidas con heteroarilo en 5 o con arilo en 5.

Info

Publication number
ES2062092T3
ES2062092T3 ES89810565T ES89810565T ES2062092T3 ES 2062092 T3 ES2062092 T3 ES 2062092T3 ES 89810565 T ES89810565 T ES 89810565T ES 89810565 T ES89810565 T ES 89810565T ES 2062092 T3 ES2062092 T3 ES 2062092T3
Authority
ES
Spain
Prior art keywords
isoquinoleinas
heteroarilo
arilo
imidazo
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89810565T
Other languages
English (en)
Inventor
William Joseph Houlihan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Application granted granted Critical
Publication of ES2062092T3 publication Critical patent/ES2062092T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)

Abstract

COMPUESTOS DE FORMULA (I), DONDE LOS SUSTITUYENTES TIENEN VARIOS SIGNIFICADOS, SON INDICADOS PARA USAR EN CONTROL DE VIAS DE VENTILACION INDUCIDAS POR PAF O ALERGENO Y EN EL TRATAMIENTO PROFILACTICO DE ASMA. UN MODO PREFERIDO DE ADMINISTRACION ES POR INHALACION.
ES89810565T 1988-07-29 1989-07-25 Nuevo uso de imidazo(2,1-a)isoquinoleinas substituidas con heteroarilo en 5 o con arilo en 5. Expired - Lifetime ES2062092T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22630588A 1988-07-29 1988-07-29
US07/302,720 US4910206A (en) 1986-07-14 1989-01-27 5-hetero-or aryl-substituted-imidazo(2,1-a)isoquinolines and their use as PAF receptor antagonists

Publications (1)

Publication Number Publication Date
ES2062092T3 true ES2062092T3 (es) 1994-12-16

Family

ID=26920416

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89810565T Expired - Lifetime ES2062092T3 (es) 1988-07-29 1989-07-25 Nuevo uso de imidazo(2,1-a)isoquinoleinas substituidas con heteroarilo en 5 o con arilo en 5.

Country Status (16)

Country Link
US (1) US4910206A (es)
EP (1) EP0357550B1 (es)
JP (1) JPH0273016A (es)
KR (1) KR910002445A (es)
AU (1) AU632487B2 (es)
CA (1) CA1336503C (es)
DE (1) DE68913397T2 (es)
DK (1) DK372089A (es)
ES (1) ES2062092T3 (es)
FI (1) FI893616L (es)
HU (1) HU206040B (es)
IE (1) IE63243B1 (es)
IL (1) IL91128A (es)
NO (1) NO177485C (es)
NZ (1) NZ230098A (es)
PT (1) PT91302B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0345931B1 (en) * 1988-04-27 1993-01-20 Schering Corporation Certain paf antagonist/antihistamine combinations and methods
US5530141A (en) * 1992-03-04 1996-06-25 Center For Innovative Technology 2,4-diaryl-1,3-dithiolanes; 2,4-diaryl-1,3-dioxolanes; 2,4-diaryl-1,3-oxathiolanes; and 2,5-diaryl-1,3-oxathiolanes for the treatment of disorders mediated by platelet activating factor or products of 5-lipoxygenase
US5639782A (en) * 1992-03-04 1997-06-17 Center For Innovative Technology Neolignan derivatives as platelet activating factor receptor antagonists and 5-lipoxygenase inhibitors
US5648486A (en) * 1992-07-13 1997-07-15 Cytomed, Inc. Compounds and methods for the treatment of inflammatory and immune disorders
US5463083A (en) 1992-07-13 1995-10-31 Cytomed, Inc. Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
US5358938A (en) * 1992-07-13 1994-10-25 Cytomed, Inc. Compounds and methods for the treatment of disorders mediated by platelet activating factor or products of 5-lipoxygenase
JPH08502243A (ja) 1992-07-13 1996-03-12 サイトメッド，インコーポレイテッド 炎症性および免疫性疾患の治療のための２，５‐ジアリールテトラヒドロ‐チオフェン、‐フランおよび類似体
US5434151A (en) * 1992-08-24 1995-07-18 Cytomed, Inc. Compounds and methods for the treatment of disorders mediated by platelet activating factor or products of 5-lipoxygenase
US5703093A (en) * 1995-05-31 1997-12-30 Cytomed, Inc. Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
US5750565A (en) 1995-05-25 1998-05-12 Cytomed, Inc. Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
US5792776A (en) * 1994-06-27 1998-08-11 Cytomed, Inc., Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
FR2756560A1 (fr) * 1996-12-04 1998-06-05 Adir Nouveaux derives de l'imidazoline, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CN1076728C (zh) * 1999-02-05 2001-12-26 浙江大学 2－芳基咪唑并[2,1－a]异喹啉的衍生物及其用途
WO2021057696A1 (zh) * 2019-09-27 2021-04-01 隆泰申医药科技(南京)有限公司 一种杂芳基类化合物及其应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4101553A (en) * 1974-01-02 1978-07-18 Sandoz, Inc. Imidazo[2,1-a]isoquinolines
HU172649B (hu) * 1975-04-24 1978-11-28 Gyogyszerkutato Intezet Sposob poluchenija novykh biologicheski aktivnykh lizergamidov
EP0258175B1 (en) * 1986-07-14 1992-04-01 Sandoz Ag 5-hetero- or aryl-substituted-imidazo[2,1-a]isoquinolines

Also Published As

Publication number Publication date
AU3901789A (en) 1990-02-01
FI893616A7 (fi) 1990-01-30
DE68913397T2 (de) 1994-08-11
IL91128A (en) 1996-01-31
IE63243B1 (en) 1995-04-05
KR910002445A (ko) 1991-02-25
IL91128A0 (en) 1990-03-19
DK372089D0 (da) 1989-07-27
HUT50630A (en) 1990-03-28
PT91302B (pt) 1995-03-01
CA1336503C (en) 1995-08-01
NZ230098A (en) 1992-02-25
NO177485C (no) 1995-09-27
DK372089A (da) 1990-01-30
IE892459L (en) 1990-01-29
DE68913397D1 (de) 1994-04-07
PT91302A (pt) 1990-02-08
JPH0273016A (ja) 1990-03-13
NO893062L (no) 1990-01-30
US4910206A (en) 1990-03-20
EP0357550A2 (en) 1990-03-07
AU632487B2 (en) 1993-01-07
EP0357550B1 (en) 1994-03-02
FI893616A0 (fi) 1989-07-28
NO893062D0 (no) 1989-07-27
FI893616L (fi) 1990-01-30
HU206040B (en) 1992-08-28
EP0357550A3 (en) 1991-04-03
NO177485B (no) 1995-06-19

Similar Documents

Publication Publication Date Title
ES2148476T3 (es) Derivados de azabicicloalcano n-substituidos como neurolepticos asf.
ES2056214T3 (es) Compuestos de benzopirido-piperidina, -piperidilideno y -piperazina, composiciones, metodos de preparacion y metodos de uso.
ES2184797T3 (es) Uso de antagonistas de serotonina (5ht3) para el tratamiento de la fibromialgia.
ES2149276T3 (es) Imidazo(4,5-c)piridin-4-aminas.
GR3036675T3 (en) Piperazino derivatives as neurokinin antagonists
ES2040838T3 (es) Compuestos piperazinil-heterociclicos.
ES2150496T3 (es) Cicloalquilimidazopiridinas condensadas.
ES2182863T3 (es) Ranolazina y piperazinas relacionadas para proteger musculos esqueleticos.
TR200000151T2 (tr) Yeni bileşimler.
ES2150989T3 (es) Nuevos derivados de quinoxalinadiona, su preparacion y empleo en medicamentos.
ES2152414T3 (es) Dihidrobenzofuranos.
MY106964A (en) Fused polycyclic compounds, compositions, methods of manufacture, and their use as paf antagonists, antihistamines and/or antiinflammatory agents.
ES2158452T3 (es) Uso de agonistas y antagonistas de estrogenos en la fabricacion de un medicamento para el tratamiento de la ateroesclerosis, independientemente de la disminucion de lipidos.
FI920023A0 (fi) Heteroarylpiperazinfoereningar som antipsykotiska aemnen.
ES2134777T3 (es) Nuevos compuestos de sulfonilo.
IL87421A (en) Pharmaceutical compositions containing 5-amino (or substituted amino) - 1,2,3-triazoles
FI902846A7 (fi) Uusia 2,5-diaryyli-tetrahydrofuraaneja ja niiden analogeja PAF-antagonisteina
ES2177656T3 (es) Derivados de antraciclinona y su utilizacion en el tratamiento de la amiloidosis.
GR3019508T3 (en) Derivatives of 2-aminopyrimidine-4-carboxamide, their preparation and therapeutic use
ES2058191T3 (es) Acidos 2-fenil-4-quinolincarboxilicos substituidos.
DE69629023D1 (de) Piperazino-derivative als neurokininantagonisten
AU4080097A (en) Piperazino derivatives as neurokinin antagonists
FR2680172B1 (fr) Nouvelles piperazinylalcoyl-3 dihydro-2,3 4h-benzoxazine-1,3 ones-4 substituees, leur preparation et leur application en therapeutique.
EP0357550A3 (en) New use of 5-heteroaryl- or 5-aryl-substituted imidazo [2,1-a] isoquinolines
DE58905079D1 (de) Neue alpha-aminocarbonsaeure-derivate, ihre herstellung und verwendung.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 357550

Country of ref document: ES