ES2062700T3 - Procedimiento para la preparacion de medicamentos en forma de perlas. - Google Patents

Procedimiento para la preparacion de medicamentos en forma de perlas.

Info

Publication number
ES2062700T3
ES2062700T3 ES91400106T ES91400106T ES2062700T3 ES 2062700 T3 ES2062700 T3 ES 2062700T3 ES 91400106 T ES91400106 T ES 91400106T ES 91400106 T ES91400106 T ES 91400106T ES 2062700 T3 ES2062700 T3 ES 2062700T3
Authority
ES
Spain
Prior art keywords
pearls
medicines
procedure
preparation
giro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91400106T
Other languages
English (en)
Inventor
Michel Deleuil
Pierre Labourt-Ibarre
Robert Rona
Eraclis Statiotis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Rhone Poulenc Rorer SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer SA filed Critical Rhone Poulenc Rorer SA
Application granted granted Critical
Publication of ES2062700T3 publication Critical patent/ES2062700T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Farming Of Fish And Shellfish (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Keying Circuit Devices (AREA)
  • Air Bags (AREA)
  • Measurement Of Force In General (AREA)

Abstract

PROCESO DE PREPARACION DE PERLAS A BASE DE UN PRINCIPIO ACTIVO FARMACEUTICO, PRESENTANDO UN PUNTO DE CRISTALIZACION NO DEFINIDO. SE MEZCLA BAJO FORMA FUNDIDA O DEGRADADA DICHO PRINCIPIO ACTIVO CON UN EXCIPIENTE FARMACEUTICO FAVORECIENDO LA SOLIDIFICACION DEL PRINCIPIO ACTIVO, SE FUERZA EL PASAJE DE LA MASA FUNDIDA A TRAVES DE UNA BOQUILLA QUE SUFRE UNA VIBRACION, SE DEJA CAER EN UN GIRO A CONTRA CORRIENTE CON UN GAS A LAS PERLAS FORMADAS QUE SE REUNEN EN LA PARTE BAJA DEL GIRO.
ES91400106T 1990-01-19 1991-01-18 Procedimiento para la preparacion de medicamentos en forma de perlas. Expired - Lifetime ES2062700T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR909000623A FR2657257B1 (fr) 1990-01-19 1990-01-19 Procede de preparation de medicaments sous forme de perles.

Publications (1)

Publication Number Publication Date
ES2062700T3 true ES2062700T3 (es) 1994-12-16

Family

ID=9392948

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91400106T Expired - Lifetime ES2062700T3 (es) 1990-01-19 1991-01-18 Procedimiento para la preparacion de medicamentos en forma de perlas.

Country Status (29)

Country Link
US (2) US5188838A (es)
EP (1) EP0438359B1 (es)
JP (1) JP3310305B2 (es)
KR (1) KR0163050B1 (es)
CN (1) CN1054189A (es)
AT (1) ATE103489T1 (es)
AU (1) AU651566B2 (es)
BG (1) BG60899B1 (es)
CA (1) CA2034413A1 (es)
CZ (1) CZ279869B6 (es)
DE (1) DE69101493T2 (es)
DK (1) DK0438359T3 (es)
ES (1) ES2062700T3 (es)
FI (1) FI102590B1 (es)
FR (1) FR2657257B1 (es)
HU (1) HU211076B (es)
IE (1) IE65102B1 (es)
IL (1) IL96984A (es)
LV (1) LV10039B (es)
NO (1) NO180516C (es)
NZ (1) NZ236820A (es)
PL (1) PL165719B1 (es)
PT (1) PT96526B (es)
RO (1) RO108646B1 (es)
RU (1) RU1837872C (es)
SK (1) SK278757B6 (es)
TW (1) TW327131B (es)
YU (1) YU7691A (es)
ZA (1) ZA91376B (es)

Families Citing this family (51)

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DE4131562A1 (de) * 1991-09-18 1993-03-25 Medac Klinische Spezialpraep Arzneistofftraeger aus festen lipidteilchen-feste lipidnanosphaeren (sln)
HUT75616A (en) * 1992-03-17 1997-05-28 Pfizer Method for prooucing porous delivery devices
DE4244466C2 (de) * 1992-12-24 1995-02-23 Pharmatech Gmbh Verfahren zur Herstellung von Pseudolatices und Mikro- oder Nanopartikeln und deren Verwendung zur Herstellung von pharmazeutischen Präparaten
FR2702968B1 (fr) * 1993-03-23 1995-06-23 Lafon Labor Procédé de préparation de particules renfermant un ingrédient actif par extrusion et lyophilisation .
US5843347A (en) * 1993-03-23 1998-12-01 Laboratoire L. Lafon Extrusion and freeze-drying method for preparing particles containing an active ingredient
US5455045A (en) * 1993-05-13 1995-10-03 Syntex (U.S.A.) Inc. High dose formulations
CA2163860A1 (en) * 1993-06-30 1995-01-12 Chung C. Hsu Method for preparing liposomes
FR2707184B1 (fr) * 1993-07-08 1995-08-11 Rhone Poulenc Nutrition Animal Procédé de préparation de sphérules contenant un principe actif alimentaire ou pharmaceutique.
FR2710500B1 (fr) * 1993-09-27 1995-12-01 Virbac Laboratoires Composition et système à administration orale pour animaux, leur procédé de préparation et leurs applications.
MX9603480A (es) * 1994-02-16 1997-12-31 Abbott Lab Procedimiento para preparar formulaciones farmaceuticas en particulas finas.
FR2720631B1 (fr) * 1994-06-03 1996-07-12 Rhone Poulenc Rorer Sa Procédé de préparation et perles obtenues contenant un principe actif présentant un point de fusion non défini.
IT1274879B (it) * 1994-08-03 1997-07-25 Saitec Srl Apparecchio e metodo per preparare forme farmaceutiche solide a rilascio controllato del principio attivo.
FR2732621B1 (fr) * 1995-04-10 1997-06-06 Rhone Poulenc Chimie Perles d'un produit presentant le phenomene de surfusion et leur procede d'obtention
FR2754177B1 (fr) * 1996-10-07 1999-08-06 Sanofi Sa Microspheres pharmaceutiques d'acide valproique pour administration orale
US6171615B1 (en) 1998-07-06 2001-01-09 Gattefoss{acute over (e)} Sustained release theophylline formulations, excipient systems and methods of production
DE19845126A1 (de) * 1998-09-30 2000-04-06 Marco Systemanalyse Entw Verfahren zur Tropfenbildung
DE19848849A1 (de) * 1998-10-22 2000-04-27 Knoll Ag Verfahren zur Herstellung von festen, sphärischen Formen, enthaltend eine biologisch aktive Substanz
ES2246238T3 (es) * 1999-06-07 2006-02-16 Altana Pharma Ag Nueva preparacion y forma de administracion que comprende un inhibidor de las bombas de protones labil en medio acido.
DE19952790A1 (de) * 1999-11-03 2001-05-17 Cognis Deutschland Gmbh Verfahren zur Herstellung von Fettstoffgranulaten
DE10009996B4 (de) * 2000-03-02 2005-10-13 Cognis Ip Management Gmbh Feststoffgranulate mit monodisperser Korngrößenverteilung, ein Verfahren zu ihrer Herstellung sowie ihre Verwendung
FR2806307B1 (fr) * 2000-03-20 2002-11-15 Mane Fils V Preparation parfumee solide sous forme de microbilles et utilisation de ladite preparation
DE10019508A1 (de) * 2000-04-19 2001-10-31 Rieter Automatik Gmbh Verfahren und Vorrichtung zur Vertropfung von Vorprodukten thermoplastischer Polyester oder Copolyester
DE10022810A1 (de) * 2000-05-10 2001-11-22 Cognis Deutschland Gmbh Granulierte Kunststoffhilfsmittel mit monodisperser Korngrößenverteilung
UA80393C2 (uk) * 2000-12-07 2007-09-25 Алтана Фарма Аг Фармацевтична композиція, яка містить інгібітор фде 4, диспергований в матриці
DE10124916A1 (de) * 2001-05-22 2002-11-28 Cognis Deutschland Gmbh Kugelförmige Lackadditive, deren Herstellung und Verwendung
US20190328679A1 (en) 2001-10-12 2019-10-31 Aquestive Therapeutics, Inc. Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions
US7357891B2 (en) 2001-10-12 2008-04-15 Monosol Rx, Llc Process for making an ingestible film
US10285910B2 (en) 2001-10-12 2019-05-14 Aquestive Therapeutics, Inc. Sublingual and buccal film compositions
US8603514B2 (en) 2002-04-11 2013-12-10 Monosol Rx, Llc Uniform films for rapid dissolve dosage form incorporating taste-masking compositions
US8765167B2 (en) 2001-10-12 2014-07-01 Monosol Rx, Llc Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions
US20070281003A1 (en) 2001-10-12 2007-12-06 Fuisz Richard C Polymer-Based Films and Drug Delivery Systems Made Therefrom
US8900497B2 (en) 2001-10-12 2014-12-02 Monosol Rx, Llc Process for making a film having a substantially uniform distribution of components
US11207805B2 (en) 2001-10-12 2021-12-28 Aquestive Therapeutics, Inc. Process for manufacturing a resulting pharmaceutical film
US20110033542A1 (en) 2009-08-07 2011-02-10 Monosol Rx, Llc Sublingual and buccal film compositions
US8900498B2 (en) 2001-10-12 2014-12-02 Monosol Rx, Llc Process for manufacturing a resulting multi-layer pharmaceutical film
MY140561A (en) 2002-02-20 2009-12-31 Nycomed Gmbh Dosage form containing pde 4 inhibitor as active ingredient
KR100995486B1 (ko) * 2002-09-28 2010-11-22 맥네일-피피씨, 인코포레이티드 개구가 있는 쉘을 포함하는 속방성 투여형
FR2848855B1 (fr) * 2002-12-23 2005-02-11 Aventis Pharma Sa Compositions pour administration orale de principes actifs necessitant un masquage du gout
US20040146553A1 (en) 2002-12-23 2004-07-29 Aventis Pharma S.A. Compositions for oral administration of active principles requiring masking of taste
ES2335498T3 (es) 2003-03-10 2010-03-29 Nycomed Gmbh Nuevo proceso para la preparacion de reflumilast.
US8663694B2 (en) * 2005-03-16 2014-03-04 Takeda Gmbh Taste masked dosage form containing roflumilast
KR100902781B1 (ko) * 2007-10-05 2009-06-12 (주)라이프코드 일체형 무균 캡슐 제조장치
CN101279220B (zh) * 2007-12-28 2011-06-08 天津天士力制药股份有限公司 利用冷却空气制备滴丸的方法及使用其方法的设备
CN103298459A (zh) * 2010-09-23 2013-09-11 莫诺索尔克斯有限公司 用于直接在包装表面上形成药用产品的方法和系统
US9149959B2 (en) 2010-10-22 2015-10-06 Monosol Rx, Llc Manufacturing of small film strips
US9545376B2 (en) 2013-01-23 2017-01-17 Arx, Llc Production of unit dose constructs
US11273131B2 (en) 2016-05-05 2022-03-15 Aquestive Therapeutics, Inc. Pharmaceutical compositions with enhanced permeation
WO2017192921A1 (en) 2016-05-05 2017-11-09 Monosol Rx, Llc Enhanced delivery epinephrine compositions
US12433850B2 (en) 2016-05-05 2025-10-07 Aquestive Therapeutics, Inc. Enhanced delivery epinephrine and prodrug compositions
US12427121B2 (en) 2016-05-05 2025-09-30 Aquestive Therapeutics, Inc. Enhanced delivery epinephrine compositions
US12465564B2 (en) 2021-10-25 2025-11-11 Aquestive Therapeutics, Inc. Oral and nasal compositions and methods of treatment

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DE2725849C3 (de) * 1977-06-08 1980-11-13 Hobeg Hochtemperaturreaktor-Brennelement Gmbh, 6450 Hanau Vorrichtung zur Herstellung von kugelförmigen Teilchen
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Also Published As

Publication number Publication date
FI910273A0 (fi) 1991-01-18
LV10039A (lv) 1994-05-10
TW327131B (en) 1998-02-21
NO910218D0 (no) 1991-01-18
PL165719B1 (pl) 1995-01-31
YU7691A (sh) 1994-04-05
CN1054189A (zh) 1991-09-04
FI102590B (fi) 1999-01-15
HU211076B (en) 1995-10-30
US5380532A (en) 1995-01-10
RU1837872C (ru) 1993-08-30
IE910176A1 (en) 1991-07-31
IL96984A0 (en) 1992-03-29
NZ236820A (en) 1991-11-26
FI910273L (fi) 1991-07-20
PT96526B (pt) 1998-06-30
IE65102B1 (en) 1995-10-04
US5188838A (en) 1993-02-23
NO180516B (no) 1997-01-27
FR2657257A1 (fr) 1991-07-26
AU6948191A (en) 1991-07-25
BG93649A (bg) 1993-12-24
DK0438359T3 (da) 1994-05-02
EP0438359B1 (fr) 1994-03-30
ATE103489T1 (de) 1994-04-15
FI102590B1 (fi) 1999-01-15
CA2034413A1 (fr) 1991-07-20
KR910014114A (ko) 1991-08-31
NO180516C (no) 1997-05-07
CZ279869B6 (cs) 1995-07-12
ZA91376B (en) 1991-11-27
BG60899B1 (bg) 1996-06-28
RO108646B1 (ro) 1994-07-29
PT96526A (pt) 1991-10-15
SK278757B6 (sk) 1998-02-04
HU910178D0 (en) 1991-08-28
NO910218L (no) 1991-07-22
JPH04212359A (ja) 1992-08-03
IL96984A (en) 1996-03-31
KR0163050B1 (ko) 1998-12-01
DE69101493T2 (de) 1994-08-04
LV10039B (en) 1995-02-20
EP0438359A1 (fr) 1991-07-24
CS9100105A2 (en) 1991-08-13
AU651566B2 (en) 1994-07-28
FR2657257B1 (fr) 1994-09-02
JP3310305B2 (ja) 2002-08-05
DE69101493D1 (de) 1994-05-05

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