ES2062786T3 - Microesferas, su procedimiento de preparacion y su utilizacion. - Google Patents

Microesferas, su procedimiento de preparacion y su utilizacion.

Info

Publication number
ES2062786T3
ES2062786T3 ES91908505T ES91908505T ES2062786T3 ES 2062786 T3 ES2062786 T3 ES 2062786T3 ES 91908505 T ES91908505 T ES 91908505T ES 91908505 T ES91908505 T ES 91908505T ES 2062786 T3 ES2062786 T3 ES 2062786T3
Authority
ES
Spain
Prior art keywords
biodegradable
microspheres
preparation procedure
polymer
substance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91908505T
Other languages
English (en)
Inventor
Gilles Spenlehauer
Michel Veillard
Thierry Verrechia
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Rhone Poulenc Rorer SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer SA filed Critical Rhone Poulenc Rorer SA
Application granted granted Critical
Publication of ES2062786T3 publication Critical patent/ES2062786T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A NUEVAS MICROESFERAS BIODEGRADABLES Y BIOCOMPATIBLES CONSTITUIDAS POR UNO O VARIOS PRINCIPIOS ACTIVOS Y POR UN POLIMERO BIODEGRADABLE Y BIOCOMPATIBLE Y POR UNA SUSTANCIA TENSIOACTIVA, ELLA TAMBIEN BIODEGRADABLE Y BIOCOMPATIBLE. EL PROCESO CONSISTE EN PREPARAR UNA SOLUCION DEL POLIMERO Y DEL PRINCIPIO ACTIVO EN UN SOLVENTE NO MISCIBLE EN AGUA QUE SE MEZCLA A CONTINUACION EN LA SOLUCION ACUOSA DE TENSIOACTIVO SEGUIDO DE UNA EVAPORACION DEL SOLVENTE.
ES91908505T 1990-04-06 1991-04-04 Microesferas, su procedimiento de preparacion y su utilizacion. Expired - Lifetime ES2062786T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR909004471A FR2660556B1 (fr) 1990-04-06 1990-04-06 Microspheres, leur procede de preparation et leur utilisation.

Publications (1)

Publication Number Publication Date
ES2062786T3 true ES2062786T3 (es) 1994-12-16

Family

ID=9395533

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91908505T Expired - Lifetime ES2062786T3 (es) 1990-04-06 1991-04-04 Microesferas, su procedimiento de preparacion y su utilizacion.

Country Status (8)

Country Link
EP (1) EP0523183B1 (es)
JP (1) JP3244502B2 (es)
CA (1) CA2076010C (es)
DE (1) DE69101144T2 (es)
DK (1) DK0523183T3 (es)
ES (1) ES2062786T3 (es)
FR (1) FR2660556B1 (es)
WO (1) WO1991015193A1 (es)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5145684A (en) * 1991-01-25 1992-09-08 Sterling Drug Inc. Surface modified drug nanoparticles
AU642066B2 (en) * 1991-01-25 1993-10-07 Nanosystems L.L.C. X-ray contrast compositions useful in medical imaging
US5399363A (en) * 1991-01-25 1995-03-21 Eastman Kodak Company Surface modified anticancer nanoparticles
ES2034891B1 (es) * 1991-08-08 1993-12-16 Cusi Lab Procedimiento de elaboracion en continuo de sistemas coloidales dispersos, en forma de nanocapsulas o nanoparticulas.
CA2078388A1 (en) * 1991-10-02 1993-04-03 Mridula Nair Biocompatible emulsion particles
DE4227752A1 (de) * 1992-08-21 1994-02-24 Basf Ag Verfahren zur Herstellung von Alkylglykosiden
US6537579B1 (en) 1993-02-22 2003-03-25 American Bioscience, Inc. Compositions and methods for administration of pharmacologically active compounds
US5916596A (en) * 1993-02-22 1999-06-29 Vivorx Pharmaceuticals, Inc. Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof
FR2721510B1 (fr) * 1994-06-22 1996-07-26 Rhone Poulenc Rorer Sa Nanoparticules filtrables dans des conditions stériles.
ATE252894T1 (de) * 1995-01-05 2003-11-15 Univ Michigan Oberflächen-modifizierte nanopartikel und verfahren für ihre herstellung und verwendung
DK0752245T3 (da) * 1995-07-05 2002-09-09 Europ Economic Community Biokompatible og bionedbrydelige nanopartikler udviklet til absorption og afgivelse af proteinholdige lægemidler
ES2306452T3 (es) * 1995-10-17 2008-11-01 Jagotec Ag Aporte de farmacos insolubles.
US6270795B1 (en) 1995-11-09 2001-08-07 Microbiological Research Authority Method of making microencapsulated DNA for vaccination and gene therapy
FR2742357B1 (fr) * 1995-12-19 1998-01-09 Rhone Poulenc Rorer Sa Nanoparticules stabilisees et filtrables dans des conditions steriles
US6143037A (en) * 1996-06-12 2000-11-07 The Regents Of The University Of Michigan Compositions and methods for coating medical devices
US20070092563A1 (en) 1996-10-01 2007-04-26 Abraxis Bioscience, Inc. Novel formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof
FR2757768B1 (fr) * 1996-12-27 1999-04-02 Biovector Therapeutics Sa Vecteur particulaire homeocharge et composition pharmaceutique ou cosmetique le contenant
US5945126A (en) * 1997-02-13 1999-08-31 Oakwood Laboratories L.L.C. Continuous microsphere process
CN101579335B (zh) 1997-06-27 2016-08-03 阿布拉科斯生物科学有限公司 药剂的制剂及其制备和应用方法
IT1293088B1 (it) * 1997-07-10 1999-02-11 Isi Ist Sierovaccinogeno Ital Microparticelle per il rilascio controllato di molecole biologicamente attive e loro uso in terapia, profilassi e diagnostica in vitro e in
US6958148B1 (en) 1998-01-20 2005-10-25 Pericor Science, Inc. Linkage of agents to body tissue using microparticles and transglutaminase
CA2276066A1 (en) * 1999-03-11 2000-09-11 Zycos Inc. Microparticles for delivery of nucleic acid
EP1202671A4 (en) 1999-08-13 2004-11-10 Point Biomedical Corp MICROPARTICLES USEFUL AS ULTRASONIC CONTRAST AGENTS FOR THE LYMPHATIC SYSTEM
AU6636000A (en) 1999-08-13 2001-03-13 Point Biomedical Corporation Hollow microspheres with controlled fragility for medical use
US7147627B2 (en) 2002-08-21 2006-12-12 Hollister Incorporated Bowel management system
WO2005003180A2 (en) 2003-04-10 2005-01-13 Pr Pharmaceuticals A method for the production of emulsion-based micro particles
AU2004259208B2 (en) 2003-07-15 2011-04-28 Evonik Corporation Method for the preparation of controlled release formulations
AU2004259209A1 (en) 2003-07-23 2005-02-03 Pr Pharmaceuticals, Inc. Controlled release compositions
CN103169729A (zh) 2005-02-18 2013-06-26 阿布拉科斯生物科学有限公司 治疗剂的组合和给予方式以及联合治疗
US8735394B2 (en) 2005-02-18 2014-05-27 Abraxis Bioscience, Llc Combinations and modes of administration of therapeutic agents and combination therapy
KR20130028727A (ko) 2010-03-29 2013-03-19 아브락시스 바이오사이언스, 엘엘씨 치료제의 약물 전달 및 유효성 향상 방법
US9393318B2 (en) 2010-03-29 2016-07-19 Abraxis Bioscience, Llc Methods of treating cancer
KR20130088116A (ko) 2010-06-04 2013-08-07 아브락시스 바이오사이언스, 엘엘씨 췌장암의 치료 방법

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4330338A (en) * 1978-10-02 1982-05-18 Purdue Research Foundation Pharmaceutical coating composition, and preparation and dosages so coated
US4384975A (en) * 1980-06-13 1983-05-24 Sandoz, Inc. Process for preparation of microspheres
CA1196864A (en) * 1983-06-10 1985-11-19 Mattheus F.A. Goosen Controlled release of injectable and implantable insulin compositions
JPS63122620A (ja) * 1986-11-12 1988-05-26 Sanraku Inc ポリ乳酸マイクロスフエア及びその製造方法
GB2207693A (en) * 1987-08-06 1989-02-08 Costain Concrete Company Limit Concrete railway sleepers

Also Published As

Publication number Publication date
DK0523183T3 (da) 1994-05-09
CA2076010C (fr) 2004-05-18
FR2660556B1 (fr) 1994-09-16
DE69101144T2 (de) 1994-05-26
JPH05507063A (ja) 1993-10-14
EP0523183B1 (fr) 1994-02-02
FR2660556A1 (fr) 1991-10-11
DE69101144D1 (de) 1994-03-17
EP0523183A1 (fr) 1993-01-20
JP3244502B2 (ja) 2002-01-07
CA2076010A1 (fr) 1991-10-07
WO1991015193A1 (fr) 1991-10-17

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