ES2062999T3 - Proceso para preparar complejos cuprato de orden superior. - Google Patents

Proceso para preparar complejos cuprato de orden superior.

Info

Publication number
ES2062999T3
ES2062999T3 ES88109047T ES88109047T ES2062999T3 ES 2062999 T3 ES2062999 T3 ES 2062999T3 ES 88109047 T ES88109047 T ES 88109047T ES 88109047 T ES88109047 T ES 88109047T ES 2062999 T3 ES2062999 T3 ES 2062999T3
Authority
ES
Spain
Prior art keywords
higher order
complex
cuprate
carbanion
carbon
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88109047T
Other languages
English (en)
Inventor
Arthur Lee Campbell
James Richard Behling
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GD Searle LLC
Original Assignee
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GD Searle LLC filed Critical GD Searle LLC
Application granted granted Critical
Publication of ES2062999T3 publication Critical patent/ES2062999T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F1/00—Compounds containing elements of Groups 1 or 11 of the Periodic Table
    • C07F1/08—Copper compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/22—Tin compounds
    • C07F7/2208—Compounds having tin linked only to carbon, hydrogen and/or halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

ESTA INVENCION SE REFIERE A UN PROCESO PARA PREPARAR COMPLEJOS CUPRATOS DE ORDEN SUPERIOR QUE CONTIENEN UN CARBANION PARA LA FORMACION DE ENLACES DE CARBONO A CARBONO EN REACCIONES TALES COMO ADICION DE 1,4 CONJUGADO. EL COMPLEJO SE FORMA POR REACCION DE UN COMPLEJO CUPRATO PRIMERO CON UN ESTANNATO TAL QUE EL CARBANION A USAR PARA FORMAR ENLACES CARBONO A CARBONO ES TRANFERIDO DESDE EL ESTANNATO AL PRIMER COMPLEJO CUPRATO PARA FORMAR UN COMPLEJO CUPRATO DE ORDEN SUPERIOR DIFERENTE. ESTE PROCESO PERMITE LA PREPARACION IN SITU DE UN COMPLEJO CUPRATO DE ORDEN SUPERIOR QUE TIENE EL CARBANION DESEADO PARA SER USADO EN UNA REACCION SINTETICA. LOS COMPLEJOS CUPRATOS DE ORDEN SUPERIOR PREPARADOS POR ESTE PROCESO SON PARTICULARMENTE UTILES PARA LA PREPARACION EFICAZ DE PROSTAGLANDINAS FARMAC/EUTICAMENTE ACTIVAS.
ES88109047T 1987-06-09 1988-06-07 Proceso para preparar complejos cuprato de orden superior. Expired - Lifetime ES2062999T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/059,695 US4777275A (en) 1987-06-09 1987-06-09 Process of preparing higher order cuprate complexes

Publications (1)

Publication Number Publication Date
ES2062999T3 true ES2062999T3 (es) 1995-01-01

Family

ID=22024644

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88109047T Expired - Lifetime ES2062999T3 (es) 1987-06-09 1988-06-07 Proceso para preparar complejos cuprato de orden superior.

Country Status (7)

Country Link
US (1) US4777275A (es)
EP (1) EP0294757B1 (es)
JP (1) JP2667875B2 (es)
AT (1) ATE103924T1 (es)
CA (1) CA1311490C (es)
DE (1) DE3888872T2 (es)
ES (1) ES2062999T3 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5011958A (en) * 1987-06-08 1991-04-30 G. D. Searle & Co. Process for preparing higher order cuprate complexes
US5072010A (en) * 1990-04-04 1991-12-10 University Of California Transmetalations from zirconium to copper intermediates
US5166382A (en) * 1990-04-04 1992-11-24 Regents Of The University Of California Transmetalations from zirconium to copper intermediates
US5055604A (en) * 1990-04-17 1991-10-08 G. D. Searle & Co. Process for preparing prostaglandin analogs using organozirconium compounds
US5405981A (en) * 1993-03-26 1995-04-11 The Regents Of The University Of California Copper catalyzed coupling reactions
US5684177A (en) * 1996-05-17 1997-11-04 Torcan Chemical Ltd. Misoprostol
EP0943607B1 (en) * 1996-11-14 2005-01-26 Daiichi Fine Chemical Co., Ltd. Process for the preparation of prostaglandins
US6388128B1 (en) 1998-10-05 2002-05-14 Alcon Manufacturing, Ltd. Stannane synthesis of prostanoids
HU231185B1 (hu) * 2017-07-11 2021-07-28 CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. Eljárás Misoprostol előállítására és tisztítására

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US30287A (en) * 1860-10-09 Propelling cars on railroads
USRE30287E (en) 1974-03-26 1980-05-27 Gist-Brocades N.V. 19 Hydroxy prostaglandins
US3965143A (en) * 1974-03-26 1976-06-22 G. D. Searle & Co. 16-Oxygenated prostanoic acid derivatives
US4271314A (en) * 1979-11-28 1981-06-02 G. D. Searle & Co. 4,5-Unsaturated prostanoic acid derivatives
US4322543A (en) * 1979-11-28 1982-03-30 G. D. Searle & Co. 4,5-Unsaturated prostanoic acid derivatives
US4529812A (en) * 1983-02-02 1985-07-16 G. D. Searle & Co. 3-Oxaprostaglandins
US4543421A (en) * 1983-05-11 1985-09-24 Miles Laboratories, Inc. Conjugate addition of organocuprates generated from copper (I) cyanide and vinyl stannanes useful in prostaglandin analog synthesis
US4499296A (en) * 1983-11-14 1985-02-12 G. D. Searle & Co. Omega cycloalkyl prostaglandins
US4578505A (en) * 1984-09-04 1986-03-25 G. D. Searle & Co. Allenic prostanoic acid derivatives
US4785124A (en) * 1987-06-08 1988-11-15 G. D. Searle & Co. Process for preparing higher order cuprate complexes

Also Published As

Publication number Publication date
US4777275A (en) 1988-10-11
DE3888872D1 (de) 1994-05-11
JP2667875B2 (ja) 1997-10-27
EP0294757A3 (en) 1990-07-11
EP0294757A2 (en) 1988-12-14
ATE103924T1 (de) 1994-04-15
CA1311490C (en) 1992-12-15
JPS63316786A (ja) 1988-12-26
DE3888872T2 (de) 1994-08-11
EP0294757B1 (en) 1994-04-06

Similar Documents

Publication Publication Date Title
MX7465E (es) Procedimiento mejorado para la obtencion de catalizadores o soportes de catalizadores a base de oxido de titanio para el proceso claus de sintesis de azufre
ES2062999T3 (es) Proceso para preparar complejos cuprato de orden superior.
BG40656A3 (bg) Метод за получаване на натриева сол на n-фосфонометилглицин
BE830476A (fr) Procede de production d'alcools inferieurs par hydratation catalytique directe d'olefines inferieures
OA05209A (fr) Procédé de production d'une préparation stable d'insuline.
GR3003572T3 (es)
FR2382425A1 (fr) Procede de preparation d'acides carboxyliques superieurs
US4139564A (en) 2-Decarboxy-2-hydroxymethyl)-16-fluoro-PGE2 compounds
EP0307827A3 (en) Novel macromolecular complexes, process for producing same and medicinal use of such complexes
ATE74881T1 (de) Herstellung von basischen aluminiumhalogeniden.
FR2421164A1 (fr) Preparation de chlorure de chloracetyle
US4203924A (en) 2-Decarboxy-2-hydroxymethyl-deoxy-9,10-didehydro-PGD2 analogs
KR880701103A (ko) 신규 복합체, 그의 제조방법 및 그 복합체의 의약용도
FR2385712A1 (fr) Procede de preparation d'esters cycliques d'acide undecanedioique
JPS5553257A (en) Manufacture of symmetrical 1*33disubstituted urea
DK172289A (da) Fremgangsmaade til fremstilling af 3-amino-2,2,4,4-tetramethylthietan ved leuckardt-reaktionen
PT78738A (pt) Processo para a preparacao de fluoreto de isobutirilo
FR2451381A1 (fr) Procede de production d'olefines combinees a un metal
GB1523747A (en) Process for producing methacrolein
US4171460A (en) 2-Decarboxy-2-hydroxymethyl-PGF1 α analogs
ZA823912B (en) A process for producing catalyst precursors
US4229377A (en) 2-Decarboxy-2-hydroxymethyl-16-fluoro-PGE2 compounds
KR890002206A (ko) 페닐디클로로포스핀의 제조방법
ES483278A1 (es) Procedimiento para la obtencion de di-(n-metil-n-fenil-tiu- ram)-disulfuro
US4461917A (en) 9-Deoxy-9-methylene-PGE compounds

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 294757

Country of ref document: ES