ES2063356T3 - Dispositivo de perfusion pancreatica artificial. - Google Patents

Dispositivo de perfusion pancreatica artificial.

Info

Publication number
ES2063356T3
ES2063356T3 ES90908389T ES90908389T ES2063356T3 ES 2063356 T3 ES2063356 T3 ES 2063356T3 ES 90908389 T ES90908389 T ES 90908389T ES 90908389 T ES90908389 T ES 90908389T ES 2063356 T3 ES2063356 T3 ES 2063356T3
Authority
ES
Spain
Prior art keywords
islands
hollow fiber
suspended
around
enclosed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90908389T
Other languages
English (en)
Inventor
William L Chick
Susan J Sullivan
Kermit M Borland
John M Harvey
Thomas E Muller
Karen E Dunleavy
Edward J Doherty
Barry A Solomon
Amy L Foley
Donald P King Jr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
WR Grace and Co Conn
WR Grace and Co
Original Assignee
WR Grace and Co Conn
WR Grace and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by WR Grace and Co Conn, WR Grace and Co filed Critical WR Grace and Co Conn
Application granted granted Critical
Publication of ES2063356T3 publication Critical patent/ES2063356T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3472—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/022—Artificial gland structures using bioreactors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/04—Metals or alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3472—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate
    • A61M1/3475—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate with filtrate treatment agent in the same enclosure as the membrane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1678—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes intracorporal

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Transplantation (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Chemical & Material Sciences (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Anesthesiology (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Inorganic Chemistry (AREA)
  • Prostheses (AREA)
  • External Artificial Organs (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Materials For Medical Uses (AREA)

Abstract

UN DISPOSITIVO QUE SIRVE COMO PANCREAS ARTIFICAL COMPRENDE UNA FIBRA HUECA (12) TENIENDO UN DIAMETRO INTERNO DE ALREDEDOR DE 5MM QUE ESTA RODEADO POR ISLETAS DE LANGERHAUS (14) ENCERRADAS EN UN ALOJAMIENTO (42). LAS ISLETAS (14) ESTAN SUSPENDIDAS EN UNA MATRIZ SEMISOLIDA QUE ASEGURA LA DISTRIBUCION DESEADA DE LAS CELULAS ALREDEDOR DE LA FIBRA HUECA (12). LA FIBRA HUECA (12) E ISLETAS SUSPENDIDAS (14) ESTAN ENCERRADAS EN UN ALOJAMIENTO (20, 22) QUE MAS ADELANTE AYUDA A LA DISTRIBUCION DESEADA DE LAS ISLETAS (14) ALREDEDOR DE LA FIBRA HUECA (12). LA FIBRA HUECA (12), TIENE UNA POROSIDAD QUE PERMITE SELECTIVAMENTE EL PASO DE SUSTANCIAS TENIENDO UN PESO MOLECULAR MENOR DE ALREDEDOR DE 100.000 DALTONS. LA MATRIZ SEMI-SOLIDA EN LA QUE ESTAN EMPOTRADAS Y SUSPENDIDAS LAS ISLETAS (14) ESTA FORMADA DE UN MATERIAL DE SOPORTE APROPIADO TAL COMO ALGINATO O AGAR.
ES90908389T 1989-08-25 1990-02-22 Dispositivo de perfusion pancreatica artificial. Expired - Lifetime ES2063356T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/398,739 US5002661A (en) 1989-08-25 1989-08-25 Artificial pancreatic perfusion device

Publications (1)

Publication Number Publication Date
ES2063356T3 true ES2063356T3 (es) 1995-01-01

Family

ID=23576610

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90908389T Expired - Lifetime ES2063356T3 (es) 1989-08-25 1990-02-22 Dispositivo de perfusion pancreatica artificial.

Country Status (10)

Country Link
US (1) US5002661A (es)
EP (1) EP0489014B1 (es)
JP (1) JPH04507051A (es)
AT (1) ATE113817T1 (es)
AU (1) AU641164B2 (es)
CA (1) CA2065390C (es)
DE (1) DE69014125T2 (es)
DK (2) DK0489014T3 (es)
ES (1) ES2063356T3 (es)
WO (1) WO1991002498A1 (es)

Families Citing this family (60)

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IT1231916B (it) * 1989-05-29 1992-01-15 Ampliscientifica S R L Pancreas artificiale indossabile
US5116494A (en) * 1989-08-25 1992-05-26 W. R. Grace & Co.-Conn. Artificial pancreatic perfusion device with temperature sensitive matrix
US5116493A (en) * 1989-08-25 1992-05-26 W. R. Grace & Co.-Conn. Artificial pancreatic perfusion device with reseedable matrix
US5427940A (en) * 1991-06-03 1995-06-27 Board Of Regents, The University Of Texas System Engineered cells producing insulin in response to glucose
US5744327A (en) * 1990-02-20 1998-04-28 Board Of Regents, The University Of Texas System Methods for producing insulin in response to non-glucose secretagogues
FI923023A7 (fi) * 1990-10-31 1992-06-29 Baxter Int Lähellään tapahtuvan verisuonittumisen aikaansaava istutemateriaali
US5713888A (en) * 1990-10-31 1998-02-03 Baxter International, Inc. Tissue implant systems
US5545223A (en) * 1990-10-31 1996-08-13 Baxter International, Inc. Ported tissue implant systems and methods of using same
US5314471A (en) * 1991-07-24 1994-05-24 Baxter International Inc. Tissue inplant systems and methods for sustaining viable high cell densities within a host
US5344454A (en) * 1991-07-24 1994-09-06 Baxter International Inc. Closed porous chambers for implanting tissue in a host
DE4108772A1 (de) * 1991-03-18 1992-09-24 Inst Textil & Faserforschung Implantierbares biohybrides organ
US5800829A (en) * 1991-04-25 1998-09-01 Brown University Research Foundation Methods for coextruding immunoisolatory implantable vehicles with a biocompatible jacket and a biocompatible matrix core
ATE156344T1 (de) * 1991-04-25 1997-08-15 Univ Brown Res Found Implantierbare, biokompatible immunisolator- trägersubstanz zum abgeben ausgesuchter, therapeutischer produkte
US5792656A (en) * 1991-06-03 1998-08-11 Board Of Regents, The University Of Texas System Methods of preparing genetically engineered cells that produce insulin in response to glucose
US6773458B1 (en) 1991-07-24 2004-08-10 Baxter International Inc. Angiogenic tissue implant systems and methods
US5453278A (en) * 1991-07-24 1995-09-26 Baxter International Inc. Laminated barriers for tissue implants
EP1099423A3 (en) * 1991-09-16 2001-11-14 Atrium Medical Corporation Controlled porosity implantable primary lumen device
US5370681A (en) * 1991-09-16 1994-12-06 Atrium Medical Corporation Polyumenal implantable organ
US5298206A (en) * 1992-02-04 1994-03-29 W. R. Grace & Co.-Conn. Method and apparatus for casting hollow fiber membranes
US5425764A (en) * 1992-07-30 1995-06-20 The University Of Toledo Bioartificial pancreas
US5387237A (en) * 1992-07-30 1995-02-07 The University Of Toledo Bioartificial pancreas
GB9311784D0 (en) * 1993-06-08 1993-07-28 Univ Alberta Vascular bioartificial organ
WO1995004521A1 (en) 1993-08-10 1995-02-16 W.L. Gore & Associates, Inc. Cell encapsulating device
US5908623A (en) 1993-08-12 1999-06-01 Cytotherapeutics, Inc. Compositions and methods for the delivery of biologically active molecules using genetically altered cells contained in biocompatible immunoisolatory capsules
SG48813A1 (en) * 1993-08-12 1998-05-18 Cytotherapeutics Inc Improved composition and methods for the delivery of biologically active molecules using genetically altered cells contained in biocompatible immunoisolatory capsules
JPH08503715A (ja) * 1993-09-24 1996-04-23 バクスター、インターナショナル、インコーポレイテッド 埋め込み装置の血管化を促進するための方法
US5550050A (en) * 1994-04-15 1996-08-27 Cytotherapeutics, Inc. Method for implanting encapsulated cells in a host
US6156305A (en) * 1994-07-08 2000-12-05 Baxter International Inc. Implanted tumor cells for the prevention and treatment of cancer
US5935849A (en) * 1994-07-20 1999-08-10 Cytotherapeutics, Inc. Methods and compositions of growth control for cells encapsulated within bioartificial organs
US5795790A (en) 1994-07-20 1998-08-18 Cytotherapeutics, Inc. Method for controlling proliferation and differentiation of cells encapsulated within bioartificial organs
US6495364B2 (en) * 1995-05-23 2002-12-17 Neurotech, S.A. Mx-1 conditionally immortalized cells
US5681740A (en) * 1995-06-05 1997-10-28 Cytotherapeutics, Inc. Apparatus and method for storage and transporation of bioartificial organs
US5741334A (en) * 1995-06-07 1998-04-21 Circe Biomedical, Inc. Artificial pancreatic perfusion device
WO1997010807A1 (en) * 1995-09-22 1997-03-27 Gore Hybrid Technologies, Inc. Improved cell encapsulation device
US5854067A (en) * 1996-01-19 1998-12-29 Board Of Regents, The University Of Texas System Hexokinase inhibitors
US6087129A (en) 1996-01-19 2000-07-11 Betagene, Inc. Recombinant expression of proteins from secretory cell lines
CA2218623A1 (en) * 1996-02-23 1997-08-28 Circe Biomedical, Inc. Novel artificial pancreas
US5976780A (en) * 1996-07-16 1999-11-02 Shah; Kumarpal A. Encapsulated cell device
ZA9710342B (en) * 1996-11-25 1998-06-10 Alza Corp Directional drug delivery stent and method of use.
US5985151A (en) * 1997-12-19 1999-11-16 Saman Ahmadi Method and apparatus of membrane separation
US6303355B1 (en) 1999-03-22 2001-10-16 Duke University Method of culturing, cryopreserving and encapsulating pancreatic islet cells
US6365385B1 (en) 1999-03-22 2002-04-02 Duke University Methods of culturing and encapsulating pancreatic islet cells
US8252044B1 (en) 2000-11-17 2012-08-28 Advanced Bio Prosthestic Surfaces, Ltd. Device for in vivo delivery of bioactive agents and method of manufacture thereof
US9107605B2 (en) * 2000-11-17 2015-08-18 Advanced Bio Prosthetic Surfaces, Ltd., A Wholly Owned Subsidiary Of Palmaz Scientific, Inc. Device for in vivo delivery of bioactive agents and method of manufacture thereof
US10398830B2 (en) * 2000-11-17 2019-09-03 Vactronix Scientific, Llc Device for in vivo delivery of bioactive agents and method of manufacture thereof
AU2003294541A1 (en) * 2002-12-24 2004-07-22 An-Go-Gen Inc. Encapsulated cell for therapy
CA2635534C (en) * 2005-12-30 2014-07-29 Neurotech Usa Inc. Micronized device for the delivery of biologically active molecules and methods of use thereof
US9540630B2 (en) * 2008-09-17 2017-01-10 Beta O2 Technologies Ltd. Optimization of alginate encapsulation of islets for transplantation
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JP2012524544A (ja) * 2009-04-23 2012-10-18 ニューロテック ユーエスエー， インコーポレイテッド プロスタグランジンＦ２アルファ（ＰＧＦ２ａ）を産生する細胞系およびその使用
WO2011154941A2 (en) 2010-06-07 2011-12-15 Beta-O2 Technologies Ltd. Multiple-layer immune barrier for donor cells
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Also Published As

Publication number Publication date
JPH04507051A (ja) 1992-12-10
WO1991002498A1 (en) 1991-03-07
AU5733390A (en) 1991-04-03
EP0489014A1 (en) 1992-06-10
EP0489014B1 (en) 1994-11-09
DK23192A (da) 1992-02-24
AU641164B2 (en) 1993-09-16
CA2065390C (en) 1996-09-24
DE69014125T2 (de) 1995-03-23
US5002661A (en) 1991-03-26
DE69014125D1 (de) 1994-12-15
DK0489014T3 (da) 1995-05-01
DK23192D0 (da) 1992-02-24
ATE113817T1 (de) 1994-11-15
CA2065390A1 (en) 1991-02-26

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