ATE156344T1 - Implantierbare, biokompatible immunisolator- trägersubstanz zum abgeben ausgesuchter, therapeutischer produkte - Google Patents

Implantierbare, biokompatible immunisolator- trägersubstanz zum abgeben ausgesuchter, therapeutischer produkte

Info

Publication number
ATE156344T1
ATE156344T1 AT92912606T AT92912606T ATE156344T1 AT E156344 T1 ATE156344 T1 AT E156344T1 AT 92912606 T AT92912606 T AT 92912606T AT 92912606 T AT92912606 T AT 92912606T AT E156344 T1 ATE156344 T1 AT E156344T1
Authority
AT
Austria
Prior art keywords
vehicle
biocompatible
individual
cells
immunoisolatory
Prior art date
Application number
AT92912606T
Other languages
English (en)
Inventor
Keith E Dionne
Dwaine F Emerich
Diane Hoffman
David W Scharp
Paul E Lacy
Patrick Aebischer
Paul R Sanberg
Lisa Christenson
Orion D Hegre
Alfred V Vasconcellos
Michael J Lysaght
Frank T Gentile
Original Assignee
Univ Brown Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Brown Res Found filed Critical Univ Brown Res Found
Application granted granted Critical
Publication of ATE156344T1 publication Critical patent/ATE156344T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0092—Hollow drug-filled fibres, tubes of the core-shell type, coated fibres, coated rods, microtubules or nanotubes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/39—Pancreas; Islets of Langerhans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816—Wall or shell material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0012—Cell encapsulation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0062—General methods for three-dimensional culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0613—Cells from endocrine organs
    • C12N5/0614—Adrenal gland
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0656—Adult fibroblasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0676—Pancreatic cells
    • C12N5/0677—Three-dimensional culture, tissue culture or organ culture; Encapsulated cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/126—Immunoprotecting barriers, e.g. jackets, diffusion chambers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/126—Immunoprotecting barriers, e.g. jackets, diffusion chambers
    • A61K2035/128—Immunoprotecting barriers, e.g. jackets, diffusion chambers capsules, e.g. microcapsules
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Cell Biology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Virology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Psychology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Nanotechnology (AREA)
  • Ophthalmology & Optometry (AREA)
AT92912606T 1991-04-25 1992-04-22 Implantierbare, biokompatible immunisolator- trägersubstanz zum abgeben ausgesuchter, therapeutischer produkte ATE156344T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US69240391A 1991-04-25 1991-04-25

Publications (1)

Publication Number Publication Date
ATE156344T1 true ATE156344T1 (de) 1997-08-15

Family

ID=24780436

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92912606T ATE156344T1 (de) 1991-04-25 1992-04-22 Implantierbare, biokompatible immunisolator- trägersubstanz zum abgeben ausgesuchter, therapeutischer produkte

Country Status (15)

Country Link
US (10) US5800828A (de)
EP (1) EP0585368B1 (de)
JP (2) JP4215273B2 (de)
AT (1) ATE156344T1 (de)
AU (2) AU666118B2 (de)
CA (1) CA2109085C (de)
DE (1) DE69221484T2 (de)
DK (1) DK0585368T3 (de)
ES (1) ES2107537T3 (de)
FI (1) FI934545A7 (de)
GR (1) GR3025301T3 (de)
HK (1) HK1001832A1 (de)
NO (1) NO308198B1 (de)
SG (1) SG47470A1 (de)
WO (1) WO1992019195A1 (de)

Families Citing this family (511)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5786216A (en) * 1987-11-17 1998-07-28 Cytotherapeutics, Inc. Inner-supported, biocompatible cell capsules
SG47470A1 (en) * 1991-04-25 1998-04-17 Univ Brown Res Found Implantable biocompatible immunoisolatory vehicle for delivery of a selected therapeutic products
US5824331A (en) * 1992-02-24 1998-10-20 Encelle, Inc. Bioartificial devices and cellular matrices therefor
US5834005A (en) * 1992-02-24 1998-11-10 Encelle, Inc. Bioartificial devices and cellular matrices therefor
US6352707B1 (en) 1992-02-24 2002-03-05 Anton-Lewis Usala Transplant encapsulation in a hydrogel matrix to obscure immune recognition
US5830492A (en) * 1992-02-24 1998-11-03 Encelle, Inc. Bioartificial devices and cellular matrices therefor
US6231881B1 (en) 1992-02-24 2001-05-15 Anton-Lewis Usala Medium and matrix for long-term proliferation of cells
KR950703910A (ko) * 1992-11-16 1995-11-17 윌리암 엠.잭슨 미소 다공성 매크로캡슐(microporous macrocapsules)
US5709854A (en) * 1993-04-30 1998-01-20 Massachusetts Institute Of Technology Tissue formation by injecting a cell-polymeric solution that gels in vivo
AU678843B2 (en) * 1993-08-10 1997-06-12 W.L. Gore & Associates, Inc. Cell encapsulating device
SG48813A1 (en) * 1993-08-12 1998-05-18 Cytotherapeutics Inc Improved composition and methods for the delivery of biologically active molecules using genetically altered cells contained in biocompatible immunoisolatory capsules
US5908623A (en) * 1993-08-12 1999-06-01 Cytotherapeutics, Inc. Compositions and methods for the delivery of biologically active molecules using genetically altered cells contained in biocompatible immunoisolatory capsules
US5534404A (en) * 1993-12-10 1996-07-09 Cytotherapeutics, Inc. Glucose responsive insulin secreting β-cell lines and method for producing same
US5550050A (en) 1994-04-15 1996-08-27 Cytotherapeutics, Inc. Method for implanting encapsulated cells in a host
CA2147810A1 (en) * 1994-04-25 1995-10-26 Susumu Yoshida Biologically active substance-secreting hybrid gel
AU779272B2 (en) * 1994-04-25 2005-01-13 Genentech Inc. Biologically active substance-secreting hybrid gel
US6703017B1 (en) 1994-04-28 2004-03-09 Ixion Biotechnology, Inc. Reversal of insulin-dependent diabetes by islet-producing stem cells, islet progenitor cells and islet-like structures
US5834029A (en) * 1994-07-20 1998-11-10 Cytotherapeutics, Inc. Nerve guidance channel containing bioartificial three-dimensional hydrogel extracellular matrix derivatized with cell adhesive peptide fragment
US5853717A (en) * 1994-07-20 1998-12-29 Cytotherapeutics, Inc. Methods and compositions of growth control for cells encapsulated within bioartificial organs
US5935849A (en) * 1994-07-20 1999-08-10 Cytotherapeutics, Inc. Methods and compositions of growth control for cells encapsulated within bioartificial organs
US5853385A (en) * 1994-08-26 1998-12-29 Cytotherapeutics, Inc. Encapsulated PC12 cell transplants for treatment of Parkinson's disease
FR2724320B1 (fr) * 1994-09-13 1996-12-20 Transgene Sa Nouvel implant pour le traitement des maladies acquises
US20030152909A1 (en) * 1994-11-16 2003-08-14 Mitrani Eduardo N. In vitro micro-organs, and uses related thereto
WO2003035851A1 (en) * 2001-10-23 2003-05-01 Yissum Research Development Company Of The Hebrew University Of Jerusalem In vitro micro-organs, and uses related thereto
US6126936A (en) * 1995-03-10 2000-10-03 Biohybrid Technologies Llc Microcapsules and composite microreactors for immunoisolation of cells
US5830460A (en) 1995-03-13 1998-11-03 University Of South Florida Sertoli cells as transplantation facilitator for cell transplantation
US6495364B2 (en) * 1995-05-23 2002-12-17 Neurotech, S.A. Mx-1 conditionally immortalized cells
US5681740A (en) * 1995-06-05 1997-10-28 Cytotherapeutics, Inc. Apparatus and method for storage and transporation of bioartificial organs
US5837234A (en) * 1995-06-07 1998-11-17 Cytotherapeutics, Inc. Bioartificial organ containing cells encapsulated in a permselective polyether suflfone membrane
US5741685A (en) * 1995-06-07 1998-04-21 Children's Medical Center Corporation Parenchymal cells packaged in immunoprotective tissue for implantation
WO1997010807A1 (en) * 1995-09-22 1997-03-27 Gore Hybrid Technologies, Inc. Improved cell encapsulation device
WO1997012635A1 (en) * 1995-10-02 1997-04-10 Cytotherapeutics, Inc. Method for treating amyotrophic lateral sclerosis
US6283951B1 (en) * 1996-10-11 2001-09-04 Transvascular, Inc. Systems and methods for delivering drugs to selected locations within the body
DE69637842D1 (de) 1995-10-26 2009-04-02 Paul P Latta Induktion von immunologischer Toleranz
US6299895B1 (en) 1997-03-24 2001-10-09 Neurotech S.A. Device and method for treating ophthalmic diseases
US5672361A (en) * 1996-03-29 1997-09-30 Desmos, Inc. Laminin 5 for growth of pancreatic islet cells
US7297331B2 (en) * 1996-04-03 2007-11-20 The Rogosin Institute Beads containing restricted cancer cells producing material suppressing cancer cell proliferation
US6224912B1 (en) 1996-04-03 2001-05-01 The Rogo Institute Cancer-cell proliferation-suppressing material produced by cancer cells restricted by entrapment
WO1997038707A1 (en) * 1996-04-17 1997-10-23 Cytotherapeutics, Inc. Method and device for delivery of apoptosis-inducing molecules
US6027721A (en) * 1996-05-20 2000-02-22 Cytotherapeutics, Inc. Device and method for encapsulated gene therapy
IL118376A0 (en) * 1996-05-22 1996-09-12 Univ Ben Gurion Polysaccharide sponges for cell culture and transplantation
US6054142A (en) * 1996-08-01 2000-04-25 Cyto Therapeutics, Inc. Biocompatible devices with foam scaffolds
US6458574B1 (en) * 1996-09-12 2002-10-01 Transkaryotic Therapies, Inc. Treatment of a α-galactosidase a deficiency
FR2753086B1 (fr) * 1996-09-12 1999-02-26 Hospal R & D Int Dispositif et procede de fabrication d'une capsule tubulaire segmentee contenant un milieu biologiquement actif
US6200589B1 (en) 1996-09-13 2001-03-13 The University Of Akron Biological implants of semipermeable amphiphilic membranes
US6083725A (en) * 1996-09-13 2000-07-04 Transkaryotic Therapies, Inc. Tranfected human cells expressing human α-galactosidase A protein
US6593290B1 (en) 1996-11-01 2003-07-15 Genentech, Inc. Treatment of inner ear hair cells
US6156728A (en) * 1996-11-01 2000-12-05 Genentech, Inc. Treatment of inner ear hair cells
US5952226A (en) * 1996-11-05 1999-09-14 Modex Therapeutiques Hypoxia responsive EPO producing cells
US9155496B2 (en) 1997-03-04 2015-10-13 Dexcom, Inc. Low oxygen in vivo analyte sensor
US7899511B2 (en) 2004-07-13 2011-03-01 Dexcom, Inc. Low oxygen in vivo analyte sensor
ZA986077B (en) 1997-07-09 2000-01-10 Genentech Inc ErbB4 receptor-specific neuregulin related ligands and uses therefor.
US6121415A (en) 1997-07-09 2000-09-19 Genentech, Inc. ErbB4 receptor-specific neuregolin related ligands and uses therefor
AU8577498A (en) * 1997-07-22 1999-02-16 General Hospital Corporation, The Modulation of multicellular aggregates by solid stress
US6994856B1 (en) 1997-07-24 2006-02-07 Genentech, Inc. ErbB4 receptor-specific neuregulin related ligands and uses therefor
US6287558B1 (en) 1997-08-01 2001-09-11 Biohybrio Technologies Llc Devices containing cells or tissue and an agent that inhibits damage by a host cell molecule
US6368612B1 (en) * 1997-12-12 2002-04-09 Biohybrid Technologies Llc Devices for cloaking transplanted cells
US7687057B2 (en) 1998-01-09 2010-03-30 Yissum Research Development Company Of The Hebrew University Of Jerusalem In vitro micro-organs, and uses related thereto
US5922339A (en) * 1998-01-27 1999-07-13 Usala; Anton-Lewis Compositions and methods for biocompatible implants
US6872387B1 (en) 1998-02-24 2005-03-29 The Regents Of The University Of Michigan Three-dimensional hydrogel/cell system
US7691829B2 (en) * 1998-03-24 2010-04-06 Petito George D Composition and method for healing tissues
US20050208114A1 (en) * 1998-03-24 2005-09-22 Petito George D Composition and method for healing tissues
US6303136B1 (en) 1998-04-13 2001-10-16 Neurotech S.A. Cells or tissue attached to a non-degradable filamentous matrix encapsulated by a semi-permeable membrane
US6949816B2 (en) 2003-04-21 2005-09-27 Motorola, Inc. Semiconductor component having first surface area for electrically coupling to a semiconductor chip and second surface area for electrically coupling to a substrate, and method of manufacturing same
US9066695B2 (en) 1998-04-30 2015-06-30 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US6175752B1 (en) 1998-04-30 2001-01-16 Therasense, Inc. Analyte monitoring device and methods of use
US8688188B2 (en) 1998-04-30 2014-04-01 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8480580B2 (en) 1998-04-30 2013-07-09 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8465425B2 (en) 1998-04-30 2013-06-18 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8974386B2 (en) 1998-04-30 2015-03-10 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8346337B2 (en) 1998-04-30 2013-01-01 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
WO1999058042A2 (en) * 1998-05-14 1999-11-18 Abraham Shahar Specially devised neuronal implants for reconstruction of damaged central nervous system
AU3623199A (en) * 1998-05-15 1999-12-06 Modex Therapeutiques, S.A. Flat sheet cell encapsulation device
WO1999066797A1 (en) 1998-06-22 1999-12-29 Worden Charles E Enriched platelet wound healant
US6593133B1 (en) 1998-07-06 2003-07-15 Nsgene A/S Neurotrophic factors
NO983911D0 (no) 1998-08-26 1998-08-26 Norsk Hydro As Alginatkapsler til bruk ved behandling av hjernesvulst
WO2000029206A1 (en) * 1998-11-13 2000-05-25 Sensor Technologies Inc. Monodisperse preparations useful with implanted devices
US6713293B1 (en) 1999-02-08 2004-03-30 Friedrich Grummt Encapsulated cells containing an amplified expression vector as a drug delivery device
US6903244B1 (en) 1999-02-26 2005-06-07 University Of Utah Research Foundation Mice which are +/− or −/− for the elastin gene as models for vascular disease
US6495161B1 (en) * 1999-03-09 2002-12-17 Vivorx, Inc. Cytoprotective biocompatible containment systems for biologically active materials and methods of making same
US6365385B1 (en) 1999-03-22 2002-04-02 Duke University Methods of culturing and encapsulating pancreatic islet cells
US6303355B1 (en) 1999-03-22 2001-10-16 Duke University Method of culturing, cryopreserving and encapsulating pancreatic islet cells
US6361771B1 (en) 1999-04-06 2002-03-26 Neurotech S.A. ARPE-19 as a platform cell line for encapsulated cell-based delivery
US20050265977A1 (en) * 1999-04-30 2005-12-01 Elliott Robert B Xenotransplant for CNS therapy
AU4440000A (en) * 1999-04-30 2000-11-17 Diatranz Limited Xenotransplant for cns therapy
US20090047325A1 (en) * 1999-04-30 2009-02-19 Neurotrophincell Pty. Limited Xenotransplant for cns therapy
US20040213768A1 (en) * 1999-04-30 2004-10-28 Elliott Robert Bartlett Preparation for biotransplantation and xenotransplantion and uses thereof
US6558665B1 (en) * 1999-05-18 2003-05-06 Arch Development Corporation Encapsulating particles with coatings that conform to size and shape of the particles
US6471689B1 (en) * 1999-08-16 2002-10-29 Thomas Jefferson University Implantable drug delivery catheter system with capillary interface
AU7719300A (en) * 1999-09-27 2001-04-30 Ixion Biotechnology, Inc. Reversal of insulin-dependent diabetes by islet-producing stem cells, islet progenitor cells and islet-like structures
ATE337096T1 (de) * 1999-10-20 2006-09-15 Gentra Systems Inc Mix- und giessapparat mit drehbarem arm und zugehörigem gefäss
US6878543B1 (en) 1999-10-25 2005-04-12 Nsgene Sa Cultures of GFAP+ nestin+ cells that differentiate to neurons
US6365171B1 (en) 1999-11-04 2002-04-02 The University Of Akron Amphiphilic networks, implantable immunoisolatory devices and methods of preparation
US8012500B2 (en) 2000-01-01 2011-09-06 Beta-O2 Technologies Ltd. Implantable device
DK1248640T3 (da) * 2000-01-20 2007-02-12 Diabcell Pty Ltd Xenotransplantation af svineöer og deres fremstilling
US20020106346A1 (en) * 2000-03-06 2002-08-08 Shah Kumarpal A. Immune modulation with polystyrene sulfonate
US20030167054A1 (en) * 2000-05-05 2003-09-04 Lawrence Rosenberg Device for cell implantation
NZ523461A (en) 2000-05-31 2004-11-26 Encelle Inc Method of treating chronic ulcers
US20050095268A1 (en) * 2000-06-12 2005-05-05 Acorn Cardiovascular, Inc. Cardiac wall tension relief with cell loss management
US6730016B1 (en) * 2000-06-12 2004-05-04 Acorn Cardiovascular, Inc. Cardiac disease treatment and device
EP1333846B1 (de) * 2000-10-17 2012-04-18 Diabcell Pty Limited Zubereitung und xenotransplantation von langerhans-inseln von schweinen
US6560471B1 (en) 2001-01-02 2003-05-06 Therasense, Inc. Analyte monitoring device and methods of use
US7442370B2 (en) 2001-02-01 2008-10-28 Biogen Idec Ma Inc. Polymer conjugates of mutated neublastin
US7232425B2 (en) * 2001-03-02 2007-06-19 Sorenson Development, Inc. Apparatus and method for specific interstitial or subcutaneous diffusion and dispersion of medication
US7276580B2 (en) 2001-03-12 2007-10-02 Biogen Idec Ma Inc. Neurotrophic factors
US7252982B2 (en) * 2001-03-15 2007-08-07 Massachusetts Institute Of Technology Tissue engineering enhanced by the transfer of a growth factor gene
US20030073608A1 (en) * 2001-04-10 2003-04-17 Woolf Nancy J. Process for treating disease
CA2388723C (en) * 2001-06-06 2012-10-23 Becton, Dickinson & Company Method of providing a substrate with a ready-to-use, uniformly distributed extracellular matrix
WO2002100335A2 (en) * 2001-06-08 2002-12-19 Boehringer Ingelheim Pharmaceuticals, Inc. Methods for improving cell line activity in immunoisolation devices
WO2002101796A2 (en) * 2001-06-12 2002-12-19 Verteq, Inc. Megasonic cleaner and dryer system
US8815793B2 (en) * 2001-07-20 2014-08-26 Northwestern University Polymeric compositions and related methods of use
US7618937B2 (en) * 2001-07-20 2009-11-17 Northwestern University Peptidomimetic polymers for antifouling surfaces
US7858679B2 (en) * 2001-07-20 2010-12-28 Northwestern University Polymeric compositions and related methods of use
EP1281767A3 (de) 2001-07-31 2003-05-28 Aladar A. Szalay Lichtausstrahlende Mikroorganismen und Zellen für die Diagnose und Therapie von Tumoren
EP1424957A2 (de) 2001-09-14 2004-06-09 Francis J. Martin Mikrofabrizierte nanoporen-vorrichtung für die verzögerte freisetzung eines therapeutischen mittels
EP1438395B1 (de) * 2001-09-28 2011-11-30 Diabcell Pty Limited Züchtung von fremdtransplantationsmaterial in kultur
US7988685B2 (en) * 2001-11-01 2011-08-02 Regents Of The University Of Minnesota Hydrogel compositions, devices, and microscale components
US7468242B2 (en) * 2001-11-05 2008-12-23 Medgenics, Inc. Dermal micro organs, methods and apparatuses for producing and using the same
US8501396B2 (en) 2001-11-05 2013-08-06 Medgenics Medical Israel Ltd. Dermal micro-organs, methods and apparatuses for producing and using the same
KR100954987B1 (ko) * 2001-11-05 2010-04-29 메드제닉스 인코포레이티드 조직 기재 치료를 위한 폐쇄된 자동화 시스템, 이를 이용한 투약 및 투여 방법
US8088568B2 (en) 2001-11-05 2012-01-03 Medgentics, Inc. Dermal micro-organs, methods and apparatuses for producing and using the same
NZ515310A (en) * 2001-11-07 2004-08-27 Diabcell Pty Ltd Methods of treatment and delivery modes
WO2003054146A2 (en) * 2001-11-14 2003-07-03 Northwestern University Self-assembly and mineralization of peptide-amphiphile nanofibers
AU2002351164A1 (en) * 2001-11-26 2003-06-10 Molecular Reflections, Inc. Microscale immobilization of molecules using a hydrogel and methods of use thereof
US8260393B2 (en) 2003-07-25 2012-09-04 Dexcom, Inc. Systems and methods for replacing signal data artifacts in a glucose sensor data stream
US9247901B2 (en) 2003-08-22 2016-02-02 Dexcom, Inc. Systems and methods for replacing signal artifacts in a glucose sensor data stream
US7828728B2 (en) 2003-07-25 2010-11-09 Dexcom, Inc. Analyte sensor
US8364229B2 (en) 2003-07-25 2013-01-29 Dexcom, Inc. Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise
US8010174B2 (en) 2003-08-22 2011-08-30 Dexcom, Inc. Systems and methods for replacing signal artifacts in a glucose sensor data stream
US7613491B2 (en) 2002-05-22 2009-11-03 Dexcom, Inc. Silicone based membranes for use in implantable glucose sensors
US9282925B2 (en) 2002-02-12 2016-03-15 Dexcom, Inc. Systems and methods for replacing signal artifacts in a glucose sensor data stream
WO2003070749A2 (en) * 2002-02-15 2003-08-28 Northwestern University Self-assembly of peptide-amphiphile nanofibers under physiological conditions
US20080086792A1 (en) 2006-10-13 2008-04-17 Thomas Charles Kuracina Method and apparatus for diverting sweat, liquid, moisture or the like from an eye
WO2003072155A1 (en) 2002-02-21 2003-09-04 Encelle, Inc. Cross-linked bioactive hydrogel matrices
US20030170278A1 (en) * 2002-03-11 2003-09-11 Wolf David E. Microreactor and method of determining a microreactor suitable for a predetermined mammal
BR122017016940B8 (pt) * 2002-04-25 2021-07-27 Transkaryotic Therapies Inc método para preparação de uma composição farmacêutica compreendendo alfa-galactosidase a
US20050008629A1 (en) * 2002-05-08 2005-01-13 Interpore Orthopaedics, A Delaware Corporation Encapsulated AGF cells
WO2003095359A2 (en) * 2002-05-08 2003-11-20 The Board Of Trustees Of The Leland Stanford Junior University Nanotube mat with an array of conduits
US8173372B2 (en) * 2002-05-16 2012-05-08 Absorber Ab Methods of donor specific crossmatching
EP1369491A1 (de) * 2002-06-05 2003-12-10 Aladar A. Szalay Lichtemittierende Mikroorganismen und Zellen für die Diagnose und Therapie von Krankheiten assoziiert mit Wunden oder entzündetem Gewebe
US20030228261A1 (en) * 2002-06-05 2003-12-11 Aladar Szalay Light emitting microorganisms and cells for diagnosis and therapy of diseases associated with wounded or inflamed tissue
AU2003242967A1 (en) * 2002-07-12 2004-02-02 Yissum Research Development Company Of The Hebrew University Of Jerusalem Method and device for inducing biological processes by micro-organs
US20080171012A1 (en) * 2007-01-11 2008-07-17 Phillip Messersmith Fouling Resistant Coatings and Methods of Making Same
US8911831B2 (en) * 2002-07-19 2014-12-16 Northwestern University Surface independent, surface-modifying, multifunctional coatings and applications thereof
US7163545B2 (en) * 2002-07-29 2007-01-16 Mayo Foundation For Medical Education And Research Spinal cord surgical implant
US7534761B1 (en) 2002-08-21 2009-05-19 North Western University Charged peptide-amphiphile solutions and self-assembled peptide nanofiber networks formed therefrom
US20050069572A1 (en) * 2002-10-09 2005-03-31 Jennifer Elisseeff Multi-layered polymerizing hydrogels for tissue regeneration
JP4571776B2 (ja) * 2002-11-05 2010-10-27 Ｊｘ日鉱日石エネルギー株式会社 潤滑油組成物
US7554021B2 (en) * 2002-11-12 2009-06-30 Northwestern University Composition and method for self-assembly and mineralization of peptide amphiphiles
US7683025B2 (en) * 2002-11-14 2010-03-23 Northwestern University Synthesis and self-assembly of ABC triblock bola peptide amphiphiles
US20060018882A1 (en) * 2004-06-21 2006-01-26 Kaemmerer William F Medical devices and methods for delivering compositions to cells
AU2002952993A0 (en) 2002-11-29 2002-12-12 The Corporation Of The Trustees Of The Order Of The Sisters Of Mercy In Queensland Therapeutic and diagnostic agents
US20060251630A1 (en) * 2002-12-24 2006-11-09 An-Go-Gen Inc. Encapsulated cell therapy
KR100486367B1 (ko) * 2003-01-14 2005-04-29 학교법인연세대학교 외벽에 반투막이 형성된 생분해성 이중 다공성 스캐폴드및 이를 이용한 조직세포 배양방법
PT2857036T (pt) 2003-01-31 2017-03-13 Mount Sinai School Of Medicine Of N Y Univ Terapia combinada para o tratamento de distúrbios de deficiência proteica
MXPA05008483A (es) 2003-02-11 2006-03-10 Univ Northwestern Metodos y materiales para revestimientos de superficie nanocristalinos y union de nanofibras de anfililos peptidicos sobre las mismas.
WO2004094592A2 (en) 2003-04-18 2004-11-04 Biogen Idec Ma Inc. Polymer-conjugated glycosylated neublastin
US7459152B2 (en) * 2003-04-23 2008-12-02 Rush University Medical Center Erythropoietin administration to improve graft survival
EP2377403A1 (de) 2003-05-01 2011-10-19 Medgenics, Inc. Genetisch modifizierter dermisches mikroorgan-ausdrückender Faktor VIII
ATE423134T1 (de) 2003-06-10 2009-03-15 Nsgene As Verbesserte sezernierung von neublastin
WO2005047458A2 (en) 2003-06-18 2005-05-26 Genelux Corporation Modified recombinant vaccina viruses and other microorganisms, uses thereof
WO2004113516A1 (en) * 2003-06-24 2004-12-29 Diabcell Pty Limited Porcine islets cultured with porcine sertoli cells for xenotransplantation
US7651596B2 (en) 2005-04-08 2010-01-26 Dexcom, Inc. Cellulosic-based interference domain for an analyte sensor
US20070173709A1 (en) * 2005-04-08 2007-07-26 Petisce James R Membranes for an analyte sensor
US8423113B2 (en) 2003-07-25 2013-04-16 Dexcom, Inc. Systems and methods for processing sensor data
US7761130B2 (en) 2003-07-25 2010-07-20 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US9763609B2 (en) 2003-07-25 2017-09-19 Dexcom, Inc. Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise
JP4708342B2 (ja) * 2003-07-25 2011-06-22 デックスコム・インコーポレーテッド 埋設可能な装置に用いる酸素増大膜システム
US9135402B2 (en) 2007-12-17 2015-09-15 Dexcom, Inc. Systems and methods for processing sensor data
US8886273B2 (en) 2003-08-01 2014-11-11 Dexcom, Inc. Analyte sensor
US8369919B2 (en) 2003-08-01 2013-02-05 Dexcom, Inc. Systems and methods for processing sensor data
US7494465B2 (en) 2004-07-13 2009-02-24 Dexcom, Inc. Transcutaneous analyte sensor
US8761856B2 (en) 2003-08-01 2014-06-24 Dexcom, Inc. System and methods for processing analyte sensor data
US8845536B2 (en) 2003-08-01 2014-09-30 Dexcom, Inc. Transcutaneous analyte sensor
US7925321B2 (en) 2003-08-01 2011-04-12 Dexcom, Inc. System and methods for processing analyte sensor data
US20190357827A1 (en) 2003-08-01 2019-11-28 Dexcom, Inc. Analyte sensor
US8160669B2 (en) 2003-08-01 2012-04-17 Dexcom, Inc. Transcutaneous analyte sensor
US7519408B2 (en) 2003-11-19 2009-04-14 Dexcom, Inc. Integrated receiver for continuous analyte sensor
US7774145B2 (en) 2003-08-01 2010-08-10 Dexcom, Inc. Transcutaneous analyte sensor
US8275437B2 (en) 2003-08-01 2012-09-25 Dexcom, Inc. Transcutaneous analyte sensor
US7778680B2 (en) 2003-08-01 2010-08-17 Dexcom, Inc. System and methods for processing analyte sensor data
US7591801B2 (en) 2004-02-26 2009-09-22 Dexcom, Inc. Integrated delivery device for continuous glucose sensor
US20100168542A1 (en) 2003-08-01 2010-07-01 Dexcom, Inc. System and methods for processing analyte sensor data
US7920906B2 (en) 2005-03-10 2011-04-05 Dexcom, Inc. System and methods for processing analyte sensor data for sensor calibration
US20140121989A1 (en) 2003-08-22 2014-05-01 Dexcom, Inc. Systems and methods for processing analyte sensor data
US8233959B2 (en) 2003-08-22 2012-07-31 Dexcom, Inc. Systems and methods for processing analyte sensor data
EP1667516A4 (de) 2003-08-29 2009-11-11 Inst Medical W & E Hall Verfahren zur auswahl von tiermodellen von tieren, die mutagenese unterzogen worden sind, und verwendung von myb-transkriptionsfaktoren zum screening
SE526959C2 (sv) * 2003-10-02 2005-11-29 Tikomed Ab Bioartificellt implantat innefattande en semipermeabel barriär samt förfarande för reducering av risken för bildning av bindrväv vid implantatet efter implantering genom att barriären förses med en permeabel beläggning av bioaktiv metall
ES2342397T3 (es) 2003-10-20 2010-07-06 Nsgene A/S Vector virico para su uso en terapia genica in vivo de la enfermedad de parkinson.
US8916184B2 (en) 2003-11-07 2014-12-23 University Of Connecticut Artificial tissue systems and uses thereof
US9247900B2 (en) 2004-07-13 2016-02-02 Dexcom, Inc. Analyte sensor
US11633133B2 (en) 2003-12-05 2023-04-25 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
WO2005056576A2 (en) 2003-12-05 2005-06-23 Northwestern University Branched peptide amphiphiles, related epitope compounds and self assembled structures thereof
US8423114B2 (en) 2006-10-04 2013-04-16 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US8287453B2 (en) 2003-12-05 2012-10-16 Dexcom, Inc. Analyte sensor
EP2239567B1 (de) 2003-12-05 2015-09-02 DexCom, Inc. Kalibrierverfahren für einen kontinuierlichen Analytsensor
US8774886B2 (en) 2006-10-04 2014-07-08 Dexcom, Inc. Analyte sensor
US8364231B2 (en) 2006-10-04 2013-01-29 Dexcom, Inc. Analyte sensor
ATE541580T1 (de) 2003-12-05 2012-02-15 Univ Northwestern Selbst anordnende peptid-amphiphile und relevante verfahren für die abgabe von wachstumsfaktor
EP2316331B1 (de) 2003-12-09 2016-06-29 Dexcom, Inc. Signalverarbeitung in einem durchgehenden Analytsensor
US7780973B2 (en) * 2003-12-15 2010-08-24 Ethicon Endo-Surgery, Inc. Method and device for minimally invasive implantation of biomaterial
AU2011204947B2 (en) * 2003-12-15 2013-05-09 Ethicon Endo-Surgery, Inc. Method and device for minimally invasive implantation of biomaterial
NZ547767A (en) 2003-12-24 2010-05-28 Inst Medical W & E Hall Therapeutic agents and uses therefor
WO2005079257A2 (en) * 2004-02-12 2005-09-01 Dexcom, Inc. Biointerface with macro- and micro- architecture
US8808228B2 (en) 2004-02-26 2014-08-19 Dexcom, Inc. Integrated medicament delivery device for use with continuous analyte sensor
CA2559110A1 (en) * 2004-03-09 2005-09-15 Absorber Ab Endothelial progenitor cells and methods of use thereof
US20050208090A1 (en) * 2004-03-18 2005-09-22 Medtronic, Inc. Methods and systems for treatment of neurological diseases of the central nervous system
CN1950397B (zh) 2004-03-30 2012-05-16 Ns基因公司 生长因子NsG33的治疗用途
US8792955B2 (en) 2004-05-03 2014-07-29 Dexcom, Inc. Transcutaneous analyte sensor
JP4980211B2 (ja) 2004-05-12 2012-07-18 ウォルター アンド エリザ ホール インスティテュート オブ メディカル リサーチ 細胞単離方法
WO2006127694A2 (en) 2004-07-13 2006-11-30 Dexcom, Inc. Analyte sensor
US8452368B2 (en) 2004-07-13 2013-05-28 Dexcom, Inc. Transcutaneous analyte sensor
US7857760B2 (en) 2004-07-13 2010-12-28 Dexcom, Inc. Analyte sensor
US7783333B2 (en) 2004-07-13 2010-08-24 Dexcom, Inc. Transcutaneous medical device with variable stiffness
US8989833B2 (en) 2004-07-13 2015-03-24 Dexcom, Inc. Transcutaneous analyte sensor
US8565848B2 (en) 2004-07-13 2013-10-22 Dexcom, Inc. Transcutaneous analyte sensor
NZ553080A (en) * 2004-07-29 2010-10-29 Univ Miami A device for receiving implanted biological material
EP2594259A1 (de) 2004-08-04 2013-05-22 Brookwood Pharmaceuticals, Inc. Verfahren zur Herstellung von Abgabevorrichtungen und damit erhaltene Vorrichtungen
US8075904B2 (en) * 2004-08-11 2011-12-13 California Institute Of Technology High aspect ratio template and method for producing same for central and peripheral nerve repair
KR101241551B1 (ko) 2004-08-19 2013-03-11 바이오겐 아이덱 엠에이 인코포레이티드 전환 성장 인자 베타 패밀리 단백질의 리폴딩
KR101215697B1 (ko) 2004-08-19 2012-12-28 바이오겐 아이덱 엠에이 인코포레이티드 뉴블라스틴 변형체
US20060046960A1 (en) * 2004-09-02 2006-03-02 Mckay William F Controlled and directed local delivery of anti-inflammatory compositions
US20060046961A1 (en) * 2004-09-02 2006-03-02 Mckay William F Controlled and directed local delivery of anti-inflammatory compositions
US20060093639A1 (en) * 2004-10-29 2006-05-04 Starkebaum Warren L Method and device for destroying body tissue
US7772201B2 (en) 2004-11-17 2010-08-10 “University of Maryland, Baltimore” Highly branched HK peptides as effective carriers of siRNA
US20070009668A1 (en) * 2004-11-18 2007-01-11 Wyman Jason L Microencapsulation of particles in a polymer solution by selective withdrawal through a high viscosity low density fluid and subsequent crosslinking
GB2420976B (en) * 2004-11-19 2006-12-20 Zvi Finkelstein Therapeutic implant
US7833513B2 (en) 2004-12-03 2010-11-16 Rhode Island Hospital Treatment of Alzheimer's Disease
CN101150954A (zh) * 2005-01-21 2008-03-26 西北大学 包封细胞的方法和组合物
CA2598251A1 (en) * 2005-03-04 2006-09-14 Northwestern University Angiogenic heparin binding peptide amphiphiles
US8133178B2 (en) 2006-02-22 2012-03-13 Dexcom, Inc. Analyte sensor
US20090076360A1 (en) 2007-09-13 2009-03-19 Dexcom, Inc. Transcutaneous analyte sensor
CA2603391A1 (en) 2005-04-01 2006-10-05 Nsgene A/S A human immortalised neural precursor cell line
US8744546B2 (en) 2005-05-05 2014-06-03 Dexcom, Inc. Cellulosic-based resistance domain for an analyte sensor
US20060252027A1 (en) * 2005-05-05 2006-11-09 Petisce James R Cellulosic-based resistance domain for an analyte sensor
NZ536009A (en) 2005-04-18 2007-01-26 Neurotrophincell Pty Ltd Choroid plexus preparation and uses thereof
US20090075375A1 (en) * 2005-04-18 2009-03-19 Neurotrophincell Pty Limited Choroid plexus preparation and uses thereof
US7588775B2 (en) * 2005-04-23 2009-09-15 E-L Management Corp. Silicone elastomer exfoliating compositions
JP5010584B2 (ja) * 2005-05-17 2012-08-29 エヌエスゲーネ・アクティーゼルスカブ 活性因子によって生物を治療する移植可能な療法システム
AU2006247065B8 (en) 2005-05-17 2012-07-12 Amicus Therapeutics, Inc. A method for the treatment of Pompe disease using 1-deoxynojirimycin derivatives
NZ540597A (en) * 2005-06-08 2007-02-23 Neurotrophincell Pty Ltd A method for preventing the onset of type I diabetes comprising administering an implantable composition comprising living choroid plexus cells
US7616111B2 (en) * 2005-06-20 2009-11-10 Carestream Health, Inc. System to monitor the ingestion of medicines
US7782189B2 (en) * 2005-06-20 2010-08-24 Carestream Health, Inc. System to monitor the ingestion of medicines
DK2407484T3 (en) 2005-06-24 2016-09-05 The Walter And Eliza Hall Inst Of Medical Res Therapeutic pro-apoptotic BH3-like molecules, and methods of generating and / or selecting those
US8357666B2 (en) 2005-08-01 2013-01-22 Nupotential, Inc. Reprogramming a cell by inducing a pluripotent gene through RNA interference
US20100119525A1 (en) * 2005-08-01 2010-05-13 Mount Sinai Schoool Of Medicine Of New York University Method for extending longevity using npc1l1 antagonists
US8900620B2 (en) 2005-10-13 2014-12-02 DePuy Synthes Products, LLC Drug-impregnated encasement
US20070190165A1 (en) * 2005-10-21 2007-08-16 Brey Eric M Tissue-specific basement membrane gels
US20070116680A1 (en) * 2005-11-18 2007-05-24 Rensselaer Polytechnic Institute Stem cells within gel microenvironments
AU2006332971B2 (en) 2005-12-30 2013-03-07 Neurotech Usa, Inc. Micronized device for the delivery of biologically active molecules and methods of use thereof
US20070190036A1 (en) * 2006-01-04 2007-08-16 Seda Kizilel Microencapsulation of pancreatic islets within a thin coat of glucagon-like peptide-1 functionalized poly(ethylene glycol)
US9757061B2 (en) 2006-01-17 2017-09-12 Dexcom, Inc. Low oxygen in vivo analyte sensor
US7732539B2 (en) * 2006-02-16 2010-06-08 National Science Foundation Modified acrylic block copolymers for hydrogels and pressure sensitive wet adhesives
TWI501774B (zh) 2006-02-27 2015-10-01 Biogen Idec Inc 神經性病症之治療
ES2450065T3 (es) * 2006-03-01 2014-03-21 Biogen Idec Ma Inc. Composiciones y métodos para la administración de proteínas de la familia de ligandos del GDNF
US20080071158A1 (en) 2006-06-07 2008-03-20 Abbott Diabetes Care, Inc. Analyte monitoring system and method
TW200819540A (en) 2006-07-11 2008-05-01 Genelux Corp Methods and compositions for detection of microorganisms and cells and treatment of diseases and disorders
WO2008011006A2 (en) 2006-07-18 2008-01-24 University Of Utah Research Foundation Methods for treating pain and screening analgesic compounds
WO2008091386A2 (en) * 2006-08-04 2008-07-31 Northwestern University Biomimetic modular adhesive complex: material, methods and applications therefore
WO2008019352A1 (en) 2006-08-04 2008-02-14 Nerites Corporation Biomimetic compounds and synthetic methods therefor
JP5191489B2 (ja) 2006-08-23 2013-05-08 エスヴイアイピー ２ エルエルシー 摂食行動を変更するデバイス及び方法
CA2662209C (en) * 2006-08-29 2015-02-17 The University Of Akron Implantable devices for producing insulin
WO2008033375A2 (en) 2006-09-14 2008-03-20 Medgenics Ltd. Long lasting drug formulations
US8454948B2 (en) 2006-09-14 2013-06-04 Medgenics Medical Israel Ltd. Long lasting drug formulations
WO2008062417A2 (en) * 2006-11-22 2008-05-29 Beta O2 Technologies Ltd. Protecting algae from body fluids
ES2659988T3 (es) 2006-11-28 2018-03-20 Beta O2 Technologies Ltd. Suministro de oxígeno para el transplante celular y la vascularización
US7980000B2 (en) * 2006-12-29 2011-07-19 Applied Materials, Inc. Vapor dryer having hydrophilic end effector
US8673286B2 (en) 2007-04-09 2014-03-18 Northwestern University DOPA-functionalized, branched, poly(aklylene oxide) adhesives
US8383092B2 (en) * 2007-02-16 2013-02-26 Knc Ner Acquisition Sub, Inc. Bioadhesive constructs
EP2134853B1 (de) 2007-04-03 2018-07-18 Oxyrane UK Limited Glycosylierung von molekülen
US8076295B2 (en) * 2007-04-17 2011-12-13 Nanotope, Inc. Peptide amphiphiles having improved solubility and methods of using same
ES2476253T3 (es) 2007-05-01 2014-07-14 Biogen Idec Ma Inc. P�ptidos de neublastina para su uso en el aumento de la vascularizaci�n en tejido con flujo sanguíneo deteriorado
US20200037874A1 (en) 2007-05-18 2020-02-06 Dexcom, Inc. Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise
JP2010528754A (ja) * 2007-06-04 2010-08-26 エスヴィーアイピー ８ エルエルシー 組織を固着可能な装置
WO2009110917A1 (en) * 2007-06-07 2009-09-11 Osteotherapeutics, L.L.C. Bone cement compositions for use as growth factor carriers and methods of making same
US20080306434A1 (en) 2007-06-08 2008-12-11 Dexcom, Inc. Integrated medicament delivery device for use with continuous analyte sensor
AU2008266060B2 (en) * 2007-06-13 2013-08-29 Fmc Corporation Alginate coated, polysaccharide gel-containing foam composite, preparative methods, and uses thereof
US20090004455A1 (en) * 2007-06-27 2009-01-01 Philippe Gravagna Reinforced composite implant
US8932619B2 (en) * 2007-06-27 2015-01-13 Sofradim Production Dural repair material
WO2009020964A2 (en) * 2007-08-08 2009-02-12 Biogen Idec Ma Inc. Anti-neublastin antibodies and uses thereof
AU2008289461A1 (en) 2007-08-23 2009-02-26 Intrexon Corporation Methods and compositions for diagnosing disease
US20090068250A1 (en) * 2007-09-07 2009-03-12 Philippe Gravagna Bioresorbable and biocompatible compounds for surgical use
US8821431B2 (en) 2007-09-07 2014-09-02 Beta O2 Technologies Ltd. Air gap for supporting cells
US8093038B2 (en) * 2007-09-17 2012-01-10 Illinois Institute Of Technology Apparatus and method for encapsulating pancreatic cells
US20100278798A1 (en) * 2007-09-27 2010-11-04 The Trustees Of Columbia University In The City Of New York Methods and systems for forming biocompatible materials
WO2009045370A2 (en) 2007-09-28 2009-04-09 Intrexon Corporation Therapeutic gene-switch constructs and bioreactors for the expression of biotherapeutic molecules, and uses thereof
US20090090214A1 (en) * 2007-10-04 2009-04-09 Chung Yuan Christian University Method for forming nano-scale metal particles
EP2227132B1 (de) 2007-10-09 2023-03-08 DexCom, Inc. Integriertes insulin-abgabesystem mit kontinuierlichem glucosesensor
US8417312B2 (en) 2007-10-25 2013-04-09 Dexcom, Inc. Systems and methods for processing sensor data
US9308068B2 (en) * 2007-12-03 2016-04-12 Sofradim Production Implant for parastomal hernia
US9839395B2 (en) 2007-12-17 2017-12-12 Dexcom, Inc. Systems and methods for processing sensor data
WO2009079555A2 (en) * 2007-12-17 2009-06-25 Anna Love Soft tissue filler
CA2709712C (en) 2007-12-20 2016-05-10 Surmodics Pharmaceuticals, Inc. Process for preparing microparticles having a low residual solvent volume
WO2009086535A2 (en) * 2007-12-27 2009-07-09 The Trustees Of Columbia University In The City Of New York Systems and methods for forming patterned extracellular matrix materials
US8591455B2 (en) 2008-02-21 2013-11-26 Dexcom, Inc. Systems and methods for customizing delivery of sensor data
US8396528B2 (en) 2008-03-25 2013-03-12 Dexcom, Inc. Analyte sensor
US8682408B2 (en) 2008-03-28 2014-03-25 Dexcom, Inc. Polymer membranes for continuous analyte sensors
US8583204B2 (en) 2008-03-28 2013-11-12 Dexcom, Inc. Polymer membranes for continuous analyte sensors
US11730407B2 (en) 2008-03-28 2023-08-22 Dexcom, Inc. Polymer membranes for continuous analyte sensors
US20090247855A1 (en) 2008-03-28 2009-10-01 Dexcom, Inc. Polymer membranes for continuous analyte sensors
EP2276838A4 (de) 2008-04-07 2012-02-01 Nupotential Inc Neuprogrammierung einer zelle mittels induzierung eines pluripotenten gens anhand von rna-interferenz
WO2009125332A1 (en) * 2008-04-07 2009-10-15 Peter Bromley New and safe procedure for immunization against infectious diseases agents
JP2011523560A (ja) 2008-06-02 2011-08-18 ダナ−ファーバー キャンサー インスティテュート インク． Ｘｂｐ１ペプチド、ｃｄ１３８ペプチドおよびｃｓ１ペプチド
EP2303390A4 (de) * 2008-06-03 2011-11-30 Svip 8 Llc Im gewebe verankerte vorrichtungen
US9242026B2 (en) * 2008-06-27 2016-01-26 Sofradim Production Biosynthetic implant for soft tissue repair
EP2195013B1 (de) 2008-07-24 2011-11-02 NsGene A/S Therapeutische verwendung eines wachstumsfaktors, metrnl
US10842645B2 (en) 2008-08-13 2020-11-24 Smed-Ta/Td, Llc Orthopaedic implant with porous structural member
CA2734183C (en) * 2008-08-13 2016-11-01 Smed-Ta/Td, Llc Orthopaedic implant with spatially varying porosity
US9700431B2 (en) 2008-08-13 2017-07-11 Smed-Ta/Td, Llc Orthopaedic implant with porous structural member
WO2010019781A1 (en) * 2008-08-13 2010-02-18 Smed-Ta/Td, Llc Drug delivery implants
US9616205B2 (en) 2008-08-13 2017-04-11 Smed-Ta/Td, Llc Drug delivery implants
ES2647919T3 (es) 2008-08-13 2017-12-27 Smed-Ta/Td, Llc Implantes de suministro de fármaco
JP5687622B2 (ja) * 2008-08-29 2015-03-18 スメド−ティーエイ／ティーディー・エルエルシー 整形外科インプラント
US9446168B2 (en) 2010-06-07 2016-09-20 Beta-O2 Technologies Ltd. Multiple-layer immune barrier for donor cells
WO2010032242A1 (en) 2008-09-17 2010-03-25 Beta O2 Technologies Ltd. Optimization of alginate encapsulation of islets for transplantation
EP4227675B1 (de) 2008-09-19 2024-12-11 DexCom, Inc. Partikelhaltige membran und partikelelektrode für analytsensoren
US8043271B2 (en) 2008-11-26 2011-10-25 Beta 02 Technologies Ltd. Apparatus for transportation of oxygen to implanted cells
CN102325878A (zh) * 2008-12-23 2012-01-18 斯特姆塞尔思加利福尼亚有限公司 少突胶质前体细胞的靶向细胞群及制备与使用方法
EP2389435B1 (de) 2009-01-23 2015-11-04 NsGene A/S Verbesserte zelllinien und ihre verwendung für verkapselte zell-bio-abgabe
EP2389191A2 (de) 2009-01-23 2011-11-30 NsGene A/S Expression von neuropeptiden in säugetierzellen
US9511093B2 (en) 2009-03-23 2016-12-06 The Texas A & M University System Compositions of mesenchymal stem cells to regenerate bone
US9446194B2 (en) 2009-03-27 2016-09-20 Dexcom, Inc. Methods and systems for promoting glucose management
BRPI1010517A2 (pt) 2009-04-09 2017-01-31 Amicus Therapeutics Inc métodos para prevenção e/ou tratamento de doenças de armazenamento lisossomal
AU2010236584A1 (en) * 2009-04-13 2011-11-10 Northwestern University Novel peptide-based scaffolds for cartilage regeneration and methods for their use
BRPI0902039B8 (pt) 2009-06-09 2021-05-25 Anhanguera Educacional Ltda composição farmacêutica e uso de composição farmacêutica para o tratamento, profilaxia ou prevenção de doenças neoplásicas em humanos e animais
JP5850416B2 (ja) * 2009-06-19 2016-02-03 国立大学法人九州大学 細胞組織体の製造方法
FR2949688B1 (fr) 2009-09-04 2012-08-24 Sofradim Production Tissu avec picots revetu d'une couche microporeuse bioresorbable
WO2011035134A1 (en) * 2009-09-17 2011-03-24 The Ohio State University Microdevices for implantation comprising thermogenic cells for treating a metabolic disease
JP5675820B2 (ja) * 2009-09-22 2015-02-25 エボニック コーポレイションＥｖｏｎｉｋ Ｃｏｒｐｏｒａｔｉｏｎ 様々な生物活性剤担持構成を有するインプラントデバイス
US9598682B2 (en) 2009-09-29 2017-03-21 Vib Vzw Hydrolysis of mannose-1-phospho-6-mannose linkage to phospho-6-mannose
KR20120100962A (ko) 2009-10-02 2012-09-12 박스터 헬쓰케어 에스.에이. 신장 손상을 치료하는데 사용하기 위한 조혈 줄기 세포
DK2490532T3 (en) 2009-10-19 2017-02-27 Amicus Therapeutics Inc Hitherto UNKNOWN COMPOSITIONS FOR PREVENTION AND / OR TREATMENT OF DEGENERATIVE DISORDERS IN THE CENTRAL Nervous System
PT2995306T (pt) 2009-10-19 2019-03-29 Amicus Therapeutics Inc Novas composições para prevenção e/ou tratamento de disfunções de armazenamento lisossomal
US20110106062A1 (en) * 2009-11-05 2011-05-05 Ecole Polytechnique Federale De Lausanne System and Method For In Vivo Delivery of Antibodies and Fragments Thereof
JP2013511272A (ja) 2009-11-19 2013-04-04 オキシレイン ユーケー リミテッド 哺乳類様複合ｎ−グリカンを生成する酵母株
US20110130465A1 (en) * 2009-12-01 2011-06-02 Nerites Corporation Coatings for prevention of biofilms
WO2011079222A2 (en) * 2009-12-23 2011-06-30 Boston Scientific Scimed, Inc. Less traumatic method of delivery of mesh-based devices into human body
EP2547328B1 (de) * 2010-02-11 2017-06-07 Ecole Polytechnique Fédérale de Lausanne (EPFL) Ccr7-liganden-verabreichung und co-verabreichung in einer immuntherapie
US9517250B2 (en) 2010-04-28 2016-12-13 The J. David Gladstone Institutes Methods for generating cardiomyocytes
EP3399026B1 (de) 2010-06-14 2024-06-26 The Scripps Research Institute Neuprogrammierung von zellen für ein neues zellschicksal
CN103339149B (zh) 2010-06-14 2016-02-03 H.隆德贝克有限公司 SorLA和GDNF-家族配体受体之间的相互作用的调节
JP2013532152A (ja) 2010-06-15 2013-08-15 メドジェニクス・メディカル・イスラエル・リミテッド 長期持続性の医薬製剤
AU2011279250B2 (en) 2010-07-12 2014-12-04 California Institute Of Technology Biocompatible substrate for facilitating interconnections between stem cells and target tissues and methods for implanting same
WO2012027494A1 (en) 2010-08-24 2012-03-01 Regents Of The University Of Minnesota Bispecific targeting reagents
US9475709B2 (en) 2010-08-25 2016-10-25 Lockheed Martin Corporation Perforated graphene deionization or desalination
WO2012042386A2 (en) 2010-09-29 2012-04-05 Oxyrane Uk Limited Mannosidases capable of uncapping mannose-1-phospho-6-mannose linkages and demannosylating phosphorylated n-glycans and methods of facilitating mammalian cellular uptake of glycoproteins
SG189110A1 (en) 2010-09-29 2013-05-31 Oxyrane Uk Ltd De-mannosylation of phosphorylated n-glycans
KR101886029B1 (ko) 2010-10-01 2018-08-07 호바 세라퓨틱스 에이피에스 무해자극통증, 통각과민증, 자발통증 및 헛통증의 치료를 위한 메테오린의 용도
WO2012064821A2 (en) 2010-11-09 2012-05-18 Knc Ner Acquisition Sub, Inc. Adhesive compounds and methods use for hernia repair
KR102302069B1 (ko) * 2010-11-10 2021-09-14 인리젠 장기 확대를 위한 주사가능 제제
EP2646007B1 (de) 2010-12-02 2016-12-21 Neurotech USA, Inc. Antiangiogene antikörpergerüste und löslichen rezeptoren sekretierende zellinien und verwendungen davon
BRPI1008258B1 (pt) * 2010-12-16 2020-03-17 Cellprotect Biotecnologia Ltda - Me Composição biopolimérica para o encapsulamento de células, método de produção de uma composição biopolimérica para o encapsulamento de células, método para promover a citoproteção de células e uso de uma composição biopolimérica para o encapsulamento de células
CA2862765A1 (en) 2011-01-04 2012-07-12 Brown University Nanotubes as carriers of nucleic acids into cells
US8360765B2 (en) 2011-01-07 2013-01-29 Covidien Lp Systems and method for forming a coaxial implant
FR2972626B1 (fr) 2011-03-16 2014-04-11 Sofradim Production Prothese comprenant un tricot tridimensionnel et ajoure
US9848809B2 (en) 2011-04-15 2017-12-26 Dexcom, Inc. Advanced analyte sensor calibration and error detection
US8877489B2 (en) 2011-12-05 2014-11-04 California Institute Of Technology Ultrathin parylene-C semipermeable membranes for biomedical applications
WO2012149468A2 (en) 2011-04-29 2012-11-01 University Of Southern California Instruments and methods for the implantation of cell-seeded substrates
AU2012268441B2 (en) 2011-06-06 2016-05-12 Kineta One, Llc ShK-based pharmaceutical compositions and methods of manufacturing and using the same
US20120315255A1 (en) 2011-06-07 2012-12-13 Wisconsin Alumni Research Foundation Hepatocyte Based Insulin Gene Therapy For Diabetes
FR2977789B1 (fr) 2011-07-13 2013-07-19 Sofradim Production Prothese pour hernie ombilicale
FR2977790B1 (fr) 2011-07-13 2013-07-19 Sofradim Production Prothese pour hernie ombilicale
US20130017264A1 (en) * 2011-07-15 2013-01-17 Piramal Life Sciences Limited Alginate tube drug delivery system and method therefor
WO2013032940A1 (en) 2011-08-26 2013-03-07 Dexcom, Inc. Polymer membranes for continuous analyte sensors
EP2753347B1 (de) 2011-09-05 2016-08-03 NsGene A/S Behandlung von allodynie, hyperalgesie, spontanen schmerzen und phantomschmerzen
CN103781499B (zh) 2011-09-30 2016-09-28 索弗拉狄姆产品公司 轻质网的可逆硬化
AU2012313983B2 (en) 2011-09-30 2017-01-19 Sofradim Production Multilayer implants for delivery of therapeutic agents
US20130096170A1 (en) 2011-10-14 2013-04-18 Hospira, Inc. Methods of treating pediatric patients using dexmedetomidine
BR112014010091B1 (pt) 2011-10-27 2022-11-08 Wellstat Ophthalmics Corporation Ácido nucleico, vetor viral, preparação farmacêutica, uso destes, método para produção de uma proteína rdcvf, e método in vitro ou ex vivo de secreção de uma proteína rdcvf a partir de uma célula
KR20140097256A (ko) 2011-11-02 2014-08-06 할사이온, 인크. 상처 치료를 위한 방법들 및 조성물들
US9248013B2 (en) 2011-12-05 2016-02-02 California Institute Of Technology 3-Dimensional parylene scaffold cage
TWI590843B (zh) 2011-12-28 2017-07-11 信迪思有限公司 膜及其製造方法
FR2985271B1 (fr) 2011-12-29 2014-01-24 Sofradim Production Tricot a picots
FR2985170B1 (fr) 2011-12-29 2014-01-24 Sofradim Production Prothese pour hernie inguinale
US8242158B1 (en) 2012-01-04 2012-08-14 Hospira, Inc. Dexmedetomidine premix formulation
WO2013126590A2 (en) 2012-02-21 2013-08-29 Baxter International Inc. Pharmaceutical composition comprising cd34+ cells
JP6194324B2 (ja) 2012-03-15 2017-09-06 オキシレイン ユーケー リミテッド ポンペ病の処置のための方法および材料
CA2868459A1 (en) 2012-03-27 2013-10-03 Amicus Therapeutics, Inc. Polymorphs of (3r,4r,5s)-5-(difluoromethyl)piperidine-3,4-diol fumarate and uses thereof
US9834809B2 (en) 2014-02-28 2017-12-05 Lockheed Martin Corporation Syringe for obtaining nano-sized materials for selective assays and related methods of use
US10980919B2 (en) 2016-04-14 2021-04-20 Lockheed Martin Corporation Methods for in vivo and in vitro use of graphene and other two-dimensional materials
US10653824B2 (en) 2012-05-25 2020-05-19 Lockheed Martin Corporation Two-dimensional materials and uses thereof
US10376845B2 (en) 2016-04-14 2019-08-13 Lockheed Martin Corporation Membranes with tunable selectivity
US10005038B2 (en) 2014-09-02 2018-06-26 Lockheed Martin Corporation Hemodialysis and hemofiltration membranes based upon a two-dimensional membrane material and methods employing same
US9744617B2 (en) 2014-01-31 2017-08-29 Lockheed Martin Corporation Methods for perforating multi-layer graphene through ion bombardment
US10203295B2 (en) 2016-04-14 2019-02-12 Lockheed Martin Corporation Methods for in situ monitoring and control of defect formation or healing
EP2854884A1 (de) 2012-05-30 2015-04-08 Neurotech USA, Inc. Implantierbare kryokonservierte zellkulturvorrichtungen und verwendungen davon
US9289453B2 (en) * 2012-06-14 2016-03-22 Ramot At Tel-Aviv University Ltd. Transplantation of cells into the nasal cavity and the subarachnoid cranial space
IN2015DN00934A (de) 2012-08-01 2015-06-12 United Therapeutics Corp
ES2869701T3 (es) 2012-08-01 2021-10-25 United Therapeutics Corp Tratamiento de hipertensión arterial pulmonar con células progenitoras endoteliales tratadas con prostaciclina
FR2994185B1 (fr) 2012-08-02 2015-07-31 Sofradim Production Procede de preparation d’une couche poreuse a base de chitosane
FR2995778B1 (fr) 2012-09-25 2015-06-26 Sofradim Production Prothese de renfort de la paroi abdominale et procede de fabrication
FR2995779B1 (fr) 2012-09-25 2015-09-25 Sofradim Production Prothese comprenant un treillis et un moyen de consolidation
FR2995788B1 (fr) 2012-09-25 2014-09-26 Sofradim Production Patch hemostatique et procede de preparation
WO2014049446A2 (en) 2012-09-28 2014-04-03 Sofradim Production Packaging for a hernia repair device
US9788765B2 (en) 2012-09-28 2017-10-17 Dexcom, Inc. Zwitterion surface modifications for continuous sensors
CA2888803A1 (en) 2012-11-05 2014-05-08 Jooeun Bae Xbp1, cd138, and cs1 peptides, pharmaceutical compositions that include the peptides, and methods of using such peptides and compositions
CN114558032B (zh) 2012-12-21 2025-07-29 安斯泰来再生医药协会 由多能干细胞制备血小板的方法及其组合物
AU2014205557B2 (en) 2013-01-09 2017-08-10 United Therapeutics Corporation Treatment of vasculopathy with prostacyclin and mesenchymal stem cells
US20190040368A1 (en) 2013-03-05 2019-02-07 Oxyrane Uk Limited Production of catalytically active type i sulfatase
ES2681602T3 (es) 2013-03-07 2018-09-14 Viacyte, Inc. Ensamblaje de dispositivo de encapsulación celular tridimensional de gran capacidad
USD720469S1 (en) 2013-03-07 2014-12-30 Viacyte, Inc. Cell encapsulation device
US9592475B2 (en) 2013-03-12 2017-03-14 Lockheed Martin Corporation Method for forming perforated graphene with uniform aperture size
US9555007B2 (en) * 2013-03-14 2017-01-31 Massachusetts Institute Of Technology Multi-layer hydrogel capsules for encapsulation of cells and cell aggregates
US10405961B2 (en) 2013-03-14 2019-09-10 Cell and Molecular Tissue Engineering, LLC Coated surgical mesh, and corresponding systems and methods
US10130288B2 (en) 2013-03-14 2018-11-20 Cell and Molecular Tissue Engineering, LLC Coated sensors, and corresponding systems and methods
US10172791B2 (en) * 2013-03-14 2019-01-08 Massachusetts Institute Of Technology Multi-layer hydrogel capsules for encapsulation of cells and cell aggregates
US9737250B2 (en) 2013-03-15 2017-08-22 Dexcom, Inc. Membrane for continuous analyte sensors
WO2014152511A1 (en) 2013-03-15 2014-09-25 The Jackson Laboratory Methods for promoting wound healing and hair growth
DE102013004595A1 (de) 2013-03-15 2014-09-18 Emergent Product Development Germany Gmbh RSV-Impfstoffe
JP6681826B2 (ja) 2013-05-31 2020-04-15 ザ ユニバーシティ オブ ユタ リサーチ ファウンデイション コノトキシンペプチド、医薬組成物およびそれらの使用
FR3006581B1 (fr) 2013-06-07 2016-07-22 Sofradim Production Prothese a base d’un textile pour voie laparoscopique
FR3006578B1 (fr) 2013-06-07 2015-05-29 Sofradim Production Prothese a base d’un textile pour voie laparoscopique
AU2014281010B2 (en) 2013-06-21 2018-05-10 DePuy Synthes Products, Inc. Films and methods of manufacture
US9572918B2 (en) 2013-06-21 2017-02-21 Lockheed Martin Corporation Graphene-based filter for isolating a substance from blood
WO2015042580A1 (en) 2013-09-23 2015-03-26 Biogen Idec Ma Inc. Compositions and methods for treatment of neuropathic pain
CA2938273A1 (en) 2014-01-31 2015-08-06 Peter V. Bedworth Perforating two-dimensional materials using broad ion field
EP3099645A4 (de) 2014-01-31 2017-09-27 Lockheed Martin Corporation Verfahren zur formung von verbundstrukturen mit einem zweidimensionalen material unter verwendung einer porösen, nichtbeschädigenden trägerschicht
US9598438B2 (en) 2014-02-12 2017-03-21 Amicus Therapeutics, Inc. Sugar derivatives comprising sulfur-containing moieties and methods of making same and methods of using the same for the treatment of MPS IIIC
CA2942496A1 (en) 2014-03-12 2015-09-17 Lockheed Martin Corporation Separation membranes formed from perforated graphene
US9775842B2 (en) 2014-03-14 2017-10-03 Rhode Island Hospital Nanocarriers and their processing for diagnostics and therapeutics
WO2015159889A1 (ja) * 2014-04-14 2015-10-22 学校法人福岡大学 インスリン産生細胞移植方法
US9675627B2 (en) 2014-04-14 2017-06-13 Amicus Therapeutics, Inc. Dosing regimens for treating and/or preventing cerebral amyloidoses
EP3142485B1 (de) * 2014-05-12 2021-04-28 Roosterbio, Inc. Druckfertige zellen und integrierte vorrichtungen
US10729579B2 (en) 2014-07-11 2020-08-04 National Institutes Of Health Surgical tool and method for ocular tissue transplantation
US9775978B2 (en) 2014-07-25 2017-10-03 Warsaw Orthopedic, Inc. Drug delivery device and methods having a retaining member
CA2950166C (en) 2014-07-25 2023-08-01 Becton, Dickinson And Company Analyte test strip assays, and test strips and kits for use in practicing the same
US9764122B2 (en) 2014-07-25 2017-09-19 Warsaw Orthopedic, Inc. Drug delivery device and methods having an occluding member
EP3000489B1 (de) 2014-09-24 2017-04-05 Sofradim Production Verfahren zur Herstellung einer Antihaft-Sperrschicht
EP3000433B1 (de) 2014-09-29 2022-09-21 Sofradim Production Vorrichtung zur Einführung einer Prothese zur Hernie-Behandlung in einen Einschnitt und flexible textile Prothese
EP3000432B1 (de) 2014-09-29 2022-05-04 Sofradim Production Textilbasierte Prothese für die Behandlung von Leistenbruch
WO2016059635A1 (en) 2014-10-13 2016-04-21 Glusense Ltd. Analyte-sensing device
EP3029189B1 (de) 2014-12-05 2021-08-11 Sofradim Production Prothetisches poröses Netz, sein Herstellungsverfahren und Hernienprothese
US9238090B1 (en) 2014-12-24 2016-01-19 Fettech, Llc Tissue-based compositions
EP3059255B1 (de) 2015-02-17 2020-05-13 Sofradim Production Verfahren zur Herstellung einer Matrix auf Chitosanbasis mit faseroptischem Verstärkungselement
EP3085337B1 (de) 2015-04-24 2022-09-14 Sofradim Production Prothese zur unterstützung einer bruststruktur
AU2016267579B2 (en) 2015-05-27 2024-02-01 Neurotech Usa, Inc. Use of encapsulated cell therapy for treatment of ophthalmic disorders
EP3106185B1 (de) 2015-06-19 2018-04-25 Sofradim Production Synthetische prothese mit einem gewirk und einem nichtporösen film und verfahren zur formung davon
AU2016303048A1 (en) 2015-08-05 2018-03-01 Lockheed Martin Corporation Perforatable sheets of graphene-based material
MX2018001559A (es) 2015-08-06 2018-09-27 Lockheed Corp Modificacion de nanoparticula y perforacion de grafeno.
US10179128B2 (en) 2015-08-31 2019-01-15 Amicus Therapeutics, Inc. Regimens for treating and preventing lysosomal disorders and degenerative disorders of the central nervous system
JP6895674B2 (ja) * 2015-10-21 2021-06-30 国立大学法人 東京大学 マイクロチューブ、マイクロチューブの製造方法、及びマイクロチューブの製造装置
AU2016345063B2 (en) 2015-10-27 2021-08-05 The Council Of The Queensland Institute Of Medical Research A method of treatment and agents useful for same
US10076650B2 (en) 2015-11-23 2018-09-18 Warsaw Orthopedic, Inc. Enhanced stylet for drug depot injector
AU2016381968B2 (en) 2015-12-30 2020-03-19 Dexcom, Inc. Biointerface layer for analyte sensors
EP3195830B1 (de) 2016-01-25 2020-11-18 Sofradim Production Prothese zur hernienreparatur
CA3020874A1 (en) 2016-04-14 2017-10-19 Lockheed Martin Corporation Two-dimensional membrane structures having flow passages
EP3442697A4 (de) 2016-04-14 2020-03-18 Lockheed Martin Corporation Selektive grenzflächenminderung von graphendefekten
CA3020686A1 (en) 2016-04-14 2017-10-19 Lockheed Martin Corporation Method for treating graphene sheets for large-scale transfer using free-float method
WO2017183030A1 (en) 2016-04-20 2017-10-26 Glusense Ltd. Fret-based glucose-detection molecules
USD802755S1 (en) 2016-06-23 2017-11-14 Warsaw Orthopedic, Inc. Drug pellet cartridge
EP3272877A1 (de) 2016-07-18 2018-01-24 ETH Zurich B-zell-mimetische zellen
US20190282710A1 (en) 2016-07-18 2019-09-19 Eth Zurich B-cell-mimetic cells
NL2017294B1 (en) 2016-08-05 2018-02-14 Univ Erasmus Med Ct Rotterdam Natural cryptic exon removal by pairs of antisense oligonucleotides.
WO2018039203A1 (en) 2016-08-23 2018-03-01 Oncopep, Inc. Peptide vaccines and durvalumab for treating multiple myeloma
US20190209669A1 (en) 2016-08-23 2019-07-11 Oncopep, Inc. Peptide vaccines and durvalumab for treating breast cancer
EP3312325B1 (de) 2016-10-21 2021-09-22 Sofradim Production Verfahren zur herstellung eines netzes mit einem daran befestigten nahtmaterial mit widerhaken und dadurch erhaltenes netz
US11571444B2 (en) 2016-10-24 2023-02-07 United Therapeutics Corporation Enhancement of MSC immunomodulatory properties by treprostinil
US10434261B2 (en) 2016-11-08 2019-10-08 Warsaw Orthopedic, Inc. Drug pellet delivery system and method
JP7088564B2 (ja) 2016-11-10 2022-06-21 ヴィアサイト，インコーポレイテッド 細胞送達装置におけるｐｄｘ１膵臓内胚葉細胞及びその方法
JP6892874B2 (ja) * 2016-11-11 2021-06-23 富士フイルム株式会社 免疫隔離膜、移植用チャンバー、および移植用デバイス
EP3539575A4 (de) 2016-11-11 2019-11-13 FUJIFILM Corporation Immunisolationsmembran, transplantationskammer und transplantationsvorrichtung
SG10202107367SA (en) 2016-12-31 2021-08-30 Bioxcel Therapeutics Inc Use of sublingual dexmedetomidine for the treatment of agitation
WO2018200618A1 (en) 2017-04-25 2018-11-01 Amicus Therapeutics, Inc. Novel compositions for preventing and/or treating degenerative disorders of the central nervous system and/or lysosomal storage disorders
EP3398554B1 (de) 2017-05-02 2025-06-25 Sofradim Production Prothese zur leistenbruch reparatur
WO2019004378A1 (ja) 2017-06-29 2019-01-03 富士フイルム株式会社 移植用チャンバーおよび移植用デバイス
JP6870087B2 (ja) 2017-06-29 2021-05-12 富士フイルム株式会社 移植用チャンバー、移植用チャンバーの製造方法、移植用デバイス、および多孔質膜の融着方法
JP6790266B2 (ja) 2017-06-29 2020-11-25 富士フイルム株式会社 移植用チャンバーおよび移植用デバイス
US10744313B2 (en) 2017-07-27 2020-08-18 University Of Utah Research Foundation Therapeutic delivery device
CN111655280B (zh) 2017-09-01 2025-01-14 达纳-法伯癌症研究所股份有限公司 用于治疗癌症的bcma和taci抗原特异的免疫原性肽
WO2019083960A1 (en) 2017-10-24 2019-05-02 Oncopep, Inc. PEPTIDE VACCINES AND HDAC INHIBITORS FOR THE TREATMENT OF MULTIPLE MYELOMA
US11331022B2 (en) 2017-10-24 2022-05-17 Dexcom, Inc. Pre-connected analyte sensors
US12059463B2 (en) 2017-10-24 2024-08-13 Oncopep, Inc. Peptide vaccines and pembrolizumab for treating breast cancer
EP3928687B1 (de) 2017-10-24 2024-06-26 Dexcom, Inc. Tragbare vorrichtung mit vorverbundenem analytsensor
US11701379B2 (en) 2018-03-26 2023-07-18 Rhode Island Hospital In vitro and in vivo intracellular delivery of siRNA via self-assembled nanopieces
WO2019195055A1 (en) * 2018-04-04 2019-10-10 Sigilon Therapeutics, Inc. Implantable particles and related methods
ES3004544T3 (en) 2018-06-27 2025-03-12 Bioxcel Therapeutics Inc Film formulations containing dexmedetomidine and methods of producing them
UY38389A (es) * 2018-09-27 2020-04-30 Sigilon Therapeutics Inc Dispositivos implantables para terapia celular y métodos relacionados
US11160791B2 (en) 2018-11-01 2021-11-02 Medefil, Inc. Dexmedetomidine injection premix formulation in ready to use (RTU) bags
EP3653171B1 (de) 2018-11-16 2024-08-21 Sofradim Production Implantate zur weichgewebereparatur
US12448429B2 (en) 2019-03-06 2025-10-21 Dana-Farber Cancer Institute, Inc. T cell receptors specific to b-cell maturation antigen for treatment of cancer
CA3144606A1 (en) 2019-06-28 2020-12-30 Mochida Pharmaceutical Co., Ltd. Transplantation device using chemically crosslinked alginic acid
JP6601931B1 (ja) * 2019-07-17 2019-11-06 株式会社セルファイバ 細胞ファイバ製造システム、細胞ファイバ製造方法及びプログラム
US20240024288A1 (en) 2019-07-19 2024-01-25 Bioxcel Therapeutics, Inc. Non-sedating dexmedetomidine treatment regimens
EP3777827A1 (de) * 2019-08-14 2021-02-17 MaxiVax SA Implantierbare kapsel
CN116075326B (zh) * 2019-09-10 2025-12-16 加泰罗尼亚生物工程基础研究所 多层细胞胶囊及其用途
US11260146B2 (en) 2019-11-27 2022-03-01 Terumo Medical Corporation Seal-healing valve for a medical instrument
US12064330B2 (en) 2020-04-28 2024-08-20 Covidien Lp Implantable prothesis for minimally invasive hernia repair
EP4268855A4 (de) 2020-12-22 2024-09-04 Mochida Pharmaceutical Co., Ltd. Transplantationsvorrichtung mit chemisch vernetzter alginsäure
WO2022197982A1 (en) 2021-03-19 2022-09-22 Dexcom, Inc. Drug releasing membrane for analyte sensor
CA3217602A1 (en) 2021-05-06 2022-11-10 Kenneth Petersen Prevention and treatment of chemotherapy-induced neuropathic pain
EP4337694A1 (de) 2021-05-12 2024-03-20 Dana-Farber Cancer Institute, Inc. Lag3- und gal3-hemmer, xbp1, cs1 und cd138-peptide und verfahren zur verwendung davon
EP4401634A1 (de) 2021-09-15 2024-07-24 Dexcom, Inc. Bioaktive freisetzungsmembran für analytsensor
MX2024005230A (es) * 2021-10-29 2024-08-27 Sigilon Therapeutics Inc Composiciones para terapias basadas en celulas y metodos relacionados.
CN118488846A (zh) 2021-12-10 2024-08-13 霍巴治疗公司 伤害性疼痛的治疗
AU2023215476A1 (en) 2022-02-02 2024-08-22 Dexcom, Inc. Sensing systems and methods for diagnosing, staging, treating, and assessing risks of liver disease using monitored analyte data.
CA3234453A1 (en) 2022-02-23 2023-08-31 Dexcom, Inc. Sensing systems and methods for providing decision support around kidney health and/or diabetes
CN119451708A (zh) * 2022-04-28 2025-02-14 株式会社可乐丽 免疫隔离装置
AU2023278859A1 (en) 2022-06-01 2025-01-02 Dexcom, Inc. Systems and methods for optimizing treatment using physiological profiles
WO2024050126A2 (en) 2022-09-02 2024-03-07 Dexcom, Inc. Continuous analyte sensor devices and methods
JP2026501637A (ja) 2022-12-30 2026-01-16 デックスコム・インコーポレーテッド グルコース及びケトンのハイブリッド監視のための感知システム及び方法
US11806334B1 (en) 2023-01-12 2023-11-07 Bioxcel Therapeutics, Inc. Non-sedating dexmedetomidine treatment regimens
US20240342313A1 (en) 2023-03-30 2024-10-17 Pharma Cinq, Llc Vector encoding rod-derived cone viability factor and human igk signal sequence
WO2024216298A1 (en) 2023-04-14 2024-10-17 Dexcom, Inc. Sensing systems and methods for providing optimized exercise guidance to healthy hosts and athletes using continuously monitored analyte data
CN121174988A (zh) 2023-04-14 2025-12-19 德克斯康公司 用于使用连续监测的分析物数据向代谢不良用户提供优化的锻炼指导的感测系统和方法
US20250049355A1 (en) 2023-08-01 2025-02-13 Dexcom, Inc. Systems and methods for providing therapy management recommendations for diabetic patients and patients with liver disease
DE102023209675A1 (de) * 2023-10-02 2025-04-03 Robert Bosch Gesellschaft mit beschränkter Haftung Verfahren und Vorrichtung für das gezielte Binden einer Matrix einer Zellkultur
WO2025144778A1 (en) 2023-12-28 2025-07-03 Dexcom, Inc. Systems and methods for providing therapy management guidance related to liver disease decompensation to users with liver disease
US20250221642A1 (en) 2024-01-05 2025-07-10 Dexcom, Inc. Polymers with dual functionality
US20250311973A1 (en) 2024-04-09 2025-10-09 Dexcom, Inc. Systems and methods for providing therapy management guidance to patients to optimize glp-1 therapy effectiveness
WO2025226760A1 (en) 2024-04-22 2025-10-30 Dexcom, Inc. Systems and methods for providing therapy management guidance for diagnosis and management of kidney disease
US20260091133A1 (en) 2024-09-27 2026-04-02 Pharma Cinq, Llc Rod-derived cone viability factor fusion protein

Family Cites Families (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3093831A (en) * 1959-10-22 1963-06-18 Jordan Gerhard Paul Wilhelm Artificial gland
US3615024A (en) * 1968-08-26 1971-10-26 Amicon Corp High flow membrane
US4324683A (en) * 1975-08-20 1982-04-13 Damon Corporation Encapsulation of labile biological material
US4251387A (en) * 1979-04-17 1981-02-17 Damon Corporation Process for preparing semipermeable microcapsules
US4352883A (en) * 1979-03-28 1982-10-05 Damon Corporation Encapsulation of biological material
US4409331A (en) * 1979-03-28 1983-10-11 Damon Corporation Preparation of substances with encapsulated cells
US4391909A (en) * 1979-03-28 1983-07-05 Damon Corporation Microcapsules containing viable tissue cells
US4298002A (en) * 1979-09-10 1981-11-03 National Patent Development Corporation Porous hydrophilic materials, chambers therefrom, and devices comprising such chambers and biologically active tissue and methods of preparation
US4353888A (en) * 1980-12-23 1982-10-12 Sefton Michael V Encapsulation of live animal cells
US4407957A (en) * 1981-03-13 1983-10-04 Damon Corporation Reversible microencapsulation of a core material
NO161446C (no) * 1981-03-13 1989-08-16 Damon Biotech Inc Fremgangsmaate for dyrking av celler som er avhengige av forankring.
NO158284C (no) * 1981-03-13 1988-08-17 Damon Biotech Inc Fremgangsmaate for selektiv oppbrytning av en permeabel membran.
NO163060C (no) * 1981-03-13 1990-03-28 Damon Biotech Inc Fremgangsmaate for fremstilling av substanser som dannes av levende celler som produserer interferoner eller antistoffer.
WO1984001287A1 (en) * 1982-09-29 1984-04-12 Theodore E Spielberg Encapsulated genetically programmed living organisms producing therapeutic substances
US4479796A (en) * 1982-11-15 1984-10-30 Medtronic, Inc. Self-regenerating drug administration device
EP0127989A3 (de) * 1983-06-01 1986-03-26 Connaught Laboratories Limited Mikroverkapselung von lebenden Gewebe und Zellen
US4689293A (en) * 1983-06-06 1987-08-25 Connaught Laboratories Limited Microencapsulation of living tissue and cells
US4806355A (en) * 1983-06-06 1989-02-21 Connaught Laboratories Limited Microencapsulation of living tissue and cells
EP0147939A2 (de) * 1983-11-15 1985-07-10 JOHNSON & JOHNSON Einpflanzbarer Modul zur Regulierung der Glykämie
US4663286A (en) * 1984-02-13 1987-05-05 Damon Biotech, Inc. Encapsulation of materials
US4749620A (en) * 1984-02-15 1988-06-07 Massachusetts Institute Of Technology Encapsulated active material system
FR2559780B1 (fr) * 1984-02-21 1990-05-04 Tech Cuir Centre Systemes biocompatibles implantables a base de collagene permettant la conservation et/ou la culture cellulaires et/ou la liberation controlee de principes actifs
US4686098A (en) * 1984-05-14 1987-08-11 Merck & Co., Inc. Encapsulated mouse cells transformed with avian retrovirus-bovine growth hormone DNA, and a method of administering BGH in vivo
CA1215922A (en) * 1984-05-25 1986-12-30 Connaught Laboratories Limited Microencapsulation of living tissue and cells
DE3506288A1 (de) * 1984-09-06 1986-03-13 Johannes 7900 Ulm Reinmüller Vorrichtung zum einlegen in wunden und wundhoehlen
GB8500121D0 (en) * 1985-01-03 1985-02-13 Connaught Lab Microencapsulation of living cells
US4868121A (en) * 1985-02-07 1989-09-19 Mcdonnell Douglas Corporation Islet isolation process
US4663288A (en) * 1985-05-22 1987-05-05 Nabisco Brands, Inc. Process for purification of enzymes
US4997443A (en) * 1985-08-26 1991-03-05 Hana Biologics, Inc. Transplantable artificial tissue and process
US4902295A (en) * 1985-08-26 1990-02-20 Hana Biologics, Inc. Transplantable artificial tissue
US4976709A (en) * 1988-12-15 1990-12-11 Sand Bruce J Method for collagen treatment
DE3545237A1 (de) * 1985-12-20 1987-06-25 Juergen Dr Med Schrezenmeir Vorrichtung fuer die aufnahme und zum einbringen von geweben in den menschlichen koerper sowie hierfuer verwendbares instrument
ES2024418B3 (es) * 1985-12-26 1992-03-01 Taisho Pharmaceutical Co Ltd Capsula blanda sin costura.
AU6940087A (en) * 1986-01-23 1987-08-14 Ltl Associates Covalent membranes
IL79052A0 (en) * 1986-06-06 1986-11-30 Univ Ramot Device and process for production of alginate-shell beads containing biologically active material
WO1988000237A1 (en) * 1986-06-27 1988-01-14 Damon Biotech, Inc. Covalent membranes
US4883666A (en) * 1987-04-29 1989-11-28 Massachusetts Institute Of Technology Controlled drug delivery system for treatment of neural disorders
US5026365A (en) * 1987-04-29 1991-06-25 The University Of Massachusetts Method and apparatus for therapeutically treating immunological disorders and disease states
US4911717A (en) * 1987-06-18 1990-03-27 Gaskill Iii Harold V Intravasular artificial organ
US4942129A (en) * 1987-07-28 1990-07-17 Queen's University At Kingston Multiple membrane microencapsulation
GB2212067B (en) * 1987-11-12 1991-08-07 Michael Robin Baugh Board game apparatus
US5182111A (en) * 1987-11-17 1993-01-26 Boston University Research Foundation In vivo delivery of active factors by co-cultured cell implants
US5156844A (en) * 1987-11-17 1992-10-20 Brown University Research Foundation Neurological therapy system
US5106627A (en) * 1987-11-17 1992-04-21 Brown University Research Foundation Neurological therapy devices
US5283187A (en) * 1987-11-17 1994-02-01 Brown University Research Foundation Cell culture-containing tubular capsule produced by co-extrusion
US5158881A (en) * 1987-11-17 1992-10-27 Brown University Research Foundation Method and system for encapsulating cells in a tubular extrudate in separate cell compartments
US4892538A (en) * 1987-11-17 1990-01-09 Brown University Research Foundation In vivo delivery of neurotransmitters by implanted, encapsulated cells
GB2211103A (en) * 1987-12-18 1989-06-28 Flaxman Binns Frances Julia Toy or games equipment
US5011472A (en) * 1988-09-06 1991-04-30 Brown University Research Foundation Implantable delivery system for biological factors
US5011486A (en) * 1988-11-18 1991-04-30 Brown University Research Foundation Composite nerve guidance channels
US5082670A (en) * 1988-12-15 1992-01-21 The Regents Of The University Of California Method of grafting genetically modified cells to treat defects, disease or damage or the central nervous system
JP2738881B2 (ja) * 1989-06-21 1998-04-08 ブラウン ユニバーシティ リサーチ ファウンデイション 神経治療システム
WO1991000119A1 (en) * 1989-06-30 1991-01-10 Baxter International Inc. Implantable device
EP0480976B1 (de) * 1989-07-01 1994-04-13 ZF FRIEDRICHSHAFEN Aktiengesellschaft Rückschaltsicherung
US5002661A (en) * 1989-08-25 1991-03-26 W. R. Grace & Co.-Conn. Artificial pancreatic perfusion device
CA2040429C (en) * 1989-09-04 1996-12-17 Yoshihiro Tomita Relay and exchange system for time division multiplex data
GB2238059A (en) * 1989-11-17 1991-05-22 Command International Inc Electrolytic gas generating apparatus for producing a combustible mixture of hydrogen and oxygen by electrolysis of water for particular use in gas welding
EP0502949A4 (en) * 1989-12-05 1993-02-24 Trancel Corporation Homologous guluronic acid alginate coating composition for in-vivo application and implantation and method of using same
WO1991009119A1 (en) * 1989-12-13 1991-06-27 Trancel Corporation Improved alginate microcapsules, methods of making and using same
WO1991010470A1 (en) * 1990-01-08 1991-07-25 Brown University Research Foundation Devices and methods for enhanced delivery of active factors
US5084350A (en) * 1990-02-16 1992-01-28 The Royal Institution For The Advance Of Learning (Mcgill University) Method for encapsulating biologically active material including cells
AU651654B2 (en) * 1992-01-14 1994-07-28 Endo Pharmaceuticals Solutions Inc. Manufacture of water-swellable hydrophilic articles and drug delivery devices
WO1992007525A1 (en) * 1990-10-31 1992-05-14 Baxter International Inc. Close vascularization implant material
US5144069A (en) * 1990-12-13 1992-09-01 Minnesota Mining And Manufacturing Company Process for the preparation of fluoroaliphatic aminocarboxylate surfactants
US5158844A (en) * 1991-03-07 1992-10-27 The Dexter Corporation Battery separator
SG47470A1 (en) 1991-04-25 1998-04-17 Univ Brown Res Found Implantable biocompatible immunoisolatory vehicle for delivery of a selected therapeutic products
WO1993000128A1 (en) * 1991-06-28 1993-01-07 Brown University Research Foundation Renewable neural implant device and method
ATE161707T1 (de) * 1991-06-28 1998-01-15 Univ Brown Res Found Kapselextrusionssysteme
DK0550719T3 (da) * 1991-06-28 1997-09-01 Univ Brown Res Found Neutralt implanteringssystem
AU2502592A (en) * 1991-08-23 1993-03-16 Denise Faustman Implantable immunoisolated therapeutic devices
AU4114493A (en) * 1992-04-24 1993-11-29 Polymer Technology Group, Inc., The Method of culturing viable cells and method of regulating the level of a compound in a body fluid
WO1993021902A1 (en) * 1992-04-24 1993-11-11 Somatix Therapy Corporation Biocompatible, therapeutic, implantable device
BE1009510A5 (nl) * 1995-07-24 1997-04-01 Dijk Aart Van Programmeerbare logische besturingseenheid.

Also Published As

Publication number Publication date
US6960351B2 (en) 2005-11-01
US5871767A (en) 1999-02-16
NO933842L (no) 1993-10-25
US6083523A (en) 2000-07-04
EP0585368B1 (de) 1997-08-06
EP0585368A4 (de) 1994-04-13
JP4215273B2 (ja) 2009-01-28
JPH06507412A (ja) 1994-08-25
AU682796B2 (en) 1997-10-16
US5834001A (en) 1998-11-10
AU666118B2 (en) 1996-02-01
US20040185083A1 (en) 2004-09-23
US5798113A (en) 1998-08-25
NO308198B1 (no) 2000-08-14
FI934545A0 (fi) 1993-10-14
DE69221484D1 (de) 1997-09-11
US5800828A (en) 1998-09-01
US5869077A (en) 1999-02-09
CA2109085C (en) 2003-03-11
US5874099A (en) 1999-02-23
US6322804B1 (en) 2001-11-27
DK0585368T3 (da) 1998-03-16
JP2007314569A (ja) 2007-12-06
DE69221484T2 (de) 1998-02-19
GR3025301T3 (en) 1998-02-27
HK1001832A1 (en) 1998-07-10
CA2109085A1 (en) 1992-10-26
WO1992019195A1 (en) 1992-11-12
AU2004192A (en) 1992-12-21
US20020150603A1 (en) 2002-10-17
SG47470A1 (en) 1998-04-17
AU3902095A (en) 1996-02-01
FI934545A7 (fi) 1993-12-01
EP0585368A1 (de) 1994-03-09
ES2107537T3 (es) 1997-12-01

Similar Documents

Publication Publication Date Title
DE69221484D1 (de) Implantierbare, biokompatible immunisolator-trägersubstanz zum abgeben ausgesuchter, therapeutischer produkte
Orive et al. Biocompatibility of microcapsules for cell immobilization elaborated with different type of alginates
Jang et al. Immune reactions of lymphocytes and macrophages against PEG-grafted pancreatic islets
AU7432796A (en) Retrievable bioartificial implants
CA2166074A1 (en) Implantable system for cell growth control
AU6989094A (en) Compositions and methods for treating cancer and hyperproliferative disorders
HUT64595A (en) Method for producing mammalian cytokine, il-11
Bubbers et al. Studies on the synthetic capacity and antigenic expression of glutaraldehyde-fixed target cells
EP0127989A3 (de) Mikroverkapselung von lebenden Gewebe und Zellen
DE2967036D1 (en) Vaccine and method of making
Morrow et al. H-2 antigen class: effect on mouse islet allograft rejection
CA2250880A1 (en) Implantable agarose-collagen beads containing cells which produce a diffusible biological product, and uses thereof
Rokstad et al. Transplantation of alginate microcapsules with proliferating cells in mice: capsular overgrowth and survival of encapsulated cells of mice and human origin
Weber The in vitro response of chicken B cell populations to lipopolysaccharide
GR3022646T3 (en) Composition for controlled release of an active substance and method for the preparation of such a composition.
King et al. The role of capsule composition and biologic responses in the function of transplanted microencapsulated islets of langerhans1
PT1227824E (pt) Dispositivo de transplante/implante e metodo para a sua producao
WO2002100335A2 (en) Methods for improving cell line activity in immunoisolation devices
Miura et al. In Vitro Effect of Erythropoietin on the Spleen of the Polycythemic Mouse, III: Limited Exposure to Erythropietin and Actinomycin D
EP0328420A3 (de) De-N-acetylsialsäure enthaltende Ganglioside und ihre Verwendung als Modifikatoren der Zellphysiologie
Ghiladi et al. Compounds stimulating growth and multiplication in ciliates
Palladino et al. Induction in B2/B2 chickens of immunity to transplantable carcinogen-induced fibrosarcomas mediated by T-cell monocyte cooperation: Role of delayed hypersensitivity to unrelated antigens
Jara et al. Sequential co-transplantation of hepatic cells and pancreatic islets in wistar rats with long-evans or wistar rats as recipients
Tomomatsu et al. Application of a Local Drug Delivery System to Periodontal Therapy
Kaplan et al. Interferon-gamma production: an in vitro model utilizing cell encapsulation technology

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification