ES2063851T3 - Compuestos con accion selectiva sobre receptores de adenosina. - Google Patents

Compuestos con accion selectiva sobre receptores de adenosina.

Info

Publication number
ES2063851T3
ES2063851T3 ES90105919T ES90105919T ES2063851T3 ES 2063851 T3 ES2063851 T3 ES 2063851T3 ES 90105919 T ES90105919 T ES 90105919T ES 90105919 T ES90105919 T ES 90105919T ES 2063851 T3 ES2063851 T3 ES 2063851T3
Authority
ES
Spain
Prior art keywords
adenosine
activity
compounds
adenosine receptors
selective action
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90105919T
Other languages
English (en)
Inventor
Norton P Peet
Nelsen L Lentz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2063851T3 publication Critical patent/ES2063851T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)

Abstract

ES DESCUBIERTA ADENOSINA QUE ACTUA SELECTIVAMENTE EN RECEPTORES DE ADENOSINA Y QUE ACTUA EN GENERAL COMO ANTAGONISTAS DE ADENOSINA. DE ESTUDIOS IN VITRO ES CONOCIDO QUE LOS EFECTOS FISIOLOGICOS ESPECIFICOS PUEDEN SER DISTINGUIDOS COMO RESULTADO DE ESTA SELECTIVIDAD Y QUE LA ACTIVIDAD DEL RECEPTOR DE ADENOSINA IN VITRO SE CORRELACIONA CON LA ACTIVIDAD DEL RECEPTOR DE ADENOSINA IN VIVO. LAS PREPARACIONES FARMACEUTICAS DE LOS COMPONENTES SOMETIDOS PUEDEN SER PREPARADOS EN LAS BASES DE LA ACTIVIDAD ENLAZANTE SELECTIVA DE LOS COMPONENTES DESCUBIERTOS AQUI, QUE PUEDEN SER ESPERADOS PARA INCREMENTAR CIERTOS EFECTOS FISIOLOGICOS MIENTRAS SE MINIMIZAN OTROS, TALES COMO DISMINUIR LA PRESION SANGUINEA SIN DISMINUIR EL RITMO DEL CORAZON.
ES90105919T 1989-03-29 1990-03-28 Compuestos con accion selectiva sobre receptores de adenosina. Expired - Lifetime ES2063851T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US33040089A 1989-03-29 1989-03-29

Publications (1)

Publication Number Publication Date
ES2063851T3 true ES2063851T3 (es) 1995-01-16

Family

ID=23289598

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90105919T Expired - Lifetime ES2063851T3 (es) 1989-03-29 1990-03-28 Compuestos con accion selectiva sobre receptores de adenosina.

Country Status (18)

Country Link
EP (1) EP0390111B1 (es)
JP (1) JP3014000B2 (es)
KR (1) KR0150635B1 (es)
CN (1) CN1029972C (es)
AR (1) AR245720A1 (es)
AT (1) ATE111466T1 (es)
AU (1) AU623755B2 (es)
CA (1) CA2013381C (es)
DE (1) DE69012388T2 (es)
ES (1) ES2063851T3 (es)
FI (1) FI95133C (es)
HU (1) HU203349B (es)
IE (1) IE63545B1 (es)
IL (1) IL93893A (es)
NO (1) NO173997C (es)
NZ (1) NZ233077A (es)
PT (1) PT93589B (es)
ZA (1) ZA902282B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2988711B2 (ja) * 1989-10-20 1999-12-13 協和醗酵工業株式会社 縮合プリン誘導体
ZA914727B (en) * 1990-06-21 1992-03-25 Schering Corp Polycyclic guanine derivatives
DE19629378A1 (de) * 1996-07-20 1998-01-29 Boehringer Ingelheim Kg Neue Triazolopurine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
ES2238335T3 (es) * 1999-12-24 2005-09-01 Kyowa Hakko Kogyo Co., Ltd. Derivados de purina condensados.

Also Published As

Publication number Publication date
EP0390111A2 (en) 1990-10-03
HU901857D0 (en) 1990-08-28
IE901142L (en) 1990-09-29
JP3014000B2 (ja) 2000-02-28
NZ233077A (en) 1992-12-23
CA2013381C (en) 2000-06-20
KR0150635B1 (ko) 1998-10-15
CN1045974A (zh) 1990-10-10
KR900014390A (ko) 1990-10-23
NO901424D0 (no) 1990-03-28
ZA902282B (en) 1990-12-28
PT93589B (pt) 1996-06-28
DE69012388T2 (de) 1995-04-27
IE63545B1 (en) 1995-05-17
JPH02289574A (ja) 1990-11-29
AU5218290A (en) 1990-10-04
NO173997C (no) 1994-03-02
IL93893A (en) 1994-07-31
FI95133C (fi) 1995-12-27
EP0390111B1 (en) 1994-09-14
PT93589A (pt) 1990-11-20
AR245720A1 (es) 1994-02-28
DE69012388D1 (de) 1994-10-20
IL93893A0 (en) 1990-12-23
CA2013381A1 (en) 1990-09-29
FI901550A0 (fi) 1990-03-28
EP0390111A3 (en) 1991-05-08
ATE111466T1 (de) 1994-09-15
HU203349B (en) 1991-07-29
FI95133B (fi) 1995-09-15
AU623755B2 (en) 1992-05-21
NO173997B (no) 1993-11-22
NO901424L (no) 1990-10-01
CN1029972C (zh) 1995-10-11
HUT54160A (en) 1991-01-28

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